Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis: Residence Time and in Vivo Activity

ACS Chemical Biology - Tập 4 Số 3 - Trang 221-231 - 2009
Hao Lu1, Kathleen England2, Christopher am Ende3, J.J. Truglio4, Sylvia R. Luckner5, Bharat Reddy3, Nicole L. Marlenee2, Susan E. Knudson2, D. L. Knudson2, Richard A. Bowen2, Caroline Kisker5, Richard A. Slayden2, Peter J. Tonge3
1Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York11794-3400, USA.
2Rocky Mountain Regional Center of Excellence and Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682
3Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400
4Center for Structural Biology, Stony Brook University, Stony Brook, New York 11794-5115
5Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, Versbacher Str. 9, 97078 Würzburg, Germany

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