Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine
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Chen X, Yang L, Oppenheim JJ, Howard MZ (2002) Cellular pharmacology studies of shikonin derivatives. Phytother Res 16:199–209. doi: 10.1002/ptr.1100
Staniforth V, Wang SY, Shyur LF, Yang NS (2004) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. J Biol Chem 279:5877–5885. doi: 10.1074/jbc.M309185200
Su PF, Staniforth V, Li CJ, Wang CY, Chiao MT, Wang SY, Shyur LF, Yang NS (2008) Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues. J Biomed Sci 15:813–822. doi: 10.1007/s11373-008-9266-7
Chiu SC, Yang NS (2007) Inhibition of tumor necrosis factor-alpha through selective blockade of Pre-mRNA splicing by shikonin. Mol Pharmacol 71:1640–1645. doi: 10.1124/mol.106.032821
Chiu SC, Tsao SW, Hwang PI, Vanisree S, Chen YA, Yang NS (2010) Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling. BMC Genomics 11:513. doi: 10.1186/1471-2164-11-513
Lee HJ, Magesh V, Nam D, Lee EO, Ahn KS, Jung MH, Kim DK, Kim JY, Kim SH (2008) Shikonin, acetylshikonin, and isobutyroylshikonin inhibit VEGF-induced angiogenesis and suppress tumor growth in lewis lung carcinoma-bearing mice. Yakugaku zasshi: J Pharm Soc Jpn 128:1681–1688
Wang Z, Liu T, Gan L, Wang T, Yuan X, Zhang B, Chen H, Zheng Q (2010) Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity. Eur J Pharmacol 643:211–217. doi: 10.1016/j.ejphar.2010.06.027
Ko FN, Lee YS, Kuo SC, Chang YS, Teng CM (1995) Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma. Biochim Biophys Acta 1268:329–334
An S, Park YD, Paik YK, Jeong TS, Lee WS (2007) Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon. Bioorg Med Chem Lett 17:1112–1116. doi: 10.1016/j.bmcl.2006.11.024
Chang IC, Huang YJ, Chiang TI, Yeh CW, Hsu LS (2010) Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. Biol Pharm Bull 33:816–824
Yang H, Zhou P, Huang H et al (2009) Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo. Int J Cancer 124:2450–2459. doi: 10.1002/ijc.24195
Han W, Li L, Qiu S, Lu Q, Pan Q, Gu Y, Luo J, Hu X (2007) Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther 6:1641–1649. doi: 10.1158/1535-7163.MCT-06-0511
Garg AD, Nowis D, Golab J, Vandenabeele P, Krysko DV, Agostinis P (2010) Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation. Biochim Biophys Acta 1805:53–71. doi: 10.1016/j.bbcan.2009.08.003
Zitvogel L, Apetoh L, Ghiringhelli F, Kroemer G (2008) Immunological aspects of cancer chemotherapy. Nat Rev Immunol 8:59–73. doi: 10.1038/nri2216
Tesniere A, Apetoh L, Ghiringhelli F, Joza N, Panaretakis T, Kepp O, Schlemmer F, Zitvogel L, Kroemer G (2008) Immunogenic cancer cell death: a key-lock paradigm. Curr Opin Immunol 20:504–511. doi: 10.1016/j.coi.2008.05.007
Dhodapkar MV, Dhodapkar KM, Palucka AK (2008) Interactions of tumor cells with dendritic cells: balancing immunity and tolerance. Cell Death Differ 15:39–50. doi: 10.1038/sj.cdd.4402247
Wen CC, Chen HM, Chen SS et al (2011) Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines. J Biomed Sci 18:44. doi: 10.1186/1423-0127-18-44
Steinman RM, Pope M (2002) Exploiting dendritic cells to improve vaccine efficacy. J Clin Invest 109:1519–1526. doi: 10.1172/JCI15962
Takeda K, Kaisho T, Akira S (2003) Toll-like receptors. Annu Rev Immunol 21:335–376. doi: 10.1146/annurev.immunol.21.120601.141126
Janeway CA Jr (1989) Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 54(Pt 1):1–13
Matzinger P (1994) Tolerance, danger, and the extended family. Annu Rev Immunol 12:991–1045. doi: 10.1146/annurev.iy.12.040194.005015
Kono H, Rock KL (2008) How dying cells alert the immune system to danger. Nat Rev Immunol 8:279–289. doi: 10.1038/nri2215
Tait SW, Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 11:621–632. doi: 10.1038/nrm2952
Hong SJ, Dawson TM, Dawson VL (2004) Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. Trends Pharmacol Sci 25:259–264. doi: 10.1016/j.tips.2004.03.005
Casares N, Pequignot MO, Tesniere A et al (2005) Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med 202:1691–1701. doi: 10.1084/jem.20050915
Jordan MA, Wendell K, Gardiner S, Derry WB, Copp H, Wilson L (1996) Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 56:816–825
Obeng EA, Carlson LM, Gutman DM, Harrington WJ Jr, Lee KP, Boise LH (2006) Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 107:4907–4916. doi: 10.1182/blood-2005-08-3531
Hong SH, Kim J, Kim JM, Lee SY, Shin DS, Son KH, Han DC, Sung YK, Kwon BM (2007) Apoptosis induction of 2′-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. Biochem Pharmacol 74:557–565. doi: 10.1016/j.bcp.2007.05.016
Lomonosova E, Ryerse J, Chinnadurai G (2009) BAX/BAK-independent mitoptosis during cell death induced by proteasome inhibition? Mol Cancer Res 7:1268–1284. doi: 10.1158/1541-7786.MCR-08-0183
Kepp O, Senovilla L, Galluzzi L, Panaretakis T, Tesniere A, Schlemmer F, Madeo F, Zitvogel L, Kroemer G (2009) Viral subversion of immunogenic cell death. Cell Cycle 8:860–869
Hsu PC, Huang YT, Tsai ML, Wang YJ, Lin JK, Pan MH (2004) Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells. J Agric Food Chem 52:6330–6337. doi: 10.1021/jf0495993
Ruan M, Yan M, Yang WJ, Qu XZ, Zhou XJ, Chen WT, Zhang CP (2010) Role of NF-kappaB pathway in shikonin induced apoptosis in oral squamous cell carcinoma Tca-8113 cells. Shanghai J Stomatol 19:66–71
Shi M, Xiang J (2006) CD4+ T cell-independent maintenance and expansion of memory CD8+ T cells derived from in vitro dendritic cell activation. Int Immunol 18:887–895. doi: 10.1093/intimm/dxl025
Pavelko KD, Heckman KL, Hansen MJ, Pease LR (2008) An effective vaccine strategy protective against antigenically distinct tumor variants. Cancer Res 68:2471–2478. doi: 10.1158/0008-5472.CAN-07-5937
Staniforth V, Chiu LT, Yang NS (2006) Caffeic acid suppresses UVB radiation-induced expression of interleukin-10 and activation of mitogen-activated protein kinases in mouse. Carcinogenesis 27:1803–1811. doi: 10.1093/carcin/bgl006
Jung MY, Son MH, Kim SH, Cho D, Kim TS (2011) IL-32gamma induces the maturation of dendritic cells with Th1- and Th17-polarizing ability through enhanced IL-12 and IL-6 production. J Immunol 186:6848–6859. doi: 10.4049/jimmunol.1003996
Blomberg K, Granberg C, Hemmila I, Lovgren T (1986) Europium-labelled target cells in an assay of natural killer cell activity. I. A novel non-radioactive method based on time-resolved fluorescence. J Immunol Methods 86:225–229
Ott M, Norberg E, Zhivotovsky B, Orrenius S (2009) Mitochondrial targeting of tBid/Bax: a role for the TOM complex? Cell Death Differ 16:1075–1082. doi: 10.1038/cdd.2009.61
Ashe PC, Berry MD (2003) Apoptotic signaling cascades. Prog Neuropsychopharmacol Biol Psychiatry 27:199–214. doi: 10.1016/S0278-5846(03)00016-2
Hsu YT, Youle RJ (1997) Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem 272:13829–13834
Yethon JA, Epand RF, Leber B, Epand RM, Andrews DW (2003) Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis. J Biol Chem 278:48935–48941. doi: 10.1074/jbc.M306289200
Antonsson B, Montessuit S, Lauper S, Eskes R, Martinou JC (2000) Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem J 345(Pt 2):271–278
Antonsson B, Montessuit S, Sanchez B, Martinou JC (2001) Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J Biol Chem 276:11615–11623. doi: 10.1074/jbc.M010810200
Gonzalez-Gronow M, Selim MA, Papalas J, Pizzo SV (2009) GRP78: a multifunctional receptor on the cell surface. Antioxid Redox Signal 11:2299–2306. doi: 10.1089/ARS.2009.2568
Al-Hashimi AA, Caldwell J, Gonzalez-Gronow M et al (2010) Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores. J Biol Chem 285:28912–28923. doi: 10.1074/jbc.M110.119107
Obeid M, Tesniere A, Ghiringhelli F et al (2007) Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 13:54–61. doi: 10.1038/nm1523
Chaput N, De Botton S, Obeid M, Apetoh L, Ghiringhelli F, Panaretakis T, Flament C, Zitvogel L, Kroemer G (2007) Molecular determinants of immunogenic cell death: surface exposure of calreticulin makes the difference. J Mol Med (Berl) 85:1069–1076. doi: 10.1007/s00109-007-0214-1
Lasunskaia EB, Fridlianskaia I, Arnholdt AV, Kanashiro M, Guzhova I, Margulis B (2010) Sub-lethal heat shock induces plasma membrane translocation of 70-kDa heat shock protein in viable, but not in apoptotic, U-937 leukaemia cells. Acta Pathol Microbiol Immunol Scand 118:179–187. doi: 10.1111/j.1600-0463.2009.02576.x
Spisek R, Charalambous A, Mazumder A, Vesole DH, Jagannath S, Dhodapkar MV (2007) Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. Blood 109:4839–4845. doi: 10.1182/blood-2006-10-054221
Datta R, Oki E, Endo K, Biedermann V, Ren J, Kufe D (2000) XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage. J Biol Chem 275:31733–31738. doi: 10.1074/jbc.M910231199
Yuan BZ, Chapman JA, Reynolds SH (2008) Proteasome inhibitor MG132 induces apoptosis and inhibits invasion of human malignant pleural mesothelioma cells. Transl Oncol 1:129–140
Meylan E, Tschopp J, Karin M (2006) Intracellular pattern recognition receptors in the host response. Nature 442:39–44. doi: 10.1038/nature04946
Seong SY, Matzinger P (2004) Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat Rev Immunol 4:469–478. doi: 10.1038/nri1372
Korbelik M, Zhang W, Merchant S (2011) Involvement of damage-associated molecular patterns in tumor response to photodynamic therapy: surface expression of calreticulin and high-mobility group box-1 release. Cancer Immunol Immunother 60:1431–1437. doi: 10.1007/s00262-011-1047-x
Basu S, Binder RJ, Ramalingam T, Srivastava PK (2001) CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity 14:303–313
Iezzi G, Sonderegger I, Ampenberger F, Schmitz N, Marsland BJ, Kopf M (2009) CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells. Proc Natl Acad Sci USA 106:876–881. doi: 10.1073/pnas.0810769106
Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT (2009) Late developmental plasticity in the T helper 17 lineage. Immunity 30:92–107. doi: 10.1016/j.immuni.2008.11.005