Small interfering RNA for cancer treatment: overcoming hurdles in delivery

Acta Pharmaceutica Sinica B - Tập 10 Số 11 - Trang 2075-2109 - 2020
Nitin B. Charbe1,2, Nikhil D. Amnerkar3, B. Ramesh2, Murtaza M. Tambuwala4, Hamid A. Bakshi4, Alaa A. A. Aljabali5, Saurabh C. Khadse6, Rajendran Satheeshkumar1, Saurabh Satija7,8, Meenu Metha7,8, Dinesh Kumar Chellappan9, Garima Shrivastava10, Gaurav Gupta11, Poonam Negi12, Kamal Dua7,13,12, Flavia C. Zacconi14
1Departamento de Quimica Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile
2Sri Adichunchunagiri College of Pharmacy, Sri Adichunchunagiri University, BG Nagar, Karnataka 571418, India
3Adv V. R. Manohar Institute of Diploma in Pharmacy, Nagpur, Maharashtra 441110, India
4School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, Northern Ireland BT52 1SA, UK
5Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University, Irbid 21163, Jordan
6Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Dist. Dhule, Maharashtra 425 405, India
7Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW, 2007, Australia
8School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India
9Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia
10Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi, 110016, India
11School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, 302017, India
12School of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, India
13Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) and School of Biomedical Sciences and Pharmacy, University of Newcastle, NSW 2308, Australia
14Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago 4860, Chile

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