India Project Team of ICGC (2013) Mutational landscape of gingivobuccal oral squamous cell carcinoma reveals new recurrently mutated genes and molecular subgroups. Nat Commun 4:2873
Anantharaman D, Chaubal PM, Kannan S, Bhisey RA, Mahimkar MB (2007) Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator. Carcinogenesis 28(7):1455–1462
Parkin DM, Bray F, Ferlay J et al (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108
Jayalekshmi PA, Gangadharan P, Akiba S et al (2011) Oral cavity cancer risk in relation to tobacco chewing, bidi smoking among men in Karunagappally, Kerala, India: Karunagappally cohort study. Cancer Sci 102:460–467
Du L, Shen J, Weems A, Lu S-L (2012) Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma. J Oncol 2012:1–12
Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind SJ (2009) Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 45:324–334
Leemans CR, Braakhuis BJ, Brakenhoff RH (2011) The molecular biology of head and neck cancer. Nat Rev Cancer 11:9–22
Kang S, Bader AG, Vogt PK (2005) Phosphatisidynositol 3 kinase mutations identified in human cancer are oncogenic. PNAS 102(3):802–807
Qiu W, Schönleben F, Li X et al (2006) PIK3CA mutations in head and neck squamous cell carcinoma. Clin Cancer Res 12:1441–1446
Ma Z et al (2013) Role of KAI1/CD82 polymorphisms in colon cancer risk in Han Chinese population. Med Oncol 30(3):668
Xing JC, Tufano RP, Murugan AK, Liu D, Wand G et al (2012) Single nucleotide polymorphism rs17849071 G/T in the PIK3CA gene is inversely associated with follicular thyroid cancer and PIK3CA amplification. PLoS One 7(11):e49192
Liu P, Cheng H, Roberts TM et al (2009) Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 8:627–644
Collins F, Brooks L, Chakravarti A (1998) A DNA polymorphism discovery resource for research on human genetic variation. Genome Res 8(12):1229–1231
Wang X, Tomso D, Liu X, Bell D (2005) Single nucleotide polymorphism in transcriptional regulatory regions and expression of environmentally responsive genes. Toxicol Appl Pharmacol 207(2):84–90
Liu Z, Wei S, Ma H, Zhao M, Myers JN, Weber RS, Sturgis EM, Wei Q (2011) A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck. Carcinogenesis 32(11):1668–1674
Shah S, Shah S, Padh H, Kalia K (2015) Genetic alterations of the PIK3CA oncogene in human oral squamous cell carcinoma in an Indian population. Oral Surg Oral Med Oral Pathol Oral Radiol 120(5):628–635
Kostakis GC, Papadogeorgakis N, Koumaki V, Kamakari S, Koumaki D, Alexandridis C (2010) Absence of hotspot mutations in exons 9 and 20 of the PIK3CA gene in human oral squamous cell carcinoma in the Greek population. Oral Surg Oral Med Oral Pathol Oral Radiol 109:53–58
Tanwar R, Iyengar AR, Nagesh KS, Patil S, Subhash BV (2015) Prevalence of glutathione S-transferase M1 null polymorphism in tobacco users, oral leukoplakia and oral squamous cell carcinoma patients in South Indian population: a polymerase chain reaction study. Contemp Clin Dent 6(Suppl 1):S59–S64
Kietthubthew S, Sriplung H, Au W, Ishida T (2006) Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand. Int J Hyg Environ Health 209(1):21–29
Tu H, Wu C, Kao S, Liu C, Liu T, Lui M (2007) Functional − 1562 C-to-T polymorphism in matrix metalloproteinase-9 (MMP-9) promoter is associated with the risk for oral squamous cell carcinoma in younger male areca users. J Oral Pathol Med 36(7):409–414
Yen C, Liu S, Chen C, Tseng H, Chuang L, Yang C et al (2008) Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan. J Oral Pathol Med 37(5):271–277
Dahia PM (2000) PTEN, a unique tumor suppressor gene. Endocr Relat Cancer 7:115–129
Yamada KM, Araki M (2001) Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Sci 114:2375–2382
Bu S, Asano Y, Bujor A, Highland K, Hant F, Trojanowska M (2010) Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. Arthritis Rheum 62:2117–2126
Hao LS, Zhang XL, An JY, Karlin J, Tian XP, Dun ZN, Xie SR, Chen S (2009) PTEN expression is down-regulated in liver tissues of rats with hepatic fibrosis induced by biliary stenosis. APMIS 117:681–691
Kato M, Putta S, Wang M, Yuan H, Lanting L, Nair I, Gunn A, Nakagawa Y, Shimano H, Todorov I, Rossi JJ, Natarajan R (2009) TGF beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nat Cell Biol 11:881–889
Xia H, Diebold D, Nho R, Perlman D, Kleidon J, Kahm J, Avdulov S, Peterson M, Nerva J, Bitterman P, Henke C (2008) Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis. J Exp Med 205:1659–1672
Kuwano K (2006) PTEN as a new agent in the fight against fibrogenesis. Am J Respir Crit Care Med 173:5–6
Teunissen BE, Smeets PJ, Willemsen PH, De Windt LJ, Van der Vusse GJ, Van Bilsen M (2007) Activation of PPAR delta inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts. Cardiovasc Res 75:519–529
Shah S, Jajal D, Mishra G, Kalia K (2017) Genetic profile of PTEN gene in Indian oral squamous cell carcinoma primary tumors. J Oral Pathol Med 46(2):106–111