Signaling to NF-κB by Toll-like receptors
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Lemaitre, 1996, The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults, Cell, 86, 973, 10.1016/S0092-8674(00)80172-5
Gilmore, 2006, Introduction to NF-kappaB: players, pathways, perspectives, Oncogene, 25, 6680, 10.1038/sj.onc.1209954
Karin, 2005, NF-kappaB: linking inflammation and immunity to cancer development and progression, Nat. Rev. Immunol., 5, 749, 10.1038/nri1703
Li, 2005, Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1), Proc. Natl Acad. Sci. USA, 102, 12425, 10.1073/pnas.0505997102
West, 2006, Recognition and signaling by toll-like receptors, Annu. Rev. Cell Dev. Biol., 22, 409, 10.1146/annurev.cellbio.21.122303.115827
Hemmi, 2002, Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway, Nat. Immunol., 3, 196, 10.1038/ni758
Hoshino, 2002, Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation, Int. Immunol., 14, 1225, 10.1093/intimm/dxf089
Yamamoto, 2002, Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4, Nature, 420, 324, 10.1038/nature01182
Horng, 2002, The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors, Nature, 420, 329, 10.1038/nature01180
Yamamoto, 2003, Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway, Science, 301, 640, 10.1126/science.1087262
Hoebe, 2003, Identification of Lps2 as a key transducer of MyD88-independent TIR signalling, Nature, 424, 743, 10.1038/nature01889
Yamamoto, 2003, TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway, Nat. Immunol., 4, 1144, 10.1038/ni986
Kawai, 2001, Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes, J. Immunol., 167, 5887, 10.4049/jimmunol.167.10.5887
Kawai, 1999, Unresponsiveness of MyD88-deficient mice to endotoxin, Immunity, 11, 115, 10.1016/S1074-7613(00)80086-2
Kobayashi, 2002, IRAK-M is a negative regulator of Toll-like receptor signaling, Cell, 110, 191, 10.1016/S0092-8674(02)00827-9
Adhikari, 2007, Ubiquitin-mediated activation of TAK1 and IKK, Oncogene, 26, 3214, 10.1038/sj.onc.1210413
Chen, 2006, Finding NEMO by K63-linked polyubiquitin chain, Cell Death Differ., 13, 1835, 10.1038/sj.cdd.4402014
Sanjo, 2003, TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling, Mol. Cell. Biol., 23, 1231, 10.1128/MCB.23.4.1231-1238.2003
Shim, 2005, TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo, Genes Dev., 19, 2668, 10.1101/gad.1360605
Yamamoto, 2006, Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling, Nat. Immunol., 7, 962, 10.1038/ni1367
Yamamoto, 2002, A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling, J. Immunol., 169, 6668, 10.4049/jimmunol.169.12.6668
Jiang, 2004, Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adaptor inducing IFN-beta, Proc. Natl Acad. Sci. USA, 101, 3533, 10.1073/pnas.0308496101
Sato, 2005, Essential function for the kinase TAK1 in innate and adaptive immune responses, Nat. Immunol., 6, 1087, 10.1038/ni1255
Meylan, 2004, RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappaB activation, Nat. Immunol., 5, 503, 10.1038/ni1061
Cusson-Hermance, 2005, Rip1 mediates the Trif-dependent toll-like receptor 3 and 4-induced NF-kappa B activation but does not contribute to IRF-3 activation, J. Biol. Chem., 280, 36560, 10.1074/jbc.M506831200
Gohda, 2004, TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling, J. Immunol., 173, 2913, 10.4049/jimmunol.173.5.2913
Hacker, 2006, Regulation and function of IKK and IKK-related kinases, Sci. STKE, 2006, re13, 10.1126/stke.3572006re13
Shimada, 1999, IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases, Int. Immunol., 11, 1357, 10.1093/intimm/11.8.1357
Peters, 2000, IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex, Mol. Cell, 5, 513, 10.1016/S1097-2765(00)80445-1
Pomerantz, 1999, NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase, EMBO J., 18, 6694, 10.1093/emboj/18.23.6694
Nomura, 2000, NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation, Genes Cells, 5, 191, 10.1046/j.1365-2443.2000.00315.x
Bonnard, 2000, Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription, EMBO J., 19, 4976, 10.1093/emboj/19.18.4976
Gerondakis, 2006, Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models, Oncogene, 25, 6781, 10.1038/sj.onc.1209944
Hemmi, 2004, The roles of two IkappaB Kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection, J. Exp. Med., 199, 1641, 10.1084/jem.20040520
Sharma, 2003, Triggering the interferon antiviral response through an IKK-related pathway, Science, 300, 1148, 10.1126/science.1081315
Fitzgerald, 2003, IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway, Nat. Immunol., 4, 491, 10.1038/ni921
Honda, 2006, Type I interferon gene induction by the interferon regulatory factor family of transcription factors, Immunity, 25, 349, 10.1016/j.immuni.2006.08.009
McWhirter, 2004, IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts, Proc. Natl Acad. Sci. USA, 101, 233, 10.1073/pnas.2237236100
Perry, 2004, Differential requirement for TANK-binding kinase-1 in type I interferon responses to Toll-like receptor activation and viral infection, J. Exp. Med., 199, 1651, 10.1084/jem.20040528
Hacker, 2006, Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6, Nature, 439, 204, 10.1038/nature04369
Oganesyan, 2006, Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response, Nature, 439, 208, 10.1038/nature04374
Covert, 2005, Achieving stability of lipopolysaccharide-induced NF-kappaB activation, Science, 309, 1854, 10.1126/science.1112304
Werner, 2005, Stimulus specificity of gene expression programs determined by temporal control of IKK activity, Science, 309, 1857, 10.1126/science.1113319
Sakaguchi, 2003, Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock, Biochem. Biophys. Res. Commun., 306, 860, 10.1016/S0006-291X(03)01049-0
Liu, 2005, IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors, Annu. Rev. Immunol., 23, 275, 10.1146/annurev.immunol.23.021704.115633
Kato, 2005, Cell type specific involvement of RIG-I in antiviral response, Immunity, 23, 19, 10.1016/j.immuni.2005.04.010
Hemmi, 2003, The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets, J. Immunol., 170, 3059, 10.4049/jimmunol.170.6.3059
Honda, 2005, IRF-7 is the master regulator of type-I interferon-dependent immune responses, Nature, 434, 772, 10.1038/nature03464
Kawai, 2004, Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6, Nat. Immunol., 5, 1061, 10.1038/ni1118
Honda, 2004, Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling, Proc. Natl Acad. Sci. USA, 101, 15416, 10.1073/pnas.0406933101
Matsui, 2006, Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells, J. Immunol., 177, 5785, 10.4049/jimmunol.177.9.5785
Uematsu, 2005, Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) plays an essential role for TLR7- and TLR9-mediated interferon-a_induction, J. Exp. Med., 201, 915, 10.1084/jem.20042372
Hoshino, 2006, IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9, Nature, 440, 949, 10.1038/nature04641
Yamamoto, 2004, Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta, Nature, 430, 218, 10.1038/nature02738
Kuwata, 2006, IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation, Immunity, 24, 41, 10.1016/j.immuni.2005.11.004
Ishii, 2006, ‘Toll’ gates for future immunotherapy, Curr. Pharm. Des., 12, 4135, 10.2174/138161206778743484
Mata-Haro, 2007, The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4, Science, 316, 1628, 10.1126/science.1138963
Akazawa, 2007, Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells, Proc. Natl Acad. Sci. USA, 104, 252, 10.1073/pnas.0605978104
Ii, 2006, A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling, Mol. Pharmacol., 69, 1288, 10.1124/mol.105.019695
Yoneyama, 2004, The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses, Nat. Immunol., 5, 730, 10.1038/ni1087
Kato, 2006, Differential role of MDA5 and RIG-I in the recognition of RNA viruses, Nature, 441, 101, 10.1038/nature04734
Kawai, 2005, IPS-1; an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction, Nat. Immunol., 6, 981, 10.1038/ni1243
Seth, 2005, Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF3, Cell, 122, 669, 10.1016/j.cell.2005.08.012
Meylan, 2005, Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus, Nature, 437, 1167, 10.1038/nature04193
Xu, 2005, VISA is an adapter protein required for virus-triggered IFN-beta signaling, Mol. Cell, 19, 727, 10.1016/j.molcel.2005.08.014
Saha, 2006, Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif, EMBO J., 25, 3257, 10.1038/sj.emboj.7601220
Takahashi, 2006, Roles of Caspase-8 and Caspase-10 in antiviral innate immune responses, J. Immunol., 176, 4520, 10.4049/jimmunol.176.8.4520
Zhao, 2007, The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways, Nat. Immunol., 8, 592, 10.1038/ni1465
Tenoever, 2007, Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity, Science, 315, 1274, 10.1126/science.1136567
Stockinger, 2004, IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism, J. Immunol., 173, 7416, 10.4049/jimmunol.173.12.7416
O’Connell, 2005, Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1, J. Immunol., 174, 1602, 10.4049/jimmunol.174.3.1602
Ishii, 2006, A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA, Nat. Immunol., 7, 40, 10.1038/ni1282
Stetson, 2006, Recognition of cytosolic DNA activates an IRF3-dependent innate immune response, Immunity, 24, 93, 10.1016/j.immuni.2005.12.003
Kumar, 2006, Essential role of IPS-1 in innate immune responses against RNA viruses, J. Exp. Med., 203, 1795, 10.1084/jem.20060792
Sun, 2006, The specific and essential role of MAVS in antiviral innate immune responses, Immunity, 24, 633, 10.1016/j.immuni.2006.04.004