Anagnou NP, O' Brien SJ, Shimada T, Nash WG, Chen MJ, Nienhuis AW (1984) Chromosomal organisation of the human dihydrofolate reductase genes: dispersion, selective amplification and a novel form of polymorphism. Proc Natl Acad Sci USA 81:5170–5174
Biedermann KA, Sun J, Giaccia AJ, Tosto LM, Brown JM (1991) Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci USA 88:1394–1397
Blöcher D, Sigut D, Hannan MA (1991) Fibroblasts from ataxia telangiectasia (AT) and AT heterozygotes show an enhanced level of residual DNA double-strand breaks after low dose-rateγ-irradiation as assayed by pulsed field gel electrophoresis. Int J Radiat Biol 60:791–802
Bosma GC, Custer RP, Bosma MJ (1983) A severe combined immunodeficiency mutation in the mouse. Nature 301:527–530
Budach W, Hartford A, Gioioso D, Freeman J, Taghian A, Suit HD (1992) Tumors arising in SCID mice share enhanced radiation sensitivity of SCID normal tissues. Cancer Res 52:6292–6296
Carbonari M, Cherchi M, Paganelli R, Giannini G, Galli E, Gaetano C, Papetti C, Fiorilli M (1990) Relative increase of T cells expressing the gamma/delta rather than the alpha/beta receptor in ataxia-telangiectasia. N Engl J Med 322:73–76
Chadwick KH, Leenhouts HP (1981) The molecular theory of radiation biology. Springer, Berlin Heidelberg New York
Coquerelle TM, Weibezahn KF, Lücke-Huhle C (1987) Rejoining of double strand breaks in normal human and ataxia-telangiectasia fibroblasts after exposure to 60Coγ-rays, 241 AM α-particles or bleomycin. Int J Radiat Biol 51:209–218
Fulop GM, Phillips RA (1990) The scid mutation in mice causes a general defect in DNA repair. Nature 347:479–482
Gasser CS, Simonsen CC, Schilling JW, Schimke RT (1982) Expression of abbreviated mouse dihydrofolate reductase genes in cultured hamster cells. Proc Natl Acad Sci USA 79:6522–6526
Giulotto E, Bertoni L, Attolini C, Rainaldi G, Anglana M (1991) BHK cell lines with increased rates of gene amplification are hypersensitive to ultraviolet light. Proc Natl Acad Sci USA 88:3484–3488
Hendrickson EA, Qin X-Q, Bump EA, Schatz DG, Oettinger M, Weaver DT (1991) A link between double-strand break-related repair and V(D)J recombination: the scid mutation. Proc Natl Acad Sci USA 88:4061–4065
Hinrichs S (1986) Methotrexat Resistenz durch Genamplifikation in menschlichen Hautfibroblasten. Diplomarbeit, Universität Karlsruhe
Itoh M, Hamatani K, Komatsu K, Araki R, Takayama K, Abe M (1993) Human chromosome 8 (p12 → q22) complements radiosensitivity in the severe combined immune deficiency (SCID) mouse. Radiat Res 134:364–368
Komatsu K, Yoshida M, Okumura Y (1993) Murine scid cells complement ataxia-telangiectasia cells and show a normal post-irradiation response of DNA synthesis. Int J Radiat Biol 63:725–730
Lavi S, Etkin S (1981) Carcinogen-mediated induction of SV40 DNA snythesis in SV40 transformed Chinese hamster embryo cells. Carcinogenesis 2:417–423
Lücke-Huhle C, Comper W, Hieber L, Pech M (1982) Comparative study of G2 delay and survival after241 Americium-α and60Cobalt-γ irradiation. Radiat Environ Biophys 20:171–185
Lücke-Huhle C, Hinrichs S, Speit G (1987) DHFR gene amplification in cultured skin fibroblasts of ataxia telangiectasia patients after methotrexate selection. Carcinogenesis 8:1801–1806
Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning. A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
Meyn MS (1993) High spontaneous intrachromosomal recombination rates in ataxia-telangiectasia. Science 260:1327–1330
Minty AJ, Caravatti M, Robert B, Cohen A, Daubas P, Weydert A, Gros F, Buckingham ME (1981) Mouse actin messenger RNAs. J Biol Chem 256:1008–1014
Painter RB, Young BR (1980) Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc Natl Acad Sci USA 77:7315–7317
Powell S, Whitaker S, Peacock J, McMillan T (1993) Ataxia telangiectasia: an investigation of the repair defect in the cell line AT5BIVA by plasmid reconstitution. Mutat Res 294:9–20
Rigby PWJ, Dieckmann M, Rhodes C, Berg P (1977) Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase. J Mol Biol 113:237–251
Ritter S, Kraft-Weyrather W, Scholz M, Kraft G (1992) Induction of chromosome aberrations in mammalian cells after heavy ion exposure. Adv Space Res 12:119–125
Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503–517
Tlsty TD (1990) Normal diploid human and rodent cells lack a detectable frequency of gene amplification. Proc Natl Acad Sci USA 87:3132–3136
Wright JA, Smith HS, Watt FM, Hancock MC, Hudson DL, Stark GR (1990) DNA amplification is rare in normal human cells. Proc Natl Acad Sci USA 87:1791–1795