Sexual Dysfunction in Men and Women with Diabetes: A Reflection of their Complications?
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Global Report on Diabetes 2016
Filardi T.; Ghinassi B.; Di Baldassarre A.; Tanzilli G.; Morano S.; Lenzi A.; Basili S.; Crescioli C.; Cardiomyopathy associated with diabetes: the central role of the cardiomyocyte. Int J Mol Sci 2019,20(13),E3299
Kouidrat Y.; Pizzol D.; Cosco T.; Thompson T.; Carnaghi M.; Bertoldo A.; Solmi M.; Stubbs B.; Veronese N.; High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies. Diabet Med 2017,34(9),1185-1192
Pontiroli A.E.; Cortelazzi D.; Morabito A.; Female sexual dysfunction and diabetes: a systematic review and meta-analysis. J Sex Med 2013,10(4),1044-1051
Cho N.H.; Shaw J.E.; Karuranga S.; Huang Y.; da Rocha Fernandes J.D.; Ohlrogge A.W.; Malanda B.; IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 2018,138,271-281
Montorsi P.; Ravagnani P.M.; Galli S.; Rotatori F.; Briganti A.; Salonia A.; Rigatti P.; Montorsi F.; The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease. Am J Cardiol 2005,96(12B),19M-23M
Meller S.M.; Stilp E.; Walker C.N.; Mena-Hurtado C.; The link between vasculogenic erectile dysfunction, coronary artery disease, and peripheral artery disease: role of metabolic factors and endovascular therapy. J Invasive Cardiol 2013,25(6),313-319
Sims E.A.; Danforth E.; Horton E.S.; Bray G.A.; Glennon J.A.; Salans L.B.; Endocrine and metabolic effects of experimental obesity in man. Recent Prog Horm Res 1973,29,457-496
Kahn S.E.; Hull R.L.; Utzschneider K.M.; Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006,444(7121),840-846
Corona G.; Rastrelli G.; Monami M.; Saad F.; Luconi M.; Lucchese M.; Facchiano E.; Sforza A.; Forti G.; Mannucci E.; Maggi M.; Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. Eur J Endocrinol 2013,168(6),829-843
Allen M.S.; Walter E.E.; Health-related lifestyle factors and sexual dysfunction: a meta-analysis of population-based research. J Sex Med 2018,15(4),458-475
Corona G.; Isidori A.M.; Aversa A.; Burnett A.L.; Maggi M.; Endocrinologic control of men’s sexual desire and arousal/erection. J Sex Med 2016,13(3),317-337
Sansone A.; Romanelli F.; Gianfrilli D.; Lenzi A.; Endocrine evaluation of erectile dysfunction. Endocrine 2014,46(3),423-430
Corona G.; Goulis D.G.; Huhtaniemi I.; Zitzmann M.; Toppari J.; Forti G.; Vanderschueren D.; Wu F.C.; European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology. Andrology 2020,8(5),970-987
Grossmann M.; Hypogonadism and male obesity: Focus on unresolved questions. Clin Endocrinol 2018,89(1),11-21
Haider K.S.; Haider A.; Saad F.; Doros G.; Hanefeld M.; Dhindsa S.; Dandona P.; Traish A.; Remission of type 2 diabetes following long-term treatment with injectable testosterone undecanoate in patients with hypogonadism and type 2 diabetes: 11-year data from a real-world registry study. Diabetes Obes Metab 2020,22(11),2055-2068
Miner M.; Esposito K.; Guay A.; Montorsi P.; Goldstein I.; Cardiometabolic risk and female sexual health: the Princeton III summary. J Sex Med 2012,9(3),641-651
Carosa E.; Sansone A.; Jannini E.A.; Management of endocrine disease: Female sexual dysfunction for the endocrinologist. Eur J Endocrinol 2020,182(6),R101
Rahmanian E.; Salari N.; Mohammadi M.; Jalali R.; Evaluation of sexual dysfunction and female sexual dysfunction indicators in women with type 2 diabetes: a systematic review and meta-analysis. Diabetol Metab Syndr 2019,11,73
Giraldi A.; Kristensen E.; Sexual dysfunction in women with diabetes mellitus. J Sex Res 2010,47(2),199-211
Traish A.M.; Botchevar E.; Kim N.N.; Biochemical factors modulating female genital sexual arousal physiology. J Sex Med 2010,7(9),2925-2946
Maseroli E.; Fanni E.; Cipriani S.; Scavello I.; Pampaloni F.; Battaglia C.; Fambrini M.; Mannucci E.; Jannini E.A.; Maggi M.; Vignozzi L.; Cardiometabolic risk and female sexuality: focus on clitoral vascular resistance. J Sex Med 2016,13(11),1651-1661
Coppola A.; Gallotti P.; Choussos D.; Pujia A.; Montalcini T.; Gazzaruso C.; Association between clitoral tissue perfusion and female sexual dysfunction in healthy women of reproductive age: a pilot study. Int J Impot Res 2020,32(2),221-225
Mollaioli D.; Ciocca G.; Limoncin E.; Di Sante S.; Gravina G.L.; Carosa E.; Lenzi A.; Jannini E.A.F.; Lifestyles and sexuality in men and women: the gender perspective in sexual medicine. Reprod Biol Endocrinol 2020,18(1),10
Kolotkin R.L.; Crosby R.D.; Gress R.E.; Hunt S.C.; Engel S.G.; Adams T.D.; Health and health-related quality of life: differences between men and women who seek gastric bypass surgery. Surg Obes Relat Dis 2008,4(5),651-658
Kolotkin R.L.; Binks M.; Crosby R.D.; Østbye T.; Gress R.E.; Adams T.D.; Obesity and sexual quality of life. Obesity 2006,14(3),472-479
Guay A.T.; ED2: erectile dysfunction = endothelial dysfunction. Endocrinol Metab Clin North Am 2007,36(2),453-463
Corona G.; Forti G.; Maggi M.; Why can patients with erectile dysfunction be considered lucky? The association with testosterone deficiency and metabolic syndrome. Aging Male 2008,11(4),193-199
Jannini E.A.S.M.; SM = SM: The interface of systems medicine and sexual medicine for facing non-communicable diseases in a gender-dependent manner. Sex Med Rev 2017,5(3),349-364
Romanelli F.; Sansone A.; Lenzi A.; Erectile dysfunction in aging male. Acta Biomed 2010,81(Suppl. 1),89-94
Isidori A.M.; Buvat J.; Corona G.; Goldstein I.; Jannini E.A.; Lenzi A.; Porst H.; Salonia A.; Traish A.M.; Maggi M.; A critical analysis of the role of testosterone in erectile function: from pathophysiology to treatment-a systematic review. Eur Urol 2014,65(1),99-112
Corona G.; Sansone A.; Pallotti F.; Ferlin A.; Pivonello R.; Isidori A.M.; Maggi M.; Jannini E.A.; People smoke for nicotine, but lose sexual and reproductive health for tar: a narrative review on the effect of cigarette smoking on male sexuality and reproduction. J Endocrinol Invest 2020,43(10),1391-1408
Esposito K.; Giugliano D.; The metabolic syndrome and inflammation: association or causation? Nutr Metab Cardiovasc Dis 2004,14(5),228-232
Maiorino M.I.; Bellastella G.; Giugliano D.; Esposito K.; From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome. J Endocrinol Invest 2018,41(11),1249-1258
Mohamad N.V.; Wong S.K.; Wan Hasan W.N.; Jolly J.J.; Nur-Farhana M.F.; Ima-Nirwana S.; Chin K.Y.; The relationship between circulating testosterone and inflammatory cytokines in men. Aging Male 2019,22(2),129-140
Sansone A.; Mollaioli D.; Ciocca G.; Addressing male sexual and reproductive health in the wake of COVID-19 outbreak. J Endocrinol Invest Published online 2020 Jul 13.2021,44(2),223-231
Fedele D.; Coscelli C.; Santeusanio F.; Bortolotti A.; Chatenoud L.; Colli E.; Landoni M.; Parazzini F.; Erectile dysfunction in diabetic subjects in Italy. Gruppo Italiano Studio Deficit Erettile nei Diabetici. Diabetes Care 1998,21(11),1973-1977
Boeri L.; Capogrosso P.; Pederzoli F.; Ventimiglia E.; Frego N.; Chierigo F.; Montanari E.; Montorsi F.; Salonia A.; Unrecognized prediabetes is highly prevalent in men with erectile dysfunction-results from a cross-sectional study. J Sex Med 2018,15(8),1117-1124
Lue T.F.; Brant W.O.; Shindel A.; Bella A.J.; Endotext South Dartmouth (MA): MDTextcom, Inc 2017
Same R.V.; Miner M.M.; Blaha M.J.; Feldman D.I.; Billups K.L.; Erectile dysfunction: an early sign of cardiovascular disease. Curr Cardiovasc Risk Rep 2015,9,49
Morano S.; Gatti A.; Mandosi E.; Tiberti C.; Fallarino M.; Cipriani R.; Buchetti B.; Gandini L.; Sgrò P.; Jannini E.A.; Lenti L.; Lenzi A.; Circulating monocyte oxidative activity is increased in patients with type 2 diabetes and erectile dysfunction. J Urol 2007,177(2),655-659
Morano S.; Mandosi E.; Fallarino M.; Gatti A.; Tiberti C.; Sensi M.; Gandini L.; Buchetti B.; Lenti L.; Jannini E.A.; Lenzi A.; Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. Eur Urol 2007,52(6),1768-1774
Adeva-Andany M.M.; Funcasta-Calderón R.; Fernández-Fernández C.; Ameneiros-Rodríguez E.; Domínguez-Montero A.; Subclinical vascular disease in patients with diabetes is associated with insulin resistance. Diabetes Metab Syndr 2019,13(3),2198-2206
Raggi P.; Screening for atherosclerotic cardiovascular disease in patients with type 2 diabetes mellitus: controversies and guidelines. Can J Diabetes 2020,44(1),86-92
Corona G.; Jannini E.A.; Maggi M.; Inventories for male and female sexual dysfunctions. Int J Impot Res 2006,18(3),236-250
Maseroli E.; Scavello I.; Vignozzi L.; Cardiometabolic risk and female sexuality-part i. risk factors and potential pathophysiological underpinnings for female vasculogenic sexual dysfunction syndromes. Sex Med Rev 2018,6(4),508-524
Maseroli E.; Scavello I.; Vignozzi L.; Cardiometabolic risk and female sexuality-part II. understanding (and overcoming) gender differences: the key role of an adequate methodological approach. Sex Med Rev 2018,6(4),525-534
Sansone A.; Aversa A.; Corona G.; Fisher A.D.; Isidori A.M.; La Vignera S.; Limoncin E.; Maggi M.; Merico M.; Jannini E.A.; Management of premature ejaculation: a clinical guideline from the Italian Society of Andrology and Sexual Medicine (SIAMS). J Endocrinol Invest Epub 2020 Oct 30.2021 May,44(5),1103-1118
Jannini E.A.; Lombardo F.; Lenzi A.; Correlation between ejaculatory and erectile dysfunction. Int J Androl 2005,28(Suppl. 2),40-45
El-Sakka A.I.; Premature ejaculation in non-insulin-dependent diabetic patients. Int J Androl 2003,26(6),329-334
Corona G.; Giorda C.B.; Cucinotta D.; Guida P.; Nada E.; The SUBITO-DE study: sexual dysfunction in newly diagnosed type 2 diabetes male patients. J Endocrinol Invest SUBITO-DE study group2013,36(10),864-868
Bellastella G.; Maiorino M.I.; Olita L.; Della Volpe E.; Giugliano D.; Esposito K.; Premature ejaculation is associated with glycemic control in Type 1 diabetes. J Sex Med 2015,12(1),93-99
Corona G.; Giorda C.B.; Cucinotta D.; Guida P.; Nada E.; Sexual dysfunction at the onset of type 2 diabetes: the interplay of depression, hormonal and cardiovascular factors. J Sex Med Gruppo di studio SUBITO-DE2014,11(8),2065-2073
Maiorino M.I.; Bellastella G.; Della Volpe E.; Casciano O.; Scappaticcio L.; Cirillo P.; Giugliano D.; Esposito K.; Erectile dysfunction in young men with type 1 diabetes. Int J Impot Res 2017,29(1),17-22
Goldstein I.; Chambers R.; Tang W.; Stecher V.; Hassan T.; Realworld observational results from a database of 48 million men in the United States: Relationship of cardiovascular disease, diabetes mellitus and depression with age and erectile dysfunction. Int J Clin Pract 2018,72(4),e13078
Albasheer O.B.; Mahfouz M.S.; Solan Y.; Khan D.A.; Muqri M.A.; Almutairi H.A.; Alelyani A.M.; Alahmed H.A.; Depression and related risk factors among patients with type 2 diabetes mellitus, Jazan area, KSA: A cross-sectional study. Diabetes Metab Syndr 2018,12(2),117-121
Avasthi A.; Grover S.; Bhansali A.; Dash R.J.; Gupta N.; Sharan P.; Sharma S.; Erectile dysfunction in diabetes mellitus contributes to poor quality of life. Int Rev Psychiatry 2011,23(1),93-99
De Berardis G.; Franciosi M.; Belfiglio M.; Di Nardo B.; Greenfield S.; Kaplan S.H.; Pellegrini F.; Sacco M.; Tognoni G.; Valentini M.; Nicolucci A.; Erectile dysfunction and quality of life in type 2 diabetic patients: a serious problem too often overlooked. Diabetes Care Quality of Care and Outcomes in Type 2 Diabetes (QuED) Study Group2002,25(2),284-291
Ciocca G.; Carosa E.; Stornelli M.; Limoncin E.; Gravina G.L.; Iannarelli R.; Sperandio A.; Di Sante S.; Lenzi A.; Lauro D.; Jannini E.A.; Post-traumatic stress disorder, coping strategies and type 2 diabetes: psychometric assessment after L’Aquila earthquake. Acta Diabetol 2015,52(3),513-521
Franciosi M.; Pellegrini F.; De Berardis G.; Belfiglio M.; Cavaliere D.; Di Nardo B.; Greenfield S.; Kaplan S.H.; Sacco M.; Tognoni G.; Valentini M.; Nicolucci A.; The impact of blood glucose self-monitoring on metabolic control and quality of life in type 2 diabetic patients: an urgent need for better educational strategies. Diabetes Care QuED Study Group2001,24(11),1870-1877
Enzlin P.; Mathieu C.; Van Den Bruel A.; Vanderschueren D.; Demyttenaere K.; Prevalence and predictors of sexual dysfunction in patients with type 1 diabetes. Diabetes Care 2003,26(2),409-414
Bultrini A.; Carosa E.; Colpi E.M.; Poccia G.; Iannarelli R.; Lembo D.; Lenzi A.; Jannini E.A.; Possible correlation between type 1 diabetes mellitus and female sexual dysfunction: case report and literature review. J Sex Med 2004,1(3),337-340
Maiorino M.I.; Bellastella G.; Castaldo F.; Petrizzo M.; Giugliano D.; Esposito K.; Sexual function in young women with type 1 diabetes: the METRO study. J Endocrinol Invest 2017,40(2),169-177
Yenice M.G.; Danacıoğlu Y.O.; Mert M.; Karakaya P.; Seker K.G.; Akkaş F.; Şimşek A.; Şahin S.; Taşçı A.I.; Evaluation of factors affecting sexual dysfunction in female patients with diabetes mellitus. Arch Endocrinol Metab 2020,64(3),319-325
Nowosielski K.; Skrzypulec-Plinta V.; Mediators of sexual functions in women with diabetes. J Sex Med 2011,8(9),2532-2545
Bąk E.; Marcisz C.; Krzemińska S.; Dobrzyn-Matusiak D.; Foltyn A.; Drosdzol-Cop A.; Relationships of sexual dysfunction with depression and acceptance of illness in women and men with type 2 diabetes mellitus. Int J Environ Res Public Health [Internet].2017,14(9),E1073
Sansone A.; Sansone M.; Lenzi A.; Romanelli F.; Testosterone replacement therapy: the emperor’s new clothes. Rejuvenation Res 2017,20(1),9-14
Corona G.; Rastrelli G.; Reisman Y.; Sforza A.; Maggi M.; The safety of available treatments of male hypogonadism in organic and functional hypogonadism. Expert Opin Drug Saf 2018,17(3),277-292
Dolci S.; Belmonte A.; Santone R.; Giorgi M.; Pellegrini M.; Carosa E.; Piccione E.; Lenzi A.; Jannini E.A.; Subcellular localization and regulation of type-1C and type-5 phosphodiesterases. Biochem Biophys Res Commun 2006,341(3),837-846
Prasad S.; Wilkinson J.; Gatzoulis M.A.; Sildenafil in primary pulmonary hypertension. N Engl J Med 2000,343(18),1342
Yang H-M.; Jin S.; Jang H.; Kim J-Y.; Lee J-E.; Kim J.; Kim H.S.; Sildenafil reduces neointimal hyperplasia after angioplasty and inhibits platelet aggregation via activation of cgmp-dependent protein kinase. Sci Rep 2019,9(1),7769
Giannattasio S.; Corinaldesi C.; Colletti M.; Di Luigi L.; Antinozzi C.; Filardi T.; Scolletta S.; Basili S.; Lenzi A.; Morano S.; Crescioli C.; The phosphodiesterase 5 inhibitor sildenafil decreases the proinflammatory chemokine IL-8 in diabetic cardiomyopathy: in vivo and in vitro evidence. J Endocrinol Invest 2019,42(6),715-725
Anderson S.G.; Hutchings D.C.; Woodward M.; Rahimi K.; Rutter M.K.; Kirby M.; Hackett G.; Trafford A.W.; Heald A.H.; Phosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality. Heart 2016,102(21),1750-1756
Saisho Y.; Metformin and inflammation: its potential beyond glucose-lowering effect. Endocr Metab Immune Disord Drug Targets 2015,15(3),196-205
Pastor-Villaescusa B.; Cañete M.D.; Caballero-Villarraso J.; Hoyos R.; Latorre M.; Vázquez-Cobela R.; Plaza-Díaz J.; Maldonado J.; Bueno G.; Leis R.; Gil Á.; Cañete R.; Aguilera C.M.; Metformin for obesity in prepubertal and pubertal children: a randomized controlled trial. Pediatrics 2017,140(1),e20164285
Jing Y.; Wu F.; Li D.; Yang L.; Li Q.; Li R.; Metformin improves obesity-associated inflammation by altering macrophages polarization. Mol Cell Endocrinol 2018,461,256-264
Goldberg R.B.; Aroda V.R.; Bluemke D.A.; Barrett-Connor E.; Budoff M.; Crandall J.P.; Dabelea D.; Horton E.S.; Mather K.J.; Orchard T.J.; Schade D.; Watson K.; Temprosa M.; Effect of long-term metformin and lifestyle in the diabetes prevention program and its outcome study on coronary artery calcium. Circulation Diabetes prevention program research group2017,136(1),52-64
Giagulli V.A.; Carbone M.D.; Ramunni M.I.; Licchelli B.; De Pergola G.; Sabbà C.; Guastamacchia E.; Triggiani V.; Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism. Andrology 2015,3(6),1094-1103
Matsubara J.; Sugiyama S.; Sugamura K.; Nakamura T.; Fujiwara Y.; Akiyama E.; Kurokawa H.; Nozaki T.; Ohba K.; Konishi M.; Maeda H.; Izumiya Y.; Kaikita K.; Sumida H.; Jinnouchi H.; Matsui K.; Kim-Mitsuyama S.; Takeya M.; Ogawa H.; A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. J Am Coll Cardiol 2012,59(3),265-276
Assaly R.; Gorny D.; Compagnie S.; Mayoux E.; Bernabe J.; Alexandre L.; Giuliano F.; Behr-Roussel D.; The favorable effect of empagliflozin on erectile function in an experimental model of type 2 diabetes. J Sex Med 2018,15(9),1224-1234
Corona G.; Fagioli G.; Mannucci E.; Romeo A.; Rossi M.; Lotti F.; Sforza A.; Morittu S.; Chiarini V.; Casella G.; Di Pasquale G.; Bandini E.; Forti G.; Maggi M.; Penile doppler ultrasound in patients with erectile dysfunction (ED): role of peak systolic velocity measured in the flaccid state in predicting arteriogenic ED and silent coronary artery disease. J Sex Med 2008,5(11),2623-2634
Shao N.; Yu X-Y.; Yu Y-M.; Li B-W.; Pan J.; Wu W-H.; Zhang H.J.; Ma X.F.; Hao M.; Kuang H.Y.; Short-term combined treatment with exenatide and metformin is superior to glimepiride combined metformin in improvement of serum testosterone levels in type 2 diabetic patients with obesity. Andrologia 2018,50(7),e13039
Wing R.R.; Bond D.S.; Gendrano I.N.; Wadden T.; Bahnson J.; Lewis C.E.; Brancati F.; Schneider S.; Kitabchi A.E.; Van Dorsten B.; Rosen R.C.; Effect of intensive lifestyle intervention on sexual dysfunction in women with type 2 diabetes: results from an ancillary Look AHEAD study. Diabetes Care Sexual Dysfunction Subgroup of the Look AHEAD Research Group2013,36(10),2937-2944