Simple pA2 estimation of partial agonists: Comparison with the kaumann-blinks method

Journal of Pharmacological Methods - Tập 19 - Trang 47-56 - 1988
Gerald Pöch1, Isolde Zimmermann1
1From the Institut für Pharmakodynamik und Toxikologie, Karl-Franzens-Universität Graz, Universitätsplatz, Graz, Austria

Tài liệu tham khảo

Ariëns, 1956, A theoretical basis of molecular pharmacology. Part I: interaction of one or two compounds with one receptor system, Arzneim-Forsch, 6, 282 Arunlakshana, 1959, Some quantitative uses of drug antagonists, Br J Pharmacol, 14, 48 Kaumann, 1980, β-Adrenoceptor blocking agents as partial agonists in isolated heart muscle: Dissociation of stimulation and blockade, Naunyn-Schmiedeberg Arch Pharmacol, 311, 237, 10.1007/BF00569403 Kukovetz, 1976, Wirkung von Fendilin auf Herz und glatte Muskulatur, Arzneim-Forsch, 26, 1321 Levy, 1967, A comparison of the adrenergic receptor blocking properties of 1-(4'-methyl-phenyl)-2-isopropylamino-propanol-HCl and propranolol, J Pharmacol Exp Ther, 156, 452 Müller-Schweinitzer, 1974, Investigations on the mode of action of ergotamine in the isolated femoral vein of the dog, Br J Pharmacol, 51, 441, 10.1111/j.1476-5381.1974.tb10680.x Pöch, 1981, Quantitative Ermittlung potenzierender oder hemmender Kombinationswirkungen gleichsinnig wirkender Pharmaka. Vorteile einer Dosis-Wirkungs-Kurven-Methode gegenüber der Isobolen-Methode, Arzneim-Forsch, 31, 1135 Pöch, 1980, Quantitative estimation of overadditive and underadditive drug effects by means of theoretical, additive dose-response curves, J Pharmacol Meth, 4, 179, 10.1016/0160-5402(80)90036-4 (Erratum 5:183). Pöch, 1986, Simple pA2-estimation of partial agonists, Naunyn-Schmiedeberg Arch Pharmacol, 322, R1 Van den Brink, 1977, General theory of drug-receptor interactions. Drug-receptor interaction models. Calculation of drug parameters, 169 Waud, 1968, Pharmacological receptors, Pharmacol Rev, 20, 49 Winter-Holzinger, 1979, Qualitative und quantitative Bestimmung der Aktivier- und Blockier-barkeit adrenerger Rezeptoren des Typs β2