Skeletal manifestations in a streptozotocin-induced C57BL/6 model of Type 1 diabetes

Bell, 1994, Gender differences in the metabolic response to graded numbers of transplanted islets of langerhans, Endocrinology, 135, 2681, 10.1210/endo.135.6.7988458 Bortolin, 2015, Protection against T1DM-induced bone loss by zinc supplementation: biomechanical, histomorphometric, and molecular analyses in STZ-induced diabetic rats, PLoS One, 10, 10.1371/journal.pone.0125349 Botolin, 2007, Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice, Endocrinology, 148, 198, 10.1210/en.2006-1006 Bouillon, 1991, Diabetic bone disease, Calcif. Tissue Int., 49, 155, 10.1007/BF02556109 Bouillon, 1992, Diabetic bone disease. Low turnover osteoporosis related to decreased IGF-I production, Verh K Acad Geneeskd Belg, 54, 365 Chandramouli, 2018, Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia, Sci. Rep., 8, 2346, 10.1038/s41598-018-20703-8 Cignachi, 2020, Bone regeneration in a mouse model of type 1 diabetes: influence of sex, vitamin D3, and insulin, Life Sci., 263, 118593, 10.1016/j.lfs.2020.118593 Cortright, 1996, Diabetes reduces growth and body composition more in male than in female rats, Physiol. Behav., 60, 1233, 10.1016/S0031-9384(96)00222-3 Dholakia, 2015, Determination of RBC survival in C57BL/6 and C57BL/6-Tg (UBC-GFP) mice, Comp. Med., 65, 5 Du, 2016, Sex differences in the effect of HbA1c-de fi ned diabetes on a wide range of cardiovascular disease risk factors, Ann. Med., 48, 34, 10.3109/07853890.2015.1127406 Einhorn, 1988, The mineral and mechanical properties of bone in chronic experimental diabetes, J. Orthop. Res., 6, 7, 10.1002/jor.1100060303 Fowlkes, 2008, Runt-related transcription factor 2 (RUNX2) and RUNX2-related osteogenic genes are down-regulated throughout osteogenesis in type 1 diabetes mellitus, Endocrinology, 149, 1697, 10.1210/en.2007-1408 G. D. F, 2019, Sex differences and correlates of poor glycaemic control in type 2 diabetes: a cross-sectional study in Brazil and Venezuela, BMJ Open, 9, e023401, 10.1136/bmjopen-2018-023401 Goh, 2008, Clinical review: the role of advanced glycation end products in progression and complications of diabetes, J. Clin. Endocrinol. Metab., 93, 1143, 10.1210/jc.2007-1817 Gupte, 2015, Estrogen: an emerging regulator of insulin action and mitochondrial function, J.Diabetes Res., 2015, 10.1155/2015/916585 Gurley, 2006, Impact of genetic background on nephropathy in diabetic mice, Am. J. Physiol. Renal Physiol., 290, F214, 10.1152/ajprenal.00204.2005 Hamada, 2007, Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice: a possible role of oxidative stress, Bone, 40, 1408, 10.1016/j.bone.2006.12.057 Hayashi, 2006, Strain differences in the diabetogenic activity of streptozotocin in mice, Biol. Pharm. Bull., 29, 1110, 10.1248/bpb.29.1110 Hie, 2011, Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation, Int. J. Mol. Med., 28, 455 Horcajada-Molteni, 2001, Amylin and bone metabolism in streptozotocin-induced diabetic rats, J. Bone Miner. Res., 16, 958, 10.1359/jbmr.2001.16.5.958 Hough, 2016, MECHANISMS IN ENDOCRINOLOGY: mechanisms and evaluation of bone fragility in type 1 diabetes mellitus, Eur. J. Endocrinol., 174, R127, 10.1530/EJE-15-0820 Inaba, 1995, Influence of high glucose on 1,25-dihydroxyvitamin D3-induced effect on human osteoblast-like MG-63 cells, J. Bone Miner. Res., 10, 1050, 10.1002/jbmr.5650100709 Jeffcoate, 2005, The role of proinflammatory cytokines in the cause of neuropathic osteoarthropathy (acute charcot foot) in diabetes, Lancet, 366, 2058, 10.1016/S0140-6736(05)67029-8 Jin, 2013, The expression of inflammatory genes is upregulated in peripheral blood of patients with type 1 diabetes, Diabetes Care, 36, 2794, 10.2337/dc12-1986 Junod, 1967, Studies of the diabetogenic action of streptozotocin, Proc. Soc. Exp. Biol. Med., 126, 201, 10.3181/00379727-126-32401 Kahanovitz, 2017, Type 1 diabetes - a clinical perspective, Point Care, 16, 37, 10.1097/POC.0000000000000125 Kohler, 2021, The effect of single versus group muCT on the detection of trabecular and cortical disease phenotypes in mouse bones, JBMR Plus, 5, 10.1002/jbm4.10473 Le May, 2006, Estrogens protect pancreatic B-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice, PNAS, 103, 6, 10.1073/pnas.0602956103 Leiter, 1985, Differential susceptibility of BALB/c sublines to diabetes induction by multi-dose streptozotocin treatment, Curr. Top. Microbiol. Immunol., 122, 78 Lew, 2017, On the mechanism of human red blood cell longevity: roles of calcium, the sodium pump, PIEZO1, and gardos channels, Front. Physiol., 8, 977, 10.3389/fphys.2017.00977 Lu, 2003, Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation, Endocrinology, 144, 346, 10.1210/en.2002-220072 Meng, 2015, J. Biol. Chem., 290, 28189, 10.1074/jbc.M115.669499 Motyl, 2009, Streptozotocin, type I diabetes severity and bone, Biol. Proced. Online, 11, 296, 10.1007/s12575-009-9000-5 Nahdi, 2017, Elucidation of molecular mechanisms of streptozotocin-induced oxidative stress, apoptosis, and mitochondrial dysfunction in rin-5F pancreatic β-cells, Oxidative Med. Cell. Longev., 2017, 10.1155/2017/7054272 Nakamura, 1984, The role of thymic immunity and insulitis in the development of streptozocin-induced diabetes in mice, Diabetes, 33, 894, 10.2337/diab.33.9.894 Ndisang, 2017, Insulin resistance, type 1 and type 2 diabetes, and related complications 2017, J. Diabetes Res., 2017, 10.1155/2017/1478294 Ni, 2019, FK506 prevented bone loss in streptozotocin-induced diabetic rats via enhancing osteogenesis and inhibiting adipogenesis, Ann. Transl. Med., 7, 265, 10.21037/atm.2019.05.44 Niu, 2016, Broad infiltration of macrophages leads to a proinflammatory state in streptozotocin-induced hyperglycemic mice, J. Immunol., 197, 3293, 10.4049/jimmunol.1502494 Palta, 2014, The trajectory of IGF-1 across age and duration of type 1 diabetes, Diabetes Metab. Res. Rev., 30, 777, 10.1002/dmrr.2554 Portal-Nunez, 2010, Alterations of the Wnt/beta-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice, FEBS Lett., 584, 3095, 10.1016/j.febslet.2010.05.047 2020 Santana, 2003, A role for advanced glycation end products in diminished bone healing in type 1 diabetes, Diabetes, 52, 1502, 10.2337/diabetes.52.6.1502 Schwartz, 2002, Older women with diabetes have a higher risk of falls: a prospective study, Diabetes Care, 25, 1749, 10.2337/diacare.25.10.1749 Shaw, 2009, Global estimates of the prevalence of diabetes for 2010 and 2030, Diabetes Res. Clin. Pract., 87, 10 Sherwani, 2016, Significance of HbA1c test in diagnosis and prognosis of diabetic patients, Biomark. Insights, 11, 95, 10.4137/BMI.S38440 Sroga, 2021, Controlled formation of carboxymethyllysine in bone matrix through designed glycation reaction, JBMR Plus, 5, 10.1002/jbm4.10548 Starup-Linde, 2019, Type 1 diabetes and bone fragility: links and risks, Diabetes Metab. Syndr. Obes., 12, 2539, 10.2147/DMSO.S191091 Sundararaghavan, 2017, Diabetes and bone health: latest evidence and clinical implications, Ther. Adv. Musculoskelet. Dis., 9, 67, 10.1177/1759720X16687480 Tramunt, 2020, Sex differences in metabolic regulation and diabetes susceptibility, Diabetologia, 63, 453, 10.1007/s00125-019-05040-3 Tsentidis, 2016, Higher levels of s-RANKL and osteoprotegerin in children and adolescents with type 1 diabetes mellitus may indicate increased osteoclast signaling and predisposition to lower bone mass: a multivariate cross-sectional analysis, Osteoporos. Int., 27, 1631, 10.1007/s00198-015-3422-5 Wallace, 2019, Skeletal hard tissue biomechanics Weinberg, 2014, Streptozotocin-induced diabetes in rats diminishes the size of the osteoprogenitor pool in bone marrow, Diabetes Res. Clin. Pract., 103, 35, 10.1016/j.diabres.2013.11.015 Yamagishi, 2005, Possible participation of advanced glycation end products in the pathogenesis of osteoporosis in diabetic patients, Med. Hypotheses, 65, 1013, 10.1016/j.mehy.2005.07.017 Zhao, 2013, Osteogenic potential of bone marrow stromal cells derived from streptozotocin-induced diabetic rats, Int. J. Mol. Med., 31, 614, 10.3892/ijmm.2013.1227 Zhou, 2006, Regulation of osteoclast function and bone mass by RAGE, J. Exp. Med., 203, 1067, 10.1084/jem.20051947 2011