Smoothing reference centile curves: The lms method and penalized likelihood

Statistics in Medicine - Tập 11 Số 10 - Trang 1305-1319 - 1992
Tim Cole1, P. J. Green2
1MRC Dunn Nutrition Unit, Cambridge, U.K.
2Department of Mathematics, University of Bristol, Bristol BS8 1TW, U. K.

Tóm tắt

AbstractReference centile curves show the distribution of a measurement as it changes according to some covariate, often age. The LMS method summarizes the changing distribution by three curves representing the median, coefficient of variation and skewness, the latter expressed as a Box‐Cox power. Using penalized likelihood the three curves can be fitted as cubic splines by non‐linear regression, and the extent of smoothing required can be expressed in terms of smoothing parameters or equivalent degrees of freedom. The method is illustrated with data on triceps skinfold in Gambian girls and women, and body weight in U.S.A. girls.

Từ khóa


Tài liệu tham khảo

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Thông tin xuất bản

Statistics in Medicine

Tập 11 Số 10

1305-1319

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