Simultaneous Voltammetric Determination of Ascorbic Acid, Paracetamol, and Caffeine Using Electrochemically Reduced Graphene-Oxide-Modified Electrode

Journal of Nanomaterials - Tập 2018 - Trang 1-15 - 2018
Nguyen Hai Phong1, Trần Thanh Tâm Toàn1, Mai Xuan Tinh1, Trần Ngọc Tuyền1, Tran Xuan Mau1, Đinh Quang Khiếu1
1HU-University of Sciences, Hue 530000, Vietnam

Tóm tắt

In the present paper, graphene oxide was directly electrodeposited by means of cyclic voltammetric techniques on the glassy-carbon electrode (GCE) to obtain a reduced graphene-oxide-modified electrode (ErGO/GCE). Cyclic voltammetry (CV) and differential pulse anodic stripping voltammetry (DP-ASV) had been utilized to study the electrochemical behavior of ErGO/GCE toward ascorbic acid (AA), paracetamol (PA), and caffeine (CA). Differential pulse voltammetry results show that AA, PA, and CA could be detected selectively and sensitively on ErGO/GCE with peak-to-peak separation of 312 mV and 756 mV for AA–PA and PA–CA, respectively. The factors affecting the voltammetric signals such as pH, scan rate, and interferents were addressed. The results reveal that the ErGO/GCE-modified electrode exhibits excellent electrochemical activity in the oxidation of PA, CA, and AA. The detection limits are 0.36 μM, 0.25 μM, and 0.23 μM for AA, PA and CA, respectively, suggesting that the ErGO/GCE can be utilized with high sensitivity and selectivity for the simultaneous determination of these compounds. Finally, the proposed method was successfully used to determine AA, PA, and CA in pharmaceutical preparations.

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Journal of Nanomaterials

Tập 2018

1-15

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