Sialic acid–binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β2-integrin–dependent function in human eosinophils

Rosenberg, 2013, Eosinophils: changing perspectives in health and disease, Nat Rev Immunol, 13, 9, 10.1038/nri3341 Hogan, 2008, Eosinophils: biological properties and role in health and disease, Clin Exp Allergy, 38, 709, 10.1111/j.1365-2222.2008.02958.x Valent, 2009, Pathogenesis, classification, and therapy of eosinophilia and eosinophil disorders, Blood Rev, 23, 157, 10.1016/j.blre.2009.01.001 Wechsler, 2012, Novel targeted therapies for eosinophilic disorders, J Allergy Clin Immunol, 130, 563, 10.1016/j.jaci.2012.07.027 Macauley, 2014, Siglec-mediated regulation of immune cell function in disease, Nat Rev Immunol, 14, 653, 10.1038/nri3737 Bochner, 2015, Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation, J Allergy Clin Immunol, 135, 598, 10.1016/j.jaci.2014.11.031 Floyd, 2000, Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily, J Biol Chem, 275, 861, 10.1074/jbc.275.2.861 Kikly, 2000, Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils, J Allergy Clin Immunol, 105, 1093, 10.1067/mai.2000.107127 Foussias, 2000, Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene, Biochem Biophys Res Commun, 278, 775, 10.1006/bbrc.2000.3866 Nutku, 2003, Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis, Blood, 101, 5014, 10.1182/blood-2002-10-3058 Nutku, 2005, Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury, Biochem Biophys Res Commun, 336, 918, 10.1016/j.bbrc.2005.08.202 Nutku-Bilir, 2008, Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways, Am J Respir Cell Mol Biol, 38, 121, 10.1165/rcmb.2007-0154OC Kano, 2013, Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation, J Allergy Clin Immunol, 132, 437, 10.1016/j.jaci.2013.03.024 Na, 2012, IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils, Cytokine, 57, 169, 10.1016/j.cyto.2011.10.007 Taylor, 1999, The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2, J Biol Chem, 274, 11505, 10.1074/jbc.274.17.11505 Angata, 2001, Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters, J Biol Chem, 276, 45128, 10.1074/jbc.M108573200 Kitzig, 2002, Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1, Biochem Biophys Res Commun, 296, 355, 10.1016/S0006-291X(02)00885-9 Avril, 2005, Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation, J Biol Chem, 280, 19843, 10.1074/jbc.M502041200 Kano, 2017, Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family kinases, Immunobiology, 222, 343, 10.1016/j.imbio.2016.09.006 Hansel, 1989, Purification of human blood eosinophils by negative selection using immunomagnetic beads, J Immunol Methods, 122, 97, 10.1016/0022-1759(89)90339-6 Hudson, 2009, Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis x, J Pharmacol Exp Ther, 330, 608, 10.1124/jpet.109.152439 Wilkerson, 2016, The peripheral blood eosinophil proteome, J Proteome Res, 15, 1524, 10.1021/acs.jproteome.6b00006 Villen, 2008, The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry, Nat Protoc, 3, 1630, 10.1038/nprot.2008.150 Huang da, 2009, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat Protoc, 4, 44, 10.1038/nprot.2008.211 Huang da, 2009, Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists, Nucleic Acids Res, 37, 1, 10.1093/nar/gkn923 Kato, 1998, Ligation of the beta2 integrin triggers activation and degranulation of human eosinophils, Am J Respir Cell Mol Biol, 18, 675, 10.1165/ajrcmb.18.5.2885 Simon, 2000, Integrin expression by eosinophils, Allergy, 55, 791, 10.1034/j.1398-9995.2000.00030.x Bochner, 2000, Systemic activation of basophils and eosinophils: markers and consequences, J Allergy Clin Immunol, 106, S292, 10.1067/mai.2000.110164 Dri, 1991, Eosinophil activation on biologic surfaces. Production of O2- in response to physiologic soluble stimuli is differentially modulated by extracellular matrix components and endothelial cells, J Immunol, 147, 613, 10.4049/jimmunol.147.2.613 Bruhns, 2012, Properties of mouse and human IgG receptors and their contribution to disease models, Blood, 119, 5640, 10.1182/blood-2012-01-380121 Trnka, 2008, A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria, Free Radic Biol Med, 44, 1406, 10.1016/j.freeradbiomed.2007.12.036 Pfeiffer, 1997, Interference of carboxy-PTIO with nitric oxide- and peroxynitrite-mediated reactions, Free Radic Biol Med, 22, 787, 10.1016/S0891-5849(96)00407-8 Wagner, 2009, Signal integration by JNK and p38 MAPK pathways in cancer development, Nat Rev Cancer, 9, 537, 10.1038/nrc2694 McCubrey, 2006, Reactive oxygen species-induced activation of the MAP kinase signaling pathways, Antioxid Redox Signal, 8, 1775, 10.1089/ars.2006.8.1775 Vlahos, 1994, A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), J Biol Chem, 269, 5241, 10.1016/S0021-9258(17)37680-9 Young, 1997, Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site, J Biol Chem, 272, 12116, 10.1074/jbc.272.18.12116 Bennett, 2001, SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase, Proc Natl Acad Sci U S A, 98, 13681, 10.1073/pnas.251194298 Cao, 2011, Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?, Immunology, 132, 18, 10.1111/j.1365-2567.2010.03368.x Hayman, 1985, Vitronectin—a major cell attachment-promoting protein in fetal bovine serum, Exp Cell Res, 160, 245, 10.1016/0014-4827(85)90173-9 Johansson, 2013, alpha(M)beta(2) integrin-mediated adhesion and motility of IL-5-stimulated eosinophils on periostin, Am J Respir Cell Mol Biol, 48, 503, 10.1165/rcmb.2012-0150OC McMillan, 2013, Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signaling, Blood, 121, 2084, 10.1182/blood-2012-08-449983 Barthel, 2008, Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma, J Leukoc Biol, 83, 1, 10.1189/jlb.0607344 Johansson, 2013, Anti-IL-5 attenuates activation and surface density of beta(2) -integrins on circulating eosinophils after segmental antigen challenge, Clin Exp Allergy, 43, 292, 10.1111/j.1365-2222.2012.04065.x Han, 2014, IL-5 induces suspended eosinophils to undergo unique global reorganization associated with priming, Am J Respir Cell Mol Biol, 50, 654, 10.1165/rcmb.2013-0181OC Horie, 1994, CD11b/CD18 (Mac-1) is required for degranulation of human eosinophils induced by human recombinant granulocyte-macrophage colony-stimulating factor and platelet-activating factor, J Immunol, 152, 5457, 10.4049/jimmunol.152.11.5457 Nathan, 1987, Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes, J Clin Invest, 80, 1550, 10.1172/JCI113241 Panday, 2015, NADPH oxidases: an overview from structure to innate immunity-associated pathologies, Cell Mol Immunol, 12, 5, 10.1038/cmi.2014.89 McMillan, 2014, Siglec-E promotes beta2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung, J Biol Chem, 289, 20370, 10.1074/jbc.M114.574624 Nguyen, 2014, Role of Siglec-7 in apoptosis in human platelets, PLoS One, 9, e106239, 10.1371/journal.pone.0106239 Brazil, 2004, Advances in protein kinase B signalling: AKTion on multiple fronts, Trends Biochem Sci, 29, 233, 10.1016/j.tibs.2004.03.006 Plas, 2005, Akt-dependent transformation: there is more to growth than just surviving, Oncogene, 24, 7435, 10.1038/sj.onc.1209097 Nogueira, 2008, Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis, Cancer Cell, 14, 458, 10.1016/j.ccr.2008.11.003 Plotnikov, 2011, The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation, Biochim Biophys Acta, 1813, 1619, 10.1016/j.bbamcr.2010.12.012 Hasala, 2007, c-Jun N-terminal kinase mediates constitutive human eosinophil apoptosis, Pulm Pharmacol Ther, 20, 580, 10.1016/j.pupt.2006.06.004 Sakamoto, 2006, Involvement of p38 MAP kinase in not only activation of the phagocyte NADPH oxidase induced by formyl-methionyl-leucyl-phenylalanine but also determination of the extent of the activity, J Biochem, 140, 739, 10.1093/jb/mvj204 El Benna, 1996, Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK, Arch Biochem Biophys, 334, 395, 10.1006/abbi.1996.0470 Detmers, 1998, Role of stress-activated mitogen-activated protein kinase (p38) in beta 2-integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst, J Immunol, 161, 1921, 10.4049/jimmunol.161.4.1921 Lynch, 1999, 'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils, Br J Pharmacol, 128, 1149, 10.1038/sj.bjp.0702892 Lynch, 2001, Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils, Br J Pharmacol, 134, 797, 10.1038/sj.bjp.0704314 Ali, 2014, Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus, J Exp Med, 211, 1231, 10.1084/jem.20131853 Yu, 2017, Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties, Glycobiology, 27, 657, 10.1093/glycob/cwx026 Persson, 2014, Theirs but to die and do: primary lysis of eosinophils and free eosinophil granules in asthma, Am J Respir Crit Care Med, 189, 628, 10.1164/rccm.201311-2069OE