Single nuclei RNA sequencing of the rat AP and NTS following GDF15 treatment

Bauskin, 2006, Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer, Cancer Research, 66, 4983, 10.1158/0008-5472.CAN-05-4067 Tsai, 2018, The MIC-1/GDF15-GFRAL pathway in energy homeostasis: implications for obesity, cachexia, and other associated diseases, Cell Metabolism, 28, 353, 10.1016/j.cmet.2018.07.018 Staff, 2010, Growth differentiation factor-15 as a prognostic biomarker in ovarian cancer, Gynecologic Oncology, 118, 237, 10.1016/j.ygyno.2010.05.032 Mullican, 2018, Uniting GDF15 and GFRAL: therapeutic opportunities in obesity and beyond, Trends in Endocrinology and Metabolism, 29, 560, 10.1016/j.tem.2018.05.002 Brown, 2003, MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma, Clinical Cancer Research, 9, 2642 Skipworth, 2010, Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer, British Journal of Cancer, 102, 665, 10.1038/sj.bjc.6605532 Koopmann, 2004, Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers, Clinical Cancer Research, 10, 2386, 10.1158/1078-0432.CCR-03-0165 Breit, 2011, The TGF-beta superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism, Growth Factors, 29, 187, 10.3109/08977194.2011.607137 Adela, 2015, GDF-15 as a target and biomarker for diabetes and cardiovascular diseases: a translational prospective, Journal of Diabetes Research, 2015, 490842, 10.1155/2015/490842 Bao, 2019, Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmo Diet and Cancer-Cardiovascular Cohort, Diabetologia, 62, 78, 10.1007/s00125-018-4751-7 Borner, 2020, GDF15 induces anorexia through nausea and emesis, Cell Metabolism, 31, 351, 10.1016/j.cmet.2019.12.004 Borner, 2020, GDF15 induces an aversive visceral malaise state that drives anorexia and weight loss, Cell Reports, 31, 107543, 10.1016/j.celrep.2020.107543 Johnen, 2007, Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1, Nature Medicine, 13, 1333, 10.1038/nm1677 Tsai, 2014, The anorectic actions of the TGFbeta cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract, PLoS One, 9, 10.1371/journal.pone.0100370 Breit, 2017, Targeting obesity and cachexia: identification of the GFRAL receptor-MIC-1/GDF15 pathway, Trends in Molecular Medicine, 23, 1065, 10.1016/j.molmed.2017.10.005 Emmerson, 2017, The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL, Nature Medicine, 23, 1215, 10.1038/nm.4393 Hsu, 2017, Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15, Nature, 550, 255, 10.1038/nature24042 Mullican, 2017, GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates, Nature Medicine, 23, 1150, 10.1038/nm.4392 Yang, 2017, GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand, Nature Medicine, 23, 1158, 10.1038/nm.4394 Hesketh, 2008, Chemotherapy-induced nausea and vomiting, New England Journal of Medicine, 358, 2482, 10.1056/NEJMra0706547 Babic, 2014, The role of vagal neurocircuits in the regulation of nausea and vomiting, European Journal of Pharmacology, 722, 38, 10.1016/j.ejphar.2013.08.047 Jiang, 2021, Emerging roles of growth differentiation factor-15 in brain disorders (Review), Experimental and Therapeutic Medicine, 22, 1270, 10.3892/etm.2021.10705 Harlid, 2021, Risk-predictive and diagnostic biomarkers for colorectal cancer; a systematic review of studies using pre-diagnostic blood samples collected in prospective cohorts and screening settings, Cancers, 13, 10.3390/cancers13174406 Meijers, 2021 Olson, 2021, Neural mechanisms of cancer cachexia, Cancers, 13, 10.3390/cancers13163990 Wittekind, 2021, Genome-wide association and transcriptome analysis suggests total serum ghrelin to be linked with GFRAL, European Journal of Endocrinology, 184, 847, 10.1530/EJE-20-1220 Dowsett, 2021, A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing, Molecular Metabolism, 53, 101240, 10.1016/j.molmet.2021.101240 Ludwig, 2021, A genetic map of the mouse dorsal vagal complex and its role in obesity, Nat Metab, 3, 530, 10.1038/s42255-021-00363-1 Zhang, 2021, Area postrema cell types that mediate nausea-associated behaviors, Neuron, 109, 461, 10.1016/j.neuron.2020.11.010 Cui, 2021, The role of glia in the physiology and pharmacology of GLP-1: implications for obesity, diabetes, and neurodegenerative processes including glaucoma, British Journal of Pharmacology Grill, 2012, Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance, Cell Metabolism, 16, 296, 10.1016/j.cmet.2012.06.015 Kanoski, 2016, GLP-1 and weight loss: unraveling the diverse neural circuitry, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 310, R885, 10.1152/ajpregu.00520.2015 Borner, 2021, GIP receptor agonism attenuates GLP-1 receptor agonist induced nausea and emesis in preclinical models, Diabetes, 10.2337/db21-0459 Reiner, 2020 Mathys, 2019, Single-cell transcriptomic analysis of Alzheimer's disease, Nature, 570, 332, 10.1038/s41586-019-1195-2 Nagy, 2020, Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons, Nature Neuroscience, 10.1038/s41593-020-0621-y Schirmer, 2019, Neuronal vulnerability and multilineage diversity in multiple sclerosis, Nature, 573, 75, 10.1038/s41586-019-1404-z Velmeshev, 2019, Single-cell genomics identifies cell type-specific molecular changes in autism, Science, 364, 685, 10.1126/science.aav8130 Nagy, 2020, Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons, Nature Neuroscience, 23, 771, 10.1038/s41593-020-0621-y Osorio, 2020, Systematic determination of the mitochondrial proportion in human and mice tissues for single-cell RNA sequencing data quality control, Bioinformatics Zhang, 2020, Area postrema cell types that mediate nausea-associated behaviors, Neuron Mase, 2020, Notch1 and Notch2 collaboratively maintain radial glial cells in mouse neurogenesis, Neurosciences Research Pollen, 2015, Molecular identity of human outer radial glia during cortical development, Cell, 163, 55, 10.1016/j.cell.2015.09.004 Kramer, 2014, Causal analysis approaches in ingenuity pathway analysis, Bioinformatics, 30, 523, 10.1093/bioinformatics/btt703 Liberzon, 2011, Molecular signatures database (MSigDB) 3.0, Bioinformatics, 27, 1739, 10.1093/bioinformatics/btr260 Rochette, 2020, Insights into mechanisms of GDF15 and receptor GFRAL: therapeutic targets, Trends in Endocrinology and Metabolism, 31, 939, 10.1016/j.tem.2020.10.004 Schreiber, 1995, Hormone delivery systems to the brain-transthyretin, Experimental and Clinical Endocrinology & Diabetes, 103, 75, 10.1055/s-0029-1211332 Zheng, 2016, Central transthyretin acts to decrease food intake and body weight, Scientific Reports, 6, 24238, 10.1038/srep24238 Worth, 2020, The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling, Elife, 9, 10.7554/eLife.55164 Cimino, 2021, Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15, Proceedings of the National Academy of Sciences of the U S A, 118, 10.1073/pnas.2106868118 Sharma, 2019, The extracellular protein, transthyretin is an oxidative stress biomarker, Frontiers in Physiology, 10, 5, 10.3389/fphys.2019.00005 Dyer, 2016, The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity, Neuroscience, 325, 89, 10.1016/j.neuroscience.2016.03.056 Heald, 2006, Insulin-like growth factor binding protein-2 (IGFBP-2) is a marker for the metabolic syndrome, Experimental and Clinical Endocrinology & Diabetes, 114, 371, 10.1055/s-2006-924320 Shen, 2008, Brain apolipoprotein E: an important regulator of food intake in rats, Diabetes, 57, 2092, 10.2337/db08-0291 Johnen, 2012, Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE(-/-) mice from the development of atherosclerosis, Cardiovascular Pathology, 21, 499, 10.1016/j.carpath.2012.02.003