Signal Transduction in Neutrophil Chemotaxis

Sievers, E. L., and Dale, D. C. (1996) Blood Rev., 10, 95–100. Lipnick, R. N., Iliopoulos, A., Salata, K., Hershey, J., Melnick, D., and Tsokos, G. C. (1996) Clin. Exp. Rheumatol., 14, 95–98. Thrasher, A. J., Keep, N. H., Wientjes, F., and Segal, A. W. (1994) Biochim. Biophys. Acta, 1227, 1–24. Williams, F. M. (1994) in Immunopharmacology of Neutrophils(Hellewell, P. G., and Williams, T. J., eds.) Academic Press, London, pp. 245–257. Savage, C. O. S., and Rees, A. J. (1994) in Immunopharmacology of Neutrophils(Hellewel, P. G., and Williams, T. J., eds.) Academic Press, London, pp. 259–273. Hasleton, P. S., and Roberts, T. E. (1999) Histopathology, 34, 285–294. Lefkowith, J. B. (1997) Kidney Int., 51, 1469–1475. Kwiatkowska, K., and Sobota, A. (1999) Bioessays, 21, 422–431. Segal, A. W., and Shatwell, K. P. (1997) Ann. N. Y. Acad. Sci., 832, 215–222. Gullberg, U., Andersson, E., Garwicz, D., Lindmark, A., and Olsson, I. (1997) Eur. J. Haematol., 58, 137–153. Worthen, G. S., Schwab, B. 3d, Elson, E. L., and Downey, G. P. (1989) Science, 245, 183–186. Springer, T. A. (1995) Annu. Rev. Physiol., 57, 827–872. Fechheimer, M., and Zigmond, S. H. (1983) Cell Motil., 3, 349–361. Valerius, N. H., Stendahl, O., Hartwig, J. H., and Stossel, T. P. (1981) Cell, 24, 195–202. Wymann, M. P., Kernen, P., Bengtsson, T., Andersson, T., Baggiolini, M., and Deranleau, D. A. (1990) J. Biol. Chem., 265, 619–622. Carter, S. B. (1967) Nature, 213, 261–264. Becker, E. L., Davis, A. T., Estensen, R. D., and Quie, P. G. (1972) J. Immunol., 108, 396–402. Zigmond, S. H., and Hirsch, J. G. (1972) Exp. Cell Res., 73, 383–393. Norgauer, J., Kownatzki, E., Seifert, R., and Aktories, K. (1988) J. Clin. Invest., 82, 1376–1382. Condeelis, J. (1993) Annu. Rev. Cell Biol., 9, 411–444. Elson, E. L., Felder, S. F., Jay, P. Y., Kolodney, M. S., and Pasternak, C. (1999) Biochem. Soc. Symp., 65, 299–314. Coates, T. D. (1996) Curr. Opin. Hematol., 3, 41–47. Wymann, M. P., Kernen, P., Deranleau, D. A., Dewald, B., von Tscharner, V., and Baggiolini, M. (1987) Biochem. Biophys. Res. Commun., 147, 361–368. Franke, K., and Gruler, H. (1994) Z. Naturforch. [C], 49, 241–249. Hartman, R. S., Lau, K., Chou, W., and Coates, T. D. (1994) Biophys. J., 67, 2535–2545. Tarr, P. E. (1996) Med. Oncol., 13, 133–140. Anderlini, P., Przepiorka, D., Champlin, R., and Korbling, M. (1996) Blood, 88, 2819–2825. Smith, W. B., Gamble, J. R., and Vadas, M. A. (1994) Exp. Hematol., 22, 329–334. Yong, K. L. (1996) Br. J. Haematol., 94, 40–47. Harakawa, N., Sasada, M., Maeda, A., Asagoe, K., Nohgawa, M., Takano, K., Matsuda, Y., Yamamoto, K., and Okuma, M. (1997) Leukoc. Biol., 61, 500–506. Ihle, J. N., Witthuhn, B. A., Quelle, F. W., Yamamoto, K., and Silvennoinen, O. (1995) Annu. Rev. Immunol., 13, 369–398. Ming, W. J., Bersani, L., and Mantovani, A. (1987) J. Immunol., 138, 1469–1474. Lukacs, N. W., Strieter, R. M., Chensue, S. W., Widmer, M., and Kunkel, S. L. (1995) J. Immunol., 154, 5411–5417. Loike, J. D., el Khoury, J., Cao, L., Richards, C. P., Rascoff, H., Mandeville, J. T., Maxfield, F. R., and Silverstein, S. C. (1995) J. Exp. Med., 181, 1763–1772. Menegazzi, R., Cramer, R., Patriarca, P., Scheurich, P., and Dri, P. (1994) Blood, 84, 287–293. Bazzoni, F., and Beutler, B. (1996) N. Engl. J. Med., 334, 1717–1725. Wallach, D., Varfolomeev, E. E., Malinin, N. L., Goltsev, Y. V., Kovalenko, A. V., and Boldin, M. P. (1999) Annu. Rev. Immunol., 17, 331–367. Peppelenbosch, M., Boone, E., Jones, G. E., van Deventer, S. J., Haegeman, G., Fiers, W., Grooten, J., and Ridley, A. J. (1999) J. Immunol., 162, 837–845. Newman, I., and Wilkinson, P. C. (1989) Immunology, 66, 318–320. Mrowietz, U., Ternowitz, T., Schroder, J. M., and Christophers, E. (1989) Scand. J. Immunol., 30, 373–377. Seino, K., Iwabuchi, K., Kayagaki, N., Miyata, R., Nagaoka, I., Matsuzawa, A., Fukao, K., Yagita, H., and Okumura, K. (1998) J. Immunol., 161, 4484–4488. Ottonello, L., Tortolina, G., Amelotti, M., and Dallegri, F. (1999) J. Immunol., 162, 3601–3606. Thelen, M., Uguccioni, M., and Bosiger, J. (1995) Biochem. Biophys. Res. Commun., 217, 1255–1262. Oldenborg, P. A., and Sehlin, J. (1998) J. Leukoc. Biol., 63, 203–208. Hubbard, S. R. (1999) Prog. Biophys. Mol. Biol., 71, 343–358. Zimmerman, C. M., and Padgett, R. W. (2000) Gene, 249, 17–30. Reibman, J., Meixler, S., Lee, T. C., Gold, L. I., Cronstein, B. N., Haines, K. A., Kolasinski, S. L., and Weissmann, G. (1991) Proc. Natl. Acad. Sci. USA, 88, 6805–6809. Hannigan, M., Zhan, L., Ai, Y., and Huang, C. K. (1998) Biochem. Biophys. Res. Commun., 246, 55–58. Haines, K. A., Kolasinski, S. L., Cronstein, B. N., Reibman, J., Gold, L. I., and Weissmann, G. (1993) J. Immunol., 151, 1491–1499. Boulay, F., Naik, N., Giannini, E., Tardif, M., and Brouchon, L. (1997) Ann. N. Y. Acad. Sci., 832, 69–84. Panaro, M. A., and Mitolo, V. (1999) Immunopharmacol. Immunotoxicol., 21, 397–419. Hanahan, D. J. (1986) Annu. Rev. Biochem., 55, 483–509. Crooks, S. W., and Stockley, R. A. (1998) Int. J. Biochem. Cell Biol., 30, 173–178. Gerard, C., and Gerard, N. P. (1994) Annu. Rev. Immunol., 12, 775–808. Baggiolini, M. (1998) Nature, 392, 565–568. Moser, B., Loetscher, M., Piali, L., and Loetscher, P. (1998) Int. Rev. Immunol., 16, 323–344. Bockaert, J., and Pin, J. P. (1999) EMBO J., 18, 1723–1729. Baldwin, J. M. (1993) EMBO J., 12, 1693–1703. Unger, V. M., Hargrave, P. A., Baldwin, J. M., and Schertler, G. F. (1997) Nature, 389, 203–206. Murphy, P. M. (1994) Annu. Rev. Immunol., 12, 593–633. Mery, L., and Boulay, F. (1994) J. Biol. Chem., 269, 3457–3463. Gayle, R. B. 3d., Sleath, P. R., Srinivason, S., Birks, C. W., Weerawarna, K. S., Cerretti, D. P., Kozlosky, C. J., Nelson, N., Vanden Bos, T., and Beckmann, M. P. (1993) J. Biol. Chem., 268, 7283–7289. Ahuja, S. K., Lee, J. C., and Murphy, P. M. (1996) J. Biol. Chem., 271, 225–232. Monteclaro, F. S., and Charo, I. F. (1996) J. Biol. Chem., 271, 19084–19092. Quehenberger, O., Pan, Z. K., Prossnitz, E. R., Cavanagh, S. L., Cochrane, C. G., and Ye, R. D. (1997) Biochem. Biophys. Res. Commun., 238, 377–381. Bourne, H. R. (1997) Curr. Opin. Cell Biol., 9, 134–142. Farrens, D. L., Altenbach, C., Yang, K., Hubbell, W. L., and Khorana, H. G. (1996) Science, 274, 768–770. Baranski, T. J., Herzmark, P., Lichtarge, O., Gerber, B. O., Trueheart, J., Meng, E. C., Iiri, T., Sheikh, S. P., and Bourne, H. R. (1999) J. Biol. Chem., 274, 15757–15765. Scheer, A., Fanelli, F., Costa, T., De Benedetti, P. G., and Cotecchia, S. (1996) EMBO J., 15, 3566–3578. Parent, J. L., Le Gouill, C., Rola-Pleszczynski, M., and Stankova, J. (1996) Biochem. Biophys. Res. Commun., 219, 968–975. Schreiber, R. E., Prossnitz, E. R., Ye, R. D., Cochrane, C. G., and Bokoch, G. M. (1994) J. Biol. Chem., 269, 326–331. Xie, W., Jiang, H., Wu, Y., and Wu, D. (1997) J. Biol. Chem., 272, 24948–24951. Carlson, S. A., Chatterjee, T. K., and Fisher, R. A. (1996) J. Biol. Chem., 271, 23146–23153. Becker, E. L., Kermode, J. C., Naccache, P. H., Yassin, R., Marsh, M. L., Munoz, J. J., and Sha'afi, R. I. (1985) J. Cell Biol., 100, 1641–1646. Goldman, D. W., Chang, F. H., Gifford, L. A., Goetzl, E. J., and Bourne, H. R. (1985) J. Exp. Med., 162, 145–156. Lad, P. M., Olson, C. V., and Grewal, I. S. (1986) FEBS Lett., 200, 91–96. Wu, D., LaRosa, G. J., and Simon, M. I. (1993) Science, 261, 101–103. Hamm, H. E., and Gilchrist, A. (1996) Curr. Opin. Cell Biol., 8, 189–196. Parent, C. A., and Devreotes, P. N. (1999) Science, 284, 765–770. Neptune, E. R., and Bourne, H. R. (1997) Proc. Natl. Acad. Sci. USA, 94, 14489–14494. Arai, H., Tsou, C. L., and Charo, I. F. (1997) Proc. Natl. Acad. Sci. USA, 94, 14495–14499. Neptune, E. R., Iiri, T., and Bourne, H. R. (1999) J. Biol. Chem., 274, 2824–2828. Jin, T., Amzel, M., Devreotes, P. N., and Wu, L. (1998) Mol. Biol. Cell, 9, 2949–2961. Nern, A., and Arkowitz, R. A. (1998) Nature, 391, 195–198. Virchow, S., Ansorge, N., Rosskopf, D., Rubben, H., and Siffert, W. (1999) Naunyn. Schmiedebergs. Arch. Pharmacol., 360, 27–32. Clapham, D. E., and Neer, E. J. (1997) Annu. Rev. Pharmacol. Toxicol., 37, 167–203. Wang, T., Pentyala, S., Rebecchi, M. J., and Scarlata, S. (1999) Biochemistry, 38, 1517–1524. Katan, M. (1998) Biochim. Biophys. Acta, 1436, 5–17. Mellor, H., and Parker, P. J. (1998) Biochem. J., 332, 281–292. Park, D., Jhon, D. Y., Kriz, R., Knopf, J., and Rhee, S. G. (1992) J. Biol. Chem., 267, 16048–16055. Jiang, H., Kuang, Y., Wu, Y., Xie, W., Simon, M. I., and Wu, D. (1997) Proc. Natl. Acad. Sci. USA, 94, 7971–7975. Li, Z., Jiang, H., Xie, W., Zhang, Z., Smrcka, A. V., and Wu, D. (2000) Science, 287, 1046–1049. Babior, B. M. (1995) Curr. Opin. Hematol., 2, 55–60. Bengtsson, T., Rundquist, I., Stendahl, O., Wymann, M. P., and Andersson, T. (1988) J. Biol. Chem., 263, 17385–17289. Perez, H. D., Elfman, F., Marder, S., Lobo, E., and Ives, H. E. (1989) J. Clin. Invest., 83, 1963–1970. Niggli, V., and Keller, H. (1993) Exp. Cell Res., 204, 346–355. Laudanna, C., Mochly-Rosen, D., Liron, T., Constantin, G., and Butcher, E. C. (1998) J. Biol. Chem., 273, 30306–30315. Xiao, Y. Q., Minami, K., Mue, S., and Ohuchi, K. (1998) Eur. J. Pharmacol., 360, 195–204. Kent, J. D., Sergeant, S., Burns, D. J., and McPhail, L. C. (1996) J. Immunol., 157, 4641–4647. Stasia, M. J., Strulovici, B., Daniel-Issakani, S., Pelosin, J. M., Dianoux, A. C., Chambaz, E., and Vignais, P. V. (1990) FEBS Lett., 274, 61–64. Niggli, V., and Keller, H. (1991) J. Biol. Chem., 266, 7927–7932. Wymann, M. P., and Pirola, L. (1998) Biochim. Biophys. Acta, 1436, 127–150. Bernstein, H. G., Keilhoff, G., Reiser, M., Freese, S., and Wetzker, R. (1998) Cell. Mol. Biol., 44, 973–983. Hirsch, E., Katanaev, V. L., Garlanda, C., Azzolino, O., Pirola, L., Silengo, L., Sozzani, S., Mantovani, A., Altruda, F., and Wymann, M. P. (2000) Science, 287, 1049–1053. Stephens, L., Smrcka, A., Cooke, F. T., Jackson, T. R., Sternweis, P. C., and Hawkins, P. T. (1994) Cell, 77, 83–93. Stoyanov, B., Volinia, S., Hanck, T., Rubio, I., Loubtchenkov, M., Malek, D., Stoyanova, S., Vanhaesebroeck, B., Dhand, R., Nurnberg, B., Gierschik, P., Seedorf, K., Hsuan, J. J., Waterfield, M. D., and Wetzker, R. (1995) Science, 269, 690–693. Leopoldt, D., Hanck, T., Exner, T., Maier, U., Wetzker, R., and Nurnberg, B. (1998) J. Biol. Chem., 273, 7024–7029. Stephens, L. R., Eguinoa, A., Erdjument-Bromage, H., Lui, M., Cooke, F., Coadwell, J., Smrcka, A. S., Thelen, M., Cadwallader, K., Tempst, P., and Hawkins, P. T. (1997) Cell, 89, 105–114. Krugmann, S., Hawkins, P. T., Pryer, N., and Braselmann, S. (1999) J. Biol. Chem., 274, 17152–17258. Bondeva, T., Pirola, L., Bulgarelli-Leva, G., Rubio, I., Wetzker, R., and Wymann, M. P. (1998) Science, 282, 293–296. Wymann, M. P., Pirola, L., Katanaev, V. L., and Bulragelli-Leva, G. (1999) Biochem. Soc. Trans., 27, 629. Lopez-Ilasaca, M., Crespo, P., Pellici, P. G., Gutkind, J. S., and Wetzker, R. (1997) Science, 275, 394–397. Rubio, I., Rodriguez-Viciana, P., Downward, J., and Wetzker, R. (1997) Biochem. J., 326, 891–895. Choi, K. Y., Satterberg, B., Lyons, D. M., and Elion, E. A. (1994) Cell, 78, 499–512. Wymann, M. P., Bulgarelli-Leva, G., Zvelebil, M. J., Pirola, L., Vanhaesebroeck, B., Waterfield, M. D., and Panayotou, G. (1996) Mol. Cell Biol., 16, 1722–1733. Stoyanova, S., Bulgarelli-Leva, G., Kirsch, C., Hanck, T., Klinger, R., Wetzker, R., and Wymann, M. P. (1997) Biochem. J., 324, 489–495. Arcaro, A., and Wymann, M. P. (1993) Biochem. J., 296, 297–301. Niggli, V., and Keller, H. (1997) Eur. J. Pharmacol., 335, 43–52. Knall, C., Young, S., Nick, J. A., Buhl, A. M., Worthen, G. S., and Johnson, G. L. (1996) J. Biol. Chem., 271, 2832–2838. Knall, C., Worthen, G. S., and Johnson, G. L. (1997) Proc. Natl. Acad. Sci. USA, 94, 3052–3057. Baggiolini, M., Dewald, B., Schnyder, J., Ruch, W., Cooper, P. H., and Payne, T. G. (1987) Exp. Cell Res., 169, 408–418. Katada, T., Kurosu, H., Okada, T., Suzuki, T., Tsujimoto, N., Takasuga, S., Kontani, K., Hazeki, O., and Ui, M. (1999) Chem. Phys. Lipids, 98, 79–86. Vicente-Manzanares, M., Rey, M., Jones, D. R., Sancho, D., Mellado, M., Rodriguez-Frade, J. M., del Pozo, M. A., Yanez-Mo, M., de Ana, A. M., Martinez-A. C., Merida, I., and Sanchez-Madrid, F. (1999) J. Immunol., 163, 4001–4012. Murga, C., Fukuhara, S., and Gutkind, J. S. (2000) J. Biol. Chem., 275, 12069–12073. Belisle, B., and Abo, A. (2001) J. Biol. Chem., in press. Sasaki, T., Irie-Sasaki, J., Jones, R. G., Oliveira-dos-Santos, A. J., Stanford, W. L., Bolon, B., Wakeham, A., Itie, A., Bouchard, D., Kozieradzki, I., Joza, N., Mak, T. W., Ohashi, P. S., Suzuki, A., and Penninger, J. M. (2000) Science, 287, 1040–1046. Katanaev, V. L., and Wymann, M. P., unpublished. Shaw, G. (1996) Bioessays, 18, 35–46. Rebecchi, M. J., and Scarlata, S. (1998) Annu. Rev. Biophys. Biomol. Struct., 27, 503–528. Bottomley, M. J., Salim, K., and Panayotou, G. (1998) Biochim. Biophys. Acta, 1436, 165–183. Belham, C., Wu, S., and Avruch, J. (1999) Curr. Biol., 9, R93–96. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Curr. Biol., 7, 261–269. Currie, R. A., Walker, K. S., Gray, A., Deak, M., Casamayor, A., Downes, C. P., Cohen, P., Alessi, D. R., and Lucocq, J. (1999) Biochem. J., 337, 575–583. Chou, M. M., Hou, W., Johnson, J., Graham, L. K., Lee, M. H., Chen, C. S., Newton, A. C., Schaffhausen, B. S., and Toker, A. (1998) Curr. Biol., 8, 1069–1077. Le Good, J. A., Ziegler, W. H., Parekh, D. B., Alessi, D. R., Cohen, P., and Parker, P. J. (1998) Science, 281, 2042–2045. Dutil, E. M., Toker, A., and Newton, A. C. (1998) Curr. Biol., 8, 1366–1375. Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., and Avruch, J. (1998) Curr. Biol., 8, 69–81. Cheng, X., Ma, Y., Moore, M., Hemmings, B. A., and Taylor, S. S. (1998) Proc. Natl. Acad. Sci. USA, 95, 9849–9854. Stephens, L., Anderson, K., Stokoe, D., Erdjument-Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R., Reese, C. B., McCormick, F., Tempst, P., Coadwell, J., and Hawkins, P. T. (1998) Science, 279, 710–714. Klippel, A., Kavanaugh, W. M., Pot, D., and Williams, L. T. (1997) Mol. Cell Biol., 17, 338–344. Franke, T. F., Kaplan, D. R., Cantley, L. C., and Toker, A. (1997) Science, 275, 665–668. Neet, K., and Hunter, T. (1996) Genes Cells, 1, 147–169. Satterthwaite, A. B., Li, Z., and Witte, O. N. (1998) Semin. Immunol., 10, 309–316. Tsukada, S., Simon, M. I., Witte, O. N., and Katz, A. (1994) Proc. Natl. Acad. Sci. USA, 91, 11256–11260. Langhans-Rajasekaran, S. A., Wan, Y., and Huang, X. Y. (1995) Proc. Natl. Acad. Sci. USA, 92, 8601–8605. Fukuda, M., Kojima, T., Kabayama, H., and Mikoshiba, K. (1996) J. Biol. Chem., 271, 30303–30306. Rameh, L. E., Arvidsson, A. K., Carraway, K. L. 3rd, Couvillon, A. D., Rathbun, G., Crompton, A., VanRenterghem, B., Czech, M. P., Ravichandran, K. S., Burakoff, S. J., Wang, D. S., Chen, C. S., and Cantley, L. C. (1997) J. Biol. Chem., 272, 22059–22066. Mano, H., Ishikawa, F., Nishida, J., Hirai, H., and Takaku, F. (1990) Oncogene, 5, 1781–1786. Kaukonen, J., Lahtinen, I., Laine, S., Alitalo, K., and Palotie, A. (1996) Br. J. Haematol., 94, 455–460. Weil, D., Power, M. A., Smith, S. I., and Li, C. L. (1997) Blood, 90, 4332–4340. Gaudry, M., Caon, A. C., Gilbert, C., Lille, S., and Naccache, P. H. (1992) J. Leukoc. Biol., 51, 103–108. Yasui, K., Yamazaki, M., Miyabayashi, M., Tsuno, T., and Komiyama, A. (1994) J. Immunol., 152, 5922–5929. Nore, B. F., Vargas, L., Mohamed, A. J., Branden, L. J., Backesjo, C. M., Islam, T. C., Mattsson, P. T., Hultenby, K., Christensson, B., and Smith, C. I. (2000) Eur. J. Immunol., 30, 145–154. Aspenstrom, P. (1999) Exp. Cell Res., 246, 20–25. Van Aelst, L., and D'souza-Schorey, C. (1997) Genes Dev., 11, 2295–2322. Olofsson, B. (1999) Cell. Signal., 11, 545–554. Symons, M. (1996) Trends Biochem. Sci., 21, 178–181. Bokoch, G. M. (1994) Curr. Opin. Cell Biol., 6, 212–218. Hall, A. (1998) Science, 279, 509–514. Ridley, A. J. (1999) Prog. Mol. Subcell. Biol., 22, 1–22. Ridley, A. J., and Hall, A. (1992) Cell, 70, 389–399. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., and Hall, A. (1992) Cell, 70, 401–410. Kozma, R., Ahmed, S., Best, A., and Lim, L. (1995) Mol. Cell Biol., 15, 1942–1952. Nobes, C. D., and Hall, A. (1995) Cell, 81, 53–62. Norman, J. C., Price, L. S., Ridley, A. J., Hall, A., and Koffer, A. (1994) J. Cell Biol., 126, 1005–1015. Ridley, A. J., Comoglio, P. M., and Hall, A. (1995) Mol. Cell Biol., 15, 1110–1122. Allen, W. E., Jones, G. E., Pollard, J. W., and Ridley, A. J. (1997) J. Cell Sci., 110, 707–720. Kozma, R., Sarner, S., Ahmed, S., and Lim, L. (1997) Mol. Cell Biol., 17, 1201–1211. Quinn, M. T., Evans, T., Loetterle, L. R., Jesaitis, A. J., and Bokoch, G. M. (1993) J. Biol. Chem., 268, 20983–20987. Bokoch, G. M., Bohl, B. P., and Chuang, T. H. (1994) J. Biol. Chem., 269, 31674–31679. Benard, V., Bohl, B. P., and Bokoch, G. M. (1999) J. Biol. Chem., 274, 13198–13204. Therrien, S., and Naccache, P. H. (1989) J. Cell Biol., 109, 1125–1132. Redmond, T., Tardif, M., and Zigmond, S. H. (1994) J. Biol. Chem., 269, 21657–21663. Katanaev, V. L., and Wymann, M. P. (1998) J. Cell Sci., 111, 1583–1594. Zigmond, S. H., Joyce, M., Borleis, J., Bokoch, G. M., and Devreotes, P. N. (1997) J. Cell Biol., 138, 363–374. Katanaev, V. L. (2000) Neutrophil Chemotaxis: Crucial Role of Phosphoinositide 3 Kinase Gamma and Rho Family GTP Binding Proteins: PhD thesis, University of Fribourg, Fribourg, Switzerland. Stasia, M. J., Jouan, A., Bourmeyster, N., Boquet, P., and Vignais, P. V. (1991) Biochem. Biophys. Res. Commun., 180, 615–622. Laudanna, C., Campbell, J. J., and Butcher, E. C. (1996) Science, 271, 981–983. Redowicz, M. J. (1999) Arch. Biochem. Biophys., 364, 122–124. Niggli, V. (1999) FEBS Lett., 445, 69–72. Heyworth, P. G., Bohl, B. P., Bokoch, G. M., and Curnutte, J. T. (1994) J. Biol. Chem., 269, 30749–30752. Roberts, A. W., Kim, C., Zhen, L., Lowe, J. B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J. D., Borneo, J. B., Bradford, G. B., Atkinson, S. J., Dinauer, M. C., and Williams, D. A. (1999) Immunity, 10, 183–196. Ambruso, D. R., Knall, C., Abell, A. N., Panepinto, J., Kurkchubasche, A., Thurman, G., Gonzalez-Aller, C., Hiester, A., deBoer, M., Harbeck, R. J., Oyer, R., Johnson, G. L., and Roos, D. (2000) Proc. Natl. Acad. Sci. USA, 97, 4654–4659. Daniels, R. H., and Bokoch, G. M. (1999) Trends Biochem. Sci., 24, 350–355. Huang, R., Lian, J. P., Robinson, D., and Badwey, J. A. (1998) Mol. Cell Biol., 18, 7130–7138. Dharmawardhane, S., Brownson, D., Lennartz, M., and Bokoch, G. M. (1999) J. Leukoc. Biol., 66, 521–527. Sanchez-Madrid, F., and del Pozo, M. A. (1999) EMBO J., 18, 501–511. Reif, K., and Cantrell, D. A. (1998) Immunity, 8, 395–401. Kozasa, T., Jiang, X., Hart, M. J., Sternweis, P. M., Singer, W. D., Gilman, A. G., Bollag, G., and Sternweis, P. C. (1998) Science, 280, 2109–2111. Hart, M. J., Jiang, X., Kozasa, T., Roscoe, W., Singer, W. D., Gilman, A. G., Sternweis, P. C., and Bollag, G. (1998) Science, 280, 2112–2114. Barrett, K., Leptin, M., and Settleman, J. (1997) Cell, 91, 905–915. Cerione, R. A., and Zheng, Y. (1996) Curr. Opin. Cell Biol., 8, 216–222. Zheng, Y., Zangrilli, D., Cerione, R. A., and Eva, A. (1996) J. Biol. Chem., 271, 19017–19020. Olson, M. F., Sterpetti, P., Nagata, K., Toksoz, D., and Hall, A. (1997) Oncogene, 15, 2827–2831. Michiels, F., Stam, J. C., Hordijk, P. L., van der Kammen, R. A., Ruuls-Van Stalle, L., Feltkamp, C. A., and Collard, J. G. (1997) J. Cell Biol., 137, 387–398. Mahadevan, D., Thanki, N., Singh, J., McPhie, P., Zangrilli, D., Wang, L. M., Guerrero, C., LeVine, H. 3rd, Humblet, C., Saldanha, J., et al. (1995) Biochemistry, 34, 9111–9117. Nishida, K., Kaziro, Y., and Satoh, T. (1999) FEBS Lett., 459, 186–190. Ma, A. D., Metjian, A., Bagrodia, S., Taylor, S., and Abrams, C. S. (1998) Mol. Cell Biol., 18, 4744–4751. Han, J., Luby-Phelps, K., Das, B., Shu, X., Xia, Y., Mosteller, R. D., Krishna, U. M., Falck, J. R., White, M. A., and Broek, D. (1998) Science, 279, 558–560. Lemmon, M. A. (1999) Biochem. Soc. Trans., 27, 617–624. Isakoff, S. J., Cardozo, T., Andreev, J., Li, Z., Ferguson, K. M., Abagyan, R., Lemmon, M. A., Aronheim, A., and Skolnik, E. Y. (1998) EMBO J., 17, 5374–5387. Butty, A. C., Pryciak, P. M., Huang, L. S., Herskowitz, I., and Peter, M. (1998) Science, 282, 1511–1516. Fackler, O. T., Luo, W., Geyer, M., Alberts, A. S., and Peterlin, B. M. (1999) Mol. Cell, 3, 729–739. Scita, G., Nordstrom, J., Carbone, R., Tenca, P., Giardina, G., Gutkind, S., Bjarnegard, M., Betsholtz, C., and Di Fiore, P. P. (1999) Nature, 401, 290–293. Aspenstrom, P. (1999) Curr. Opin. Cell Biol., 11, 95–102. Chong, L. D., Traynor-Kaplan, A., Bokoch, G. M., and Schwartz, M. A. (1994) Cell, 79, 507–513. Hartwig, J. H., Bokoch, G. M., Carpenter, C. L., Janmey, P. A., Taylor, L. A., Toker, A., and Stossel, T. P. (1995) Cell, 82, 643–653. Tolias, K. F., Cantley, L. C., and Carpenter, C. L. (1995) J. Biol. Chem., 270, 17656–17659. Ren, X. D., Bokoch, G. M., Traynor-Kaplan, A., Jenkins, G. H., Anderson, R. A., and Schwartz, M. A. (1996) Mol. Biol. Cell, 7, 435–442. Tolias, K. F., Couvillon, A. D., Cantley, L. C., and Carpenter, C. L. (1998) Mol. Cell Biol., 18, 762–770. Oude Weernink, P. A., Schulte, P., Guo, Y., Wetzel, J., Amano, M., Kaibuchi, K., Haverland, S., Voss, M., Schmidt, M., Mayr, G. W., and Jakobs, K. H. (2000) J. Biol. Chem., 275, 10168–10174. Janmey, P. A. (1994) Annu. Rev. Physiol., 56, 169–191. Janmey, P. A., Iida, K., Yin, H. L., and Stossel, T. P. (1987) J. Biol. Chem., 262, 12228–12236. Heiss, S. G., and Cooper, J. A. (1991) Biochemistry, 30, 8753–8758. Shibasaki, Y., Ishihara, H., Kizuki, N., Asano, T., Oka, Y., and Yazaki, Y. (1997) J. Biol. Chem., 272, 7578–7581. Azuma, T., Witke, W., Stossel, T. P., Hartwig, J. H., and Kwiatkowski, D. J. (1998) EMBO J., 17, 1362–1370. Carpenter, C. L., Tolias, K. F., Van Vugt, A., and Hartwig, J. (1999) Adv. Enzyme Regul., 39, 299–312. Janmey, P. A. (1998) Physiol. Rev., 78, 763–781. Korchak, H. M., Vienne, K., Wilkenfeld, C., Roberts, C., Rich, A. M., and Weissmann, G. (1985) Trans. Assoc. Am. Physicians, 98, 224–232. Bamburg, J. R., McGough, A., and Ono, S. (1999) Trends Cell Biol., 9, 364–370. Aizawa, H., Sutoh, K., and Yahara, I. (1996) J. Cell Biol., 132, 335–344. Meberg, P. J., and Bamburg, J. R. (2000) J. Neurosci., 20, 2459–2469. Carlier, M. F., and Pantaloni, D. (1997) J. Mol. Biol., 269, 459–467. Maciver, S. K., Zot, H. G., and Pollard, T. D. (1991) J. Cell Biol., 115, 1611–1620. Moriyama, K., Iida, K., and Yahara, I. (1996) Genes Cells, 1, 73–86. Arber, S., Barbayannis, F. A., Hanser, H., Schneider, C., Stanyon, C. A., Bernard, O., and Caroni, P. (1998) Nature, 393, 805–809. Yang, N., Higuchi, O., Ohashi, K., Nagata, K., Wada, A., Kangawa, K., Nishida, E., and Mizuno, K. (1998) Nature, 393, 809–812. Sumi, T., Matsumoto, K., Takai, Y., and Nakamura, T. (1999) J. Cell Biol., 147, 1519–1532. Edwards, D. C., Sanders, L. C., Bokoch, G. M., and Gill, G. N. (1999) Nat. Cell Biol., 1, 253–259. Maekawa, M., Ishizaki, T., Boku, S., Watanabe, N., Fujita, A., Iwamatsu, A., Obinata, T., Ohashi, K., Mizuno, K., and Narumiya, S. (1999) Science, 285, 895–898. Okada, K., Takano-Ohmuro, H., Obinata, T., and Abe, H. (1996) Exp. Cell Res., 227, 116–122. Heyworth, P. G., Robinson, J. M., Ding, J., Ellis, B. A., and Badwey, J. A. (1997) Histochem. Cell Biol., 108, 221–233. Djafarzadeh, S., and Niggli, V. (1997) Exp. Cell Res., 236, 427–435. Harrington, W. F., and Rodgers, M. E. (1984) Annu. Rev. Biochem., 53, 35–73. Warrick, H. M., and Spudich, J. A. (1987) Annu. Rev. Cell Biol., 3, 379–421. Knecht, D. A., and Loomis, W. F. (1987) Science, 236, 1081–1086. De Lozanne, A., and Spudich, J. A. (1987) Science, 236, 1086–1091. Goodson, H. V., Anderson, B. L., Warrick, H. M., Pon, L. A., and Spudich, J. A. (1996) J. Cell Biol., 133, 1277–1291. Kitayama, C., Sugimoto, A., and Yamamoto, M. (1997) J. Cell Biol., 137, 1309–1319. Takubo, T., and Tatsumi, N. (1997) Anal. Quant. Cytol. Histol., 19, 233–238. Hofman, P., d'Andrea, L., Guzman, E., Selva, E., Le Negrate, G., Far, D. F., Lemichez, E., Boquet, P., and Rossi, B. (1999) Eur. Cytokine Netw., 10, 227–236. Rengan, R., and Omann, G. M. (1999) Biochem. Biophys. Res. Commun., 262, 479–486. Tan, J. L., Ravid, S., and Spudich, J. A. (1992) Annu. Rev. Biochem., 61, 721–759. Adelstein, R. S., Conti, M. A., and Anderson, W., Jr. (1973) Proc. Natl. Acad. Sci. USA, 70, 3115–3119. Kuczmarski, E. R., and Spudich, J. A. (1980) Proc. Natl. Acad. Sci. USA, 77, 7292–7296. Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y., and Kaibuchi, K. (1996) J. Biol. Chem., 271, 20246–20249. Kawano, Y., Fukata, Y., Oshiro, N., Amano, M., Nakamura, T., Ito, M., Matsumura, F., Inagaki, M., and Kaibuchi, K. (1999) J. Cell Biol., 147, 1023–1038. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K. (1996) Science, 273, 245–248. Sanders, L. C., Matsumura, F., Bokoch, G. M., and de Lanerolle, P. (1999) Science, 283, 2083–2085. Ridley, A. J., and Hall, A. (1994) EMBO J., 13, 2600–2610. Qiu, R. G., Abo, A., and Steven Martin, G. (2000) Curr. Biol., 10, 697–707. Aspenstrom, P. (1997) Curr. Biol., 7, 479–487. Snapper, S. B., and Rosen, F. S. (1999) Annu. Rev. Immunol., 17, 905–929. Ma, L., Cantley, L. C., Janmey, P. A., and Kirschner, M. W. (1998) J. Cell Biol., 140, 1125–1136. Moreau, V., and Way, M. (1998) FEBS Lett., 427, 353–356. Ma, L., Rohatgi, R., and Kirschner, M. W. (1998) Proc. Natl. Acad. Sci. USA, 95, 15362–15367. Rohatgi, R., Ma, L., Miki, H., Lopez, M., Kirchhausen, T., Takenawa, T., and Kirschner, M. W. (1999) Cell, 97, 221–231. Mullins, R. D., and Pollard, T. D. (1999) Curr. Biol., 9, 405–415. Machesky, L. M., Atkinson, S. J., Ampe, C., Vandekerckhove, J., and Pollard, T. D. (1994) J. Cell Biol., 127, 107–115. Winter, D., Podtelejnikov, A. V., Mann, M., and Li, R. (1997) Curr. Biol., 7, 519–529. Welch, M. D., Iwamatsu, A., and Mitchison, T. J. (1997) Nature, 385, 265–269. Machesky, L. M., Reeves, E., Wientjes, F., Mattheyse, F. J., Grogan, A., Totty, N. F., Burlingame, A. L., Hsuan, J. J., and Segal, A. W. (1997) Biochem. J., 328, 105–112. Mullins, R. D., Stafford, W. F., and Pollard, T. D. (1997) J. Cell Biol., 136, 331–343. Mullins, R. D., Kelleher, J. F., Xu, J., and Pollard, T. D. (1998) Mol. Biol. Cell, 9, 841–852. Mullins, R. D., Heuser, J. A., and Pollard, T. D. (1998) Proc. Natl. Acad. Sci. USA, 95, 6181–6186. Svitkina, T. M., and Borisy, G. G. (1999) J. Cell Biol., 145, 1009–1026. Welch, M. D., Rosenblatt, J., Skoble, J., Portnoy, D. A., and Mitchison, T. J. (1998) Science, 281, 105–108. Pollard, T. D., and Cooper, J. A. (1986) Annu. Rev. Biochem., 55, 987–1035. Blanchoin, L., Amann, K. J., Higgs, H. N., Marchand, J. B., Kaiser, D. A., and Pollard, T. D. (2000) Nature, 404, 1007–1011. Yarar, D., To, W., Abo, A., and Welch, M. D. (1999) Curr. Biol., 9, 555–558. Machesky, L. M., Mullins, R. D., Higgs, H. N., Kaiser, D. A., Blanchoin, L., May, R. C., Hall, M. E., and Pollard, T. D. (1999) Proc. Natl. Acad. Sci. USA, 96, 3739–3744. Machesky, L. M., and Insall, R. H. (1998) Curr. Biol., 8, 1347–1356. Aspenstrom, P., Lindberg, U., and Hall, A. (1996) Curr. Biol., 6, 70–75. Symons, M., Derry, J. M., Karlak, B., Jiang, S., Lemahieu, V., Mccormick, F., Francke, U., and Abo, A. (1996) Cell, 84, 723–734. Kolluri, R., Tolias, K. F., Carpenter, C. L., Rosen, F. S., and Kirchhausen, T. (1996) Proc. Natl. Acad. Sci. USA, 93, 5615–5618. Miki, H., Miura, K., and Takenawa, T. (1996) EMBO J., 15, 5326–5335. Miki, H., Sasaki, T., Takai, Y., and Takenawa, T. (1998) Nature, 391, 93–96. Miki, H., Suetsugu, S., and Takenawa, T. (1998) EMBO J., 17, 6932–6941. Kim, A. S., Kakalis, L. T., Abdul-Manan, N., Liu, G. A., and Rosen, M. K. (2000) Nature, 404, 151–158. Nagase, T., Seki, N., Ishikawa, K., Ohira, M., Kawarabayasi, Y., Ohara, O., Tanaka, A., Kotani, H., Miyajima, N., and Nomura, N. (1996) DNA Res., 3, 321–329. Zicha, D., Allen, W. E., Brickell, P. M., Kinnon, C., Dunn, G. A., Jones, G. E., and Thrasher, A. J. (1998) Br. J. Haematol., 101, 659–665. Suetsugu, S., Miki, H., and Takenawa, T. (1999) Biochem. Biophys. Res. Commun., 260, 296–302. Wymann, M. P., Sozzani, S., Altruda, F., Mantovani, A., and Hirsch, E. (2000) Immunol. Today, 21, 260–264. Montell, D. J. (1999) Development, 126, 3035–3046. Sutherland, J. D., and Witke, W. (1999) Curr. Opin. Cell Biol., 11, 142–151. Parent, C. A., and Devreotes, P. N. (1999) Annu. Rev. Biochem., 65, 411–440. Wu, L., Valkema, R., Van Haastert, P. J., and Devreotes, P. N. (1995) J. Cell Biol., 129, 1667–1675. Xiao, Z., Zhang, N., Murphy, D. B., and Devreotes, P. N. (1997) J. Cell Biol., 139, 365–374. Jin, T., Zhang, N., Long, Y., Parent, C. A., and Devreotes, P. N. (2000) Science, 287, 1034–1036. Parent, C. A., Blacklock, B. J., Froehlich, W. M., Murphy, D. B., and Devreotes, P. N. (1998) Cell, 95, 81–91. Servant, G., Weiner, O. D., Herzmark, P., Balla, T., Sedat, J. W., and Bourne, H. R. (2000) Science, 287, 1037–1040. Meili, R., Ellsworth, C., Lee, S., Reddy, T. B., Ma, H., and Firtel, R. A. (1999) EMBO J., 18, 2092–2105. Meili, R., Ellsworth, C., and Firtel, R. A. (2000) Curr. Biol., 10, 708–717. Allen, W. E., Zicha, D., Ridley, A. J., and Jones, G. E. (1998) J. Cell Biol., 141, 1147–1157. Arkowitz, R. A. (1999) Trends Cell Biol., 9, 20–27. Stowers, L., Yelon, D., Berg, L. J., and Chant, J. (1995) Proc. Natl. Acad. Sci. USA, 92, 5027–5031. Williamson, M. P., and Madison, V. S. (1990) Biochemistry, 29, 2895–2905. Lodi, P. J., Garrett, D. S., Kuscewski, J., Tsang, M. L. S., Weatherbee, J. A., Leonard, W. J., Gronenborn, A. M., and Clore, G. M. (1994) Science, 263, 1762–1767. Clore, G. M., Appella, E., Yamada, M., Matsushima, K., and Gronenborn, A. M. (1990) Biochemistry, 29, 1689–1696.