Sự khác biệt về giới tính trong mối liên hệ giữa tình trạng hôn nhân và nguy cơ tử vong do bệnh tim mạch, ung thư và tử vong do mọi nguyên nhân: một nghiên cứu hệ thống và phân tích tổng hợp từ 7,881,040 cá nhân

Yafeng Wang1, Yurui Jiao2, Jing Nie3, Adrienne O’Neil4, Wentao Huang5, Lei Zhang6, Han Jian-zhi7, Hao Líu8, Yun Zhu2, Chuanhua Yu1, Mark Woodward9
1Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, 185 Donghu Road, Wuchang District, Wuhan 430071, China
2Department of endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan, China
3Department of Sociology & Institute for Empirical Social Science Research, School of Humanities and Social Sciences, Xi’an Jiaotong University, Xi’an, China
4Melbourne School of Population and Global Health, University of Melbourne, Carlton, Australia
5School of Nursing, Guangdong Pharmaceutical University, Guangzhou, China
6Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital of Fudan University, Shanghai, China
7Faculty of Psychology, Beijing Normal University, Beijing, China
8Department of Ophthalmology, The First People’s Hospital of Xianyang City, Xianyang, China
9The George Institute for Global Health, University of Oxford, Oxford, UK

Tóm tắt

Tóm tắt Mục đích

Để xác định liệu có sự khác biệt về giới tính trong mối quan hệ giữa tình trạng hôn nhân và bệnh tim mạch (CVD), bệnh tim mạch vành (CHD), ung thư và tỷ lệ tử vong do mọi nguyên nhân trong dân số chung, cũng như khám phá tác động tiềm năng của độ tuổi, địa điểm, thời gian theo dõi và năm công bố đến những kết quả này.

Phương pháp

Một tìm kiếm hệ thống đã được thực hiện trong PubMed và EMBASE từ khi bắt đầu cho đến tháng 4 năm 2018 và việc xem xét các tài liệu tham khảo để thu thập rủi ro tương đối theo giới tính và khoảng tin cậy 95%. Những thông tin này được sử dụng để xác định tỷ lệ RRs (RRR) từ phụ nữ so với nam giới và CI 95% cho từng nghiên cứu. RRs và RRRs cho mỗi kết quả sau đó được tổng hợp bằng cách sử dụng phân tích tổng hợp mô hình ngẫu nhiên với trọng số biến thể nghịch.

Từ khóa

#bệnh tim mạch #bệnh ung thư #tỷ lệ tử vong #tình trạng hôn nhân #phân tích tổng hợp #giới tính

Tài liệu tham khảo

Tatangelo G, McCabe M, Campbell S, Szoeke C. Gender, marital status and longevity. Maturitas. 2017;100:64–9. https://doi.org/10.1016/j.maturitas.2017.03.002.

American Census Bureau. Number of single-person households in the U.S. from 1960 to 2017 (in millions). 2017. https://www.statista.com/statistics/242022/number-of-single-person-households-in-the-us/. Accessed 21 Sept 2019.

National Bureau of Statistics. China statistical yearbook 2017. http://www.xiaze.org/2017/. Accessed 21 Sept 2019.

Waite LJJD. Does marriage matter? Demography. 1995;32:483–507.

Hu YR, Goldman NJD. Mortality differentials by marital status: an international comparison. Demography. 1990;27:233–50.

Wyke S, Ford G. Competing explanations for associations between marital status and health. Soc Sci Med. 1992;34:523–32.

Umberson D. Gender, marital status and the social control of health behavior. Soc Sci Med. 1992;34:907–17.

Chin B, Murphy MLM, Janicki-Deverts D, Cohen S. Marital status as a predictor of diurnal salivary cortisol levels and slopes in a community sample of healthy adults. Psychoneuroendocrinology. 2017;78:68–75. https://doi.org/10.1016/j.psyneuen.2017.01.016.

Matthews K, Schwartz J, Cohen S, Seeman T. Diurnal cortisol decline is related to coronary calcification: CARDIA study. Psychosom Med. 2006;68:657–61.

Dekker MJ, Koper JW, Aken MOV, et al. Salivary cortisol is related to atherosclerosis of carotid arteries. J Clin Endocrinol Metab. 2008;93:3741–7. https://doi.org/10.1210/jc.2008-0496.

Sephton SE, Sapolsky RM, Kraemer HC, Spiegel D. Diurnal cortisol rhythm as a predictor of breast cancer survival. J Natl Cancer Inst. 2013;30:S163–S70.

Sephton SE, Lush E, Dedert EA, et al. Diurnal cortisol rhythm as a predictor of lung cancer survival. J Natl Cancer Inst. 2000;92:994–1000. https://doi.org/10.1016/j.bbi.2012.07.019.

Anagnostis P, Athyros VG, Tziomalos K, Karagiannis A, Mikhailidis DP. Clinical review: the pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. J Clin Endocrinol Metab. 2009;94:2692–701. https://doi.org/10.1210/jc.2009-0370.

Brunner EJ, Hemingway H, Walker BR, et al. Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome. Circulation. 2002;106:2659–65.

Stringhini S, Carmeli C, Jokela M, et al. Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women. Lancet. 2017;389:1229–37. https://doi.org/10.1016/S0140-6736(16)32380-7.

Brunner E. Commentary: education, education, education. Int J Epidemiol. 2001;30:1126–8.

Leong DP, Joseph PG, Mckee M, et al. Reducing the global burden of cardiovascular disease, part 2: prevention and treatment of cardiovascular disease. Circ Res. 2017;121:695. https://doi.org/10.1161/CIRCRESAHA.117.311849.

Beauchamp A, Peeters A, Wolfe R, et al. Inequalities in cardiovascular disease mortality: the role of behavioural, physiological and social risk factors. J Epidemiol Community Health. 2010;64:542–8. https://doi.org/10.1136/jech.2009.094516.

Wong CW, Kwok CS, Narain A, et al. Marital status and risk of cardiovascular diseases: a systematic review and meta-analysis. Heart. 2018. https://doi.org/10.1136/heartjnl-2018-313005.

Eaker ED, Sullivan LM, Kellyhayes M, D'Agostino RB Sr, Benjamin E. Marital status, marital strain, and risk of coronary heart disease or total mortality: the Framingham offspring study. Psychosom Med. 2007;69:509.

Breeze E, Sloggett A, Fletcher A. Socioeconomic and demographic predictors of mortality and institutional residence among middle aged and older people: results from the longitudinal study. J Epidemiol Community Health. 1999;53:765–74.

Fuhrer R, Dufouil C, Antonucci TC, et al. Psychological disorder and mortality in French older adults: do social relations modify the association? Am J Epidemiol. 1999;149:116–26.

Robards J, Evandrou M, Falkingham J, Vlachantoni A. Marital status, health and mortality. Maturitas. 2012;73:295–9. https://doi.org/10.1016/j.maturitas.2012.08.007.

Manzoli L, Villari P, Pirone GM, Boccia A. Marital status and mortality in the elderly: a systematic review and meta-analysis. Soc Sci Med. 2007;64:77–94. https://doi.org/10.1016/j.socscimed.2006.08.031.

Kilpi F, Konttinen H, Silventoinen K, Martikainen P. Living arrangements as determinants of myocardial infarction incidence and survival: a prospective register study of over 300,000 Finnish men and women. Soc Sci Med. 2015;133:93–100. https://doi.org/10.1016/j.socscimed.2015.03.054.

Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA. 2000;283:2008–12.

GA Wells, B Shea, D O'Connell, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses http://www.evidencebasedpublichealth.de/download/Newcastle_Ottowa_Scale_Pope_Bruce.pdf. Accessed 20 Sept 2019.

Huxley R, Barzi F, Woodward M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ. 2006;332:73–6. https://doi.org/10.1136/bmj.38678.389583.7C.

Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–58.

Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60. https://doi.org/10.1136/bmj.327.7414.557.

Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2015;56:455–63.

Va P, Yang WS, Nechuta S, et al. Marital status and mortality among middle age and elderly men and women in urban Shanghai. PLoS One. 2011;6:e26600. https://doi.org/10.1371/journal.pone.0026600.

Frisch M, Simonsen J. Marriage, cohabitation and mortality in Denmark: national cohort study of 6.5 million persons followed for up to three decades (1982–2011). Int J Epidemiol. 2013;42:559–78. https://doi.org/10.1093/ije/dyt024.

Nilsson PM, Johansson SE, Sundquist J. Low educational status is a risk factor for mortality among diabetic people. Diabet Med. 1998;15:213–9.

Molloy GJ, Stamatakis E, Randall G, et al. Marital status, gender and cardiovascular mortality: Behavioural, psychological distress and metabolic explanations. Soc Sci Med. 2009;69:223–8. https://doi.org/10.1016/j.socscimed.2009.05.010.

Dupre ME, Beck AN, Meadows SO. Marital trajectories and mortality among US adults. Am J Epidemiol. 2009;170:546. https://doi.org/10.1093/aje/kwp194.

Scafato E, Galluzzo L, Gandin C, et al. Marital and cohabitation status as predictors of mortality: a 10-year follow-up of an Italian elderly cohort. Soc Sci Med. 2008;67:1456–64. https://doi.org/10.1016/j.socscimed.2008.06.026.

Stimpson JP, Kuo YF, Ray LA, Raji MA, Peek MK. Risk of mortality related to widowhood in older Mexican Americans. Ann Epidemiol. 2007;17:313–9.

Ikeda A, Iso H, Toyoshima H, et al. Marital status and mortality among Japanese men and women: the Japan collaborative cohort study. BMC Public Health. 2007;7:1–7.

Smith KR, Waitzman NJ. Effects of marital status on the risk of mortality in poor and non-poor neighborhoods. Ann Epidemiol. 1997;7:343–9.

Jaffe DH, Eisenbach Z, Neumark YD, Manor O. Individual, household and neighborhood socioeconomic status and mortality: a study of absolute and relative deprivation. Soc Sci Med. 2005;60:989–97.

Nilsson PM, Nilsson JA, Ostergren PO, Berglund G. Social mobility, marital status, and mortality risk in an adult life course perspective: the Malmö preventive project. Scand J Public Health. 2005;33:412.

Hurt LS, Ronsmans CS, Saha S. Effects of education and other socioeconomic factors on middle age mortality in rural Bangladesh. J Epidemiol Community Health. 2004;58:315–20.

Strand BH, Tverdal A. Can cardiovascular risk factors and lifestyle explain the educational inequalities in mortality from ischaemic heart disease and from other heart diseases? 26 year follow up of 50 000 Norwegian men and women. J Epidemiol Community Health. 2004;58:705–9.

Malyutina S, Bobak M, Simonova G, et al. Education, marital status, and total and cardiovascular mortality in Novosibirsk, Russia: a prospective cohort study. Ann Epidemiol. 2004;14:244–9.

Nagata C, Takatsuka N, Shimizu H. The impact of changes in marital status on the mortality of elderly Japanese. Ann Epidemiol. 2003;13(4):218–22.

Johnson NJ, Backlund E, Sorlie PD, Loveless CA. Marital status and mortality: the national longitudinal mortality study. Ann Epidemiol. 2000;10:224–38.

Iwasaki M, Otani T, Sunaga R, et al. Social networks and mortality based on the Komo-Ise cohort study in Japan. Int J Epidemiol. 2002;31:1208–18.

Robles TF, Kiecolt-Glaser JK. The physiology of marriage: pathways to health. Physiol Behav. 2003;79:409–16.

Zhang Z, Mark D. Hayward. gender, the marital life course, and cardiovascular disease in late midlife. J Marriage Fam. 2010;68:639–57.

Yan XY, Huang SM, Huang CQ, Wu WH, Qin Y. Marital status and risk for late life depression: a meta-analysis of the published literature. J Int Med Res. 2011;39:1142. https://doi.org/10.1177/147323001103900402.

Huang MF, Yen CF, Lung FW. Moderators and mediators among panic, agoraphobia symptoms, and suicidal ideation in patients with panic disorder. Compr Psychiatry. 2010;51:243–9. https://doi.org/10.1016/j.comppsych.2009.07.005.

Goldman NJD. Marriage selection and mortality patterns: inferences and fallacies. Demography. 1993;30:189–208.

Manfredini R, De GA, Tiseo R, et al. Marital status, cardiovascular diseases, and cardiovascular risk factors: a review of the evidence. J Women's Health (Larchmt). 2017;26:624–32. https://doi.org/10.1089/jwh.2016.6103.

Kajantie E, Phillips DIJP. The effects of sex and hormonal status on the physiological response to acute psychosocial stress. Psychoneuroendocrinology. 2006;31:151–78. https://doi.org/10.1016/j.psyneuen.2005.07.002.

Kudielka BM, Kirschbaum C. Sex differences in HPA axis responses to stress: a review. Biol Psychol. 2005;69:113–32. https://doi.org/10.1016/j.biopsycho.2004.11.009.

Verma R, Balhara YP, Gupta CS. Gender differences in stress response: role of developmental and biological determinants. Ind Psychiatry J. 2012;20:4–10. https://doi.org/10.4103/0972-6748.98407.

Yang XP, Reckelhoff JF. Estrogen, hormonal replacement therapy and cardiovascular disease. Curr Opin Nephrol Hypertens. 2012;20:133–8. https://doi.org/10.1097/MNH.0b013e3283431921.

Wang X, Smith GI, Patterson BW, et al. Testosterone increases the muscle protein synthesis rate but does not affect very-low-density lipoprotein metabolism in obese premenopausal women. Am J Physiol Endocrinol Metab. 2012;302:E740–6. https://doi.org/10.1152/ajpendo.00533.2011.

Engström G, Hedblad B, Rosvall M, Janzon L, Lindgärde F. Occupation, marital status, and low-grade inflammation: mutual confounding or independent cardiovascular risk factors? Arterioscler Thromb Vasc Biol. 2006;26:643–8. https://doi.org/10.1161/01.ATV.0000200100.14612.bb.

Evans MR, Goldsmith AR. The effects of testosterone on antibody production and plumage coloration in male house sparrows (Passer domesticus). Behav Ecol Sociobiol. 2000;47:156–63.

Pinheiro AO, Pereira VL Jr, Baltatu OC, Campos LA. Cardiac autonomic dysfunction in elderly women with myocardial infarction. Curr Med Res Opin. 2015;31:1849–54. https://doi.org/10.1185/03007995.2015.1074065.

Listed N. Marriage and men's health. Harv Mens Health Watch. 2010;14:1–3.

Addis ME, Mahalik JR. Men, masculinity, and the contexts of help seeking. Am Psychol. 2003;58:5–14.

Kendler KS, Myers J, Prescott CA. Sex differences in the relationship between social support and risk for major depression: a longitudinal study of opposite-sex twin pairs. Am J Psychiatry. 2005;162:250–6. https://doi.org/10.1176/appi.ajp.162.2.250.

Staehelin K, Schindler C, Spoerri A, Zemp Stutz E. Swiss National Cohort Study Group. Marital status, living arrangement and mortality: does the association vary by gender? J Epidemiol Community Health. 2012;66:e22. https://doi.org/10.1136/jech.2010.128397.

Gross SM, Gary TL, Browne DC, LaVeist TA. Gender differences in body image and health perceptions among graduating seniors from a historically black college. J Natl Med Assoc. 2005;97:1608–19.

Mccreary DR, Sadava SW. Gender differences in relationships among perceived attractiveness, life satisfaction, and health in adults as a function of body mass index and perceived weight. Psychol Men Masculinity. 2001;2:108–16.

Costa MG, Petrucci GD, Lessa HB. Change in body weight and body image in young adults: a longitudinal study. BMC Public Health. 2015;15:1–7. https://doi.org/10.1186/s12889-015-1579-7.

O'Neil A, Scovelle AJ, Milner AJ, Kavanagh A. Gender/sex as a social determinant of cardiovascular risk. Circulation. 2018;137:854–64. https://doi.org/10.1161/CIRCULATIONAHA.117.028595.

Redondo-Sendino Á, Guallar-Castillón P, Banegas JR, Rodríguez-Artalejo F. Gender differences in the utilization of health-care services among the older adult population of Spain. BMC Public Health. 2006;6:1–9. https://doi.org/10.1186/1471-2458-6-155.

Wilsnack RW, Wilsnack SC, Kristjanson AF, Vogeltanz-Holm ND, Gmel G. Gender and alcohol consumption: patterns from the multinational GENACIS project. Addiction. 2010;104:1487–500. https://doi.org/10.1111/j.1360-0443.2009.02696.x.

Bots SH, Peters SAE, Woodward M. Sex differences in coronary heart disease and stroke mortality: a global assessment of the effect of ageing between 1980 and 2010. BMJ Glob Health. 2017;2:e000298. https://doi.org/10.1136/bmjgh-2017-000298.

Pan JJ, Fallon MB. Gender and racial differences in nonalcoholic fatty liver disease. World J Hepatol. 2014;6:274–83. https://doi.org/10.4254/wjh.v6.i5.274.

Yeluru A, Nguyen P, Le AK, et al. Gender differences in outcomes of cirrhosis in a large cohort of patients in the United States. Gastroenterology. 2017;152:S1142. https://doi.org/10.1016/S0016-5085(17)33835-0 Accessed 18 Sept 2019.

Perreault L, Ma Y, Dagogo-Jack S, et al. Sex differences in diabetes risk and the effect of intensive lifestyle modification in the diabetes prevention program. Diabetes Care. 2008;31:1416–21. https://doi.org/10.2337/dc07-2390.

RydeN L, Grant PJ, Anker SD, et al. ESC guidelines on diabetes, pre-diabetes and diseases of the cardiovascular system developed in cooperation with the EASD. Kardiol Pol. 2013;71(Suppl 11(XI)):S319–94. https://doi.org/10.5603/KP.2013.0289.

Regensteiner JG, Golden S, Huebschmann AG, et al. Sex differences in the cardiovascular consequences of diabetes mellitus: a scientific statement from the American Heart Association. Circulation. 2015;132:2424–47. https://doi.org/10.1161/CIR.0000000000000343.

Orth-Gomer K, Wamala SP, Horsten M, et al. Marital stress worsens prognosis in women with coronary heart disease: the Stockholm female coronary risk study. JAMA. 2000;284:3008–14.

Lyons JG, Cauley JA, Fredman L. The effect of transitions in caregiving status and intensity on perceived stress among 992 female caregivers and noncaregivers. J Gerontol A Biol Sci Med Sci. 2015;70:1018–23. https://doi.org/10.1093/gerona/glv001.