Significance of MHC class II haplotypes and IgG Fc receptors in SLE
Tóm tắt
Từ khóa
Tài liệu tham khảo
Tsao BP (2002) The genetics of human lupus. In: Wallace DJ, Hahn BH (eds) Dubois’ lupus erythematosus, 6th edn. Lippincott Williams and Wilkins, Philadelphia, pp 97–119
Takai T (2002) Roles of Fc receptors in autoimmunity. Nat Rev 2:580–592
Su K, Wu J, Edberg JC, Li X, Ferguson P, Cooper GS, Langefeld CD, Kinmerly RP (2004) A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcγRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus. J Immunol 172:7186–7191
Blank MC, Stefanescu RN, Masuda E, Marti F, King PD, Redecha PB, Wurzburger RJ, Peterson MG, Tanaka S, Pricop L (2005) Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus. Hum Genet 117:220–227
Knight GJ, Adams DD, Purves HD (1977) The genes contributing of the NZB mouse to the renal disease of NZB × NZW hybrid. Clin Exp Immunol 28:352–358
Hirose S, Jiang Y, Hamano Y, Shirai T (2000) Genetic aspects if inherent B-cell abnormalities associated with SLE and B-cell malignancy: lessons from New Zealand mouse models. Int Rev Immunol 19:389–421
Hirose S, Nagawas R, Sekikawa I, Hamaoki M, Ishida Y, Sato H, Shirai T (1983) Enhancing effect of H-2-linked NZW gene(s) on the autoimmune traits of (NZB × NZW)F1 mice. J Exp Med 158:228–233
Hirose S, Ueda G, Noguchi K, Okada T, Sekikawa I, Sato H, Shirai T (1986) Requirement of H-2 heterozygosity for autoimmunity in (NZB × NZW)F1 hybrid mice. Eur J Immunol 16:1631–1633
Hirose S, Kinoshita K, Nozawa S, Nishimura H, Shirai T (1990) Effects of major histocompatibility complex on autoimmune disease of H-2-congenic New Zealand mice. Int Immunol 2:1091–1095
Gotoh Y, Takashima T, Noguchi K, Nishimura H, Tokushima M, Shirai T, Kimoto M (1993) Mixed haplotype Aβz/Aαd class II molecule in (NZB × NZW) F1 mice detected by T cell clones. J Immunol 150:4777–4787
Tokushima M, Koarada S, Hirose S, Gotoh Y, Nishimura H, Shirai T, Miyake K, Kimoto M (1994) In vivo induction of IgG anti-DNA antibody by autoreactive mixed haplotype Aβz/Aαd MHC class II molecule-specific CD4+ T-cell clones. Immunology 83:221–226
Ghatak S, Sainit K, Owen FL, Datta SK (1987) T-cell-receptor β- and I-A β-chain genes of normal SWR mice are linked with lupus nephritis in NZB × SWR crosses. Proc Natl Acad Sci USA 84:6850–6853
Morel L, Rudofsky UH, Longmate JA, Schiffenbauer J, Wakeland EK (1994) Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1:219–229
Vyse TJ, Rozzo SJ, Drake CG, Izui S, Kotzin BL (1997) Control of multiple autoantibodies linked with a lupus nephritis susceptibility loci in New Zealand black mice. J Immunol 158:5566–5574
Braunstein NS, Germain RN (1987) Allele-specific control of Ia molecule surface expression and conformation: implications for a general model of Ia structure–function relationships. Pro Natl Acad Sci USA 84:2921–2925
Nishimura H, Ishikawa S, Nozawa S, Awaji M, Saito J, Abe M, Gotoh Y, Tokushima M, Kimoto M, Akakura S, Tsurui H, Hirose S, Shirai T (1996) Effects of transgenic mixed-haplotype major histocompatibility complex class II molecules AαdAβz on autoimmune disease in New Zealand mice. Int Immunol 8:967–976
Taki S, Hirose S, Kinoshita K, Nishimura H, Shimamura T, Hamuro J, Shirai T (1992) Somatically mutated IgG anti-DNA antibody clonally related to germ-line encoded IgM anti-DNA antibody. Eur J Immunol 22:987–992
Hirose S, Wakiya M, Kawano-Nishi Y, Jiang Y, Sanokawa R, Taki S, Shimamura T, Kinoshita K, Tsurui H, Nishimura H, Shirai T (1993) Somatic diversification and affinity maturation of IgM and IgG anti-DNA antibodies in murine lupus. Eur J Immunol 23:2813–2820
Jongeneel CV, Acha-Orbea H, Blankenstein T (1990) A polymorphic microsatellite in the tumor necrosis factor α promoter identifies an allele unique to the NZW mouse strain. J Exp Med 171:2141–2146
Jacob CO, Hwang F, Lewis GD, Stall AM (1991) Tumor necrosis factor alpha in murine systemic lupus erythematosus disease model: implications for genetic predisposition and immune regulation. Cytokine 3:551–561
Jacob CO, McDevitt HO (1988) Tumor necrosis factor-α in murine autoimmune ‘lupus’ nephritis. Nature 331:356–358
Fujimura T, Hirose S, Jiang Y, Kodera S, Ohmuro H, Zhang D, Hamano Y, Ishida H, Furukawa S, Shirai T (1998) Dissection of the effects of tumor necrosis factor-α and class II gene polymorphisms within the major histocompatibility complex on murine systemic lupus erythematosus. Int Immunol 10:1467–1472
Mathis DJ, Benoist CO, Williams VE II, Kanter MR, McDevitt HO (1983) The murine E alpha immune response gene. Cell 32:745–754
Sciffenbauer J, McCarthy DM, Nygard NR, Woulfe SL, Didier DK, Schwartz BD (1989) A unique sequence of the NZW I-Eβ chain and its possible contribution to autoimmunity in the (NZB×NZW)F1 mouse. J Exp Med 170:971–984
Ogawa S, Nishimura H, Awaji M, Nozawa S, Hirose S, Shirai T (1990) Nucleotide sequence analysis of MHC class II genes in autoimmune disease-prone (NZB × NZW) F1 mice. Immunogenetics 32:63–67
Nygard NR, McCarthy DM, Schiffenbauer J, Schwartz BD (1993) Mixed haplotypes and autoimmunity. Immnunol Today 14:53–56
Hirose S, Zhang D, Nozawa S, Nishimura H, Shirai T (1994) The E-linked subregion of the major histocompatibility complex down-regulates autoimmunity in NZB × NZW F1 mice. Immunogenetics 40:150–153
Zhang D, Fujio K, Jiang Y, Zhao J, Tada N, Sudo K, Tsurui H, Nakamura K, Yamamoto K, Nishimura H, Shirai T, Hirose S (2004) Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination. Proc Natl Acad Sci USA 101:13838–13843
Merino R, Iwamoto M, Fossati L, Muniesa P, Araki K, Takahashi S, Huarte J, Yamamura KI, Vassalli JD, Izui S (1993) Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a trans gene encoding I-Eα chain. J Exp Med 178:1189–1197
Nishimoto H, Kikutani H, Yamamura K, Kishimoto T (1987) Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. Nature 328:432–434
Lund T, O’Reilly L, Hutchings P, Kanagawa O, Simpson E, Gravely R, Chandler P, Dyson J, Picard J, Edwards A, Kioussis D, Cooke A (1990) Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-Aβ-chain or normal I-Eα-chain. Nature 345:727–729
Labrecque N, Madsen L, Fugger L, Benoist C, Mathis D (1999) Toxic MHC class II beta chains. Immunity 11:515–516
Iwamoto, M, Ibnou-Zekri N, Araki K, Izui S (1996) Prevention of murine lupus by an I-Eα chain transgene: protective role of I-Eα chain-derived peptides with a high affinity to I-Aβ molecules. Eur J Immunol 26:307–314
Hanson MS, Cetkovic-Cvrlje M, Ramiya VK, Atkinson MA, Maclaren NK, Singh B, Elliott JF, Serreze DV, Leiter EH (1996) Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection. J Immunol 157:1279–1287
Kappler JW, Roehm N, Marrack P (1987) T cell tolerance by clonal elimination in the thymus. Cell 49:273–280
Bill J, Appel VB, Palmer E (1988) An analysis of T-cell receptor variable region gene expression in major histocompatibility complex disparate mice. Proc Natl Acad Sci USA 85:9184–9188
Bill J, Kanagawa O, Woodland DL, Palmer E (1989) The MHC molecule I-E is necessary but not sufficient for the clonal deletion of Vβ 11-bearing T cells. J Exp Med 169:1405–1419
Kappler JW, Staerz U, White J, Marrack PC (1988) Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332:35–40
MacDonald HR, Schneider R, Lees RK, Howe RC, Acha-Orbea H, Festenstein H, Zinkernargel RM, Hengartner H (1988) T-cell receptor Vβ use predicts reactivity and tolerance to Mls a-encoded antigens. Nature 332:40–45
Pullen AM, Marrack P, Kappler JW (1988) The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 335:796–801
Bohme J, Schuhbaur B, Kanagawa O, Benoist C, Mathis D (1990) MHC-linked protection from diabetes dissociated from clonal deletion of T cells. Science 249:293–295
Rudensky AY, Preston-Hurlburt P, Hong SC, Barlow A, Janeway CA Jr (1991) Sequence analysis of peptides bound to MHC class II molecules. Nature 353:622–627
Nakano N, Kikutani H, Nishimoto H, Kishimoto T (1991) T cell receptor V gene usage of islet β cell-reactive T cells is not restricted in non-obese diabetic mice. J Exp Med 173:1091–1097
Guardiola J, Maffei A, Lauster R, Mitchison NA, Accolla RS, Sartoris S (1996) Functional significance of polymorphism among MHC class II gene promoters. Tissue Antigens 48:615–625
Baumgard M, Moos V, Schuhbauer D, Müller B (1998) Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects. Proc Natl Acad Sci USA 95:6936–6940
Lang P, Stolpa JC, Freiberg BA, Crawford F, Kappler J, Kupfer A, Cambier JC (2001) TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-α/β dimers. Science 291:1537–1540
Nimmerjahn FP, Ravetch JV (2006) Fcγ receptors: old friends and new family members. Immunity 24:19–28
Amigorena S, Bonnerot C (1999) Fc receptor signaling and trafficking: a connection for antigen processing. Immunol Rev 172:279–284
Ono M, Bolland S, Tempost P, Ravetch JV (1996) Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB. Nature 383:263–266
Clynes R, Maizes JS, Guinamard R, Ono M, Takai T, Ravetch JV (1999) Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med 189:179–185
Samuelsson A, Towers TL, Ravetch JV (2001) Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor. Science 291:242–486
Goodnow CC (1996) Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci USA 93:2264–2271
Kono DH, Burlingame RW, Owens DG, Kuramochi A, Balderas RS, Balomenos D, Theofilopoulos AN (1994) Lupus susceptibility loci in New Zealand mice. Proc Natl Acad Sci USA 91:10168–10172
Jiang Y, Hirose S, Sanokawa-Akakura R, Abe M, Mi X, Li N, Miura Y, Shirai J, Zhang D, Hamano Y, Shirai T (1999) Genetically determined aberrant down-regulation of FcγRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus. Int Immunol 11:1685–1691
Haywood ME, Hogarth MB, Slingsby JH, Rose SJ, Allen PJ, Thompson EM, Maibaum MA, Chandler P, Davies KA, Simpson E, Walport MJ, Bernard JM (2000) Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice. Arthritis Rheum 43:349–355
Jiang Y, Hirose S, Abe M, Sanokawa-Akakura R, Ohtsuji M, Mi X, Li N, Xiu Y, Zhang D, Shirai J, Hamano Y, Fujii H, Shirai T (2000) Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility. Immunogenetics 51:429–435
Helyer BJ, Howie JB (1963) Renal disease associated with positive lupus erythematosus tests in a cross-bred strain of mice. Nature 197:197
Gavalchin J, Datta SK (1987) The NZB × SWR model of lupus nephritis. II. Autoantibodies deposited in renal lesions show a distinctive and restricted idiotypic diversity. J Immunol 138:138–148
Vidal S, Gelpi C, Rodriquez-Sanchez JL (1994) (SWR × SJL) F1 mice: a new model of lupus-like disease. J Exp Med 179:1429–1435
Bonnerot C, Choukroud V, Marloie M-A, Fridman WH (1992) Two distinct regions of the mouse β FcγR gene control its transcription. Immunobiology 185:222–234
Benoist C, Mathis D (1990) Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet. Annu Rev Immunol 8:681–715
Xiu Y, Nakamura K, Abe M, Li N, Wen XS, Jiang Y, Zhang D, Tsurui H, Matsuoka S, Hamano Y, Fujii H, Ono M, Takai T, Shimokawa T, Ra C, Shirai T, Hirose S (2002) Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses. J Immunol 169:4340–4346
Pritchard NR, Cutler AJ, Uribe S, Chadban SJ, Morley BJ, Smith KGC (2000) Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcγRII. Curr Biol 10:227–230
Rozzo SJ, Allard JD, Choubey D, Vyse TJ, Izui S, Peltz G, Kotzin BL (2001) Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus erythematosus. Immunity 15:435–443
Boackle SA, Holers VM, Chen X, Szakonyi G, Karp DR, Wakeland EK, Morel L (2001) Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein. Immunity 15:775–785
Wandstrat AE, Nguyen C, Limaye N, Chan AY, Subramanian S, Tian X-H, Yim Y-S, Pertsemlidis A, Garner Jr HR, Morel L, Wakeland EK (2004) Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity 21:769–780
Oyaizu N, Yasumizu R, Miyama-Inaba M, Nomura S, Yoshida H, Miyawaki S, Shibata Y, Mitsuoka S, Yasunaga K, Morii S, Good RA, Ikehara S (1988) (NZW × BXSB) F1 mouse: a new animal model of idiopathic thrombocytopenic purpura. J Exp Med 167:2017–2022
Kawano H, Abe M, Zhang D, Saikawa T, Fujimori M, Hirose S, Shirai T (1992) Heterozygosity of the major histocompatibility complex controls the autoimmune disease in (NZW × BXSB) F1 mice. Clin Immunol Immnopathol 65:308–314
Ida A, Hirose S, Hamano Y, Kodera S, Jiang Y, Abe M, Zhang D, Nisahimura H, Shirai T (1998) Multigenic control of lupus-associated antiphospholipid syndrome in a model of (NZW × BXSB) F1 mice. Eur J Immunol 28:2694–2703
Haywood MEK, Rogers NJ, Rose SJ, Boyle J, McDermott A, Rankin JM, Thiruudaian V, Lewis MR, Fossati-Jimack L, Izui S, Walport MJ, Morley BJ (2004) Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease. J Immunol 173:4277–4285
Haywood MEK, Rose SJ, Horswell S, Lees MJ, Fu G, Walport MJ, Morley BJ (2006) Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes. Genes Immun 3:250–263
Rudofsky UH, Evans BD, Balaban SL, Mottironi VD, Gabrielsen AE (1993) Differences in expression of lupus nephritis in New Zealand mixed H-2z homozygous inbred strains of mice derived from New Zealand Black and New Zealand White mice: origins and initial characterization. Lab Invest 68:419–426
Morel L, Blenman KR, Croker BP, Wakeland EK (2001) The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc Natl Acad Sci USA 98:1787–1792
Morel L, Mohan C, Yu Y, Croker BP, Tian N, Deng A, Wakeland EK (1997) Functional dissection of systemic lupus erythematosus using congenic mouse strains. J Immunol 158:6019–6028
Kumar KR, Li L, Yan M, Bhaskarabhatla M, Mobley AB, Nguyen C, Mooney JM, Schatzle JD, Wakeland WK, Mohan C (2006) Regulation of B cell tolerance by the lupus susceptibility gene Ly108. Science 312:1665–1669
Kurtz CB, O’Toole E, Christensen SM, Weis JH (1990) The murine complement receptor gene family. IV. Alternative splicing of Cr2 gene transcripts predicts two distinct gene products that share homologous domains with both human CR2 and CR1. J Immunol 144:3581–3591
Molina H, Kinoshita T, Inoue K, Carel J-C, Holers VM (1990) A molecular and immunochemical characterization of mouse CR2: evidence for a single gene model of mouse complement receptors 1 and 2. J Immunol 145:2974–2983
Takahashi K, Kozono Y, Waldschmidt TJ, Quigg RJ, Baron A, Holers VM (1997) Mouse complement receptors type 1 (CR1; CD35) and type 2 (CR2; CD21): expression on normal B cell subpopulations and decreased levels during development of autoimmunity in MRL/lpr mice. J Immunol 159:1557–1569
Prodeus AP, Georg S, Shen L-M, Pozdnyakova OO, Chu L, Alicot EM, Goodnow CC, Carroll MC (1998) A critical role for complement in the maintenance of self-tolerance. Immunity 9:721–731
Lin Q, Xiu Y, Jiang Y, Tsurui H, Nakamura K, Kodera S, Ohtsuji M, Ohtsuji N, Shiroiwa W, Tsukamoto K, Amano H, Amano E, Kinoshita K, Sudo K, Nishimura H, Izui S, Shirai T, Hirose S (2006) Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol (in press)
Clynes R, Dumitru C, Ravetch JV (1998) Uncoupling of immune-complex formation and kidney damage in autoimmune glomerulonephritis. Science 279:1052–1054
Matsumoto K, Watanabe N, Akikusa B, Kurasawa K, Matsumura R, Saito Y, Iwamoto I, Saito T (2003) Fc receptor–independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice. Arthritis Rheum 48:486–494
Lemoine R, Berney T, Shibata T, Fulpius T, Gyotoku Y, Shimada H, Sawada S, Izui S (1992) Induction of “wire-loop” lesions by murine monoclonal IgG3 cryoglobulins. Kidney Int 41:65–72
Azeredo da Silveira S, Kikuchi S, Fossati-Jimack L, Moll T, Saito T, Verbeek JS, Botto M, Walport MJ, Carroll M, Izui S (2002) Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med 195:665–672
Ogawa S, Nishimura H, Awaji M, Nozawa S, Hirose S, Shirai T (1990) Nucleotide sequence analysis of MHC class II genes in autoimmune disease-prone (NZB × NZW) F1 mice. Immunogenetics 32:63–67