Sexual factors and prostate cancer

BJU International - Tập 92 Số 3 - Trang 211-216 - 2003
Graham G. Giles1, Gianluca Severi2, Dallas R. English1, Margaret McCredie3, Ron Borland4, Peter Boyle2, John L. Hopper5
1Cancer Epidemiology Centre, and
2Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
3Department of Preventive & Social Medicine, Dunedin Medical School, University of Otago, Dunedin, New Zealand, and
4Centre for Behavioural Research in Cancer, The Cancer Council Victoria, Melbourne, Australia,
5Centre for Genetic Epidemiology, University of Melbourne, Melbourne, Australia

Tóm tắt

OBJECTIVETo assess whether prostate cancer might be related to hormone levels and, by inference, to differences in sexual activity.PATIENTS, SUBJECTS AND METHODSIn a case‐control study of men with prostate cancer aged < 70 years at diagnosis and age‐matched control subjects, information was collected on two aspects of sexual activity; the number of sexual partners and the frequency of total ejaculations during the third to fifth decades of life.RESULTSThere was no association of prostate cancer with the number of sexual partners or with the maximum number of ejaculations in 24 h. There was a negative trend (P < 0.01) for the association between risk and number of ejaculations in the third decade, independent of those in the fourth or fifth. Men who averaged five or more ejaculations weekly in their 20s had an odds ratio (95% confidence interval) of 0.66 (0.49–0.87) compared with those who ejaculated less often.CONCLUSIONSThe null association with the number of sexual partners argues against infection as a cause of prostate cancer in this population. Ejaculatory frequency, especially in early adult life, is negatively associated with the risk of prostate cancer, and thus the molecular biological consequences of suppressed or diminished ejaculation are worthy of further research.

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BJU International

Tập 92 Số 3

211-216

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