Significantly higher procalcitonin levels could differentiate Gram-negative sepsis from Gram-positive and fungal sepsis

Helena Brodská1, Karin Malíčková1, Václava Adámková1, Hana Benáková1, Markéta Marková Šťastná2, Tomáš Zima1
1Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U nemocnice 2, 12000, Prague 2, Czech Republic
2Institute of Clinical and Experimental Hematology, First Faculty of Medicine, Charles University in Prague and Institute of Hematology and Blood Transfusion, Prague, Czech Republic

Tóm tắt

Từ khóa


Tài liệu tham khảo

Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H et al (2006) Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 34:344–353

ACCP-SCCM Consensus Conference (1992) Definitions of sepsis and multiple organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992(20):864–874

(2003) 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis DefinitionsConference. Crit Care Med 31:4

Pierrakos CH, Vincent JL (2010) Sepsis biomarkers: a review. Cri Care 14(1):R15

Simon L, Gauvin F, Saint Louis P, Lacroix J (2004) Serum procalcitonin and C-reactive levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 39:206–217

Reinhart K, Meisner M (2011) Biomarkers in the critically ill patient: procalcitonin. Crit Care Clin 27:253–263

Brunkhorst FM, Wegscheider K, Forycki ZF, Brunkhorst R (2000) Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis and septic shock. Intensive Care Med 26:S148–S152

Reinhart K, Meisner M (2006) Markers for sepsis diagnosis: what is useful? Crit Care Clin 22:503–519

Gao H, Evans TW, Finney SJ (2008) Bench-to-bedside review: sepsis, severe sepsis and septic shock—does the nature of the infecting organism matter? Crit Care 12(3):213

Feezor RJ, Oberholzer C, Baker HV, Novick D, Rubinstein M, Moldawer LL et al (2003) Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Infect immune 7:5803–5813

Bjere A, Brusletto B, Holby EA, Kjerulf P, Brandtzaeg P (2004) Plasma Interferon gamma and interleukin 10 concentration in systemic meningococcal disease compared with severe systemic Gram-positive septic shock. Crit Care Med 32:433–438

Mohamed MA, Cunningham-Rundles S, Dean CR, Hammad TA, Nesin M (2007) Levels of proinflammatory cytokines produced from cord blood in vitro are pathogen dependent and increased in comparison to adult controls. Cytokine 39:171–177

Charles PE, Ladoire S, Aho S, Quenot JP, Doise JM, Prin S (2008) Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either gram negative or gram positive bacteria. BMC Infect Dis 8:38

Abe R, Oda S, Sadahiro T, Nakamura M, Hirayama Y, Tateishi Y (2010) Gram-negative bacteremia induces greater magnitude of inflammatory response than gram-positive bacteremia. Crit Care 14:R27

Martini A, Gottin L, Menestrina N, Schweiger V, Simion D, Vincent JL (2010) Procalcitonin levels in surgical patients at risk of candidemia. J Infect 60:425–430

Montagna MT, Coretti C, Caggiano P (2011) Procalcitonin: a possible marker of invasive fungal infection in high risk patients? J Prev Hyg 52:38–39

Vincent JL, Donadello K, Schmidt X (2011) Biomarkers in the critically ill patient: C-reactive protein. Crit Care Clin 27:241–251

Delevaux I, Andre M, Colombier M, Albuisson E, Meylheuc F, Bégueet RJ (2003) Can procalcitonin measurement help in differentiating between bacterial infection and other kinds of inflammatory processes? Rheum Dis 62:337–340