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Virus Sindbis can thiệp vào sự sao chép của virus dengue 4 và khả năng truyền bệnh của Aedes albopictus
Tóm tắt
Muỗi là tác nhân truyền nhiều loại virus arbovirus liên quan đến các đợt bùng phát bệnh ở người và động vật khác. Phần lớn các virus arbovirus quan trọng về mặt y tế thuộc về ba họ: Togaviridae, Flaviviridae và Bunyaviridae. Nhiều thành viên của các họ này có phân bố chồng chéo và chia sẻ các véc-tơ chung, làm tăng khả năng coinfection arboviral. Nghiên cứu này đã xem xét cách hai virus mô hình: virus Sindbis (SINV, Togaviridae: Alphavirus) và virus dengue-4 (DENV-4, Flaviviridae: Flavivirus) có thể tương tác trong tế bào C6/36 Aedes albopictus và trong véc-tơ muỗi Ae. albopictus. Tế bào C6/36 được đồng nhiễm, siêu nhiễm hoặc nhiễm riêng từng virus SINV và DENV-4, sau đó hai virus được định lượng tại các thời điểm khác nhau. Những con cái trưởng thành Ae. albopictus từ 4 đến 7 ngày tuổi cũng được cho ăn máu chứa một hoặc cả hai virus và tỷ lệ nhiễm virus và tỷ lệ truyền bệnh được xác định. Virus Sindbis ức chế sự sao chép của DENV-4 trong tế bào C6/36 Aedes albopictus, với sự ức chế mạnh hơn xảy ra khi hai arbovirus được tiêm đồng thời chứ không phải theo thứ tự. Thêm vào đó, Ae. albopictus được tiếp xúc đồng thời với cả hai arbovirus có tỷ lệ nhiễm DENV-4 và tỷ lệ truyền bệnh trong quần thể thấp hơn đáng kể so với những con chỉ tiếp xúc với DENV-4. Những kết quả này gợi ý rằng một số Alphavirus có thể can thiệp vào việc truyền bệnh DENV-4 bằng cách ức chế sự sao chép của nó và làm tăng tính kháng của véc-tơ. Các phát hiện cung cấp thông tin quan trọng về sự đóng góp tiềm năng của các nhiễm trùng arboviral hỗn hợp vào động lực truyền bệnh DENV.
Từ khóa
#Virus Sindbis #virus dengue-4 #Aedes albopictus #nhiễm trùng arbovirus #sao chép virus #tỷ lệ truyền bệnh.Tài liệu tham khảo
Gubler DJ. The global emergence/resurgence of arboviral diseases as public health problems. Arch Med Res. 2002;33:330–42.
Newman CM, Cerutti F, Anderson TK, Hamer GL, Walker ED, Kitron UD, et al. Culex flavivirus and West Nile virus mosquito coinfection and positive ecological association in Chicago, United States. Vector Borne Zoonotic Dis. 2011;11:1099–105.
Chahar HS, Bharaj P, Dar L, Guleria R, Kabra SK, Broor S. Co-infections with Chikungunya virus and dengue virus in Delhi, India. Emerg Infect Dis. 2009;15:1077–80.
Chang SF, Su CL, Shu PY, Yang CF, Liao TL, Cheng CH, et al. Concurrent isolation of Chikungunya virus and Dengue virus from a patient with coinfection resulting from a trip to Singapore. J Clin Microbiol. 2010;48:4586–9.
Reisen WK, Hahn DC. Comparison of immune responses of brown-headed cowbird and related blackbirds to west Nile and other mosquito-borne encephalitis viruses. J Wildl Dis. 2007;43:439–49.
Miralles R, Ferrer R, Sole RV, Moya A, Elena SF. Multiple infection dynamics has pronounced effects on the fitness of RNA viruses. J Evol Biol. 2001;14:654–62.
Zebovitz E, Brown A. Interference among group A arboviruses. J Virol. 1968;2:1283–9.
Karpf AR, Lenches E, Strauss EG, Strauss JH, Brown DT. Superinfection exclusion of alphaviruses in three mosquito cell lines persistently infected with Sindbis virus. J Virol. 1997;71:7119–23.
Eaton BT. Heterologous interference in Aedes albopictus cells infected with alphaviruses. J Virol. 1979;30:45–55.
Pepin KM, Lambeth K, Hanley KA. Asymmetric competitive suppression between strains of dengue virus. BMC Microbiol. 2008;8:28.
Pepin KM, Hanley KA. Density-dependent competitive suppression of sylvatic dengue virus by endemic dengue virus in cultured mosquito cells. Vector Borne Zoonotic Dis. 2008;8:821–8.
Beaty BJ, Bishop DH, Gay M, Fuller F. Interference between bunyaviruses in Aedes triseriatus mosquitoes. Virology. 1983;127:83–90.
Pesko K, Mores CN. Effect of sequential exposure on infection and dissemination rates for West Nile and St. Louis encephalitis viruses in Culex quinquefasciatus. Vector Borne Zoonotic Dis. 2009;9:281–6.
Kent RJ, Crabtree MB, Miller BR. Transmission of West Nile virus by Culex quinquefasciatus say infected with Culex Flavivirus Izabal. PLoS Negl Trop Dis. 2010;4:e671.
Anderson KB, Gibbons RV, Edelman R, Eckels KH, Putnak RJ, Innis BL, et al. Interference and facilitation between dengue serotypes in a tetravalent live dengue virus vaccine candidate. J Infect Dis. 2011;204:442–50.
Dittmar D, Castro A, Haines H. Demonstration of interference between dengue virus types in cultured mosquito cells using monoclonal antibody probes. J Gen Virol. 1982;59:273–82.
Beaty BJ, Rozhon EJ, Gensemer P, Bishop DH. Formation of reassortant bunyaviruses in dually infected mosquitoes. Virology. 1981;111:662–5.
Sall AA, Zanotto PM, Sene OK, Zeller HG, Digoutte JP, Thiongane Y, et al. Genetic reassortment of Rift Valley fever virus in nature. J Virol. 1999;73:8196–200.
Delatte H, Paupy C, Dehecq JS, Thiria J, Failloux AB, Fontenille D. Aedes albopictus, vector of chikungunya and dengue viruses in Reunion Island: biology and control. Parasite. 2008;15:3–13.
Charrel RN, de Lamballerie X, Raoult D. Chikungunya outbreaks: the globalization of vectorborne diseases. N Engl J Med. 2007;356:769–71.
Muturi EJ, Costanzo K, Kesavaraju B, Alto BW. Can pesticides and larval competition alter susceptibility of Aedes mosquitoes (Diptera: Culicidae) to arbovirus infection? J Med Entomol. 2011;48:429–36.
Muturi EJ, Alto BW. Larval environmental temperature and insecticide exposure alter Aedes aegypti competence for arboviruses. Vector Borne Zoonotic Dis. 2011;11:1157–63.
Durbin AP, Karron RA, Sun W, Vaughn DW, Reynolds MJ, Perreault JR, et al. Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3′-untranslated region. Am J Trop Med Hyg. 2001;65:405–13.
Ratsitorahina M, Harisoa J, Ratovonjato J, Biacabe S, Reynes JM, Zeller H, et al. Outbreak of dengue and Chikungunya fevers, Toamasina, Madagascar, 2006. Emerg Infect Dis. 2008;14:1135–7.
WHO. Outbreak news: Chikungunya and dengue, south-west Indian Ocean. Wkly Epidemiol Rec. 2006;81:106–8.
Newton SE, Short NJ, Dalgarno L. Bunyamwera virus replication in cultured Aedes albopictus (mosquito) cells: establishment of a persistent viral infection. J Virol. 1981;38:1015–24.
Brackney DE, Scott JC, Sagawa F, Woodward JE, Miller NA, Schilkey FD, et al. C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response. PLoS Negl Trop Dis. 2010;4:e856.
Sabin AB. Research on dengue during World War II. Am J Trop Med Hyg. 1952;1:30–50.
Rohani A, Potiwat R, Zamree I, Lee HL. Refractoriness of Aedes aegypti (Linnaeus) to dual infection with dengue and chikungunya virus. Southeast Asian J Trop Med Public Health. 2009;40:443–8.
Chamberlain RW, Sudia WD. Dual infections of eastern and western equine encephalitis viruses in Culex tarsalis. J Infect Dis. 1957;101:233–6.
Vazeille M, Mousson L, Martin E, Failloux AB. Orally co-Infected Aedes albopictus from La Reunion Island, Indian Ocean, can deliver both dengue and chikungunya infectious viral particles in their saliva. PLoS Negl Trop Dis. 2010;4:e706.
Sundin DR, Beaty BJ. Interference to oral superinfection of Aedes triseriatus infected with La Crosse virus. Am J Trop Med Hyg. 1988;38:428–32.
Beaty BJ, Sundin DR, Chandler LJ, Bishop DH. Evolution of bunyaviruses by genome reassortment in dually infected mosquitoes (Aedes triseriatus). Science. 1985;230:548–50.
Myles KM, Pierro DJ, Olson KE. Comparison of the transmission potential of two genetically distinct Sindbis viruses after oral infection of Aedes aegypti (Diptera: Culicidae). J Med Entomol. 2004;41:95–106.
Bennett KE, Olson KE, Munoz Mde L, Fernandez-Salas I, Farfan-Ale JA, Higgs S, et al. Variation in vector competence for dengue 2 virus among 24 collections of Aedes aegypti from Mexico and the United States. Am J Trop Med Hyg. 2002;67:85–92.
Beerntsen BT, James AA, Christensen BM. Genetics of mosquito vector competence. Microbiol Mol Biol Rev. 2000;64:115–37.
Kramer LD, Hardy JL, Presser SB, Houk EJ. Dissemination barriers for western equine encephalomyelitis virus in Culex tarsalis infected after ingestion of low viral doses. Am J Trop Med Hyg. 1981;30:190–7.
Riedel B, Brown DT. Novel antiviral activity found in the media of Sindbis virus-persistently infected mosquito (Aedes albopictus) cell cultures. J Virol. 1979;29:51–60.
Keene KM, Foy BD, Sanchez-Vargas I, Beaty BJ, Blair CD, Olson KE. RNA interference acts as a natural antiviral response to O'nyong-nyong virus (Alphavirus; Togaviridae) infection of Anopheles gambiae. Proc Natl Acad Sci U S A. 2004;101:17240–5.
Sanchez-Vargas I, Travanty EA, Keene KM, Franz AW, Beaty BJ, Blair CD, et al. RNA interference, arthropod-borne viruses, and mosquitoes. Virus Res. 2004;102:65–74.
Khoo CC, Piper J, Sanchez-Vargas I, Olson KE, Franz AW. The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegypti. BMC Microbiol. 2010;10:130.
Muturi EJ, Kim CH, Alto BW, Berenbaum MR, Schuler MA. Larval environmental stress alters Aedes aegypti competence for Sindbis virus. Trop Med Int Health. 2011;16:955–64.
Vasilakis N, Deardorff ER, Kenney JL, Rossi SL, Hanley KA, Weaver SC. Mosquitoes put the brake on arbovirus evolution: experimental evolution reveals slower mutation accumulation in mosquito than vertebrate cells. PLoS Pathog. 2009;5:e1000467.
Myles KM, Pierro DJ, Olson KE. Deletions in the putative cell receptor-binding domain of Sindbis virus strain MRE16 E2 glycoprotein reduce midgut infectivity in Aedes aegypti. J Virol. 2003;77:8872–81.
Hanley KA, Nelson JT, Schirtzinger EE, Whitehead SS, Hanson CT. Superior infectivity for mosquito vectors contributes to competitive displacement among strains of dengue virus. BMC Ecol. 2008;8:1.
Armstrong PM, Rico-Hesse R. Differential susceptibility of Aedes aegypti to infection by the American and Southeast Asian genotypes of dengue type 2 virus. Vector Borne Zoonotic Dis. 2001;1:159–68.
Armstrong PM, Rico-Hesse R. Efficiency of dengue serotype 2 virus strains to infect and disseminate in Aedes aegypti. Am J Trop Med Hyg. 2003;68:539–44.
Davis CT, Ebel GD, Lanciotti RS, Brault AC, Guzman H, Siirin M, et al. Phylogenetic analysis of North American West Nile virus isolates, 2001–2004: evidence for the emergence of a dominant genotype. Virology. 2005;342:252–65.
Leroy EM, Nkoghe D, Ollomo B, Nze-Nkogue C, Becquart P, Grard G, et al. Concurrent chikungunya and dengue virus infections during simultaneous outbreaks, Gabon, 2007. Emerg Infect Dis. 2009;15:591–3.
Lefevre T, Vantaux A, Dabire KR, Mouline K, Cohuet A. Non-genetic determinants of mosquito competence for malaria parasites. PLoS Pathog. 2013;9:e1003365.
