Rối loạn giấc ngủ ở những người sống sót trưởng thành sau khối u não ở trẻ em

Springer Science and Business Media LLC - Tập 22 - Trang 781-789 - 2012
Vikki G. Nolan1, Roxanna Gapstur2, Cynthia R. Gross2,3, Lauren A. DeSain4, Joseph P. Neglia5, Amar Gajjar6, James L. Klosky7, Thomas E. Merchant8, Marilyn Stovall9, Kirsten K. Ness10
1Department of Epidemiology and Biostatistics, University of Memphis, School of Public Health, Memphis, USA
2School of Nursing, University of Minnesota Medical School, Minneapolis, USA
3College of Pharmacy, University of Minnesota Medical School, Minneapolis, USA
4School of Public Health, University of Memphis, Memphis, USA
5Department of Pediatrics, University of Minnesota Medical School, Minneapolis, USA
6Departments of Oncology, St. Jude Children’s Research, Memphis, USA
7Department of Psychology, St. Jude Children’s Research, Memphis, USA
8Department of Radiological Sciences, St. Jude Children’s Research, Memphis, USA
9Department of Radiation Physics, MD Anderson Cancer Center, Houston, USA
10Department of Epidemiology And Cancer Control, St. Jude Children’s Research Hospital, Memphis, USA

Tóm tắt

Mục tiêu của nghiên cứu này là so sánh chất lượng giấc ngủ tự báo cáo ở những người sống sót trưởng thành sau khối u não thời thơ ấu và một nhóm đối chứng dựa trên dân số, xác định các yếu tố liên quan đến điều trị ảnh hưởng đến rối loạn giấc ngủ, và xác định tác động của béo phì sau điều trị và trầm cảm đến điểm số giấc ngủ ở những người sống sót trưởng thành sau khối u não thời thơ ấu. Những người sống sót trưởng thành được lựa chọn ngẫu nhiên (n = 78) và các thành viên của nhóm đối chứng phù hợp theo độ tuổi, giới tính và mã bưu chính (n = 78) đã hoàn thành chỉ số chất lượng giấc ngủ Pittsburgh và Bảng kiểm triệu chứng ngắn. Chất lượng giấc ngủ và tác động của các đặc điểm nhân khẩu học, điều trị và đặc điểm sau điều trị đã được đánh giá bằng phân tích hồi quy tuyến tính và logistic. Những người sống sót bệnh khối u não có khả năng mất hơn 30 phút để ngủ nhiều hơn 2.7 lần (95 % CI, 1.1, 6.5) so với nhóm đối chứng. Phụ nữ trong cả hai nhóm báo cáo chất lượng giấc ngủ kém hơn và chức năng ban ngày bị suy giảm. Trong số những người sống sót, tình trạng béo phì sau điều trị liên quan đến chức năng ban ngày kém. Những kết quả này đồng ý với các nghiên cứu trước đó liên quan đến giấc ngủ, giới tính và béo phì và xác định thời gian chờ đợi để ngủ lâu hơn là một vấn đề ở những người sống sót bệnh khối u não thời thơ ấu. Cần có thêm nghiên cứu để xác định các yếu tố ảnh hưởng đến thời gian chờ đợi ngủ và tác động của chúng đến chất lượng cuộc sống của những người sống sót trưởng thành sau khối u não ở thời thơ ấu.

Từ khóa

#rối loạn giấc ngủ #khối u não trẻ em #người sống sót trưởng thành #béo phì #trầm cảm #chất lượng giấc ngủ

Tài liệu tham khảo

American Brain Tumor. (2008). Association, Facts and Statistics. Anderson, D. M., et al. (2001). Medical and neurocognitive late effects among survivors of childhood central nervous system tumors. Cancer, 92(10), 2709–2719. Hudson, M. M., et al. (2003). Health status of adult long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. JAMA: The Journal of the American Medical Association, 290(12), 1583–1592. Mostow, E. N., et al. (1991). Quality of life in long-term survivors of CNS tumors of childhood and adolescence. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 9(4), 592–599. Pelletier, G., et al. (2002). Quality of life in brain tumor patients: the relative contributions of depression, fatigue, emotional distress, and existential issues. Journal of Neuro-Oncology, 57(1), 41–49. Clanton, N. R. et al. (2011). Fatigue, vitality, sleep, and neurocognitive functioning in adult survivors of childhood cancer: A report from the childhood cancer survivor study. Cancer, 117(11), 2559–2568. Mulrooney, D. A., et al. (2008). Fatigue and sleep disturbance in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS). Sleep, 31(2), 271–281. Poretti, A., et al. (2004). Outcome of craniopharyngioma in children: Long-term complications and quality of life. Developmental Medicine and Child Neurology, 46(4), 220–229. van der Klaauw, A. A., et al. (2007). Increased daytime somnolence despite normal sleep patterns in patients treated for nonfunctioning pituitary macroadenoma. The Journal of Clinical Endocrinology and Metabolism, 92(10), 3898–3903. Di Gennaro, G., et al. (2004). Night terrors associated with thalamic lesion. Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology, 115(11), 2489–2492. Mandrell, B. N. et al. (2012). Excessive daytime sleepiness and sleep-disordered breathing disturbances in survivors of childhood central nervous system tumors. Pediatric blood and cancer, 58(5), 746–751. Marcus, C. L., et al. (2002). Secondary narcolepsy in children with brain tumors. Sleep, 25(4), 435–439. Szucs, A., et al. (2001). Insomnia and fronto-basal tumor: A case report. European Neurology, 46(1), 54–56. Zambelis, T., Paparrigopoulos, T., & Soldatos, C. R. (2002). REM sleep behaviour disorder associated with a neurinoma of the left pontocerebellar angle. Journal of Neurology, Neurosurgery and Psychiatry, 72(6), 821–822. Constine, L. S., et al. (1993). Hypothalamic-pituitary dysfunction after radiation for brain tumors. The New England Journal of Medicine, 328(2), 87–94. Heikens, J., et al. (1998). Long-term neuro-endocrine sequelae after treatment for childhood medulloblastoma. European Journal of Cancer, 34(10), 1592–1597. Arii, J., et al. (2001). A hypersomnolent girl with decreased CSF hypocretin level after removal of a hypothalamic tumor. Neurology, 56(12), 1775–1776. Nishino, S., et al. (2000). Hypocretin (orexin) deficiency in human narcolepsy. Lancet, 355(9197), 39–40. Selbach, O., & Haas, H. L. (2006). Hypocretins: The timing of sleep and waking. Chronobiology International, 23(1–2), 63–70. Taheri, S., Zeitzer, J. M., & Mignot, E. (2002). The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annual Review of Neuroscience, 25, 283–313. Gurney, J. G., et al. (2003). Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study. Cancer, 97(3), 663–673. Lustig, R. H., et al. (2003). Risk factors for the development of obesity in children surviving brain tumors. The Journal of Clinical Endocrinology and Metabolism, 88(2), 611–616. Rosen, G. M., et al. (2003). Sleep in children with neoplasms of the central nervous system: Case review of 14 children. Pediatrics, 112(1 Pt 1), e46–e54. Armitage, R. (2000). The effects of antidepressants on sleep in patients with depression. Canadian Journal of Psychiatry. Revue canadienne de psychiatrie, 45(9), 803–809. American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders (4th ed.) text rev. Washington, American Psychiatric Association. Piccinelli, M., & Wilkinson, G. (2000). Gender differences in depression. Critical review. The British Journal of Psychiatry: The Journal of Mental science, 177, 486–492. Baldwin, D. S., & Papakostas, G. I. (2006). Symptoms of fatigue and sleepiness in major depressive disorder. The Journal of Clinical Psychiatry, 67(Suppl 6), 9–15. Zebrack, B. J., et al. (2004). Psychological outcomes in long-term survivors of childhood brain cancer: A report from the childhood cancer survivor study. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 22(6), 999–1006. Ness, K. K., et al. (2010). Physical performance limitations among adult survivors of childhood brain tumors. Cancer, 116(12), 3034–3044. Buysse, D. J., et al. (1991). Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI). Sleep, 14(4), 331–338. Derogatis, L. (2000). BSI-18, administration, scoring and procedures manual. Mineappolis: National Computer Systems. Derogatis, L. R., & Melisaratos, N. (1983). The Brief Symptom Inventory: An introductory report. Psychological Medicine, 13(3), 595–605. Recklitis, C. J., et al. (2006). Factor structure of the brief symptom inventory-18 in adult survivors of childhood cancer: Results from the childhood cancer survivor study. Psychological Assessment, 18(1), 22–32. Packer, R. J., et al. (2003). Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: Childhood cancer survivor study. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 21(17), 3255–3261. Fisher, R. (1922). On the interpretation of Χ2 from contingency tables, and the calculation of P. Journal of the Royal Statistical Society, 85(1), 87–94. Lichstein, K. L., et al. (2003). Quantitative criteria for insomnia. Behaviour Research and Therapy, 41(4), 427–445. Geisler, P., et al. (2006). The influence of age and sex on sleep latency in the MSLT-30—a normative study. Sleep, 29(5), 687–692. Baldwin, C. M., et al. (2004). Associations between gender and measures of daytime somnolence in the Sleep Heart Health Study. Sleep, 27(2), 305–311. Breslau, N., et al. (1996). Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young adults. Biological Psychiatry, 39(6), 411–418. Hara, C., Lopes Rocha F., & Lima-Costa M. F. (2004). Prevalence of excessive daytime sleepiness and associated factors in a Brazilian community: The Bambui study. Sleep Medicine, 5(1):31–36. Hublin, C., et al. (1996). Daytime sleepiness in an adult, Finnish population. Journal of Internal Medicine, 239(5), 417–423. Stradling, J. R., et al. (2000). Prevalence of sleepiness and its relation to autonomic evidence of arousals and increased inspiratory effort in a community based population of men and women. Journal of Sleep Research, 9(4), 381–388. Young, T. B. (2004). Epidemiology of daytime sleepiness: Definitions, symptomatology, and prevalence. The Journal of Clinical Psychiatry, 65(Suppl 16), 12–16. Muller, H. L., et al. (2002). Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients. The Journal of Clinical Endocrinology and Metabolism, 87(8), 3993–3996. Holbrook, A. M., et al. (2000). Meta-analysis of benzodiazepine use in the treatment of insomnia. CMAJ: Canadian Medical Association Journal = journal de l’Association medicale canadienne, 162(2):225–233. Morin, C. M., et al. (2006). Psychological and behavioral treatment of insomnia: Update of the recent evidence (1998–2004). Sleep, 29(11), 1398–1414. Morin, C. M., et al. (1999). Nonpharmacologic treatment of chronic insomnia. An American Academy of Sleep Medicine review. Sleep, 22(8), 1134–1156. National Institutes of Health. (2005). NIH State-of-the-Science conference statement on manifestations and management of chronic insomnia in adults. In NIH consensus state sci statements. Nowell, P. D., et al. (1997). Benzodiazepines and zolpidem for chronic insomnia: A meta-analysis of treatment efficacy. JAMA: The Journal of the American Medical Association, 278(24), 2170–2177. Ritterband, L. M., et al. (2011). Initial evaluation of an Internet intervention to improve the sleep of cancer survivors with insomnia. Psycho-oncology. doi:10.1002/pon.1969. Wade, A. G., et al. (2010). Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: A randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC Medicine, 8, 51. Buscemi, N., et al. (2005). The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. Journal of General Internal Medicine, 20(12), 1151–1158. Buscemi, N., et al. (2006). Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: Meta-analysis. BMJ, 332(7538), 385–393.