Sinonasal Secretory Carcinoma of Salivary Gland with High Grade Transformation: A Case Report of this Under-Recognized Diagnostic Entity with Prognostic and Therapeutic Implications

Head and Neck Pathology - Tập 12 - Trang 274-278 - 2017
Bin Xu1, Ruth Aryeequaye2, Lu Wang3, Nora Katabi2
1Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, USA
2Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA
3Department of Pathology, Memorial-Sloan-Kettering Cancer Center, New York, USA

Tóm tắt

Secretory carcinoma (SC) is a recently described salivary gland carcinoma with characteristic ETV6-NTRK3 fusion. In this case report, we described a SC of the maxillary sinus that underwent high grade transformation in a 61-year-old patient. The diagnosis was confirmed by the presence of ETV6 translocation. Within the sinonasal tract, SC is an important differential diagnosis especially of sinonasal adenocarcinoma, non-intestinal type (non-ITAC), as these two entities bears histologic and immunophenotypic similarity. Distinction between these two tumors can be challenging based on the morphology alone and may require additional immunohistochemical and molecular studies. It is important to recognize that SC can occur in the sinonasal tract as correctly diagnosing SC may be prognostic relevant and may provide new targeted therapeutic avenues for these patients.

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