Short-chain sphingolipids for enhanced cellular uptake of liposome-encapsulated amphiphilic anti-cancer drugs

BMC Proceedings - Tập 4 - Trang 1-1 - 2010
Lília RC Pedrosa1, Albert van Hell2, Wim van Blitterswijk2, Ann LB Seynhaeve1, Alexander MM Eggermont1, Timo LM ten Hagen1, Marcel Verheij2,3, Gerben A Koning1
1Laboratory Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus MC- Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
2Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
3Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, the Netherlands

Tài liệu tham khảo

Veldman RJ, Zerp S, van Blitterswijk WJ, Verheij M: N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx. Br J Cancer. 2004, 90: 917-925. 10.1038/sj.bjc.6601581. Veldman RJ, Koning GA, van Hell A, Zerp S, Vink SR, Storm G, Verheij M, van Blitterswijk WJ: Coformulated N-octanoyl-glucosylceramide improves cellular delivery and cytotoxicity of liposomal doxorubicin. J Pharmacol Exp Ther. 2005, 315: 704-710. 10.1124/jpet.105.087486. Siskind LJ: Mitochondrial ceramide and the induction of apoptosis. J Bioenerg Biomembr. 2005, 37: 143-153. 10.1007/s10863-005-6567-7.
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BMC Proceedings

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