Simple method for bleeding the unanaesthetized rat by tail venipuncture

Laboratory Animals - Tập 21 Số 3 - Trang 261-264 - 1987
S.T. Omaye1, J.H. Skala2, M. D. Gretz2, Ellen E. Schaus2, Charles E. Wade3
1Biochemistry Research Unit, Western Human Nutrition Research Center, US Department of Agriculture, Agricultural Research Service, PO Box 29997, Presidio of San Francisco, CA 94129, USA; Toxicology Division, Letterman Army Institute of Research, Presidio of San Francisco, CA, USA
2Biochemistry Research Unit, Western Human Nutrition Research Center, US Department of Agriculture, Agricultural Research Service, PO Box 29997, Presidio of San Francisco, CA 94129, USA
3Division of Combat Casualty Care, Letterman Army Institute of Research, Presidio of San Francisco, CA, USA

Tóm tắt

A technique is described for the intermittent collection of blood from the rat tail. By using commonly available equipment, blood samples can easily be obtained from rats without the need for anaesthesia. The development of this technique makes the rat more readily available as an animal model for repeated withdrawals of small blood samples for pharmacokinetic or bioavailability evaluations.

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Laboratory Animals

Tập 21 Số 3

261-264

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