Shati/Nat8l knockout mice show behavioral deficits ameliorated by atomoxetine and methylphenidate

Polanczyk, 2007, The worldwide prevalence of ADHD: a systematic review and metaregression analysis, Am. J. Psychiatry, 164, 942, 10.1176/ajp.2007.164.6.942 Willcutt, 2012, The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review, Neurotherapeutics, 9, 490, 10.1007/s13311-012-0135-8 Castellanos, 2002, Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes, Nat. Rev. Neurosci., 3, 617, 10.1038/nrn896 Gallo, 2016, Moving towards causality in attention-deficit hyperactivity disorder: overview of neural and genetic mechanisms, Lancet Psychiatry, 3, 555, 10.1016/S2215-0366(16)00096-1 Spencer, 2007, Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology, J. Pediatr. Psychol., 32, 631, 10.1093/jpepsy/jsm005 Biederman, 2006, Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study, Psychol. Med., 36, 167, 10.1017/S0033291705006410 Molina, 2005, N-acetyl-aspartate levels in the dorsolateral prefrontal cortex in the early years of schizophrenia are inversely related to disease duration, Schizophr. Res., 73, 209, 10.1016/j.schres.2004.02.001 Geschwind, 2015, Genetics and genomics of psychiatric disease, Science, 349, 1489, 10.1126/science.aaa8954 Swanson, 2000, Dopamine genes and ADHD, Neurosci. Biobehav. Rev., 24, 21, 10.1016/S0149-7634(99)00062-7 Swanson, 1998, Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): a family-based approach, Mol. Psychiatry, 3, 38, 10.1038/sj.mp.4000354 Volkow, 2007, Brain dopamine transporter levels in treatment and drug naïve adults with ADHD, Neuroimage, 34, 1182, 10.1016/j.neuroimage.2006.10.014 Volkow, 2007, Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder, Arch. Gen. Psychiatry, 64, 932, 10.1001/archpsyc.64.8.932 Volkow, 2009, Evaluating dopamine reward pathway in ADHD, JAMA, 302, 1084, 10.1001/jama.2009.1308 Spielewoy, 2000, Behavioural disturbances associated with hyperdopaminergia in dopamine-transporter knockout mice, Behav. Pharmacol., 11, 279, 10.1097/00008877-200006000-00011 Yamashita, 2013, Impaired cliff avoidance reaction in dopamine transporter knockout mice, Psychopharmacology, 227, 741, 10.1007/s00213-013-3009-9 Shen, 2004, Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters, Neuropsychopharmacology, 29, 1790, 10.1038/sj.npp.1300476 Niwa, 2007, A novel molecule shati is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference, J. Neurosci., 27, 7604, 10.1523/JNEUROSCI.1575-07.2007 Niwa, 2008, A novel molecule shati increases dopamine uptake via the induction of tumor necrosis factor-α in pheochromocytoma-12 cells, J. Neurochem., 107, 1697, 10.1111/j.1471-4159.2008.05738.x Furukawa-Hibi, 2012, Absence of SHATI/Nat8 l reduces social interaction in mice, Neurosci. Lett., 526, 79, 10.1016/j.neulet.2012.08.028 Toriumi, 2015, Deletion of SHATI/NAT8L decreases the N-acetylaspartate content in the brain and induces behavioral deficits, which can be ameliorated by administering N-acetylaspartate, Eur. Neuropsychopharmacol., 25, 2108, 10.1016/j.euroneuro.2015.08.003 Toriumi, 2014, Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence, Int. J. Neuropsychopharmacol., 17, 443, 10.1017/S1461145713001302 Toriumi, 2016, Prenatal phencyclidine treatment induces behavioral deficits through impairment of GABAergic interneurons in the prefrontal cortex, Psychopharmacology, 233, 1, 10.1007/s00213-016-4288-8 Mouri, 2014, Thyrotoropin receptor knockout changes monoaminergic neuronal system and produces methylphenidate-sensitive emotional and cognitive dysfunction, Psychoneuroendocrinology, 48, 147, 10.1016/j.psyneuen.2014.05.021 Matsuoka, 2005, Prostaglandin E receptor EP1 controls impulsive behavior under stress, Proc. Natl. Acad. Sci., 102, 16066, 10.1073/pnas.0504908102 Alkam, 2011, Evaluation of object-based attention in mice, Behav. Brain Res., 220, 185, 10.1016/j.bbr.2011.01.039 Alkam, 2013, Evaluation of cognitive behaviors in young offspring of C57BL/6J mice after gestational nicotine exposure during different time-windows, Psychopharmacology, 230, 451, 10.1007/s00213-013-3175-9 Bari, 2008, The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats, Nat. Protoc., 3, 759, 10.1038/nprot.2008.41 Bymaster, 2002, Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder, Neuropsychopharmacology, 27, 699, 10.1016/S0893-133X(02)00346-9 Carboni, 1990, Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals, J. Neurochem., 55, 1067, 10.1111/j.1471-4159.1990.tb04599.x Izenwasser, 1990, Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex, Brain Res., 520, 303, 10.1016/0006-8993(90)91719-W Elsworth, 1993, Cocaine-sensitive and −insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum, Neurochem. Int., 23, 61, 10.1016/0197-0186(93)90144-T Pozzi, 1994, Evidence that extracellular concentrations of dopamine are regulated by noradrenergic neurons in the frontal cortex of rats, J. Neurochem., 63, 195, 10.1046/j.1471-4159.1994.63010195.x Sesack, 1998, Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter, J. Neurosci., 18, 2697, 10.1523/JNEUROSCI.18-07-02697.1998 Morón, 2002, Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines, J. Neurosci., 22, 389, 10.1523/JNEUROSCI.22-02-00389.2002 Tassin, 1978, Relationship between the locomotor hyperactivity induced by A10 lesions and the destruction of the fronto-cortical dopaminergic innervation in the rat, Brain Res., 141, 267, 10.1016/0006-8993(78)90197-X Ernst, 1998, DOPA decarboxylase activity in attention deficit hyperactivity disorder adults. A [fluorine-18]fluorodopa positron emission tomographic study, J. Neurosci., 18, 5901, 10.1523/JNEUROSCI.18-15-05901.1998 Cortese, 2012, Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies, Am. J. Psychiatry, 169, 1038, 10.1176/appi.ajp.2012.11101521 Moreno, 2013, Divergent effects of D₂/₃ receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats, Psychopharmacology (Berl), 228, 19, 10.1007/s00213-013-3010-3 Robbins, 2002, The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry, Psychopharmacology, 163, 362, 10.1007/s00213-002-1154-7 Muir, 1996, The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task, Cereb. Cortex, 6, 470, 10.1093/cercor/6.3.470 Passetti, 2002, The frontal cortex of the rat and visual attentional performance: dissociable functions of distinct medial prefrontal subregions, Cereb. Cortex, 12, 1254, 10.1093/cercor/12.12.1254 Robbins, 1998, Neural systems underlying arousal and attention: implications for drug abuse, Ann. N. Y. Acad. Sci., 846, 222, 10.1111/j.1749-6632.1998.tb09740.x Granon, 2000, Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex, J. Neurosci., 20, 1208, 10.1523/JNEUROSCI.20-03-01208.2000 Chudasama, 2004, Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortex, Neuropsychopharmacology, 29, 1628, 10.1038/sj.npp.1300490 Toriumi, 2013, SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization, J. Neurosci. Res., 91, 1525, 10.1002/jnr.23273 Purper-Ouakil, 2010, Temperament and character dimensions associated with clinical characteristics and treatment outcome in attention-deficit/hyperactivity disorder boys, Compr. Psychiatry, 51, 286, 10.1016/j.comppsych.2009.08.004 Melegari, 2015, Temperamental and character profiles of preschool children with ODD, ADHD, and anxiety disorders, Compr. Psychiatry, 58, 94, 10.1016/j.comppsych.2015.01.001