Simultaneous determination of synthetic cannabinoids in illegal herbal products and blood by LC/TOF-MS, and linear regression analysis of retention time using log Pow

Huffman, 2003, 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor, Bioorgan. Med. Chem., 11, 539, 10.1016/S0968-0896(02)00451-0 Hermanns-Clausen, 2013, Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings, Addiction, 108, 534, 10.1111/j.1360-0443.2012.04078.x Shanks, 2012, Detection of JWH-018 and JWH-073 by UPLC–MS-MS in postmortem whole blood casework, J. Anal. Toxicol., 36, 145, 10.1093/jat/bks013 Labay, 2016, Synthetic cannabinoid drug use as a cause or contributory cause of death, Forensic Sci. Int., 260, 31, 10.1016/j.forsciint.2015.12.046 Teske, 2010, Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in human serum by liquid chromatography–tandem mass spectrometry, J. Chromatogr. B, 878, 2659, 10.1016/j.jchromb.2010.03.016 Uchiyama, 2015, Evaluation of an on-site drug-testing device for the detection of synthetic cannabinoids in illegal herbal products, Yakugaku Zasshi, 135, 535, 10.1248/yakushi.14-00247 Hanajiri, 2013, Changes in the prevalence of synthetic cannabinoids and cathinone derivatives in Japan until early 2012, Forensic Toxicol., 31, 44, 10.1007/s11419-012-0165-2 Kneisel, 2012, Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction, J. Mass Spectrom., 47, 825, 10.1002/jms.3020 Öztürk, 2015, Validation of JWH-018 and its metabolites in blood and urine by UPLC–MS/MS: monitoring in forensic cases, Forensic Sci. Int., 248, 88, 10.1016/j.forsciint.2014.12.029 Schaefer, 2015, Simultaneous LC-MS/MS determination of JWH-210, RCS-4, Δ9-tetrahydrocannabinol, and their main metabolites in pig and human serum, whole blood, and urine for comparing pharmacokinetic data, Anal. Bioanal. Chem., 407, 3775, 10.1007/s00216-015-8605-6 Öztürk, 2015, Application of a validated LC–MS/MS method for JWH-073 and its metabolites in blood and urine in real forensic cases, Forensic Sci. Int., 257, 165, 10.1016/j.forsciint.2015.08.013 Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG): Recommendations (method of analysis/drug identification), July-7(2011), p. 14. Akutsu, 2016, Examination of analytical method for synthetic cannabinoids in human serum by solid-phase dispersive extraction-GC/MS, Jpn. J. Forensic Sci. Technol., 21, 75, 10.3408/jafst.703 Saito, 2019, Confirmation of synthetic cannabinoids in herb and blood by HS-SPME-GC/MS, Forensic. Chem., 13, 10.1016/j.forc.2019.100156 Saito, 2014, Solid-phase dispersive extraction method for analysis of benzodiazepine drugs in serum and urine samples, J. Pharm. Biomed. Anal., 100, 28, 10.1016/j.jpba.2014.07.020 Sakamoto, 2014, Sample cleanup using solid-phase dispersive extraction for determination of vancomycin in serum, Anal. Sci., 30, 271, 10.2116/analsci.30.271 Usui, 2012, Rapid drug extraction from human whole blood using a modified QuEChERS extraction method, Leg. Med., 14, 286, 10.1016/j.legalmed.2012.04.008 Westland, 2013, QuEChERS extraction of benzodiazepines in biological matrices, J. Pharm. Anal., 3, 509, 10.1016/j.jpha.2013.04.004 Recommended methods for the Identification and Analysis of Synthetic Cannabinoid Receptor Agonists, Manual for use by National Drug Analysis Laboratories, Laboratory and Scientific Section United Nations Office on Drugs and Crime Vienna, UN document ID number: ST/NAR/48, p.25, United Nations, New York, 2013. https://www.unodc.org/documents/scientific/STNAR48_ Synthetic_Cannabinoids_ENG.pdf. On-line Lipophilicity (logP), Water Solubility (LogS) & pKa Prediction, http://www.vcclab.org/lab/alogps/start.html. Shah, 2000, Bioanalytical method validation – a revisit with a decade of progress, Parm. Res., 17, 1551