Sinigrin inhibits production of inflammatory mediators by suppressing NF-κB/MAPK pathways or NLRP3 inflammasome activation in macrophages

Schroder, 2010, The inflammasomes, Cell, 140, 821, 10.1016/j.cell.2010.01.040 Dodé, 2002, New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes, Am. J. Hum. Genet., 70, 1498, 10.1086/340786 Feldmann, 2002, Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes, Am. J. Hum. Genet., 71, 198, 10.1086/341357 Hoffman, 2001, Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome, Nat. Genet., 29, 301, 10.1038/ng756 Strowig, 2012, Inflammasomes in health and disease, Nature, 481, 278, 10.1038/nature10759 Wynn, 2013, Macrophage biology in development, homeostasis and disease, Nature, 496, 445, 10.1038/nature12034 Dostert, 2008, Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica, Science, 320, 674, 10.1126/science.1156995 Pearson, 2001, Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions, Endocr. Rev., 22, 153 Ajizian, 1999, J. Infect. Dis., 179, 939, 10.1086/314659 Uto, 2005, 6-(Methylsulfinyl)hexyl isothiocyanate suppresses inducible nitric oxide synthase expression through the inhibition of Janus kinase 2-mediated JNK pathway in lipopolysaccharide-activated murine macrophages, Biochem. Pharmacol., 70, 1211, 10.1016/j.bcp.2005.07.011 Jou, 2013, Macrophage-mediated inflammatory disorders, Mediat. Inflamm., 10.1155/2013/316482 Halsted, 2003, Dietary supplements and functional foods: 2 sides of a coin?, Am. J. Clin. Nutr., 77, 1001S, 10.1093/ajcn/77.4.1001S Ando, 2009, Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation, FEBS Lett., 583, 3649, 10.1016/j.febslet.2009.10.045 Kang, 2007, Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages, FEBS Lett., 581, 4389, 10.1016/j.febslet.2007.07.082 Magrone, 2013, The interplay between the gut immune system and microbiota in health and disease: nutraceutical intervention for restoring intestinal homeostasis, Curr. Pharm. Des., 19, 1329 Vines, 1996, My best friend's a brussels sprouts, New Sci., 2061–2, 46 Shofran, 1998, Antimicrobial properties of sinigrin and its hydrolysis products, J. Food Sci., 63, 621, 10.1111/j.1365-2621.1998.tb15798.x Zhu, 2000, Inhibition of oxidative DNA damage in vitro by extracts of brussels sprouts, Free Radic. Res., 33, 187, 10.1080/10715760000300741 Ippoushi, 2010, Sinigrin suppresses nitric oxide production in rats administered intraperitoneally with lipopolysaccharide, Food Chem., 120, 1119, 10.1016/j.foodchem.2009.11.035 Lee, 2014, The inhibitory effect of sinigrin on the production of inflammatory mediators induced by lipopolysaccharide in RAW 264.7 macrophages (1056.5), FASEB J., 28, 1056.5 Nguyen, 2015, Korean red ginseng inhibits apoptosis in neuroblastoma cells via estrogen receptor β-mediated phosphatidylinositol-3 kinase/Akt signaling, J. Ginseng Res., 39, 69, 10.1016/j.jgr.2014.06.005 Lee, 2014, Korean red ginseng saponin fraction modulates radiation effects on lipopolysaccharide-stimulated nitric oxide production in RAW264.7 macrophage cells, J. Ginseng Res., 38, 208, 10.1016/j.jgr.2014.02.001 Nussler, 1993, Inflammation, immunoregulation, and inducible nitric oxide synthase, J. Leukoc. Biol., 54, 171, 10.1002/jlb.54.2.171 Chi, 2003, Regulation of nitric oxide production from macrophages by lipopolysaccharide and catecholamines, Nitric Oxide Biol. Chem., 8, 127, 10.1016/S1089-8603(02)00148-9 Samad, 2001, Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity, Nature, 410, 471, 10.1038/35068566 Patel, 1999, Regulation of cytosolic COX-2 and prostaglandin E2 production by nitric oxide in activated murine macrophages, J. Immunol., 162, 4191, 10.4049/jimmunol.162.7.4191 Tak, 2001, NF-kappaB: a key role in inflammatory diseases, J. Clin. Invest., 107, 7, 10.1172/JCI11830 Ci, 2010, Schisantherin A exhibits anti-inflammatory properties by down-regulating NF-kappaB and MAPK signaling pathways in lipopolysaccharide-treated RAW 264.7 cells, Inflammation, 33, 126, 10.1007/s10753-009-9166-7 Ajizian, 1999, J. Infect. Dis., 179, 939, 10.1086/314659 Kao, 2005, Lipoteichoic acid induces nuclear factor-κB activation and nitric oxide synthase expression via phosphatidylinositol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages, Immunology, 115, 366, 10.1111/j.1365-2567.2005.02160.x Li, 2002, NF-kappaB regulation in the immune system, Nat. Rev. Immunol., 2, 725, 10.1038/nri910 Tian, 2003, Identification of a nuclear factor kappa B-dependent gene network, Recent Prog. Horm. Res., 58, 95, 10.1210/rp.58.1.95 Karin, 1999, How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex, Oncogene, 18, 6867, 10.1038/sj.onc.1203219 Perkins, 2007, Integrating cell-signalling pathways with NF-kappaB and IKK function, Nat. Rev. Mol. Cell Biol., 8, 49, 10.1038/nrm2083 Gilmore, 2006, Introduction to NF-kappaB: players, pathways, perspectives, Oncogene, 25, 6680, 10.1038/sj.onc.1209954 Ducut Sigala, 2004, Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit, Science, 304, 1963, 10.1126/science.1098387 Mercurio, 1999, NF-kappaB as a primary regulator of the stress response, Oncogene, 18, 6163, 10.1038/sj.onc.1203174 Won, 2004, The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase, J. Neurochem., 88, 583, 10.1046/j.1471-4159.2003.02165.x Zhang, 2002, MAPK signal pathways in the regulation of cell proliferation in mammalian cells, Cell Res., 12, 9, 10.1038/sj.cr.7290105 Lamkanfi, 2011, Emerging inflammasome effector mechanisms, Nat. Rev. Immunol., 11, 213, 10.1038/nri2936 Rathinam, 2012, Regulation of inflammasome signaling, Nat. Immunol., 13, 333, 10.1038/ni.2237 Yu, 2008, The caspase-1 inflammasome: a pilot of innate immune responses, Cell Host Microbe, 4, 198, 10.1016/j.chom.2008.08.007 Mariathasan, 2006, Cryopyrin activates the inflammasome in response to toxins and ATP, Nature, 440, 228, 10.1038/nature04515 Martinon, 2006, Gout-associated uric acid crystals activate the NALP3 inflammasome, Nature, 440, 237, 10.1038/nature04516 Duewell, 2010, NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Nature, 464, 1357, 10.1038/nature08938 Hise, 2009, An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans, Cell Host Microbe, 5, 487, 10.1016/j.chom.2009.05.002 Hornung, 2008, Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization, Nat. Immunol., 9, 847, 10.1038/ni.1631 Bours, 2006, Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation, Pharmacol. Ther., 112, 358, 10.1016/j.pharmthera.2005.04.013 Said-Sadier, 2012, Alarmins, inflammasomes and immunity, Biochem. J., 35, 437 Bauernfeind, 2009, Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression, J. Immunol., 183, 787, 10.4049/jimmunol.0901363 Hsu, 2002, Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression, J. Biol. Chem., 277, 22131, 10.1074/jbc.M111883200 Liao, 2013, Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretion, Inflamm. Res., 62, 89, 10.1007/s00011-012-0555-2