Skin DNA methylation profile in atopic dermatitis patients: A case–control study

Experimental Dermatology - Tập 29 Số 2 - Trang 184-189 - 2020
Olga Yu. Olisova1, Н Г Кочергин1, Lyailya N. Kayumova1, Т. М. Заварыкина2, Alexey A. Dmitriev3, А. Ю. Асанов4
1Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia
2N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia
3Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
4Department of Medical Genetics, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Tóm tắt

AbstractAtopic dermatitis (AD) is a worldwide disease with a complex aetiology. Both genetic and environmental factors cause a predisposition to AD. DNA methylation may be an additional predisposing factor. The goal of our study was to investigate genome‐wide methylation profiles of skin from patients with AD and healthy persons. This case–control study included 12 AD patients and 6 healthy volunteers. DNA methylation levels in skin samples were analysed using the Illumina Infinium HumanMethylation450 BeadChip. We found that the methylation profile of skin from patients with AD was significantly different from that of healthy controls. Differential DNA methylation was observed for genes involved in a number of AD‐related processes including regulation of the immune response, activation of lymphocytes, cell proliferation, apoptosis and differentiation of the epidermis. Our study indicates the involvement of epigenetic regulation in the development of atopic dermatitis.

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Experimental Dermatology

Tập 29 Số 2

184-189

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