Single nucleotide polymorphisms in JNK1 are associated with susceptibility to noise-induced hearing loss in a Chinese population
Tóm tắt
This study intended to explore the effect of C-Jun N-terminal kinases 1 (JNK1) polymorphisms on the sensitivity of individual hearing loss. A total of 1333 subjects, including 683 NIHL workers and 650 normal-hearing workers from east China, were included in this cross-sectional study. Genotyping of three JNK1 single nucleotide polymorphisms (rs9284, rs8428, and rs11598320) was performed. The relationship between different genotypes and noise-induced hearing loss was analyzed. Results show that rs11598320 TT genotype was associated with a higher risk of NIHL (OR 1.57, 95% CI 0.91–2.70). Stratified analysis indicated that the rs11598320 AT + AA genotype was associated with a decreased risk of hearing loss in subjects exposed to noise ≤ 16 years or a noise level > 92 dB (OR 0.68, 95% CI 0.50–0.93 and OR 0.64, 95% CI 0.42–0.96, respectively). The rs8428 TT genotype was associated with an increased risk of noise-induced hearing loss when the noise level was > 92 dB (OR 1.73, 95% CI 1.11–2.70). Haplotype TCT (rs9284–rs8424–rs11598320) was associated with an increased risk of noise-induced hearing loss (OR 1.30, 95% CI 1.00–1.68). Single nucleotide polymorphisms (rs11598320 and rs8424) in JNK1 can be used as new biomarkers of susceptibility for noise-induced hearing loss in Chinese workers.
Tài liệu tham khảo
Chen K, Zhou YX, Li K, Qi LX, Zhang QF, Wang MC, Xiao JH (2016) A novel three-round multiplex PCR for SNP genotyping with next generation sequencing. Anal Bioanal Chem 408(16):4371–4377. https://doi.org/10.1007/s00216-016-9536-6
Ding E, Liu J, Shen H, Gong W, Zhang H, Song H, Zhu B (2018) Notch polymorphisms associated with sensitivity of noise induced hearing loss among Chinese textile factory workers. BMC Med Genet 19(1):168. https://doi.org/10.1186/s12881-018-0676-8
Guo H, Ahmed M, Zhang F, Yao CQ, Li S, Liang Y, Hua J, Soares F, Sun Y, Langstein J, Li Y, Poon C, Bailey SD, Desai K, Fei T, Li Q, Sendorek DH, Fraser M, Prensner JR, Pugh TJ, Pomerantz M, Bristow RG, Lupien M, Feng FY, Boutros PC, Freedman ML, Walsh MJ, He HH (2016) Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer. Nat Genet 48(10):1142–1150. https://doi.org/10.1038/ng.3637
Han X, Ge R, Xie G, Li P, Zhao X, Gao L, Zhang H, Wang O, Huang F, Han F (2015) Caspase-mediated apoptosis in the cochleae contributes to the early onset of hearing loss in A/J mice. ASN Neuro. https://doi.org/10.1177/1759091415573985
Hollville E, Romero SE, Deshmukh M (2019) Apoptotic cell death regulation in neurons. FEBS J 286(17):3276–3298. https://doi.org/10.1111/febs.14970
Hong H, Jang BC (2014) Prednisone inhibits the IL-1β-induced expression of COX-2 in HEI-OC1 murine auditory cells through the inhibition of ERK-1/2, JNK-1 and AP-1 activity. Int J Mol Med 34(6):1640–1646. https://doi.org/10.3892/ijmm.2014.1967
Jiang R, Duan J, Windemuth A, Stephens JC, Judson R, Xu C (2003) Genome-wide evaluation of the public SNP databases. Pharmacogenomics 4(6):779–789. https://doi.org/10.1517/phgs.4.6.779.22821
Johnson GL, Nakamura K (2007) The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Biochim Biophys Acta 1773(8):1341–1348. https://doi.org/10.1016/j.bbamcr.2006.12.009
Kharbanda S, Saxena S, Yoshida K, Pandey P, Kaneki M, Wang Q, Cheng K, Chen YN, Campbell A, Sudha T, Yuan ZM, Narula J, Weichselbaum R, Nalin C, Kufe D (2000) Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem 275(1):322–327. https://doi.org/10.1074/jbc.275.1.322
Li X, Huo X, Liu K, Li X, Wang M, Chu H, Hu F, Sheng H, Zhang Z, Zhu B (2013) Association between genetic variations in GRHL2 and noise-induced hearing loss in Chinese high intensity noise exposed workers: a case–control analysis. Ind Health 51(6):612–621. https://doi.org/10.2486/indhealth.2012-0084
Li X, Rong X, Wang Z, Lin A (2020) Association between smoking and noise-induced hearing loss: a meta-analysis of observational studies. Int J Environ Res Public Health 17(4):1201. https://doi.org/10.3390/ijerph17041201
Lie A, Skogstad M, Johannessen HA, Tynes T, Mehlum IS, Nordby KC, Engdahl B, Tambs K (2016) Occupational noise exposure and hearing: a systematic review. Int Arch Occup Environ Health 89(3):351–372. https://doi.org/10.1007/s00420-015-1083-5
Liu J, Minemoto Y, Lin A (2004) c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis. Mol Cell Biol 24(24):10844–10856. https://doi.org/10.1128/mcb.24.24.10844-10856.2004
Liu L, Fang C, Yang J, Zhang H, Huang Y, Xuan C, Wang Y, Li S, Sha J, Zha M, Guo M (2018) The effect of noise exposure on insulin sensitivity in mice may be mediated by the JNK/IRS1 pathway. Environ Health Prev Med 23(1):6. https://doi.org/10.1186/s12199-018-0694-3
Maeda Y, Fukushima K, Omichi R, Kariya S, Nishizaki K (2013) Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. PLoS ONE 8(3):e58775. https://doi.org/10.1371/journal.pone.0058775
Meyer KB, Maia AT, O’Reilly M, Ghoussaini M, Prathalingam R, Porter-Gill P, Ambs S, Prokunina-Olsson L, Carroll J, Ponder BA (2011) A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression. PLoS Genet 7(7):e1002165. https://doi.org/10.1371/journal.pgen.1002165
Niu X, Shao R, Canlon B (2003) Suppression of apoptosis occurs in the cochlea by sound conditioning. NeuroReport 14(7):1025–1029. https://doi.org/10.1097/01.wnr.0000070830.57864.32
Parsons J, Reed MB, Torre IP (2019) Headphones and other risk factors for hearing in young adults. Noise Health 21(100):116–124. https://doi.org/10.4103/nah.NAH_35_19
Pirvola U, Xing-Qun L, Virkkala J, Saarma M, Murakata C, Camoratto AM, Walton KM, Ylikoski J (2000) Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci 20(1):43–50
Pyykkö I, Toppila E, Zou J, Kentala E (2009) Individual susceptibility to noise-induced hearing loss. Audiol Med 5:41–53. https://doi.org/10.1080/16513860601175998
Sang L, Zheng T, Min L, Zhang X, Ma X, Entenman S, Su Y, Zheng Q (2017) Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss. Int J Mol Med 40(1):146–154. https://doi.org/10.3892/ijmm.2017.3004
Shi YY, He L (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15(2):97–98. https://doi.org/10.1038/sj.cr.7290272
Stucken EZ, Hong RS (2014) Noise-induced hearing loss: an occupational medicine perspective. Curr Opin Otolaryngol Head Neck Surg 22(5):388–393. https://doi.org/10.1097/moo.0000000000000079
Tsai MS, Wang YH, Lai YY, Tsou HK, Liou GG, Ko JL, Wang SH (2018) Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice. Toxicol Lett 290:97–109. https://doi.org/10.1016/j.toxlet.2018.03.024
Wang BS, Xu K, Zhang H, Pu YP, Yin LH, Han L, Chen L, Wang N, Zhu BL, Zhang J (2019) Association between NFE2L2 gene polymorphisms and noise-induced hearing loss in a Chinese population. Biomed Environ Sci 32(6):465–470. https://doi.org/10.3967/bes2019.063
Wang J, Ruel J, Ladrech S, Bonny C, van de Water TR, Puel JL (2007) Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals. Mol Pharmacol. 71(3):654–666. https://doi.org/10.1124/mol.106.028936
Wang J, Van De Water TR, Bonny C, de Ribaupierre F, Puel JL, Zine A (2003) A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci. 23(24):8596–8607
Wu Y, Ni J, Qi M, Cao C, Shao Y, Xu L, Ma H, Yang L (2017) Associations of genetic variation in CASP3 gene with noise-induced hearing loss in a Chinese population: a case-control study. Environ Health 16(1):78. https://doi.org/10.1186/s12940-017-0280-y
Xu XR, Wang JJ, Yang QY, Jiao J, He LH, Yu SF, Gu GZ, Chen GS, Zhou WH, Wu H, Li YH, Zhang HL, Zhang ZR, Jin XN (2017) The effect of PCDH15 gene variations on the risk of noise-induced hearing loss in a Chinese population. Biomed Environ Sci BES 30(2):143–146. https://doi.org/10.3967/bes2017.019
Yamamoto K, Ichijo H, Korsmeyer SJ (1999) BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 19(12):8469–8478. https://doi.org/10.1128/mcb.19.12.8469
Yamashita D, Minami SB, Kanzaki S, Ogawa K, Miller JM (2008) Bcl-2 genes regulate noise-induced hearing loss. J Neurosci Res 86(4):920–928. https://doi.org/10.1002/jnr.21533
Ylikoski J, Xing-Qun L, Virkkala J, Pirvola U (2002) Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death. Hear Res 166(1–2):33–43. https://doi.org/10.1016/s0378-5955(01)00388-4
Yu P, Jiao J, Chen G, Zhou W, Zhang H, Wu H, Li Y, Gu G, Zheng Y, Yu Y, Yu S (2018) Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study. BMC Med Genet 19(1):4. https://doi.org/10.1186/s12881-017-0515-3
Zeke A, Misheva M, Remenyi A, Bogoyevitch MA (2016) JNK signaling: regulation and functions based on complex protein-protein partnerships. Microbiol Mol Biol Rev 80(3):793–835. https://doi.org/10.1128/mmbr.00043-14