Silymarin and caffeine combination ameliorates experimentally-induced hepatic fibrosis through down-regulation of LPAR1 expression

Biomedicine & Pharmacotherapy - Tập 101 - Trang 49-57 - 2018
Salma M. Eraky1, Mohamed El-Mesery1, Amro El-Karef2, Laila A. Eissa1, Amal M. El-Gayar1
1Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt
2Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt

Tài liệu tham khảo

Dobie, 2016, Homing in on the hepatic scar: recent advances in cell-specific targeting of liver fibrosis, F1000Research, 5, 10.12688/f1000research.8822.1 Nakatani, 2008, Effects of decorin on the expression of alpha-smooth muscle actin in a human myofibroblast cell line, Mol. Cell. Biochem., 308, 201, 10.1007/s11010-007-9629-9 Cong, 2012, Cell signals influencing hepatic fibrosis, Int. J. Hepatol., 2012 Satish, 2011, Reversal of TGF-beta1 stimulation of alpha-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren’s-derived fibroblasts, BMC Musculoskelet. Disord., 12 Biernacka, 2011, TGF-β signaling in fibrosis, Growth Factors (Chur, Switz.), 29, 196, 10.3109/08977194.2011.595714 Oude Elferink, 2015, Lysophosphatidic acid and signaling in sensory neurons, Biochim. Biophys. Acta, 1851, 61, 10.1016/j.bbalip.2014.09.004 Lin, 2010, Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance, Prostaglandins Other Lipid Mediators, 91, 130, 10.1016/j.prostaglandins.2009.02.002 Hecht, 1996, Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex, J. Cell Biol., 135, 1071, 10.1083/jcb.135.4.1071 Yung, 2014, LPA receptor signaling: pharmacology, physiology, and pathophysiology, J. Lipid Res., 55, 1192, 10.1194/jlr.R046458 Heusinger-Ribeiro, 2001, Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP, J. Am. Soc. Nephrol.: JASN, 12, 1853, 10.1681/ASN.V1291853 Gan, 2011, Blockade of lysophosphatidic acid receptors LPAR1/3 ameliorates lung fibrosis induced by irradiation, Biochem. Biophys. Res. Commun., 409, 7, 10.1016/j.bbrc.2011.04.084 Ikeda, 1998, Effects of lysophosphatidic acid on proliferation of stellate cells and hepatocytes in culture, Biochem. Biophys. Res. Commun., 248, 436, 10.1006/bbrc.1998.8983 Wu, 2000, Hepatic stellate cells: a target for the treatment of liver fibrosis, J. Gastroenterol., 35, 665, 10.1007/s005350070045 Watanabe, 2007, Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C, J. Clin. Gastroenterol., 41, 616, 10.1097/01.mcg.0000225642.90898.0e Bode, 2007, The enigmatic effects of caffeine in cell cycle and cancer, Cancer Lett., 247, 26, 10.1016/j.canlet.2006.03.032 Arauz, 2017, Coffee consumption prevents fibrosis in a rat model that mimics secondary biliary cirrhosis in humans, Nutr. Res. (New York, N.Y.), 40, 65, 10.1016/j.nutres.2017.03.008 Amer, 2017, Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: biochemical and histological study, Int. J. Immunopathol. Pharmacol., 30, 13, 10.1177/0394632017694898 Modi, 2010, Increased caffeine consumption is associated with reduced hepatic fibrosis, Hepatology (Baltim., Md.), 51, 201, 10.1002/hep.23279 Ferenci, 2016, Silymarin in the treatment of liver diseases: what is the clinical evidence?, Clin. Liver Dis., 7, 8, 10.1002/cld.522 Federico, 2017, Silymarin/silybin and chronic liver disease: a marriage of many years, Molecules (Basel, Switz.), 22 Esmat, 2013, Bioactive compounds, antioxidant potential, and hepatoprotective activity of sea cucumber (Holothuria atra) against thioacetamide intoxication in rats, Nutrition (Burbank, Los Angeles Cty., Calif.), 29, 258, 10.1016/j.nut.2012.06.004 Kim, 2017, Anti-fibrotic effects of Cuscuta chinensis with in vitro hepatic stellate cells and a thioacetamide-induced experimental rat model, Pharm. Biol., 55, 1909, 10.1080/13880209.2017.1340965 Hsu, 2015, Caffeine ameliorates hemodynamic derangements and portosystemic collaterals in cirrhotic rats, Hepatology (Baltim., Md.), 61, 1672, 10.1002/hep.27679 Ishak, 1995, Histological grading and staging of chronic hepatitis, J. Hepatol., 22, 696, 10.1016/0168-8278(95)80226-6 James, 1990, Sirius red histophotometry and spectrophotometry of sections in the assessment of the collagen content of liver tissue and its application in growing rat liver, Liver, 10, 1, 10.1111/j.1600-0676.1990.tb00428.x Chen, 2012, Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis, J. Sci. Food Agric., 92, 1441, 10.1002/jsfa.4723 Salas-Villalobos, 2017, Mechanisms involved in liver damage resolution after hepatitis C virus clearance, Med. Univ., 19, 100 Dashti, 1987, Early biochemical and histological changes in rats exposed to a single injection of thioacetamide, Pharmacol. Toxicol., 60, 171, 10.1111/j.1600-0773.1987.tb01727.x Abo El-Magd, 2015, Hepatoprotective effects of glycyrrhizin and omega-3 fatty acids on Nuclear Factor-kappa B pathway in thioacetamide-induced fibrosis in rats, Egypt. J. Basic. Appl. Sci., 2, 65, 10.1016/j.ejbas.2014.12.005 Dehmlow, 1996, Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin, Hepatology (Baltim., Md.), 23, 749, 10.1002/hep.510230415 Karimi, 2011, "Silymarin", a promising pharmacological agent for treatment of diseases, Iran. J. Basic Med. Sci., 14, 308 Low, 2004, A proteomic analysis of thioacetamide-induced hepatotoxicity and cirrhosis in rat livers, Proteomics, 4, 3960, 10.1002/pmic.200400852 Amin, 2012, Protective role of Phyllanthus niruri extract against thioacetamide-induced liver cirrhosis in rat model, Evid.-Based Complement. Altern. Med.: eCAM, 241583 Kaplowitz, 2001, Drug-induced liver disorders: implications for drug development and regulation, Drug Saf., 24, 483, 10.2165/00002018-200124070-00001 Gressner, 2007, Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests, Clin. Chim.Acta; Int. J. Clin. Chem., 381, 107, 10.1016/j.cca.2007.02.038 Cao, 2017, Autocrine lysophosphatidic acid signaling activates beta-catenin and promotes lung allograft fibrosis, J. Clin. Invest., 127, 1517, 10.1172/JCI88896 Sakai, 2017, Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor, Kidney Int., 91, 628, 10.1016/j.kint.2016.09.030 Erstad, 2017, The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer, Mol. Cell. Oncol., 4, e1311827, 10.1080/23723556.2017.1311827 Ikeda, 2003, Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells, Am. J. Physiol. Gastrointest. Liver Physiol., 285, G880, 10.1152/ajpgi.00039.2003 Watanabe, 2007, Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity, Life Sci., 81, 1009, 10.1016/j.lfs.2007.08.013 Zhao, 2015, Lysophosphatidic acid receptor 1 antagonist ki16425 blunts abdominal and systemic inflammation in a mouse model of peritoneal sepsis, Transl. Res. : J. Lab. Clin. Med., 166, 80, 10.1016/j.trsl.2015.01.008 Tager, 2008, The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak, Nat. Med., 14, 45, 10.1038/nm1685 Friedman, 2008, Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver, Physiol. Rev., 88, 125, 10.1152/physrev.00013.2007 Zhou, 2017, Detrimental effects of nicotine on thioacetamide-induced liver injury in mice, Toxicol. Mech. Methods, 1 Sferra, 2017, Expression of pro-fibrotic and anti-fibrotic molecules in dimethylnitrosamine-induced hepatic fibrosis, Pathol. Res. Pract., 213, 58, 10.1016/j.prp.2016.11.004 Shaaban, 2014, Modulation of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis by olmesartan and omega-3, Chem. Biol. Interact., 207, 81, 10.1016/j.cbi.2013.10.008 Elmahdy, 2017, Anti-fibrotic potential of human umbilical cord mononuclear cells and mouse bone marrow cells in CCl4- induced liver fibrosis in mice, Biomed. Pharmacother. = Biomed. Pharmacother., 89, 1378, 10.1016/j.biopha.2017.03.007 Huang, 2017, Effect of lamivudine and silymarin on liver fibrosis-relevant factors in HBV transgenic mice with alcohol drinking, Zhong nan da xue xue bao. Yi xue ban = J. Cent. South Univ. Med. Sci., 42, 257 Gordillo-Bastidas, 2013, Nrf2 and snail-1 in the prevention of experimental liver fibrosis by caffeine, World J. Gastroenterol., 19, 9020, 10.3748/wjg.v19.i47.9020 Arauz, 2014, Caffeine prevents experimental liver fibrosis by blocking the expression of TGF-beta, Eur. J. Gastroenterol. Hepatol., 26, 164, 10.1097/MEG.0b013e3283644e26 Paradis, 2001, High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis, Hepatology (Baltim., Md.), 34, 738, 10.1053/jhep.2001.28055 Paradis, 2002, Effects and regulation of connective tissue growth factor on hepatic stellate cells, Lab. Invest.; J. Tech. Methods Pathol., 82, 767, 10.1097/01.LAB.0000017365.18894.D3 Borkham-Kamphorst, 2007, Pro-fibrogenic potential of PDGF-D in liver fibrosis, J. Hepatol., 46, 1064, 10.1016/j.jhep.2007.01.029 Algandaby, 2017, Icariin protects against thioacetamide-induced liver fibrosis in rats: implication of anti-angiogenic and anti-autophagic properties, Pharmacol. Rep.: PR, 69, 616, 10.1016/j.pharep.2017.02.016 Park, 2016, Comparison of TGF-beta, PDGF, and CTGF in hepatic fibrosis models using DMN, CCl4, and TAA, Drug Chem. Toxicol., 39, 111, 10.3109/01480545.2015.1052143 Tache, 2011, Evidence for the involvement of TGF-beta1-CTGF axis in liver fibrogenesis secondary to hepatic viral infection, Rom. J. Morphol. Embryol. = Revue roumaine de morphologie et embryologie, 52, 409 Narkewicz, 2005, Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresia, J. Pediatric Surg., 40, 1721, 10.1016/j.jpedsurg.2005.07.056 Yang, 2015, SHSST-cyclodextrin complex inhibits TGF-beta/Smad3/CTGF to a greater extent than silymarin in a rat model of carbon tetrachloride-induced liver injury, Mol. Med. Rep., 12, 6053, 10.3892/mmr.2015.4190 Lee, 2016, Ethyl acetate fraction of Amomum xanthioides exerts antihepatofibrotic actions via the regulation of fibrogenic cytokines in a dimethylnitrosamine-induced rat model, Evid.-Based Complement. Altern. Med. : eCAM, 2016, 6014380, 10.1155/2016/6014380 El-Mihi, 2017, Naringin attenuates thioacetamide-induced liver fibrosis in rats through modulation of the PI3K/Akt pathway, Life Sci., 187, 50, 10.1016/j.lfs.2017.08.019 Yang, 2017, Evodiamine ameliorates liver fibrosis in rats via TGF-beta1/Smad signaling pathway, J. Nat. Med., 72, 145, 10.1007/s11418-017-1122-5 Yum, 2017, Protective effects of Ampelopsis brevipedunculata against in vitro hepatic stellate cells system and thioacetamide-induced liver fibrosis rat model, Pharm. Biol., 55, 1577, 10.1080/13880209.2017.1311928 Shim, 2013, Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model, J. Gastroenterol. Hepatol., 28, 1877, 10.1111/jgh.12317 Sakai, 2013, LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation, FASEB J. : Off. Publ. Fed. Am. Soc. Exp. Biol., 27, 1830, 10.1096/fj.12-219378 Zhang, 2017, Lysophosphatidic acid receptor antagonism protects against diabetic nephropathy in a type 2 diabetic model, J. Am. Soc. Nephrol.: JASN, 10.1681/ASN.2017010107