Skin Immunity
Tóm tắt
Từ khóa
Tài liệu tham khảo
Ackermann L, Harvima IT, Pelkonen J et al (1999) Mast cells in psoriatic skin are strongly positive for interferon-gamma. Br J Dermatol 140:624–633
Agerberth B, Charo J, Werr J et al (2000) The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 96:3086–3093
Agius E, Lacy KE, Vukmanovic-Stejic M et al (2009) Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J Exp Med 206:1929–1940
Ahmadzadeh M, Felipe-Silva A, Heemskerk B et al (2008) FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions. Blood 112:4953–4960
Albanesi C, Scarponi C, Giustizieri ML et al (2005) Keratinocytes in inflammatory skin diseases. Curr Drug Targets Inflamm Allergy 4:329–334
Angel CE, Lala A, Chen CJ et al (2007) CD14+ antigen-presenting cells in human dermis are less mature than their CD1a + counterparts. Int Immunol 19:1271–1279
Auffray C, Sieweke MH, Geissmann F (2009) Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 27:669–692
Baeke F, Korf H, Overbergh L et al (2011) The vitamin D analog, TX527, promotes a human CD4+ CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation. J Immunol 186:132–142
Bedoui S, Whitney PG, Waithman J et al (2009) Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol 10:488–495
Bergstresser PR, Sullivan S, Streilein JW et al (1985) Origin and function of Thy-1+ dendritic epidermal cells in mice. J Invest Dermatol 85(1 Suppl):85s–90s
Biggs L, Yu C, Fedoric B et al (2010) Evidence that vitamin D(3) promotes mast cell-dependent reduction of chronic UVB-induced skin pathology in mice. J Exp Med 207:455–463
Black AP, Ardern-Jones MR, Kasprowicz V et al (2007) Human keratinocyte induction of rapid effector function in antigen-specific memory CD4+ and CD8+ T cells. Eur J Immunol 37:1485–1493
Blair RJ, Meng H, Marchese MJ et al (1997) Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor. J Clin Invest 99:2691–2700
Bonish B, Jullien D, Dutronc Y et al (2000) Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-gamma production by NK-T cells. J Immunol 165:4076–4085
Borkowski TA, Letterio JJ, Farr AG et al (1996) A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells. J Exp Med 184:2417–2422
Bos JD, Zonneveld I, Das PK et al (1987) The skin immune system (SIS): distribution and immunophenotype of lymphocyte subpopulations in normal human skin. J Invest Dermatol 88:569–573
Boyden LM, Lewis JM, Barbee SD et al (2008) Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells. Nat Genet 40:656–662
Boyman O, Hefti HP, Conrad C et al (2004) Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha. J Exp Med 199:731–736
Boyman O, Conrad C, Dudli C et al (2005) Activation of dendritic antigen-presenting cells expressing common heat shock protein receptor CD91 during induction of psoriasis. Br J Dermatol 152:1211–1218
Boyman O, Conrad C, Tonel G et al (2007) The pathogenic role of tissue-resident immune cells in psoriasis. Trends Immunol 28:51–57
Buddenkotte J, Stroh C, Engels IH et al (2005) Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B. J Invest Dermatol 124:38–45
Byrne SN, Limon-Flores AY, Ullrich SE (2008) Mast cell migration from the skin to the draining lymph nodes upon ultraviolet irradiation represents a key step in the induction of immune suppression. J Immunol 180:4648–4655
Cai Y, Shen X, Ding C et al (2011) Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation. Immunity 35:596–610
Castle SC, Norman DC, Perls TT et al (1990) Analysis of cutaneous delayed-type hypersensitivity reaction and T cell proliferative response in elderly nursing home patients: an approach to identifying immunodeficient patients. Gerontology 36:217–229
Chacon-Salinas R, Limon-Flores AY, Chavez-Blanco AD et al (2011) Mast cell-derived IL-10 suppresses germinal center formation by affecting T follicular helper cell function. J Immunol 186:25–31
Clark RA (2010) Skin-resident T cells: the ups and downs of on site immunity. J Invest Dermatol 130:362–370
Clark RA, Chong B, Mirchandani N et al (2006) The vast majority of CLA+ T cells are resident in normal skin. J Immunol 176:4431–4439
Clark RA, Huang SJ, Murphy GF et al (2008) Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med 205:2221–2234
Conrad C, Boyman O, Tonel G et al (2007) Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med 13:836–842
Curtis BJ, Radek KA (2012) Cholinergic regulation of keratinocyte innate immunity and permeability barrier integrity: new perspectives in epidermal immunity and disease. J Invest Dermatol 132:28–42
Dawicki W, Marshall JS (2007) New and emerging roles for mast cells in host defence. Curr Opin Immunol 19:31–38
de Jongh GJ, Zeeuwen PL, Kucharekova M et al (2005) High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis. J Invest Dermatol 125:1163–1173
Demehri S, Turkoz A, Kopan R (2009) Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell 16:55–66
Dieu-Nosjean MC, Massacrier C, Homey B et al (2000) Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J Exp Med 192:705–718
Douaiher J, Succar J, Lancerotto L et al (2014) Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing. Adv Immunol 122:211–252
Dubois B, Bridon JM, Fayette J et al (1999) Dendritic cells directly modulate B cell growth and differentiation. J Leukoc Biol 66:224–230
Edele F, Molenaar R, Gutle D et al (2008) Cutting edge: instructive role of peripheral tissue cells in the imprinting of T cell homing receptor patterns. J Immunol 181:3745–3749
Egawa G, Kabashima K (2011) Skin as a peripheral lymphoid organ: revisiting the concept of the skin-associated lymphoid tissues. J Invest Dermatol 131:2178–2185
Feldmeyer L, Keller M, Niklaus G et al (2007) The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol 17:1140–1145
Foster CA, Yokozeki H, Rappersberger K et al (1990) Human epidermal T cells predominantly belong to the lineage expressing alpha/beta T cell receptor. J Exp Med 171:997–1013
Frandji P, Tkaczyk C, Oskeritzian C et al (1996) Exogenous and endogenous antigens are differentially presented by mast cells to CD4+ T lymphocytes. Eur J Immunol 26:2517–2528
Galli SJ, Tsai M (2010) Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity. Eur J Immunol 40:1843–1851
Gebhardt T, Wakim LM, Eidsmo L et al (2009) Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat Immunol 10:524–530
Ginhoux F, Collin MP, Bogunovic M et al (2007) Blood-derived dermal Langerin + dendritic cells survey the skin in the steady state. J Exp Med 204:3133–3146
Girardi M (2006) Immunosurveillance and immunoregulation by gammadelta T cells. J Invest Dermatol 126:25–31
Girardi M, Oppenheim DE, Steele CR et al (2001) Regulation of cutaneous malignancy by gammadelta T cells. Science 294:605–609
Girardi M, Lewis J, Glusac E et al (2002) Resident skin-specific gammadelta T cells provide local, nonredundant regulation of cutaneous inflammation. J Exp Med 195:855–867
Glitzner E, Korosec A, Brunner P et al (2014) Specific roles for dendritic cell subsets during initiation and progression of psoriasis. EMBO Mol Med 6:1312–1327
Gober MD, Fishelevich R, Zhao Y et al (2008) Human natural killer T cells infiltrate into the skin at elicitation sites of allergic contact dermatitis. J Invest Dermatol 128:1460–1469
Gomez de Aguero M, Vocanson M, Hacini-Rachinel F et al (2012) Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells. J Clin Invest 122:1700–1711
Gorbachev AV, Fairchild RL (2006) Activated NKT cells increase dendritic cell migration and enhance CD8+ T cell responses in the skin. Eur J Immunol 36:2494–2503
Grillon C, Matejuk A, Nadim M et al (2012) News on microenvironmental physioxia to revisit skin cell targeting approaches. Exp Dermatol 21:723–728
Guttman-Yassky E, Lowes MA, Fuentes-Duculan J et al (2007) Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. J Allergy Clin Immunol 119:1210–1217
Harder J, Bartels J, Christophers E et al (1997) A peptide antibiotic from human skin. Nature 387:861
Hayday A, Tigelaar R (2003) Immunoregulation in the tissues by gammadelta T cells. Nat Rev Immunol 3:233–242
He S, Walls AF (1998) Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells in vivo. Br J Pharmacol 125:1491–1500
Henri S, Poulin LF, Tamoutounour S et al (2010) CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med 207:189–206
Hershko AY, Rivera J (2010) Mast cell and T cell communication; amplification and control of adaptive immunity. Immunol Lett 128:98–104
Holtmeier W, Kabelitz D (2005) gammadelta T cells link innate and adaptive immune responses. Chem Immunol Allergy 86:151–183
Honda T, Egawa G, Grabbe S et al (2013) Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis. J Invest Dermatol 133:303–315
Horsmanheimo L, Harvima IT, Jarvikallio A et al (1994) Mast cells are one major source of interleukin-4 in atopic dermatitis. Br J Dermatol 131:348–353
Huang B, Lei Z, Zhang GM et al (2008) SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. Blood 112:1269–1279
Hunger RE, Sieling PA, Ochoa MT et al (2004) Langerhans cells utilize CD1a and Langerin to efficiently present nonpeptide antigens to T cells. J Clin Invest 113:701–708
Huttunen M, Naukkarinen A, Horsmanheimo M et al (2002) Transient production of stem cell factor in dermal cells but increasing expression of Kit receptor in mast cells during normal wound healing. Arch Dermatol Res 294:324–330
Iddamalgoda A, Le QT, Ito K et al (2008) Mast cell tryptase and photoaging: possible involvement in the degradation of extra cellular matrix and basement membrane proteins. Arch Dermatol Res 300(Suppl 1):S69–S76
Igyarto BZ, Haley K, Ortner D et al (2011) Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses. Immunity 35:260–272
Jones HE, Strid J, Osman M et al (2008) The role of beta2 integrins and lipopolysaccharide-binding protein in the phagocytosis of dead Neisseria meningitidis. Cell Microbiol 10:1634–1645
Kaminska R, Helisalmi P, Harvima RJ et al (1999) Focal dermal–epidermal separation and fibronectin cleavage in basement membrane by human mast cell tryptase. J Invest Dermatol 113:567–573
Kaplan DH, Kissenpfennig A, Clausen BE (2008) Insights into Langerhans cell function from Langerhans cell ablation models. Eur J Immunol 38:2369–2376
Kaporis HG, Guttman-Yassky E, Lowes MA et al (2007) Human basal cell carcinoma is associated with Foxp3+ T cells in a Th2 dominant microenvironment. J Invest Dermatol 127:2391–2398
Kashem SW, Igyarto BZ, Gerami-Nejad M et al (2015) Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation. Immunity 42:356–366
Kautz-Neu K, Noordegraaf M, Dinges S et al (2011) Langerhans cells are negative regulators of the anti-Leishmania response. J Exp Med 208:885–891
Keller M, Ruegg A, Werner S et al (2008) Active caspase-1 is a regulator of unconventional protein secretion. Cell 132:818–831
Kim BS, Wojno ED, Artis D (2013) Innate lymphoid cells and allergic inflammation. Curr Opin Immunol 25:738–744
Kitawaki T, Kadowaki N, Sugimoto N et al (2006) IgE-activated mast cells in combination with pro-inflammatory factors induce Th2-promoting dendritic cells. Int Immunol 18:1789–1799
Klages K, Mayer CT, Lahl K et al (2010) Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res 70:7788–7799
Kronenberg M (2005) Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol 23:877–900
Krueger GG, Langley RG, Leonardi C et al (2007) A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med 356:580–592
Kubo A, Nagao K, Yokouchi M et al (2009) External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers. J Exp Med 206:2937–2946
Kurebayashi Y, Nagai S, Ikejiri A et al (2013) Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells. Genes Cells 18:247–265
Lande R, Gregorio J, Facchinetti V et al (2007) Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449:564–569
Larsen CP, Steinman RM, Witmer-Pack M et al (1990) Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med 172:1483–1493
Leonardi CL, Kimball AB, Papp KA et al (2008) Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 371:1665–1674
Li T, He S (2006) Induction of IL-6 release from human T cells by PAR-1 and PAR-2 agonists. Immunol Cell Biol 84:461–466
Liang SC, Tan XY, Luxenberg DP et al (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203:2271–2279
Lopez-Bravo M, Ardavin C (2008) In vivo induction of immune responses to pathogens by conventional dendritic cells. Immunity 29:343–351
Lowes MA, Chamian F, Abello MV et al (2005) Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc Natl Acad Sci USA 102:19057–19062
Malamud V, Vaaknin A, Abramsky O et al (2003) Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-alpha, IL-6 and IL-1 beta: possible relevance to multiple sclerosis. J Neuroimmunol 138:115–122
Malbec O, Daeron M (2007) The mast cell IgG receptors and their roles in tissue inflammation. Immunol Rev 217:206–221
Malissen B, Tamoutounour S, Henri S (2014) The origins and functions of dendritic cells and macrophages in the skin. Nat Rev Immunol 14:417–428
Martinon F, Mayor A, Tschopp J (2009) The inflammasomes: guardians of the body. Annu Rev Immunol 27:229–265
Matejuk A, Leng Q, Begum MD et al (2010) Peptide-based antifungal therapies against emerging infections. Drugs Future 35:197
Mehling A, Loser K, Varga G et al (2001) Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. J Exp Med 194:615–628
Mizutani H, Schechter N, Lazarus G et al (1991) Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. J Exp Med 174:821–825
Molin D, Fischer M, Xiang Z et al (2001) Mast cells express functional CD30 ligand and are the predominant CD30L-positive cells in Hodgkin’s disease. Br J Haematol 114:616–623
Moon TC, St Laurent CD, Morris KE et al (2010) Advances in mast cell biology: new understanding of heterogeneity and function. Mucosal Immunol 3:111–128
Mora JR, Cheng G, Picarella D et al (2005) Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues. J Exp Med 201:303–316
Mueller SN, Gebhardt T, Carbone FR et al (2013) Memory T cell subsets, migration patterns, and tissue residence. Annu Rev Immunol 31:137–161
Nagao K, Ginhoux F, Leitner WW et al (2009) Murine epidermal Langerhans cells and Langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci USA 106:3312–3317
Nakae S, Suto H, Kakurai M et al (2005) Mast cells enhance T cell activation: importance of mast cell-derived TNF. Proc Natl Acad Sci USA 102:6467–6472
Nakajima S, Igyarto BZ, Honda T et al (2012) Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling. J Allergy Clin Immunol 129(1048–1055):e6
Nestle FO, Conrad C, Tun-Kyi A et al (2005) Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med 202:135–143
Nestle FO, Di Meglio P, Qin JZ et al (2009) Skin immune sentinels in health and disease. Nat Rev Immunol 9:679–691
Nickoloff BJ, Turka LA (1994) Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes. Immunol Today 15:464–469
Nickoloff BJ, Bonish B, Huang BB et al (2000) Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model system. J Dermatol Sci 24:212–225
Nishibu A, Ward BR, Jester JV et al (2006) Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli. J Invest Dermatol 126:787–796
Nomura T, Kabashima K, Miyachi Y (2014) The panoply of alphabetaT cells in the skin. J Dermatol Sci 76:3–9
Noordegraaf M, Flacher V, Stoitzner P et al (2010) Functional redundancy of Langerhans cells and Langerin + dermal dendritic cells in contact hypersensitivity. J Invest Dermatol 130:2752–2759
Ohl L, Mohaupt M, Czeloth N et al (2004) CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21:279–288
Omoto Y, Tokime K, Yamanaka K et al (2006) Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment. J Immunol 177:8315–8319
Ong PY, Ohtake T, Brandt C et al (2002) Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151–1160
Ono S, Kabashima K (2015) Proposal of inducible skin-associated lymphoid tissue (iSALT). Exp Dermatol 24:630–631
Oppenheim DE, Roberts SJ, Clarke SL et al (2005) Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nat Immunol 6:928–937
Pang L, Nie M, Corbett L et al (2006) Mast cell beta-tryptase selectively cleaves and RANTES and abrogates their eosinophil chemotactic activities. J Immunol 176:3788–3795
Peyssonnaux C, Boutin AT, Zinkernagel AS et al (2008) Critical role of HIF-1alpha in keratinocyte defense against bacterial infection. J Invest Dermatol 128:1964–1968
Piconese S, Gri G, Tripodo C et al (2009) Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation. Blood 114:2639–2648
Pierre P, Turley SJ, Gatti E et al (1997) Developmental regulation of MHC class II transport in mouse dendritic cells. Nature 388:787–792
Poulin LF, Henri S, de Bovis B et al (2007) The dermis contains Langerin + dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med 204:3119–3131
Richards H, Williams A, Jones E et al (2010) Novel role of regulatory T cells in limiting early neutrophil responses in skin. Immunology 131:583–592
Roberts SJ, Ng BY, Filler RB et al (2007) Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis. Proc Natl Acad Sci USA 104:6770–6775
Romani N, Ebner S, Tripp CH et al (2006) Epidermal Langerhans cells—changing views on their function in vivo. Immunol Lett 106:119–125
Romani N, Clausen BE, Stoitzner P (2010) Langerhans cells and more: Langerin-expressing dendritic cell subsets in the skin. Immunol Rev 234:120–141
Schauber J, Dorschner RA, Coda AB et al (2007) Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest 117:803–811
Schwarz A, Schwarz T (2010) UVR-induced regulatory T cells switch antigen-presenting cells from a stimulatory to a regulatory phenotype. J Invest Dermatol 130:1914–1921
Serbina NV, Salazar-Mather TP, Biron CA et al (2003) TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19:59–70
Sharlow ER, Paine CS, Babiarz L et al (2000) The protease-activated receptor-2 upregulates keratinocyte phagocytosis. J Cell Sci 113(Pt 17):3093–3101
Shklovskaya E, O’Sullivan BJ, Ng LG et al (2011) Langerhans cells are precommitted to immune tolerance induction. Proc Natl Acad Sci USA 108:18049–18054
Sigmundsdottir H, Butcher EC (2008) Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. Nat Immunol 9:981–987
Simon AK, Jones E, Richards H et al (2007) Regulatory T cells inhibit Fas ligand-induced innate and adaptive tumour immunity. Eur J Immunol 37:758–767
Skokos D, Botros HG, Demeure C et al (2003) Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. J Immunol 170:3037–3045
Stingl G, Tamaki K, Katz SI (1980) Origin and function of epidermal Langerhans cells. Immunol Rev 53:149–174
Stoitzner P, Romani N (2011) Langerin, the “catcher in the rye”: an important receptor for pathogens on Langerhans cells. Eur J Immunol 41:2526–2529
Stoitzner P, Tripp CH, Douillard P et al (2005) Migratory Langerhans cells in mouse lymph nodes in steady state and inflammation. J Invest Dermatol 125:116–125
Streilein JW (1983) Skin-associated lymphoid tissues (SALT): origins and functions. J Invest Dermatol 80(Suppl):12s–16s
Suto H, Nakae S, Kakurai M et al (2006) Mast cell-associated TNF promotes dendritic cell migration. J Immunol 176:4102–4112
Tamoutounour S, Guilliams M, Montanana Sanchis F et al (2013) Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity 39:925–938
Tang A, Amagai M, Granger LG et al (1993) Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature 361:82–85
Terakawa M, Tomimori Y, Goto M et al (2006) Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils. Eur J Pharmacol 538:175–181
Tiemessen MM, Jagger AL, Evans HG et al (2007) CD4+ CD25+ Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl Acad Sci USA 104:19446–19451
Toichi E, Hanada K, Hosokawa T et al (1997) Age-related decline in humoral immunity caused by the selective loss of TH cells and decline in cellular immunity caused by the impaired migration of inflammatory cells without a loss of TDTH cells in SAMP1 mice. Mech Ageing Dev 99:199–217
Tomura M, Honda T, Tanizaki H et al (2010) Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J Clin Invest 120:883–893
Tortola L, Rosenwald E, Abel B et al (2012) Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest 122:3965–3976
Toulon A, Breton L, Taylor KR et al (2009) A role for human skin-resident T cells in wound healing. J Exp Med 206:743–750
Tsai M, Grimbaldeston M, Galli SJ (2011) Mast cells and immunoregulation/immunomodulation. Adv Exp Med Biol 716:186–211
Valladeau J, Ravel O, Dezutter-Dambuyant C et al (2000) Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12:71–81
van der Aar AM, de Groot R, Sanchez-Hernandez M et al (2011) Cutting edge: virus selectively primes human langerhans cells for CD70 expression promoting CD8+ T cell responses. J Immunol 187:3488–3492
Vissinga C, Nagelkerken L, Zijlstra J et al (1990) A decreased functional capacity of CD4+ T cells underlies the impaired DTH reactivity in old mice. Mech Ageing Dev 53:127–139
Vukmanovic-Stejic M, Agius E, Booth N et al (2008) The kinetics of CD4+ Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo. J Clin Invest 118:3639–3650
Wang H, He S (2006) Induction of lactoferrin and IL-8 release from human neutrophils by tryptic enzymes via proteinase activated receptor-2. Cell Biol Int 30:688–697
Wang HW, Tedla N, Lloyd AR et al (1998) Mast cell activation and migration to lymph nodes during induction of an immune response in mice. J Clin Invest 102:1617–1626
Weidner N, Austen KF (1993) Heterogeneity of mast cells at multiple body sites. Fluorescent determination of avidin binding and immunofluorescent determination of chymase, tryptase, and carboxypeptidase content. Pathol Res Pract 189:156–162
Wohn C, Ober-Blobaum JL, Haak S et al (2013) Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice. Proc Natl Acad Sci USA 110:10723–10728
Wollenberg A, Rawer HC, Schauber J (2011) Innate immunity in atopic dermatitis. Clin Rev Allergy Immunol 41:272–281
Yang Z, Zhang B, Li D et al (2010) Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model. PLoS One 5:e8922
Yoshiki R, Kabashima K, Sugita K et al (2009) IL-10-producing Langerhans cells and regulatory T cells are responsible for depressed contact hypersensitivity in grafted skin. J Invest Dermatol 129:705–713
Yoshiki R, Kabashima K, Honda T et al (2014) IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing gammadelta T cells. J Invest Dermatol 134:1912–1921
Zaba LC, Cardinale I, Gilleaudeau P et al (2007a) Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med 204:3183–3194
Zaba LC, Fuentes-Duculan J, Steinman RM et al (2007b) Normal human dermis contains distinct populations of CD11c+ BDCA-1+ dendritic cells and CD163+ FXIIIA+ macrophages. J Clin Invest 117:2517–2525
Zahner SP, Kel JM, Martina CA et al (2011) Conditional deletion of TGF-betaR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity. J Immunol 187:5069–5076
Zanetti M (2004) Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol 75:39–48
Zhang W, Wu K, He W et al (2010) Transforming growth factor beta 1 plays an important role in inducing CD4(+)CD25(+) forkhead box P3(+) regulatory T cells by mast cells. Clin Exp Immunol 161:490–496
Zhao W, Oskeritzian CA, Pozez AL et al (2005) Cytokine production by skin-derived mast cells: endogenous proteases are responsible for degradation of cytokines. J Immunol 175:2635–2642