Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review

Vainker, S.J. (2004). Chinese Silk: A Cultural History, Rutgers Univ. Press.

Good, 2009, New evidence for early silk in the Indus civilization, Archaeometry, 51, 457, 10.1111/j.1475-4754.2008.00454.x

Xu, 2010, Five short historical earthquake surface ruptures near the Silk Road, Gansu Province, China, Seismol. Soc. Am. Bull., 100, 541, 10.1785/0120080282

Pereira, 2015, Bombyx mori Silk Fibers: An Outstanding Family of Materials, Macromol. Mater. Eng., 300, 1171, 10.1002/mame.201400276

Muffly, 2011, The history and evolution of sutures in pelvic surgery, J. R. Soc. Med., 104, 107, 10.1258/jrsm.2010.100243

Xiao, 2014, Effective removal of dyes from aqueous solution using ultrafine silk fibroin powder, Adv. Powder Technol., 25, 574, 10.1016/j.apt.2013.09.007

Ciocci, 2018, Injectable silk fibroin hydrogels functionalized with microspheres as adult stem cells-carrier systems, Int. J. Biol. Macromol., 108, 960, 10.1016/j.ijbiomac.2017.11.013

Lammel, 2010, Controlling silk fibroin particle features for drug delivery, Biomaterials, 31, 4583, 10.1016/j.biomaterials.2010.02.024

Zhou, 2017, The Use of Functionalized Silk Fibroin Films as a Platform for Optical Diffraction-Based Sensing Applications, Adv. Mater., 29, 1, 10.1002/adma.201605471

Wang, 2016, Carbonized Silk Fabric for Ultrastretchable, Highly Sensitive, and Wearable Strain Sensors, Adv. Mater., 28, 6640, 10.1002/adma.201601572

Porter, 2009, Silk as a biomimetic ideal for structural polymers, Adv. Mater., 21, 487, 10.1002/adma.200801332

Kaplan, 1994, Silk: Biology, Structure, Properties, and Genetics, Silk Polymers - Materials Science and Biotechnology, Volume 544, 2, 10.1021/bk-1994-0544.ch001

Liu, 2010, Comparative genetic diversity and genetic structure of three Chinese silkworm species Bombyx mori L. (Lepidoptera: Bombycidae), Antheraea pernyi Guérin-Meneville and Samia cynthia ricini donovan (Lepidoptera: Saturniidae), Neotrop. Entomol., 39, 967, 10.1590/S1519-566X2010000600019

Murugesh Babu, K. (2017). Silk from silkworms and spiders as high-performance fibers. Structure and Properties of High-Performance Fibers, Elsevier Ltd.

Shao, 2002, Surprising strength of silkworm silk, Nature, 418, 741, 10.1038/418741a

Murphy, 2009, Biomedical applications of chemically-modified silk fibroin, J. Mater. Chem., 19, 6443, 10.1039/b905802h

Nguyen, 2015, Crystal networks in silk fibrous materials: From hierarchical structure to ultra performance, Small, 11, 1039, 10.1002/smll.201402985

Koh, 2015, Structures, mechanical properties and applications of silk fibroin materials, Prog. Polym. Sci., 46, 86, 10.1016/j.progpolymsci.2015.02.001

Ling, 2018, Biopolymer nanofibrils: Structure, modeling, preparation, and applications, Prog. Polym. Sci., 85, 1, 10.1016/j.progpolymsci.2018.06.004

Inoue, 2000, Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with a 6:6:1 molar ratio, J. Biol. Chem., 275, 40517, 10.1074/jbc.M006897200

Huang, 2018, Silkworm silk-based materials and devices generated using bio-nanotechnology, Chem. Soc. Rev., 47, 6486, 10.1039/C8CS00187A

Numata, 2017, Silk Resin with Hydrated Dual Chemical-Physical Cross-Links Achieves High Strength and Toughness, Biomacromolecules, 18, 1937, 10.1021/acs.biomac.7b00376

Liu, 2016, ‘Nano-Fishnet’ Structure Making Silk Fibers Tougher, Adv. Funct. Mater., 26, 5534, 10.1002/adfm.201600813

Asakura, 2015, Analysis of the structure of Bombyx mori silk fibroin by NMR, Macromolecules, 48, 2345, 10.1021/acs.macromol.5b00160

Valluzzi, 1999, Orientation of silk III at the air-water interface, Int. J. Biol. Macromol., 24, 237, 10.1016/S0141-8130(99)00002-1

Jin, 2005, Water-stable silk films with reduced β-sheet content, Adv. Funct. Mater., 15, 1241, 10.1002/adfm.200400405

Li, 2015, Silk-based stabilization of biomacromolecules, J. Control. Release, 219, 416, 10.1016/j.jconrel.2015.09.037

Liu, 2010, Cytocompatibility of regenerated silk fibroin film: A medical biomaterial applicable to wound healing, J. Zhejiang Univ. Sci. B, 11, 10, 10.1631/jzus.B0900163

Holland, 2019, The Biomedical Use of Silk: Past, Present, Future, Adv. Healthc. Mater., 8, 1800465, 10.1002/adhm.201800465

Wang, 2018, Design, Fabrication, and Function of Silk-Based Nanomaterials, Adv. Funct. Mater., 28, 1805305, 10.1002/adfm.201805305

Zhou, 2018, Engineering the Future of Silk Materials through Advanced Manufacturing, Adv. Mater., 30, 1706983, 10.1002/adma.201706983

Scheibel, 2008, The elaborate structure of spider silk, Prion., 2, 154, 10.4161/pri.2.4.7490

Keten, 2010, Nanoconfinement controls stiffness, strength and mechanical toughness of Β-sheet crystals in silk, Nat. Mater., 9, 359, 10.1038/nmat2704

Sashina, 2006, Structure and solubility of natural silk fibroin, Russ. J. Appl. Chem., 79, 869, 10.1134/S1070427206060012

Nuanchai, 2010, Effect of Different Organic Solvents and Treatment Times on Secondary Structure and Thermal Properties of Silk Fibroin Films, Curr. Res. Chem., 1, 1

Altman, 2003, Silk-based biomaterials, Biomaterials, 24, 401, 10.1016/S0142-9612(02)00353-8

Williams, 2008, On the mechanisms of biocompatibility, Biomaterials, 29, 2941, 10.1016/j.biomaterials.2008.04.023

Kundu, 2013, Silk fibroin biomaterials for tissue regenerations, Adv. Drug Deliv. Rev., 65, 457, 10.1016/j.addr.2012.09.043

Meinel, 2012, Silk constructs for delivery of musculoskeletal therapeutics, Adv. Drug Deliv. Rev., 64, 1111, 10.1016/j.addr.2012.03.016

Zhou, 2010, In vitro and in vivo degradation behavior of aqueous-derived electrospun silk fibroin scaffolds, Polym. Degrad. Stab., 95, 1679, 10.1016/j.polymdegradstab.2010.05.025

Wang, 2008, In vivo degradation of three-dimensional silk fibroin scaffolds, Biomaterials, 29, 3415, 10.1016/j.biomaterials.2008.05.002

Jiao, 2017, In Vivo Characterizations of the Immune Properties of Sericin: An Ancient Material with Emerging Value in Biomedical Applications, Macromol. Biosci., 17, 1, 10.1002/mabi.201700229

Panilaitis, 2003, Macrophage responses to silk, Biomaterials, 24, 3079, 10.1016/S0142-9612(03)00158-3

Thurber, 2015, In vivo bioresponses to silk proteins, Biomaterials, 71, 145, 10.1016/j.biomaterials.2015.08.039

Horan, 2005, In vitro degradation of silk fibroin, Biomaterials, 26, 3385, 10.1016/j.biomaterials.2004.09.020

Cao, 2009, Biodegradation of silk biomaterials, Int. J. Mol. Sci., 10, 1514, 10.3390/ijms10041514

Rockwood, 2011, Materials fabrication from Bombyx mori silk fibroin, Nat. Protoc., 6, 1612, 10.1038/nprot.2011.379

Sah, 2010, The extraction of fibroin protein from Bombyx mori silk cocoon: Optimization of process parameters, Int. J. Bioinf. Res. Appl., 2, 33, 10.9735/0975-3087.2.2.33-41

Wray, 2011, Effect of processing on silk-based biomaterials: Reproducibility and biocompatibility, J. Biomed. Mater. Res. Part B, 99, 89, 10.1002/jbm.b.31875

Omenetto, 2010, New opportunities for an ancient material, Science, 329, 528, 10.1126/science.1188936

Wang, 2007, Silk coatings on PLGA and alginate microspheres for protein delivery, Biomaterials, 28, 4161, 10.1016/j.biomaterials.2007.05.036

Lin, 2016, Functionalization of Silk Fibroin Materials at Mesoscale, Adv. Funct. Mater., 26, 8885, 10.1002/adfm.201603826

Ling, 2017, Design and function of biomimetic multilayer water purification membranes, Sci. Adv., 3, e1601939, 10.1126/sciadv.1601939

Ling, 2016, Liquid Exfoliated Natural Silk Nanofibrils: Applications in Optical and Electrical Devices, Adv. Mater., 28, 7783, 10.1002/adma.201601783

Tsioris, 2012, Fabrication of silk microneedles for controlled-release drug delivery, Adv. Funct. Mater., 22, 330, 10.1002/adfm.201102012

Minoura, 1990, Physico-chemical properties of silk fibroin membrane as a biomaterial, Biomaterials, 11, 430, 10.1016/0142-9612(90)90100-5

Terada, 2016, The outermost surface properties of silk fibroin films reflect ethanol-treatment conditions used in biomaterial preparation, Mater. Sci. Eng. C, 58, 119, 10.1016/j.msec.2015.07.041

Jiang, 2007, Mechanical properties of robust ultrathin silk fibroin films, Adv. Funct. Mater., 17, 2229, 10.1002/adfm.200601136

Kapoor, 2016, Silk protein-based hydrogels: Promising advanced materials for biomedical applications, Acta Biomater., 31, 17, 10.1016/j.actbio.2015.11.034

Mondal, M. (2019). Silk-Based Hydrogels for Biomedical Applications. Cellulose-Based Superabsorbent Hydrogels, Springer. Polymers and Polymeric Composites: A Reference Series.

Chirila, 2017, A comparative investigation of Bombyx mori silk fibroin hydrogels generated by chemical and enzymatic cross-linking, Biotechnol. Appl. Biochem., 64, 771, 10.1002/bab.1552

Roli, 2014, Recent developments in regenerated silk fibroin fibers, Int. J. Res. Advent Technol., 2, 267

Kim, 2003, Silk fibroin nanofiber. Electrospinning, properties, and structure, Polym. J., 35, 185, 10.1295/polymj.35.185

Li, 2008, Porous 3-D scaffolds from regenerated Antheraea pernyi silk fibroin, Polym. Adv. Technol., 19, 207, 10.1002/pat.998

Cao, 2007, The preparation of regenerated silk fibroin microspheres, Soft Matter., 3, 910, 10.1039/b703139d

Wang, 2007, Silk microspheres for encapsulation and controlled release, J. Control. Release, 117, 360, 10.1016/j.jconrel.2006.11.021

Wang, 2010, Silk nanospheres and microspheres from silk/pva blend films for drug delivery, Biomaterials, 31, 1025, 10.1016/j.biomaterials.2009.11.002

Yeo, 2003, Simple preparation and characteristics of silk fibroin microsphere, Eur. Polym. J., 39, 1195, 10.1016/S0014-3057(02)00359-2

Kim, 2015, Effect of shear viscosity on the preparation of sphere-like silk fibroin microparticles by electrospraying, Int. J. Biol. Macromol., 79, 988, 10.1016/j.ijbiomac.2015.05.040

Wenk, 2008, Silk fibroin spheres as a platform for controlled drug delivery, J. Control. Release, 132, 26, 10.1016/j.jconrel.2008.08.005

Cui, 2013, A pilot study of macrophage responses to silk fibroin particles, J. Biomed. Mater. Res. Part A, 101, 1511, 10.1002/jbm.a.34444

Liu, 2018, Monodispersed silk fibroin microdroplets for protein stabilization, Appl. Phys. Lett., 112, 173701, 10.1063/1.5026759

Liu, 2014, Thixotropic silk nanofibril-based hydrogel with extracellular matrix-like structure, Biomater. Sci., 2, 1338, 10.1039/C4BM00214H

Yin, 2017, Self-Assembling Silk-Based Nanofibers with Hierarchical Structures, ACS Biomater. Sci. Eng., 3, 2617, 10.1021/acsbiomaterials.7b00442

Zhao, 2007, Ultrasonic technique for extracting nanofibers from nature materials, Appl. Phys. Lett., 90, 97, 10.1016/j.physletb.2007.08.083

Dong, 2016, Amorphous Silk Nanofiber Solutions for Fabricating Silk-Based Functional Materials, Biomacromolecules, 17, 3000, 10.1021/acs.biomac.6b00863

Zhang, 2014, Silk dissolution and regeneration at the nanofibril scale, J. Mater. Chem. B, 2, 3879, 10.1039/c3tb21582b

Zheng, 2018, Isolation of Silk Mesostructures for Electronic and Environmental Applications, Adv. Funct. Mater., 28, 1, 10.1002/adfm.201806380

Chen, 2018, Chemically Modified Silk Proteins, Adv. Eng. Mater., 20, 1, 10.1002/adem.201700961

Kim, 2015, Novel fabrication of fluorescent silk utilized in biotechnological and medical applications, Biomaterials, 70, 48, 10.1016/j.biomaterials.2015.08.025

Miao, 2012, Silkworms transformed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties, Proc. Natl. Acad. Sci. USA, 109, 923, 10.1073/pnas.1109420109

Tokareva, 2013, Recombinant DNA production of spider silk proteins, Microb. Biotechnol., 6, 651, 10.1111/1751-7915.12081

Cai, 2015, Reinforced and ultraviolet resistant silks from silkworms fed with titanium dioxide nanoparticles, ACS Sustain. Chem. Eng., 3, 2551, 10.1021/acssuschemeng.5b00749

Wang, 2016, Feeding Single-Walled Carbon Nanotubes or Graphene to Silkworms for Reinforced Silk Fibers, Nano Lett., 16, 6695, 10.1021/acs.nanolett.6b03597

Nisal, 2014, Uptake of Azo Dyes into Silk Glands for Production of Colored Silk Cocoons Using a Green Feeding Approach, ACS Sustain. Chem. Eng., 2, 312, 10.1021/sc400355k

Cheng, 2017, Characterization of silkworm larvae growth and properties of silk fibres after direct feeding of copper or silver nanoparticles, Mater. Des., 129, 125, 10.1016/j.matdes.2017.04.096

Lin, 2015, Engineering of fluorescent emission of silk fibroin composite materials by material assembly, Small, 11, 1205, 10.1002/smll.201402079

Marelli, 2017, Programming function into mechanical forms by directed assembly of silk bulk materials, Proc. Natl. Acad. Sci. USA, 114, 451, 10.1073/pnas.1612063114

Tao, 2010, Gold nanoparticle-doped biocompatible silk films as a path to implantable thermo-electrically wireless powering devices, Appl. Phys. Lett., 97, 1, 10.1063/1.3486157

Tao, 2015, Inkjet Printing of Regenerated Silk Fibroin: From Printable Forms to Printable Functions, Adv. Mater., 27, 4273, 10.1002/adma.201501425

Wang, 2016, Collagen/silk fibroin composite scaffold incorporated with PLGA microsphere for cartilage repair, Mater. Sci. Eng. C, 61, 705, 10.1016/j.msec.2015.12.097

Kitagawa, 2001, Physical properties of silk fibroin/chitosan blend films, J. Appl. Polym. Sci., 80, 928, 10.1002/app.1172

Lu, 2010, Green process to prepare silk fibroin/gelatin biomaterial scaffolds, Macromol. Biosci., 10, 289, 10.1002/mabi.200900258

Bhardwaj, 2015, Silk fibroin-keratin based 3D scaffolds as a dermal substitute for skin tissue engineering, Integr. Biol., 7, 53, 10.1039/C4IB00208C

Lee, 2004, Structural and physical properties of silk fibroin/alginate blend sponges, J. Appl. Polym. Sci., 93, 2174, 10.1002/app.20714

Zhou, 2013, Preparation and characterization of transparent silk fibroin/cellulose blend films, Polymer, 54, 5035, 10.1016/j.polymer.2013.07.002

Hu, 2013, Ultra-robust graphene oxide-silk fibroin nanocomposite membranes, Adv. Mater., 25, 2301, 10.1002/adma.201300179

Kim, 2014, Mechanically-reinforced electrospun composite silk fibroin nanofibers containing hydroxyapatite nanoparticles, Mater. Sci. Eng. C, 40, 324, 10.1016/j.msec.2014.04.012

Pan, 2012, Significantly reinforced composite fibers electrospun from silk fibroin/carbon nanotube aqueous solutions, Biomacromolecules, 13, 2859, 10.1021/bm300877d

Kim, 2014, All-water-based electron-beam lithography using silk as a resist, Nat. Nanotechnol., 9, 306, 10.1038/nnano.2014.47

Jiang, 2018, Protein Bricks: 2D and 3D Bio-Nanostructures with Shape and Function on Demand, Adv. Mater., 30, 1

Amsden, 2010, Rapid nanoimprinting of silk fibroin films for biophotonic applications, Adv. Mater., 22, 1746, 10.1002/adma.200903166

Perry, 2008, Nano-and micropatterning of optically transparent, mechanically robust, biocompatible silk fibroin films, Adv. Mater., 20, 3070, 10.1002/adma.200800011

Sun, 2015, Aqueous multiphoton lithography with multifunctional silk-centred bio-resists, Nat. Commun., 6, 8612, 10.1038/ncomms9612

Kim, 2012, Silk inverse opals, Nat. Photonics, 6, 818, 10.1038/nphoton.2012.264

Wang, 2017, Modulation of Multiscale 3D Lattices through Conformational Control: Painting Silk Inverse Opals with Water and Light, Adv. Mater., 29, 1, 10.1002/adma.201770273

Das, 2015, Bioprintable, cell-laden silk fibroin-gelatin hydrogel supporting multilineage differentiation of stem cells for fabrication of three-dimensional tissue constructs, Acta Biomater., 11, 233, 10.1016/j.actbio.2014.09.023

Sommer, 2016, 3D Printing of Hierarchical Silk Fibroin Structures, ACS Appl. Mater. Interfaces, 8, 34677, 10.1021/acsami.6b11440

Seib, 2013, Self-assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer, Adv. Funct. Mater., 23, 58, 10.1002/adfm.201201238

Guziewicz, 2011, Lyophilized silk fibroin hydrogels for the sustained local delivery of therapeutic monoclonal antibodies, Biomaterials, 32, 2642, 10.1016/j.biomaterials.2010.12.023

Huang, 2016, Design of Multistimuli Responsive Hydrogels Using Integrated Modeling and Genetically Engineered Silk–Elastin-Like Proteins, Adv. Funct. Mater., 26, 4113, 10.1002/adfm.201600236

Zhang, 2017, Silk Fibroin Biomaterial Shows Safe and Effective Wound Healing in Animal Models and a Randomized Controlled Clinical Trial, Adv. Healthc. Mater., 6, 1, 10.1002/adhm.201700121

Farokhi, 2018, Silk fibroin/hydroxyapatite composites for bone tissue engineering, Biotechnol. Adv., 36, 68, 10.1016/j.biotechadv.2017.10.001

Allen, 2004, Drug Delivery Systems: Entering the Mainstream, Science, 303, 1818, 10.1126/science.1095833

Fenton, 2018, Advances in Biomaterials for Drug Delivery, Adv. Mater., 30, 1, 10.1002/adma.201705328

Zhang, 2013, Advanced materials and processing for drug delivery: The past and the future, Adv. Drug Deliv. Rev., 65, 104, 10.1016/j.addr.2012.10.003

Jastrzebska, 2014, Silk as an innovative biomaterial for cancer therapy, Rep. Pract. Oncol. Radiother., 20, 1

Wu, 2016, Injectable and pH-Responsive Silk Nanofiber Hydrogels for Sustained Anticancer Drug Delivery, ACS Appl. Mater. Interfaces, 8, 17118, 10.1021/acsami.6b04424

He, 2018, An injectable silk fibroin nanofiber hydrogel hybrid system for tumor upconversion luminescence imaging and photothermal therapy, New J. Chem., 43, 2213, 10.1039/C8NJ05766D

Mottaghitalab, 2015, Silk fibroin nanoparticle as a novel drug delivery system, J. Control. Release, 206, 161, 10.1016/j.jconrel.2015.03.020

Qu, 2014, Silk fibroin nanoparticles prepared by electrospray as controlled release carriers of cisplatin, Mater. Sci. Eng. C, 44, 166, 10.1016/j.msec.2014.08.034

Tian, 2014, Doxorubicin-loaded magnetic silk fibroin nanoparticles for targeted therapy of multidrug-resistant cancer, Adv. Mater., 26, 7393, 10.1002/adma.201403562

Gupta, 2009, Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy, Int. J. Nanomed., 4, 115, 10.2147/IJN.S5581

Song, 2017, Magnetic-Silk Core-Shell Nanoparticles as Potential Carriers for Targeted Delivery of Curcumin into Human Breast Cancer Cells, ACS Biomater. Sci. Eng., 3, 1027, 10.1021/acsbiomaterials.7b00153

Montalbán, M.G., Coburn, J.M., Lozano-Perez, A.A., Cenis, J.L., Villora, G., and Kaplan, D.L. (2018). Production of curcumin-loaded silk fibroin nanoparticles for cancer therapy. Nanomaterials, 8.

Bayraktar, 2005, Silk fibroin as a novel coating material for controlled release of theophylline, Eur. J. Pharm. Biopharm., 60, 373, 10.1016/j.ejpb.2005.02.002

Pritchard, 2010, Silk fibroin encapsulated powder reservoirs for sustained release of adenosine, J. Control. Release, 144, 159, 10.1016/j.jconrel.2010.01.035

Wang, 2007, Nanolayer biomaterial coatings of silk fibroin for controlled release, J. Control. Release, 121, 190, 10.1016/j.jconrel.2007.06.006

Cheema, 2007, Silk fibroin mediated delivery of liposomal emodin to breast cancer cells, Int. J. Pharm., 341, 221, 10.1016/j.ijpharm.2007.03.043

Hofmann, 2006, Silk fibroin as an organic polymer for controlled drug delivery, J. Control. Release, 111, 219, 10.1016/j.jconrel.2005.12.009

Pritchard, 2013, Antibiotic-releasing silk biomaterials for infection prevention and treatment, Adv. Funct. Mater., 23, 854, 10.1002/adfm.201201636

Mandal, 2009, Silk fibroin/polyacrylamide semi-interpenetrating network hydrogels for controlled drug release, Biomaterials, 30, 2826, 10.1016/j.biomaterials.2009.01.040

Elia, 2013, Silk-hyaluronan-based composite hydrogels: A novel, securable vehicle for drug delivery, J. Biomater. Appl., 27, 749, 10.1177/0885328211424516

Uebersax, 2007, Silk fibroin matrices for the controlled release of nerve growth factor (NGF), Biomaterials, 28, 4449, 10.1016/j.biomaterials.2007.06.034

Wenk, 2010, The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration, Biomaterials, 31, 1403, 10.1016/j.biomaterials.2009.11.006

Lovett, 2015, Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics, Eur. J. Pharm. Biopharm., 95, 271, 10.1016/j.ejpb.2014.12.029

Uebersax, 2008, Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells, J. Control. Release, 127, 12, 10.1016/j.jconrel.2007.11.006

Demuth, 2014, Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization, Adv. Healthc. Mater., 3, 47, 10.1002/adhm.201300139

Huang, 2015, Silk-elastin-like protein biomaterials for the controlled delivery of therapeutics, Expert Opin. Drug Deliv., 12, 779, 10.1517/17425247.2015.989830

Megeeda, 2004, In vitro and in vivo evaluation of recombinant silk-elastinlike hydrogels for cancer gene therapy, J. Control. Release, 94, 433, 10.1016/j.jconrel.2003.10.027

Hatefi, 2007, Adenoviral gene delivery to solid tumors by recombinant silk-elastinlike protein polymers, Pharm. Res., 24, 773, 10.1007/s11095-006-9200-5

Greish, 2009, Silk-Elastinlike Protein Polymer Hydrogels for Localized Adenoviral Gene Therapy of Head and Neck Tumors, Biomacromolecules, 10, 2183, 10.1021/bm900356j

Farokhi, 2018, Overview of Silk Fibroin Use in Wound Dressings, Trends Biotechnol., 36, 907, 10.1016/j.tibtech.2018.04.004

Uttayarat, 2012, Antimicrobial electrospun silk fibroin mats with silver nanoparticles for wound dressing application, Fibers Polym., 13, 999, 10.1007/s12221-012-0999-6

Schneider, 2009, Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing, Acta Biomater., 5, 2570, 10.1016/j.actbio.2008.12.013

Gil, 2013, Functionalized Silk Biomaterials for Wound Healing, Adv. Healthc. Mater., 2, 206, 10.1002/adhm.201200192

Woong, 2016, Multi-biofunction of antimicrobial peptide-immobilized silk fibroin nanofiber membrane: Implications for wound healing, Acta Biomater., 39, 1

Li, 2017, Functionalized silk fibroin dressing with topical bioactive insulin release for accelerated chronic wound healing, Mater. Sci. Eng. C, 72, 394, 10.1016/j.msec.2016.11.085

Ju, 2014, Silk fibroin based hydrogel for regeneration of burn induced wounds, Tissue Eng. Regener. Med., 11, 203, 10.1007/s13770-014-0010-2

Vasconcelos, 2012, Novel silk fibroin/elastin wound dressings, Acta Biomater., 8, 3049, 10.1016/j.actbio.2012.04.035

Cai, 2010, Fabrication of Chitosan/Silk Fibroin Composite Nanofibers for Wound-dressing Applications, Int. J. Mol. Sci., 11, 3529, 10.3390/ijms11093529

Zhou, 2013, Electrospinning of carboxyethyl chitosan/poly(vinyl alcohol)/silk fibroin nanoparticles for wound dressings, Int. J. Biol. Macromol., 53, 88, 10.1016/j.ijbiomac.2012.11.013

Gu, 2013, Preparation of chitosan/silk fibroin blending membrane fixed with alginate dialdehyde for wound dressing, Int. J. Biol. Macromol., 58, 121, 10.1016/j.ijbiomac.2013.03.059

Lehmann, 2010, Design, production and biocompatibility of nanostructured porous HAp and Si-Hap ceramics as three-dimensional scaffolds for stem cell culture and differentiation, Ceram. Silik., 54, 90

Olszta, 2007, Bone structure and formation: A new perspective, Mater. Sci. Eng. R, 58, 77, 10.1016/j.mser.2007.05.001

Bianco, 2011, Electrospun poly(ε-caprolactone)-based composites using synthesized β-tricalcium phosphate, Polym. Adv. Technol., 22, 1832, 10.1002/pat.1680

Melke, 2016, Silk fibroin as biomaterial for bone tissue engineering, Acta Biomater., 31, 1, 10.1016/j.actbio.2015.09.005

Cacciotti, I. (2016). Cationic and Anionic Substitutions in Hydroxyapatite. Handbook of Bioceramics and Biocomposites, Springer.

Cacciotti, 2019, Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances, Int. J. Appl. Ceram. Technol., 16, 1864, 10.1111/ijac.13229

Sun, 2012, Direct-Write Assembly of 3D Silk/Hydroxyapatite Scaffolds for Bone Co-Cultures, Adv. Healthc. Mater., 1, 729, 10.1002/adhm.201200057

Ding, 2017, Nanoscale Silk-Hydroxyapatite Hydrogels for Injectable Bone Biomaterials, ACS Appl. Mater. Interfaces, 9, 16913, 10.1021/acsami.7b03932

Mi, 2016, Structure and properties of various hybrids fabricated by silk nanofibrils and nanohydroxyapatite, Nanoscale, 8, 20096, 10.1039/C6NR07359J

Behera, 2017, Hydroxyapatite reinforced inherent RGD containing silk fibroin composite scaffolds: Promising platform for bone tissue engineering, Nanomedicine: NBM., 13, 1745, 10.1016/j.nano.2017.02.016

Shi, 2017, Self-Healing Silk Fibroin-Based Hydrogel for Bone Regeneration: Dynamic Metal-Ligand Self-Assembly Approach, Adv. Funct. Mater., 27, 1, 10.1002/adfm.201700591

Uebersax, 2013, Biocompatibility and osteoconduction of macroporous silk fibroin implants in cortical defects in sheep, Eur. J. Pharm. Biopharm., 85, 107, 10.1016/j.ejpb.2013.05.008

Karageorgiou, 2007, BMP-silk composite matrices heal critically sized femoral defects, Bone, 41, 247, 10.1016/j.bone.2007.04.186