Sexual distress and quality of life among women with bipolar disorder
Tóm tắt
Information on the association between bipolar disorder (BD), sexual satisfaction, sexual function, sexual distress and quality of life (QoL) is sparse. This study aims, in women with BD, to (i) investigate sexual dysfunction, sexual distress, general sexual satisfaction and QoL; (ii) explore whether sexual distress was related to affective symptoms and (iii) investigate whether QoL was associated with sexual distress. The study is a questionnaire survey in an outpatient cohort of women with BD using: Changes in Sexual Functioning Questionnaire, Female Sexual Distress Scale, Altman Self-Rating Mania Scale (ASRM), Major Depression Inventory (MDI) and The World Health Organisation Quality of Life-Brief. In total, 61 women (age range 19–63, mean 33.7 years) were recruited. Overall, 54% reported sexual distress (n = 33) and 39% were not satisfied with their sexual life (n = 24). Women with BD were significantly more sexually distressed in comparison with Danish women from the background population but they did not have a higher prevalence of impaired sexual function. Better sexual function was positively associated with ASRM scores while MDI scores were associated with more distress. Finally, the group of non-sexually distressed women with BD reported higher QoL scores compared with the sexually distressed group. Women with BD exhibited a high prevalence of sexual distress and their sexual function seemed associated with their actual mood symptoms and perception of QoL.
Tài liệu tham khảo
Altman EG, Hedeker D, Peterson JL, Davis JM. The Altman Self-Rating Mania Scale. Biol Psychiatry. 1997;42(10):948–55.
Basson R, Berman J, Burnett A, Derogatis L, Ferguson D, Fourcroy J, et al. Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol. 2000;163(3):888–93.
Basson R, Leiblum S, Brotto L, Derogatis L, Fourcroy J, Fugl-Meyer K, et al. Revised definitions of women’s sexual dysfunction. J Sex Med. 2004;1(1):40–8.
Basson R, Wierman ME, van Lankveld J, Brotto L. Summary of the recommendations on sexual dysfunctions in women. J Sex Med. 2010;7:314–26.
Bech P, Rasmussen NA, Olsen LR, Noerholm V, Abildgaard W. The sensitivity and specificity of the major depression inventory, using the Present State Examination as the index of diagnostic validity. J Affect Disord. 2001;66(2–3):159–64.
Bergh SJ, Giraldi A. Sexual dysfunction associated with antidepressant agents. Ugeskr Laeger. 2014;26:176.
Brotto LA, Petkau AJ, Labrie F, Basson R. Predictors of sexual desire disorders in women. J Sex Med. 2011;8(3):742–53.
Christensen BS, Grønbaek M, Osler M, Pedersen BV, Graugaard C, Frisch M. Sexual dysfunctions and difficulties in Denmark: prevalence and associated sociodemographic factors. Arch Sex Behav. 2011a;40(1):121–32.
Christensen BS, Grønbaek M, Osler M, Pedersen BV, Graugaard C, Frisch M. Associations between physical and mental health problems and sexual dysfunctions in sexually active Danes. J Sex Med. 2011b;8(7):1890–902.
Christensen BS, Grønbaek M, Pedersen BV, Graugaard C, Frisch M. Associations of unhealthy lifestyle factors with sexual inactivity and sexual dysfunctions in Denmark. J Sex Med. 2011c;8(7):1903–16.
Clayton AH, El Haddad S, Iluonakhamhe J-P, Ponce Martinez C, Schuck AE. Sexual dysfunction associated with major depressive disorder and antidepressant treatment. Expert Opin Drug Saf. 2014;13(10):1361–74.
de Boer MK, Castelein S, Wiersma D, Schoevers RA, Knegtering H. A systematic review of instruments to measure sexual functioning in patients using antipsychotics. J Sex Res. 2014;51(4):383–9.
Dell’Osso L, Carmassi C, Carlini M, Rucci P, Torri P, Cesari D, et al. Sexual dysfunctions and suicidality in patients with bipolar disorder and unipolar depression. J Sex Med. 2009;6(11):3063–70.
Derogatis LR, Rosen R, Leiblum S, Burnett A, Heiman J. The Female Sexual Distress Scale (FSDS): initial validation of a standardised scale for assessment of sexually related personal distress in women. J Sex Marital Ther. 2002;28(4):317–30.
Eplov L, Giraldi A, Davidsen M, Garde K, Kamper-Jørgensen F. Sexual desire in a nationally representative Danish population. J Sex Med. 2007;4(1):47–56.
Ghadirian AM, Annable L, Bélanger MC. Lithium, benzodiazepines, and sexual function in bipolar patients. Am J Psychiatry. 1992;149(6):801–5.
Giraldi A, Kristensen E, Sand M. Endorsement of models describing sexual response of men and women with a sexual partner: an online survey in a population sample of Danish adults ages 20–65 years. J Sex Med. 2015;12(1):116–28.
Giraldi A, Rellini A, Pfaus JG, Bitzer J, Laan E, Jannini EA, et al. Questionnaires for assessment of female sexual dysfunction: a review and proposal for a standardised screener. J Sex Med. 2011;8(10):2681–706.
Graugaard C, Giraldi A, Frisch M, Falgaard Eplov L, Davidsen M. Self-reported sexual and psychosocial health among non-heterosexual Danes. Scand J Public Health. 2015;43(3):309–14.
Grover S, Ghosh A, Sarkar S, Chakrabarti S, Avasthi A. Sexual dysfunction in clinically stable patients with bipolar disorder receiving lithium. J Clin Psychopharmacol. 2014;34(4):475–82.
Hayes RD. Assessing female sexual dysfunction in epidemiological studies: why is it necessary to measure both low sexual function and sexually-related distress? Sex Health. 2008;5(3):215–8.
Hayes RD, Bennett CM, Fairley CK, Dennerstein L. What can prevalence studies tell us about female sexual difficulty and dysfunction? J Sex Med. 2006;3(4):589–95.
Hayes RD, Dennerstein L, Bennett CM, Sidat M, Gurrin LC, Fairley CK. Risk factors for female sexual dysfunction in the general population: exploring factors associated with low sexual function and sexual distress. J Sex Med. 2008;5(7):1681–93.
Keller A, McGarvey EL, Clayton AH. Reliability and construct validity of the Changes in Sexual Functioning Questionnaire short-form (CSFQ-14). J Sex Marital Ther. 2006;32(1):43–52.
Kopeykina I, Kim HJ, Khatun T, Boland J, Haeri S, Cohen LJ, Galynker II. Hypersexuality and couple relationships in bipolar disorder: a review. J Affect Disord. 2016;195:1–14.
McCabe MP, Sharplip ID, Atella E, Balon R, Fisher AD, Laumann EL, et al. Definitions of sexual dysfunctions in women and men: a consensus statement from the fourth international consultation on sexual medicine 2015. J Sex Med. 2016;13:135–43.
Noerholm V, Groenvold M, Watt T, Bjorner JB, Rasmussen NA, Bech P. Quality of life in the Danish general population—normative data and validity of WHOQOL-BREF using Rasch and item response theory models. Qual Life Res Int J Qual Life Asp Treat Care Rehabil. 2004;13(2):531–40.
Nørholm V. Measuring the quality of life of mentally-ill patients: is it possible to compare with quality of life of healthy population? Ugeskr Laeger. 2008;170(10):862–4.
Nørholm V, Bech P. The WHO Quality of Life (WHOQOL) Questionnaire: Danish validation study. Nord J Psychiatry. 2001;55(4):229–35.
Olsen LR, Jensen DV, Noerholm V, Martiny K, Bech P. The internal and external validity of the major depression inventory in measuring severity of depressive states. Psychol Med. 2003;33(2):351–6.
Ornat L, Martínez-Dearth R, Muñoz A, Franco P, Alonso B, Tajada M, et al. Sexual function, satisfaction with life and menopausal symptoms in middle-aged women. Maturitas. 2013;75(3):261–9.
Sanders SA, Graham CA, Milhausen RR. Predicting impaired sexual functions in women: the relevance of sexual excitation and sexual inhibition. Arch Sex Behav. 2011;37(2):241–51.
Serretti A, Chiesa A. Sexual side effects of pharmacological treatment of psychiatric diseases. Clin Pharmacol Ther. 2011a;89(1):142–7.
Serretti A, Chiesa A. A meta-analysis of sexual dysfunction in psychiatric patients taking antipsychotics. Int Clin Psychopharmacol. 2011b;26(3):130–40.
Vanwesenbeeck I, Have MT, de Graaf R. Associations between common mental disorders and sexual dissatisfaction in the general population. Br J Psychiatry. 2014;205(2):151–7.
Yatham LN, Lecrubier Y, Fieve RR, Davis KH, Harris SD, Krishnan AA. Quality of life in patients with bipolar I depression: data from 920 patients. Bipolar Disord. 2004;6(5):379–85.
Zemishlany Z, Weizman A. The impact of mental illness on sexual dysfunction. Adv Psychosom Med. 2008;29:89–106.
WHOQOL Group. Development of the World Health Organisation WHOQOL-BREF quality of life assessment. Psychol Med. 1998;28:551–8.