Significance of the degree of synaptic Zn2+ signaling in cognition

Biology of Metals - Tập 29 - Trang 177-185 - 2015
Atsushi Takeda1, Haruna Tamano1
1Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

Tóm tắt

Zinc is a trace nutrient for the brain and a signal factor to serve for brain function. A portion of zinc is released from glutamatergic (zincergic) neuron terminals in the brain. Synaptic Zn2+ signaling is involved in synaptic plasticity such as long-term potentiaion (LTP), which is a cellular mechanism of memory. The block and/or loss of synaptic Zn2+ signaling in the hippocampus and amygdala with Zn2+ chelators affect cognition, while the role of synaptic Zn2+ signal is poorly understood, because zinc-binding proteins are great in number and multi-functional. Chronic zinc deficiency also affects cognition and cognitive decline induced by zinc deficiency might be associated with the increase in plasma glucocorticoid rather than the decrease in synaptic Zn2+ signaling. On the other hand, excess glutamatergic (zincergic) neuron activity induces excess influx of extracellular Zn2+ into hippocampal neurons, followed by cognitive decline. Intracellular Zn2+ dynamics, which is linked to presynaptic glutamate release, is critical for LTP and cognitive performance. This paper deals with insight into cognition from zinc as a nutrient and signal factor.

Tài liệu tham khảo

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