Silencing LncRNA-DANCR attenuates inflammation and DSS-induced endothelial injury through miR-125b-5p

Sairenji, 2017, An update on inflammatory bowel disease, Prim Care, 44, 673, 10.1016/j.pop.2017.07.010 Zhang, 2014, Inflammatory bowel disease: pathogenesis, World J Gastroenterol, 20, 91, 10.3748/wjg.v20.i1.91 Sun, 2011, Host genetic susceptibility, dysbiosis, and viral triggers in inflammatory bowel disease, Curr Opin Gastroenterol, 27, 321, 10.1097/MOG.0b013e32834661b4 Nitzan, 2016, Role of antibiotics for treatment of inflammatory bowel disease, World J Gastroenterol, 22, 1078, 10.3748/wjg.v22.i3.1078 Gjuladin-Hellon, 2019, Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn's disease, Cochrane Database Syst Rev, 8, Cd010233 Katsanos, 2017, Inflammatory bowel disease: updates on molecular targets for biologics, Gut Liver, 11, 455, 10.5009/gnl16308 Chapman, 2020, De-escalation of immunomodulator and biological therapy in inflammatory bowel disease, Lancet Gastroenterol Hepatol, 5, 63, 10.1016/S2468-1253(19)30186-4 Axelrad, 2016, Inflammatory bowel disease and cancer: the role of inflammation, immunosuppression, and cancer treatment, World J Gastroenterol, 22, 4794, 10.3748/wjg.v22.i20.4794 Farraye, 2010, AGA medical position statement on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease, Gastroenterology, 138, 738, 10.1053/j.gastro.2009.12.037 Michielan, 2015, Intestinal permeability in inflammatory bowel disease: pathogenesis clinical evaluation, and therapy of leaky gut, Mediat Inflamm, 2015, 628157, 10.1155/2015/628157 Turner, 2009, Intestinal mucosal barrier function in health and disease, Nat Rev Immunol, 9, 799, 10.1038/nri2653 Yarani, 2018, The emerging role of lncRNAs in inflammatory bowel disease, Exp Mol Med, 50, 161, 10.1038/s12276-018-0188-9 Chen, 2018, Emerging role of lncRNAs in the normal and diseased intestinal barrier, Inflamm Res, 67, 757, 10.1007/s00011-018-1170-7 Zhang, 2019, The long noncoding RNA ROCKI regulates inflammatory gene expression, EMBO J, 38 Chen, 2017, MiR-34c and PlncRNA1 mediated the function of intestinal epithelial barrier by regulating tight junction proteins in inflammatory bowel disease, Biochem Biophys Res Commun, 486, 6, 10.1016/j.bbrc.2017.01.115 Wang, 2018, Long noncoding RNA DANCR promotes colorectal cancer proliferation and metastasis via miR-577 sponging, Exp Mol Med, 50, 57, 10.1038/s12276-018-0082-5 Zhang, 2018, Long non-coding RNA DANCR regulates proliferation and apoptosis of chondrocytes in osteoarthritis via miR-216a-5p-JAK2-STAT3 axis, Biosci Rep, 38 Mehta, 2015, Defects in the adherens junction complex (E-cadherin/beta-catenin) in inflammatory bowel disease, Cell Tissue Res, 360, 749, 10.1007/s00441-014-1994-6 Pan, 2018, Long noncoding RNA DANCR is activated by SALL4 and promotes the proliferation and invasion of gastric cancer cells, Oncotarget, 9, 1915, 10.18632/oncotarget.23019 Xu, 2018, 3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1 2,4-oxadiazole (DDO7232), a novel potent Nrf2/ARE inducer, ameliorates DSS-induced murine colitis and protects NCM460 cells against oxidative stress via ERK1/2 phosphorylation, Oxid Med Cell Longev, 2018, 3271617 Peterson, 2014, Intestinal epithelial cells: regulators of barrier function and immune homeostasis, Nat Rev Immunol, 14, 141, 10.1038/nri3608 Groschwitz, 2009, Intestinal barrier function: molecular regulation and disease pathogenesis, J Allergy Clin Immunol, 124, 3, 10.1016/j.jaci.2009.05.038 Lian, 2020, Long non-coding RNA DANCR promotes colorectal tumor growth by binding to lysine acetyltransferase 6A, Cell Signal, 67, 109502, 10.1016/j.cellsig.2019.109502 Pei, 2019, LncRNA DANCR aggravates the progression of ovarian cancer by downregulating UPF1, Eur Rev Med Pharmacol Sci, 23, 10657 Liu, 2020, LncRNA DANCR promotes sorafenib resistance via activation of IL-6/STAT3 signaling in hepatocellular carcinoma cells, Onco Targets Ther, 13, 1145, 10.2147/OTT.S229957 Jin, 2019, Long non-coding RNA DANCR as an emerging therapeutic target in human cancers, Front Oncol, 9, 1225, 10.3389/fonc.2019.01225 Yang, 2018, Silencing long non-coding RNA, differentiation antagonizing non-protein coding RNA promotes apoptosis and inhibits tumor growth in colon cancer, Oncol Lett, 16, 2865 Chassaing, 2014, Dextran sulfate sodium (DSS)-induced colitis in mice, Curr Protoc Immunol, 104, 15.25.1, 10.1002/0471142735.im1525s104 Sun, 2020, Anti-inflammatory properties and gut microbiota modulation of an alkali-soluble polysaccharide from purple sweet potato in DSS-induced colitis mice, Int J Biol Macromol, 153, 708, 10.1016/j.ijbiomac.2020.03.053 Rodriguez-Nogales, 2018, Intestinal anti-inflammatory effect of the probiotic Saccharomyces boulardii in DSS-induced colitis in mice: Impact on microRNAs expression and gut microbiota composition, J Nutr Biochem, 61, 129, 10.1016/j.jnutbio.2018.08.005 Linden, 2008, Mucins in the mucosal barrier to infection, Mucosal Immunol, 1, 183, 10.1038/mi.2008.5 Cornick, 2019, VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis, Nat Commun, 10, 4306, 10.1038/s41467-019-11811-8 Kyoko, 2014, Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis, PLoS ONE, 9, e98016, 10.1371/journal.pone.0098016 Ding, 2018, Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis, J Nat Med, 72, 857, 10.1007/s11418-018-1217-7 Xue, 2018, The effect of centrifugal force in quantification of colorectal cancer-related mRNA in plasma using targeted sequencing, Front Genet, 9, 165, 10.3389/fgene.2018.00165 Gerloff, 2020, Melanoma-derived exosomal miR-125b-5p educates tumor associated macrophages (TAMs) by targeting lysosomal acid lipase A (LIPA), Cancers (Basel), 12 Guo, 2019, The clinicopathological significance of decreased miR-125b-5p in hepatocellular carcinoma: evidence based on RT-qPCR, microRNA-microarray, and microRNA-sequencing, Int J Clin Exp Pathol, 12, 21 Hu, 2020, LncRNA CAR10 upregulates PDPK1 to promote cervical cancer development by sponging miR-125b-5p, Biomed Res Int, 2020, 4351671, 10.1155/2020/4351671 Liu, 2020, LncRNA XIST promotes the progression of laryngeal squamous cell carcinoma via sponging miR-125b-5p to modulate TRIB2, Biosci Rep Zhang, 2020, miR-125b-5p/STAT3 pathway regulated by mTORC1 plays a critical role in promoting cell proliferation and tumor growth, J Cancer, 11, 919, 10.7150/jca.33696 Diao, 2017, MicroRNA-125b-5p modulates the inflammatory state of macrophages via targeting B7-H4, Biochem Biophys Res Commun, 491, 912, 10.1016/j.bbrc.2017.07.135 Martinez, 2017, miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea, Gut, 66, 1537, 10.1136/gutjnl-2016-311477