Signaling Mechanisms in Pattern-Triggered Immunity (PTI)
Tài liệu tham khảo
Afzal, 2011, Separable fragments and membrane tethering of Arabidopsis RIN4 regulate its suppression of PAMP-triggered immunity, Plant Cell, 23, 3798, 10.1105/tpc.111.088708
Ahuja, 2012, Phytoalexins in defense against pathogens, Trends Plant Sci., 17, 73, 10.1016/j.tplants.2011.11.002
Albert, 2013, Peptides as triggers of plant defence, J. Exp. Bot., 64, 5269, 10.1093/jxb/ert275
Alves, 2013, Plant bZIP transcription factors responsive to pathogens: a review, Int. J. Mol. Sci., 14, 7815, 10.3390/ijms14047815
Ambawat, 2013, MYB transcription factor genes as regulators for plant responses: an overview, Physiol. Mol. Biol. Plants, 19, 307, 10.1007/s12298-013-0179-1
An, 2013, The function of the Mediator complex in plant immunity, Plant Signal. Behav., 8, e23182, 10.4161/psb.23182
Andreasson, 2005, The MAP kinase substrate MKS1 is a regulator of plant defense responses, EMBO J., 24, 2579, 10.1038/sj.emboj.7600737
Anthony, 2004, A protein kinase target of a PDK1 signalling pathway is involved in root hair growth in Arabidopsis, EMBO J., 23, 572, 10.1038/sj.emboj.7600068
Anthony, 2006, The Arabidopsis protein kinase PTI1-2 is activated by convergent phosphatidic acid and oxidative stress signaling pathways downstream of PDK1 and OXI1, J. Biol. Chem., 281, 37536, 10.1074/jbc.M607341200
Asai, 2002, MAP kinase signalling cascade in Arabidopsis innate immunity, Nature, 415, 977, 10.1038/415977a
Aslam, 2009, Microbe-associated molecular pattern (MAMP) signatures, synergy, size and charge: influences on perception or mobility and host defence responses, Mol. Plant Pathol., 10, 375, 10.1111/j.1364-3703.2009.00537.x
Ausubel, 2005, Are innate immune signaling pathways in plants and animals conserved?, Nat. Immunol., 6, 973, 10.1038/ni1253
Bartels, 2010, Emerging functions for plant MAP kinase phosphatases, Trends Plant Sci., 15, 322, 10.1016/j.tplants.2010.04.003
Baxter, 2014, ROS as key players in plant stress signalling, J. Exp. Bot., 65, 1229, 10.1093/jxb/ert375
Beck, 2010, Arabidopsis homologs of nucleus- and phragmoplast-localized kinase 2 and 3 and mitogen-activated protein kinase 4 are essential for microtubule organization, Plant Cell, 22, 755, 10.1105/tpc.109.071746
Bednarek, 2012, Chemical warfare or modulators of defence responses– the function of secondary metabolites in plant immunity, Curr. Opin. Plant Biol., 15, 407, 10.1016/j.pbi.2012.03.002
Benschop, 2007, Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis, Mol. Cell. Proteomics, 6, 1198, 10.1074/mcp.M600429-MCP200
Berr, 2012, Chromatin modification and remodelling: a regulatory landscape for the control of Arabidopsis defence responses upon pathogen attack, Cell Microbiol., 14, 829, 10.1111/j.1462-5822.2012.01785.x
Berriri, 2012, Constitutively active mitogen-activated protein kinase versions reveal functions of Arabidopsis MPK4 in pathogen defense signaling, Plant Cell, 24, 4281, 10.1105/tpc.112.101253
Bethke, 2009, Flg22 regulates the release of an ethylene response factor substrate from MAP kinase 6 in Arabidopsis thaliana via ethylene signaling, Proc. Natl. Acad. Sci. USA, 106, 8067, 10.1073/pnas.0810206106
Bethke, 2012, Activation of the Arabidopsis thaliana mitogen-activated protein kinase MPK11 by the flagellin-derived elicitor peptide, flg22, Mol. Plant Microbe Interact., 25, 471, 10.1094/MPMI-11-11-0281
Bigeard, 2014, Phosphorylation-dependent regulation of plant chromatin and chromatin-associated proteins, Proteomics, 14, 2127, 10.1002/pmic.201400073
Bohm, 2014, Immune receptor complexes at the plant cell surface, Curr. Opin. Plant Biol., 20C, 47, 10.1016/j.pbi.2014.04.007
Boller, 2009, A renaissance of elicitors: perception of microbe-associated molecular patterns and danger signals by pattern-recognition receptors, Annu. Rev. Plant Biol., 60, 379, 10.1146/annurev.arplant.57.032905.105346
Boudsocq, 2013, CDPKs in immune and stress signaling, Trends Plant Sci., 18, 30, 10.1016/j.tplants.2012.08.008
Boudsocq, 2010, Differential innate immune signalling via Ca(2+) sensor protein kinases, Nature, 464, 418, 10.1038/nature08794
Bretz, 2003, A translocated protein tyrosine phosphatase of Pseudomonas syringae pv. tomato DC3000 modulates plant defence response to infection, Mol. Microbiol., 49, 389, 10.1046/j.1365-2958.2003.03616.x
Buscaill, 2014, Transcriptional control of plant defence responses, Curr. Opin. Plant Biol., 20, 35, 10.1016/j.pbi.2014.04.004
Camoni, 1998, 14-3-3 proteins activate a plant calcium-dependent protein kinase (CDPK), FEBS Lett., 430, 381, 10.1016/S0014-5793(98)00696-6
Carrasco, 2014, Arabidopsis protein phosphatase DBP1 nucleates a protein network with a role in regulating plant defense, PLoS One, 9, e90734, 10.1371/journal.pone.0090734
Caspersen, 2007, Phosphorylation sites of Arabidopsis MAP kinase substrate 1 (MKS1), Biochim. Biophys. Acta, 1774, 1156, 10.1016/j.bbapap.2007.07.002
Chen, 2010, Sugar transporters for intercellular exchange and nutrition of pathogens, Nature, 468, 527, 10.1038/nature09606
Cheng, 2002, Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family, Plant Physiol., 129, 469, 10.1104/pp.005645
Cheng, 2011, Structural analysis of Pseudomonas syringae AvrPtoB bound to host BAK1 reveals two similar kinase-interacting domains in a type III effector, Cell Host Microbe, 10, 616, 10.1016/j.chom.2011.10.013
Cheng, 2012, Structural and functional analysis of VQ motif-containing proteins in Arabidopsis as interacting proteins of WRKY transcription factors, Plant Physiol., 159, 810, 10.1104/pp.112.196816
Chevalier, 2009, 14-3-3 and FHA domains mediate phosphoprotein interactions, Annu. Rev. Plant Biol., 60, 67, 10.1146/annurev.arplant.59.032607.092844
Chinchilla, 2007, A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence, Nature, 448, 497, 10.1038/nature05999
Chini, 2007, The JAZ family of repressors is the missing link in jasmonate signalling, Nature, 448, 666, 10.1038/nature06006
Cowan, 1999, Plant products as antimicrobial agents, Clin. Microbiol. Rev., 12, 564, 10.1128/CMR.12.4.564
Cui, 2010, Pseudomonas syringae effector protein AvrB perturbs Arabidopsis hormone signaling by activating MAP kinase 4, Cell Host Microbe, 7, 164, 10.1016/j.chom.2010.01.009
De Bruyne, 2014, Connecting growth and defense: the emerging roles of brassinosteroids and gibberellins in plant innate immunity, Mol. Plant, 7, 943, 10.1093/mp/ssu050
de Jong, 2004, Phosphatidic acid accumulation is an early response in the Cf-4/Avr4 interaction, Plant J., 39, 1, 10.1111/j.1365-313X.2004.02110.x
Denoux, 2008, Activation of defense response pathways by OGs and Flg22 elicitors in Arabidopsis seedlings, Mol. Plant, 1, 423, 10.1093/mp/ssn019
Djamei, 2007, Trojan horse strategy in Agrobacterium transformation: abusing MAPK defense signaling, Science, 318, 453, 10.1126/science.1148110
Dowen, 2012, Widespread dynamic DNA methylation in response to biotic stress, Proc. Natl. Acad. Sci. USA, 109, E2183, 10.1073/pnas.1209329109
Dubiella, 2013, Calcium-dependent protein kinase/NADPH oxidase activation circuit is required for rapid defense signal propagation, Proc. Natl. Acad. Sci. USA, 110, 8744, 10.1073/pnas.1221294110
Elmayan, 2007, Regulation of reactive oxygen species production by a 14-3-3 protein in elicited tobacco cells, Plant Cell Environ., 30, 722, 10.1111/j.1365-3040.2007.01660.x
Elmore, 2011, The role of the plasma membrane H+-ATPase in plant-microbe interactions, Mol. Plant, 4, 416, 10.1093/mp/ssq083
Espinosa, 2003, The Pseudomonas syringae type III-secreted protein HopPtoD2 possesses protein tyrosine phosphatase activity and suppresses programmed cell death in plants, Mol. Microbiol., 49, 377, 10.1046/j.1365-2958.2003.03588.x
Eulgem, 2007, Networks of WRKY transcription factors in defense signaling, Curr. Opin. Plant Biol., 10, 366, 10.1016/j.pbi.2007.04.020
Evrard, 2013, Regulation of the heat stress response in Arabidopsis by MPK6-targeted phosphorylation of the heat stress factor HsfA2, Peer J., 1, e59, 10.7717/peerj.59
Farmer, 1999, Calcium and phospholipid activation of a recombinant calcium-dependent protein kinase (DcCPK1) from carrot (Daucus carota L.), Biochim. Biophys. Acta, 1434, 6, 10.1016/S0167-4838(99)00166-1
Feilner, 2005, High throughput identification of potential Arabidopsis mitogen-activated protein kinases substrates, Mol. Cell. Proteomics, 4, 1558, 10.1074/mcp.M500007-MCP200
Felix, 1999, Plants have a sensitive perception system for the most conserved domain of bacterial flagellin, Plant J., 18, 265, 10.1046/j.1365-313X.1999.00265.x
Feng, 2012, Plant-bacterial pathogen interactions mediated by type III effectors, Curr. Opin. Plant Biol., 15, 469, 10.1016/j.pbi.2012.03.004
Feng, 2012, A Xanthomonas uridine 5′-monophosphate transferase inhibits plant immune kinases, Nature, 485, 114, 10.1038/nature10962
Fernandez-Calvo, 2011, The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses, Plant Cell, 23, 701, 10.1105/tpc.110.080788
Fiil, 2009, Gene regulation by MAP kinase cascades, Curr. Opin. Plant Biol., 12, 615, 10.1016/j.pbi.2009.07.017
Foissner, 2000, In vivo imaging of an elicitor-induced nitric oxide burst in tobacco, Plant J., 23, 817, 10.1046/j.1365-313X.2000.00835.x
Forzani, 2011, The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases, FEBS J., 278, 1126, 10.1111/j.1742-4658.2011.08033.x
Frei dit Frey, 2012, Plasma membrane calcium ATPases are important components of receptor-mediated signaling in plant immune responses and development, Plant Physiol., 159, 798, 10.1104/pp.111.192575
Frei dit Frey, 2014, Functional analysis of Arabidopsis immune-related MAPKs uncovers a role for MPK3 as negative regulator of inducible defenses, Genome Biol., 15, R87, 10.1186/gb-2014-15-6-r87
Galletti, 2011, Arabidopsis MPK3 and MPK6 play different roles in basal and oligogalacturonide- or flagellin-induced resistance against Botrytis cinerea, Plant Physiol., 157, 804, 10.1104/pp.111.174003
Gao, 2008, MEKK1, MKK1/MKK2 and MPK4 function together in a mitogen-activated protein kinase cascade to regulate innate immunity in plants, Cell Res., 18, 1190, 10.1038/cr.2008.300
Garcia, 2012, Role of AGC kinases in plant growth and stress responses, Cell. Mol. Life Sci., 69, 3259, 10.1007/s00018-012-1093-3
Gatz, 2013, From pioneers to team players: TGA transcription factors provide a molecular link between different stress pathways, Mol. Plant Microbe Interact., 26, 151, 10.1094/MPMI-04-12-0078-IA
Gimenez-Ibanez, 2009, AvrPtoB targets the LysM receptor kinase CERK1 to promote bacterial virulence on plants, Curr. Biol., 19, 423, 10.1016/j.cub.2009.01.054
Glazebrook, 2005, Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens, Annu. Rev. Phytopathol., 43, 205, 10.1146/annurev.phyto.43.040204.135923
Gohre, 2008, Plant pattern-recognition receptor FLS2 is directed for degradation by the bacterial ubiquitin ligase AvrPtoB, Curr. Biol., 18, 1824, 10.1016/j.cub.2008.10.063
Gomez-Gomez, 2000, FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis, Mol. Cell, 5, 1003, 10.1016/S1097-2765(00)80265-8
Gonzalez Besteiro, 2013, Phosphorylation and stabilization of Arabidopsis MAP kinase phosphatase 1 in response to UV-B stress, J. Biol. Chem., 288, 480, 10.1074/jbc.M112.434654
Gross, 2013, Nitric oxide, antioxidants and prooxidants in plant defence responses, Front. Plant Sci., 4, 419, 10.3389/fpls.2013.00419
Guo, 2003, Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor, Cell, 115, 667, 10.1016/S0092-8674(03)00969-3
Gupta, 2011, On the origins of nitric oxide, Trends Plant Sci., 16, 160, 10.1016/j.tplants.2010.11.007
Gutterson, 2004, Regulation of disease resistance pathways by AP2/ERF transcription factors, Curr. Opin. Plant Biol., 7, 465, 10.1016/j.pbi.2004.04.007
Hadiarto, 2006, Activation of Arabidopsis MAPK kinase kinase (AtMEKK1) and induction of AtMEKK1-AtMEK1 pathway by wounding, Planta, 223, 708, 10.1007/s00425-005-0126-7
Halim, 2009, PAMP-induced defense responses in potato require both salicylic acid and jasmonic acid, Plant J., 57, 230, 10.1111/j.1365-313X.2008.03688.x
Hamann, 2012, Plant cell wall integrity maintenance as an essential component of biotic stress response mechanisms, Front. Plant Sci., 3, 77, 10.3389/fpls.2012.00077
Han, 2010, Mitogen-activated protein kinase 3 and 6 regulate Botrytis cinerea-induced ethylene production in Arabidopsis, Plant J., 64, 114
He, 2006, Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunity, Cell, 125, 563, 10.1016/j.cell.2006.02.047
Heese, 2007, The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants, Proc. Natl. Acad. Sci. USA, 104, 12217, 10.1073/pnas.0705306104
Hoang, 2012, Phosphorylation by AtMPK6 is required for the biological function of AtMYB41 in Arabidopsis, Biochem. Biophys. Res. Commun., 422, 181, 10.1016/j.bbrc.2012.04.137
Hoehenwarter, 2013, Identification of novel in vivo MAP kinase substrates in Arabidopsis thaliana through use of tandem metal oxide affinity chromatography, Mol. Cell. Proteomics, 12, 369, 10.1074/mcp.M112.020560
Huang, 2000, ATMPK4, an Arabidopsis homolog of mitogen-activated protein kinase, is activated in vitro by AtMEK1 through threonine phosphorylation, Plant Physiol., 122, 1301, 10.1104/pp.122.4.1301
Huffaker, 2006, An endogenous peptide signal in Arabidopsis activates components of the innate immune response, Proc. Natl. Acad. Sci. USA, 103, 10098, 10.1073/pnas.0603727103
Ichimura, 1998, Isolation of ATMEKK1 (a MAP kinase kinase kinase)-interacting proteins and analysis of a MAP kinase cascade in Arabidopsis, Biochem. Biophys. Res. Commun., 253, 532, 10.1006/bbrc.1998.9796
Ichimura, 2006, MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis, J. Biol. Chem., 281, 36969, 10.1074/jbc.M605319200
Ishikawa, 2009, The Arabidopsis G-protein beta-subunit is required for defense response against Agrobacterium tumefaciens, Biosci. Biotechnol. Biochem., 73, 47, 10.1271/bbb.80449
Jacobs, 2011, Broad-spectrum suppression of innate immunity is required for colonization of Arabidopsis roots by the fungus Piriformospora indica, Plant Physiol., 156, 726, 10.1104/pp.111.176446
Jahn, 1997, The 14-3-3 protein interacts directly with the C-terminal region of the plant plasma membrane H(+)-ATPase, Plant Cell, 9, 1805
Jeworutzki, 2010, Early signaling through the Arabidopsis pattern recognition receptors FLS2 and EFR involves Ca-associated opening of plasma membrane anion channels, Plant J., 62, 367, 10.1111/j.1365-313X.2010.04155.x
Jones, 2006, The plant immune system, Nature, 444, 323, 10.1038/nature05286
Joo, 2008, MAPK phosphorylation-induced stabilization of ACS6 protein is mediated by the non-catalytic C-terminal domain, which also contains the cis-determinant for rapid degradation by the 26S proteasome pathway, Plant J., 54, 129, 10.1111/j.1365-313X.2008.03404.x
Kadota, 2014, Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity, Mol. Cell, 54, 43, 10.1016/j.molcel.2014.02.021
Kamiyoshihara, 2010, Turnover of LeACS2, a wound-inducible 1-aminocyclopropane-1-carboxylic acid synthase in tomato, is regulated by phosphorylation/dephosphorylation, Plant J., 64, 140
Katsir, 2008, COI1 is a critical component of a receptor for jasmonate and the bacterial virulence factor coronatine, Proc. Natl. Acad. Sci. USA, 105, 7100, 10.1073/pnas.0802332105
Kemen, 2012, Obligate biotroph parasitism: can we link genomes to lifestyles?, Trends Plant Sci., 17, 448, 10.1016/j.tplants.2012.04.005
Klimecka, 2007, Structure and functions of plant calcium-dependent protein kinases, Acta Biochim. Pol., 54, 219, 10.18388/abp.2007_3242
Kong, 2012, The MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates immunity mediated by a mitogen-activated protein kinase kinase kinase in Arabidopsis, Plant Cell, 24, 2225, 10.1105/tpc.112.097253
Kong, 2012, Recent insights into brassinosteroid signaling in plants: its dual control of plant immunity and stomatal development, Mol. Plant, 5, 1179, 10.1093/mp/sss097
Kosetsu, 2010, The MAP kinase MPK4 is required for cytokinesis in Arabidopsis thaliana, Plant Cell, 22, 3778, 10.1105/tpc.110.077164
Krol, 2010, Perception of the Arabidopsis danger signal peptide 1 involves the pattern recognition receptor AtPEPR1 and its close homologue AtPEPR2, J. Biol. Chem., 285, 13471, 10.1074/jbc.M109.097394
Kunze, 2004, The N terminus of bacterial elongation factor Tu elicits innate immunity in Arabidopsis plants, Plant Cell, 16, 3496, 10.1105/tpc.104.026765
Lachaud, 2013, 14-3-3-regulated Ca(2+)-dependent protein kinase CPK3 is required for sphingolipid-induced cell death in Arabidopsis, Cell Death Differ., 20, 209, 10.1038/cdd.2012.114
Lai, 2011, Arabidopsis sigma factor binding proteins are activators of the WRKY33 transcription factor in plant defense, Plant Cell, 23, 3824, 10.1105/tpc.111.090571
Lampard, 2008, Arabidopsis stomatal initiation is controlled by MAPK-mediated regulation of the bHLH SPEECHLESS, Science, 322, 1113, 10.1126/science.1162263
Lee, 2001, Phosphatidic acid activates a wound-activated MAPK in Glycine max, Plant J., 26, 479, 10.1046/j.1365-313x.2001.01037.x
Li, 2012, Dual-level regulation of ACC synthase activity by MPK3/MPK6 cascade and its downstream WRKY transcription factor during ethylene induction in Arabidopsis, PLoS Genet., 8, 1002767, 10.1371/journal.pgen.1002767
Li, 2014, Promoter based integration in plant defense regulation, Plant Physiol., 166, 1803, 10.1104/pp.114.248716
Li, 2014, The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity, Cell Host Microbe, 15, 329, 10.1016/j.chom.2014.02.009
Liu, 2004, Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis, Plant Cell, 16, 3386, 10.1105/tpc.104.026609
Liu, 2013, Heterotrimeric G proteins serve as a converging point in plant defense signaling activated by multiple receptor-like kinases, Plant Physiol., 161, 2146, 10.1104/pp.112.212431
Liu, 2013, Phosphorylation of the zinc finger transcriptional regulator ZAT6 by MPK6 regulates Arabidopsis seed germination under salt and osmotic stress, Biochem. Biophys. Res. Commun., 430, 1054, 10.1016/j.bbrc.2012.12.039
Longhi, 1999, Structure-activity of cutinase, a small lipolytic enzyme, Biochim. Biophys. Acta, 1441, 185, 10.1016/S1388-1981(99)00159-6
Lorek, 2013, The role of Arabidopsis heterotrimeric G-protein subunits in MLO2 function and MAMP-triggered immunity, Mol. Plant Microbe Interact., 26, 991, 10.1094/MPMI-03-13-0077-R
Lozano-Duran, 2014, The bacterial effector HopM1 suppresses PAMP-triggered oxidative burst and stomatal immunity, New Phytol., 202, 259, 10.1111/nph.12651
Lu, 2010, A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity, Proc. Natl. Acad. Sci. USA, 107, 496, 10.1073/pnas.0909705107
Ma, 2008, Innate immunity signaling: cytosolic Ca2+ elevation is linked to downstream nitric oxide generation through the action of calmodulin or a calmodulin-like protein, Plant Physiol., 148, 818, 10.1104/pp.108.125104
Ma, 2011, Chromatin configuration as a battlefield in plant-bacteria interactions, Plant Physiol., 157, 535, 10.1104/pp.111.182295
Macho, 2014, Plant PRRs and the activation of innate immune signaling, Mol. Cell, 54, 263, 10.1016/j.molcel.2014.03.028
Macho, 2014, A bacterial tyrosine phosphatase inhibits plant pattern recognition receptor activation, Science, 343, 1509, 10.1126/science.1248849
Maldonado-Bonilla, 2013, The Arabidopsis tandem zinc finger 9 protein binds RNA and mediates pathogen-associated molecular pattern-triggered immune responses, Plant Cell Physiol., 55, 412, 10.1093/pcp/pct175
Manosalva, 2011, Rice 14-3-3 protein (GF14e) negatively affects cell death and disease resistance, Plant J., 68, 777, 10.1111/j.1365-313X.2011.04728.x
Mao, 2011, Phosphorylation of a WRKY transcription factor by two pathogen-responsive MAPKs drives phytoalexin biosynthesis in Arabidopsis, Plant Cell, 23, 1639, 10.1105/tpc.111.084996
MAPK-Group, 2002, Mitogen-activated protein kinase cascades in plants: a new nomenclature, Trends Plant Sci., 7, 301, 10.1016/S1360-1385(02)02302-6
Matsuoka, 2002, Activation of AtMEK1, an Arabidopsis mitogen-activated protein kinase kinase, in vitro and in vivo: analysis of active mutants expressed in E. coli and generation of the active form in stress response in seedlings, Plant J., 29, 637, 10.1046/j.0960-7412.2001.01246.x
Melotto, 2008, Role of stomata in plant innate immunity and foliar bacterial diseases, Annu. Rev. Phytopathol., 46, 101, 10.1146/annurev.phyto.121107.104959
Mendgen, 1996, Morphogenesis and mechanisms of penetration by plant pathogenic fungi, Annu. Rev. Phytopathol., 34, 367, 10.1146/annurev.phyto.34.1.367
Meng, 2013, MAPK cascades in plant disease resistance signaling, Annu. Rev. Phytopathol., 51, 245, 10.1146/annurev-phyto-082712-102314
Meng, 2012, A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation, Plant Cell, 24, 4948, 10.1105/tpc.112.104695
Meng, 2013, Phosphorylation of an ERF transcription factor by Arabidopsis MPK3/MPK6 regulates plant defense gene induction and fungal resistance, Plant Cell, 25, 1126, 10.1105/tpc.112.109074
Merchante, 2013, Ethylene signaling: simple ligand, complex regulation, Curr. Opin. Plant Biol., 16, 554, 10.1016/j.pbi.2013.08.001
Merkouropoulos, 2008, An Arabidopsis protein phosphorylated in response to microbial elicitation, AtPHOS32, is a substrate of MAP kinases 3 and 6, J. Biol. Chem., 283, 10493, 10.1074/jbc.M800735200
Minguez, 2012, Deciphering a global network of functionally associated post-translational modifications, Mol. Syst. Biol., 8, 599, 10.1038/msb.2012.31
Mithoe, 2012, Targeted quantitative phosphoproteomics approach for the detection of phospho-tyrosine signaling in plants, J. Proteome Res., 11, 438, 10.1021/pr200893k
Mizoguchi, 1998, Identification of a possible MAP kinase cascade in Arabidopsis thaliana based on pairwise yeast two-hybrid analysis and functional complementation tests of yeast mutants, FEBS Lett., 437, 56, 10.1016/S0014-5793(98)01197-1
Monaghan, 2012, Plant pattern recognition receptor complexes at the plasma membrane, Curr. Opin. Plant Biol., 15, 349, 10.1016/j.pbi.2012.05.006
Moore, 2011, Transcription dynamics in plant immunity, Plant Cell, 23, 2809, 10.1105/tpc.111.087346
Mou, 2003, Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes, Cell, 113, 935, 10.1016/S0092-8674(03)00429-X
Mukhtar, 2011, Independently evolved virulence effectors converge onto hubs in a plant immune system network, Science, 333, 596, 10.1126/science.1203659
Mur, 2008, The hypersensitive response; the centenary is upon us but how much do we know?, J. Exp. Bot., 59, 501, 10.1093/jxb/erm239
Nakagami, 2006, A mitogen-activated protein kinase kinase kinase mediates reactive oxygen species homeostasis in Arabidopsis, J. Biol. Chem., 281, 38697, 10.1074/jbc.M605293200
Nakano, 2013, Suppression of DS1 phosphatidic acid phosphatase confirms resistance to Ralstonia solanacearum in Nicotiana benthamiana, PLoS One, 8, e75124, 10.1371/journal.pone.0075124
Naseem, 2012, The role of auxin-cytokinin antagonism in plant-pathogen interactions, PLoS Pathog., 8, e1003026, 10.1371/journal.ppat.1003026
Nguyen, 2011, Identification of a C2H2-type zinc finger transcription factor (ZAT10) from Arabidopsis as a substrate of MAP kinase, Plant Cell Rep., 31, 737, 10.1007/s00299-011-1192-x
Nguyen, 2012, Phosphorylation of the transcriptional regulator MYB44 by mitogen activated protein kinase regulates Arabidopsis seed germination, Biochem. Biophys. Res. Commun., 423, 703, 10.1016/j.bbrc.2012.06.019
Nomura, 2006, A bacterial virulence protein suppresses host innate immunity to cause plant disease, Science, 313, 220, 10.1126/science.1129523
Nomura, 2012, Chloroplast-mediated activation of plant immune signalling in Arabidopsis, Nat. Commun., 3, 926, 10.1038/ncomms1926
Nuhse, 2000, Microbial elicitors induce activation and dual phosphorylation of the Arabidopsis thaliana MAPK 6, J. Biol. Chem., 275, 7521, 10.1074/jbc.275.11.7521
Nuhse, 2007, Quantitative phosphoproteomic analysis of plasma membrane proteins reveals regulatory mechanisms of plant innate immune responses, Plant J., 51, 931, 10.1111/j.1365-313X.2007.03192.x
Nuruzzaman, 2013, Roles of NAC transcription factors in the regulation of biotic and abiotic stress responses in plants, Front. Microbiol., 4, 248, 10.3389/fmicb.2013.00248
O'Brien, 2013, Cytokinin cross-talking during biotic and abiotic stress responses, Front. Plant Sci., 4, 451
O'Brien, 2012, Reactive oxygen species and their role in plant defence and cell wall metabolism, Planta, 236, 765, 10.1007/s00425-012-1696-9
Ogasawara, 2008, Synergistic activation of the Arabidopsis NADPH oxidase AtrbohD by Ca2+ and phosphorylation, J. Biol. Chem., 283, 8885, 10.1074/jbc.M708106200
Oh, 2011, Tomato 14-3-3 protein TFT7 interacts with a MAP kinase kinase to regulate immunity-associated programmed cell death mediated by diverse disease resistance proteins, J. Biol. Chem., 286, 14129, 10.1074/jbc.M111.225086
Oh, 2010, Tomato 14-3-3 protein 7 positively regulates immunity-associated programmed cell death by enhancing protein abundance and signaling ability of MAPKKK {alpha}, Plant Cell, 22, 260, 10.1105/tpc.109.070664
Okazaki, 2014, Roles of lipids as signaling molecules and mitigators during stress response in plants, Plant J., 79, 584, 10.1111/tpj.12556
Olsen, 2013, Status of large-scale analysis of post-translational modifications by mass spectrometry, Mol. Cell. Proteomics, 12, 3444, 10.1074/mcp.O113.034181
Osbourn, 1996, Preformed antimicrobial compounds and plant defense against fungal attack, Plant Cell, 8, 1821, 10.1105/tpc.8.10.1821
Otterhag, 2006, Arabidopsis PDK1: identification of sites important for activity and downstream phosphorylation of S6 kinase, Biochimie, 88, 11, 10.1016/j.biochi.2005.07.005
Pandey, 2009, The role of WRKY transcription factors in plant immunity, Plant Physiol., 150, 1648, 10.1104/pp.109.138990
Park, 2011, Arabidopsis MAP kinase phosphatase 1 is phosphorylated and activated by its substrate AtMPK6, Plant Cell Reports, 30, 1523, 10.1007/s00299-011-1064-4
Pecher, 2014, The Arabidopsis thaliana mitogen-activated protein kinases MPK3 and MPK6 target a subclass of ‘VQ-motif’-containing proteins to regulate immune responses, New Phytol., 203, 592, 10.1111/nph.12817
Pei, 2000, Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells, Nature, 406, 731, 10.1038/35021067
Perez-Salamo, 2014, The heat shock factor A4A confers salt tolerance and is regulated by oxidative stress and the mitogen-activated protein kinases MPK3 and MPK6, Plant Physiol., 165, 319, 10.1104/pp.114.237891
Persak, 2013, Tight interconnection and multi-level control of Arabidopsis MYB44 in MAPK cascade signalling, PLoS One, 8, e57547, 10.1371/journal.pone.0057547
Petersen, 2000, Arabidopsis map kinase 4 negatively regulates systemic acquired resistance, Cell, 103, 1111, 10.1016/S0092-8674(00)00213-0
Petersen, 2009, OXI1 protein kinase is required for plant immunity against Pseudomonas syringae in Arabidopsis, J. Exp. Bot., 60, 3727, 10.1093/jxb/erp219
Pieterse, 2009, Networking by small-molecule hormones in plant immunity, Nat. Chem. Biol., 5, 308, 10.1038/nchembio.164
Pieterse, 2012, Hormonal modulation of plant immunity, Annu. Rev. Cell Dev.Biol., 28, 489, 10.1146/annurev-cellbio-092910-154055
Pitzschke, 2009, MAPK cascade signalling networks in plant defence, Curr. Opin. Plant Biol., 12, 421, 10.1016/j.pbi.2009.06.008
Pitzschke, 2014, Salt stress in Arabidopsis: lipid transfer protein AZI1 and its control by mitogen-activated protein kinase MPK3, Mol. Plant, 7, 722, 10.1093/mp/sst157
Popescu, 2009, MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays, Genes Dev., 23, 80, 10.1101/gad.1740009
Puranik, 2012, NAC proteins: regulation and role in stress tolerance, Trends Plant Sci., 17, 369, 10.1016/j.tplants.2012.02.004
Qiu, 2008, Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus, EMBO J., 27, 2214, 10.1038/emboj.2008.147
Qiu, 2008, Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1, Plant Physiol., 148, 212, 10.1104/pp.108.120006
Rademacher, 2012, Evolutionary adaptations of plant AGC kinases: from light signaling to cell polarity regulation, Front. Plant Sci., 3, 250, 10.3389/fpls.2012.00250
Raho, 2011, Phosphatidic acid production in chitosan-elicited tomato cells, via both phospholipase D and phospholipase C/diacylglycerol kinase, requires nitric oxide, J. Plant Physiol., 168, 534, 10.1016/j.jplph.2010.09.004
Ranf, 2011, Interplay between calcium signalling and early signalling elements during defence responses to microbe- or damage-associated molecular patterns, Plant J., 68, 100, 10.1111/j.1365-313X.2011.04671.x
Rasmussen, 2012, MAP kinase cascades in Arabidopsis innate immunity, Front. Plant Sci., 3, 169, 10.3389/fpls.2012.00169
Rayapuram, 2014, Identification of novel PAMP-triggered phosphorylation and dephosphorylation events in Arabidopsis thaliana by quantitative phosphoproteomic analysis, J. Proteome Res., 13, 2137, 10.1021/pr401268v
Ren, 2002, Cell death mediated by MAPK is associated with hydrogen peroxide production in Arabidopsis, J. Biol. Chem., 277, 559, 10.1074/jbc.M109495200
Rentel, 2004, Oxidative stress-induced calcium signaling in Arabidopsis, Plant Physiol., 135, 1471, 10.1104/pp.104.042663
Rentel, 2004, OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis, Nature, 427, 858, 10.1038/nature02353
Robert-Seilaniantz, 2011, Hormone crosstalk in plant disease and defense: more than just jasmonate-salicylate antagonism, Annu. Rev. Phytopathol., 49, 317, 10.1146/annurev-phyto-073009-114447
Romeis, 2014, From local to global: CDPKs in systemic defense signaling upon microbial and herbivore attack, Curr. Opin. Plant Biol., 20C, 1, 10.1016/j.pbi.2014.03.002
Ross, 2014, The Arabidopsis PEPR pathway couples local and systemic plant immunity, EMBO J., 33, 62, 10.1002/embj.201284303
Roux, 2011, The Arabidopsis leucine-rich repeat receptor-like kinases BAK1/SERK3 and BKK1/SERK4 are required for innate immunity to hemibiotrophic and biotrophic pathogens, Plant Cell, 23, 2440, 10.1105/tpc.111.084301
Sasabe, 2011, Arabidopsis thaliana MAP65-1 and MAP65-2 function redundantly with MAP65-3/PLEIADE in cytokinesis downstream of MPK4, Plant Signal. Behav., 6, 743, 10.4161/psb.6.5.15146
Sawinski, 2013, Guarding the green: pathways to stomatal immunity, Mol. Plant Microbe Interact., 26, 626, 10.1094/MPMI-12-12-0288-CR
Scheler, 2013, Nitric oxide and reactive oxygen species in plant biotic interactions, Curr. Opin. Plant Biol., 16, 534, 10.1016/j.pbi.2013.06.020
Schulz, 2013, Calcium-dependent protein kinases: hubs in plant stress signaling and development, Plant Physiol., 163, 523, 10.1104/pp.113.222539
Schweighofer, 2007, The PP2C-type phosphatase AP2C1, which negatively regulates MPK4 and MPK6, modulates innate immunity, jasmonic acid, and ethylene levels in Arabidopsis, Plant Cell, 19, 2213, 10.1105/tpc.106.049585
Segonzac, 2011, Activation of plant pattern-recognition receptors by bacteria, Curr. Opin. Microbiol., 14, 54, 10.1016/j.mib.2010.12.005
Sehnke, 2002, Consummating signal transduction: the role of 14-3-3 proteins in the completion of signal-induced transitions in protein activity, Plant Cell, 14, S339, 10.1105/tpc.010430
Serrano, 2014, The cuticle and plant defense to pathogens, Front. Plant Sci., 5, 274, 10.3389/fpls.2014.00274
Sethi, 2014, A mitogen-activated protein kinase cascade module, MKK3–MPK6 and MYC2, is involved in blue light-mediated seedling development in Arabidopsis, Plant Cell, 26, 3343, 10.1105/tpc.114.128702
Shan, 2008, Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity, Cell Host Microbe, 4, 17, 10.1016/j.chom.2008.05.017
Sheard, 2010, Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor, Nature, 468, 400, 10.1038/nature09430
Smertenko, 2006, Control of the AtMAP65-1 interaction with microtubules through the cell cycle, J. Cell Sci., 119, 3227, 10.1242/jcs.03051
Smith, 2014, Rapid bioassay to measure early reactive oxygen species production in Arabidopsis leave tissue in response to living Pseudomonas syringae, Plant Methods, 10, 6, 10.1186/1746-4811-10-6
Somerville, 2004, Toward a systems approach to understanding plant cell walls, Science, 306, 2206, 10.1126/science.1102765
Spalding, 2011, The ins and outs of cellular Ca(2+) transport, Curr. Opin. Plant Biol., 14, 715, 10.1016/j.pbi.2011.08.001
Su, 2013, Deletion of a tandem gene family in Arabidopsis: increased MEKK2 abundance triggers autoimmunity when the MEKK1-MKK1/2-MPK4 signaling cascade is disrupted, Plant Cell, 25, 1895, 10.1105/tpc.113.112102
Suarez-Rodriguez, 2007, MEKK1 is required for flg22-induced MPK4 activation in Arabidopsis plants, Plant Physiol., 143, 661, 10.1104/pp.106.091389
Sun, 2013, Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex, Science, 342, 624, 10.1126/science.1243825
Szczegielniak, 2005, A wound-responsive and phospholipid-regulated maize calcium-dependent protein kinase, Plant Physiol., 139, 1970, 10.1104/pp.105.066472
Tada, 2008, Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins, Science, 321, 952, 10.1126/science.1156970
Taylor, 2012, Tomato TFT1 is required for PAMP-triggered immunity and mutations that prevent T3S effector XopN from binding to TFT1 attenuate Xanthomonas virulence, PLoS Pathog., 8, e1002768, 10.1371/journal.ppat.1002768
Teige, 2004, The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis, Mol. Cell, 15, 141, 10.1016/j.molcel.2004.06.023
Teper, 2014, Xanthomonas euvesicatoria type III effector XopQ interacts with tomato and pepper 14-3-3 isoforms to suppress effector-triggered immunity, Plant J., 77, 297, 10.1111/tpj.12391
Testerink, 2004, Isolation and identification of phosphatidic acid targets from plants, Plant J., 39, 527, 10.1111/j.1365-313X.2004.02152.x
Testerink, 2007, Phosphatidic acid binds to and inhibits the activity of Arabidopsis CTR1, J. Exp. Bot., 58, 3905, 10.1093/jxb/erm243
Testerink, 2008, PA, a stress-induced short cut to switch-on ethylene signalling by switching-off CTR1?, Plant Signal. Behav., 3, 681, 10.4161/psb.3.9.5814
Thaler, 2012, Evolution of jasmonate and salicylate signal crosstalk, Trends Plant Sci., 17, 260, 10.1016/j.tplants.2012.02.010
Thines, 2007, JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling, Nature, 448, 661, 10.1038/nature05960
Tierens, 2001, Study of the role of antimicrobial glucosinolate-derived isothiocyanates in resistance of Arabidopsis to microbial pathogens, Plant Physiol., 125, 1688, 10.1104/pp.125.4.1688
Ton, 2009, The multifaceted role of ABA in disease resistance, Trends Plant Sci., 14, 310, 10.1016/j.tplants.2009.03.006
Torres, 2005, Functions of the respiratory burst oxidase in biotic interactions, abiotic stress and development, Curr. Opin. Plant Biol., 8, 397, 10.1016/j.pbi.2005.05.014
Torres, 2013, Functional interplay between Arabidopsis NADPH oxidases and heterotrimeric G protein, Mol. Plant Microbe Interact., 26, 686, 10.1094/MPMI-10-12-0236-R
Tsuda, 2008, Interplay between MAMP-triggered and SA-mediated defense responses, Plant J., 53, 763, 10.1111/j.1365-313X.2007.03369.x
Tsuda, 2009, Network properties of robust immunity in plants, PLoS Genet., 5, e1000772, 10.1371/journal.pgen.1000772
Urano, 2014, Heterotrimeric G protein-coupled signaling in plants, Annu. Rev. Plant Biol., 65, 365, 10.1146/annurev-arplant-050213-040133
van der Luit, 2000, Elicitation of suspension-cultured tomato cells triggers the formation of phosphatidic acid and diacylglycerol pyrophosphate, Plant Physiol., 123, 1507, 10.1104/pp.123.4.1507
van Loon, 2006, Significance of inducible defense-related proteins in infected plants, Annu. Rev. Phytopathol., 44, 135, 10.1146/annurev.phyto.44.070505.143425
Wang, 2000, Involvement of phospholipase D in wound-induced accumulation of jasmonic acid in Arabidopsis, Plant Cell, 12, 2237, 10.1105/tpc.12.11.2237
Wang, 2006, A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants, PLoS Pathog., 2, e123, 10.1371/journal.ppat.0020123
Wang, 2007, Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis, Plant Cell, 19, 63, 10.1105/tpc.106.048298
Wang, 2010, Hydrogen peroxide-mediated activation of MAP kinase 6 modulates nitric oxide biosynthesis and signal transduction in Arabidopsis, Plant Cell, 22, 2981, 10.1105/tpc.109.072959
Wang, 2010, A Pseudomonas syringae ADP-ribosyltransferase inhibits Arabidopsis mitogen-activated protein kinase kinases, Plant Cell, 22, 2033, 10.1105/tpc.110.075697
Wang, 2012, Phytosterols play a key role in plant innate immunity against bacterial pathogens by regulating nutrient efflux into the apoplast, Plant Physiol., 158, 1789, 10.1104/pp.111.189217
Wang, 2014, Arabidopsis LIP5, a positive regulator of multivesicular body biogenesis, is a critical target of pathogen-responsive MAPK cascade in plant basal defense, PLoS Pathog., 10, e1004243, 10.1371/journal.ppat.1004243
Wessling, 2014, Convergent targeting of a common host protein-network by pathogen effectors from three kingdoms of life, Cell Host Microbe, 16, 364, 10.1016/j.chom.2014.08.004
Wu, 2011, Bacterial effector HopF2 suppresses Arabidopsis innate immunity at the plasma membrane, Mol. Plant Microbe Interact., 24, 585, 10.1094/MPMI-07-10-0150
Xiang, 2008, Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases, Curr. Biol., 18, 74, 10.1016/j.cub.2007.12.020
Xie, 1998, COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility, Science, 280, 1091, 10.1126/science.280.5366.1091
Xu, 2012, Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation, EMBO J., 31, 1975, 10.1038/emboj.2012.56
Xu, 2002, The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis, Plant Cell, 14, 1919, 10.1105/tpc.003368
Xu, 2014, A chemical genetic approach demonstrates that MPK3/MPK6 activation and NADPH oxidase-mediated oxidative burst are two independent signaling events in plant immunity, Plant J., 77, 222, 10.1111/tpj.12382
Yamaguchi, 2011, Endogenous peptide elicitors in higher plants, Curr. Opin. Plant Biol., 14, 351, 10.1016/j.pbi.2011.05.001
Yamaguchi, 2006, The cell surface leucine-rich repeat receptor for AtPep1, an endogenous peptide elicitor in Arabidopsis, is functional in transgenic tobacco cells, Proc. Natl. Acad. Sci. USA, 103, 10104, 10.1073/pnas.0603729103
Yan, 2014, Perception of the plant immune signal salicylic acid, Curr. Opin. Plant Biol., 20C, 64, 10.1016/j.pbi.2014.04.006
Yang, 2009, Arabidopsis 14-3-3 lambda is a positive regulator of RPW8-mediated disease resistance, Plant J., 60, 539, 10.1111/j.1365-313X.2009.03978.x
Yeats, 2013, The formation and function of plant cuticles, Plant Physiol., 163, 5, 10.1104/pp.113.222737
Yoo, 2008, Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling, Nature, 451, 789, 10.1038/nature06543
Yoon, 2013, 14-3-3 regulates 1-aminocyclopropane-1-carboxylate synthase protein turnover in Arabidopsis, Plant Cell, 25, 1016, 10.1105/tpc.113.110106
Yu, 2012, Dynamics and biological relevance of DNA demethylation in Arabidopsis antibacterial defense, Proc. Natl. Acad. Sci. USA, 110, 2389, 10.1073/pnas.1211757110
Yun, 2011, S-nitrosylation of NADPH oxidase regulates cell death in plant immunity, Nature, 478, 264, 10.1038/nature10427
Zeng, 2012, A tomato LysM receptor-like kinase promotes immunity and its kinase activity is inhibited by AvrPtoB, Plant J., 69, 92, 10.1111/j.1365-313X.2011.04773.x
Zhang, 2007, A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants, Cell Host Microbe, 1, 175, 10.1016/j.chom.2007.03.006
Zhang, 2009, Phospholipase dalpha1 and phosphatidic acid regulate NADPH oxidase activity and production of reactive oxygen species in ABA-mediated stomatal closure in Arabidopsis, Plant Cell, 21, 2357, 10.1105/tpc.108.062992
Zhang, 2010, Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector, Cell Host Microbe, 7, 290, 10.1016/j.chom.2010.03.007
Zhang, 2012, Disruption of PAMP-induced MAP kinase cascade by a Pseudomonas syringae effector activates plant immunity mediated by the NB-LRR protein SUMM2, Cell Host Microbe, 11, 253, 10.1016/j.chom.2012.01.015
Zhao, 2014, EDR1 physically interacts with MKK4/MKK5 and negatively regulates a MAP kinase cascade to modulate plant innate immunity, PLoS Genet., 10, e1004389, 10.1371/journal.pgen.1004389
Zheng, 2014, Functionally redundant RXLR effectors from Phytophthora infestans act at different steps to suppress early flg22-triggered immunity, PLoS Pathog., 10, e1004057, 10.1371/journal.ppat.1004057
Zhou, 2014, The Pseudomonas syringae effector HopF2 suppresses Arabidopsis immunity by targeting BAK1, Plant J., 77, 235, 10.1111/tpj.12381
Zipfel, 2006, Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation, Cell, 125, 749, 10.1016/j.cell.2006.03.037
