Sex differences in brain aging and predictors of neurodegeneration in cognitively healthy older adults

Allen, 2003, Sexual dimorphism and asymmetries in the gray–white composition of the human cerebrum, NeuroImage, 18, 880, 10.1016/S1053-8119(03)00034-X Armstrong, 2019, Predictors of neurodegeneration differ between cognitively normal and subsequently impaired older adults, Neurobiol. Aging, 75, 178, 10.1016/j.neurobiolaging.2018.10.024 Barnes, 2010, Head size, age and gender adjustment in MRI studies: a necessary nuisance?, NeuroImage, 53, 1244, 10.1016/j.neuroimage.2010.06.025 Barter, 2007, HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events, N Engl. J. Med., 357, 1301, 10.1056/NEJMoa064278 Bielecki, 2016, Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin, Proc. Natl. Acad. Sci. U. S. A., 113, 14829, 10.1073/pnas.1614826113 Burt, 1995, Prevalence of hypertension in the US adult population: results from the third national health and nutrition examination survey, 1988-1991, Hypertension, 25, 305, 10.1161/01.HYP.25.3.305 Calhoun, 1998, The sexual dimorphism of high blood pressure, Cardiol. Rev., 6, 356, 10.1097/00045415-199811000-00012 Chen, 2006, Effects of cerebrovascular risk factors on gray matter volume in adults aged 60–64 years: a voxel-based morphometric study, Psychiatry Res., 147, 105, 10.1016/j.pscychresns.2006.01.009 Chung, 2009, Molecular inflammation: underpinnings of aging and age-related diseases, Ageing Res. Rev., 8, 18, 10.1016/j.arr.2008.07.002 Coffey, 1998, Sex differences in brain aging: a quantitative magnetic resonance imaging study, Arch. Neurol., 55, 169, 10.1001/archneur.55.2.169 Coffey, 1992, Quantitative cerebral anatomy of the aging human brain: a cross-sectional study using magnetic resonance imaging, Neurology, 42, 527, 10.1212/WNL.42.3.527 Cosgrove, 2007, Evolving knowledge of sex differences in brain structure, function, and chemistry, Biol. Psychiatry, 62, 847, 10.1016/j.biopsych.2007.03.001 Courchesne, 2000, Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers, Radiology, 216, 672, 10.1148/radiology.216.3.r00au37672 de Leon, 2004, MRI and CSF studies in the early diagnosis of Alzheimer's disease, J. Intern. Med., 256, 205, 10.1111/j.1365-2796.2004.01381.x Doshi, 2016, MUSE: MUlti-atlas region Segmentation utilizing Ensembles of registration algorithms and parameters, and locally optimal atlas selection, NeuroImage, 127, 186, 10.1016/j.neuroimage.2015.11.073 Driscoll, 2009, Longitudinal pattern of regional brain volume change differentiates normal aging from MCI, Neurology, 72, 1906, 10.1212/WNL.0b013e3181a82634 Driscoll, 2016, Obesity and structural brain integrity in older women: the women’s health initiative magnetic resonance imaging study, J. Gerontol. A. Biol. Sci. Med. Sci., 71, 1216, 10.1093/gerona/glw023 Erus, 2018, Longitudinally and inter-site consistent multi-atlas based parcellation of brain anatomy using harmonized atlases, NeuroImage, 166, 71, 10.1016/j.neuroimage.2017.10.026 Ferrucci, 2005, The origins of age-related proinflammatory state, Blood, 105, 2294, 10.1182/blood-2004-07-2599 Fischer, 2002, Renin angiotensin system and gender differences in the cardiovascular system, Cardiovasc. Res., 53, 672, 10.1016/S0008-6363(01)00479-5 Fjell, 2009, Minute effects of sex on the aging brain: a multisample magnetic resonance imaging study of healthy aging and Alzheimer's disease, J. Neurosci., 29, 8774, 10.1523/JNEUROSCI.0115-09.2009 Gianaros, 2006, Higher blood pressure predicts lower regional grey matter volume: consequences on short-term information processing, NeuroImage, 31, 754, 10.1016/j.neuroimage.2006.01.003 Goldstein, 2001, Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging, Cereb. Cortex, 11, 490, 10.1093/cercor/11.6.490 Gottesman, 2017, Association between midlife vascular risk factors and estimated brain amyloid deposition, JAMA, 317, 1443, 10.1001/jama.2017.3090 Green, 2000, Neuroprotective effects of estrogens: potential mechanisms of action, Int. J. Dev. Neurosci., 18, 347, 10.1016/S0736-5748(00)00017-4 Greenberg, 2008, Aging, gender, and the elderly adult brain: an examination of analytical strategies, Neurobiol. Aging, 29, 290, 10.1016/j.neurobiolaging.2006.09.016 Gur, 1999, Sex differences in brain gray and white matter in healthy young adults: correlations with cognitive performance, J. Neurosci., 19, 4065, 10.1523/JNEUROSCI.19-10-04065.1999 Gur, 1991, Gender differences in age effect on brain atrophy measured by magnetic resonance imaging, Proc. Natl. Acad. Sci. U. S. A., 88, 2845, 10.1073/pnas.88.7.2845 Huxley, 2006, Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies, BMJ, 332, 73, 10.1136/bmj.38678.389583.7C Jack, 1997, Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease, Neurology, 49, 786, 10.1212/WNL.49.3.786 Jack, 2017, Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50–95 years: a cross-sectional study, Lancet Neurol., 16, 435, 10.1016/S1474-4422(17)30077-7 Lemaître, 2005, Age- and sex-related effects on the neuroanatomy of healthy elderly, Neuroimage, 26, 900, 10.1016/j.neuroimage.2005.02.042 Lüders, 2002, Brain size and grey matter volume in the healthy human brain, Neuroreport, 13, 2371, 10.1097/00001756-200212030-00040 Luders, 2014, Why size matters: differences in brain volume account for apparent sex differences in callosal anatomy: the sexual dimorphism of the corpus callosum, Neuroimage, 84, 820, 10.1016/j.neuroimage.2013.09.040 McCarrey, 2016, Sex differences in cognitive trajectories in clinically normal older adults, Psychol. Aging, 31, 166, 10.1037/pag0000070 Miles, 2008, Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations, Atherosclerosis, 196, 298, 10.1016/j.atherosclerosis.2006.11.002 Moffat, 2000, Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype, Neurology, 55, 134, 10.1212/WNL.55.1.134 Mosca, 2011, Sex/gender differences in cardiovascular disease prevention: what a difference a decade makes, Circulation, 124, 2145, 10.1161/CIRCULATIONAHA.110.968792 Murphy, 1996, Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging, Arch. Gen. Psychiatry, 53, 585, 10.1001/archpsyc.1996.01830070031007 Nopoulos, 2000, Sexual dimorphism in the human brain: evaluation of tissue volume, tissue composition and surface anatomy using magnetic resonance imaging, Psychiatry Res., 98, 1, 10.1016/S0925-4927(99)00044-X Pacheco, 2015, Greater cortical thinning in normal older adults predicts later cognitive impairment, Neurobiol. Aging, 36, 903, 10.1016/j.neurobiolaging.2014.08.031 Patel, 2009, Acute hypertriglyceridaemia in humans increases the triglyceride content and decreases the anti-inflammatory capacity of high density lipoproteins, Atherosclerosis, 204, 424, 10.1016/j.atherosclerosis.2008.07.047 Pengas, 2009, Comparative reliability of total intracranial volume estimation methods and the influence of atrophy in a longitudinal semantic dementia cohort, J. Neuroimaging, 19, 37, 10.1111/j.1552-6569.2008.00246.x Persson, 2014, Sex differences in volume and structural covariance of the anterior and posterior hippocampus, Neuroimage, 99, 215, 10.1016/j.neuroimage.2014.05.038 Persson, 2016, Regional brain shrinkage and change in cognitive performance over two years: the bidirectional influences of the brain and cognitive reserve factors, Neuroimage, 126, 15, 10.1016/j.neuroimage.2015.11.028 Peters, 2014, Diabetes as a risk factor for stroke in women compared with men: a systematic review and meta-analysis of 64 cohorts, including 775 385 individuals and 12 539 strokes, Lancet, 383, 1973, 10.1016/S0140-6736(14)60040-4 Pfefferbaum, 1994, A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood, Arch. Neurol., 51, 874, 10.1001/archneur.1994.00540210046012 Prescott, 1998, Smoking and risk of myocardial infarction in women and men: longitudinal population study, BMJ, 316, 1043, 10.1136/bmj.316.7137.1043 Rast, 2017, APOEε4 genotype and hypertension modify 8-year cortical thinning: five occasion evidence from the Seattle Longitudinal Study, Cereb. Cortex, 28, 1934, 10.1093/cercor/bhx099 Raz, 2010, Trajectories of brain aging in middle-aged and older adults: regional and individual differences, Neuroimage, 51, 501, 10.1016/j.neuroimage.2010.03.020 Raz, 1997, Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter, Cereb. Cortex, 7, 268, 10.1093/cercor/7.3.268 Raz, 2005, Regional brain changes in aging healthy adults: general trends, individual differences and modifiers, Cereb. Cortex, 15, 1676, 10.1093/cercor/bhi044 Raz, 2009, Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension, Neuropsychology, 23, 105, 10.1037/a0013487 Resnick, 2000, One-year age changes in MRI brain volumes in older adults, Cerebral Cortex, 10, 464, 10.1093/cercor/10.5.464 Resnick, 2003, Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain, J. Neurosci., 23, 3295, 10.1523/JNEUROSCI.23-08-03295.2003 Resnick, 2009, Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI study, Neurology, 72, 135, 10.1212/01.wnl.0000339037.76336.cf Ritchie, 2018, Sex differences in the adult human brain: evidence from 5216 UK Biobank participants, Cereb. Cortex, 28, 2959, 10.1093/cercor/bhy109 Ritchie, 2015, Brain volumetric changes and cognitive ageing during the eighth decade of life, Hum. Brain Mapp., 36, 4910, 10.1002/hbm.22959 Rodrigue, 2013, Risk factors for β-amyloid deposition in healthy aging: vascular and genetic effects, JAMA Neurol., 70, 600, 10.1001/jamaneurol.2013.1342 Salat, 2004, Thinning of the cerebral cortex in aging, Cereb. Cortex, 14, 721, 10.1093/cercor/bhh032 Sampietro, 2006, HDL: the ‘new’ target of cardiovascular medicine, Int. J. Cardiol., 108, 143, 10.1016/j.ijcard.2005.04.036 Sowell, 2007, Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of age, Cereb. Cortex, 17, 1550, 10.1093/cercor/bhl066 2017 Taki, 2004, Voxel-based morphometry of human brain with age and cerebrovascular risk factors, Neurobiol. Aging, 25, 455, 10.1016/j.neurobiolaging.2003.09.002 Thambisetty, 2010, Longitudinal changes in cortical thickness associated with normal aging, Neuroimage, 52, 1215, 10.1016/j.neuroimage.2010.04.258 Wolf, 2004, Serum lipids and hippocampal volume: the link to Alzheimer's disease?, Ann. Neurol., 56, 745, 10.1002/ana.20289 Xu, 2000, Gender effects on age-related changes in brain structure, AJNR Am. J. Neuroradiol., 21, 112 Yang, 2011, Estrogen, hormonal replacement therapy and cardiovascular disease, Curr. Opin. Nephrol. Hypertens., 20, 133, 10.1097/MNH.0b013e3283431921 Yuan, 2018, Fluid intelligence and gross structural properties of the cerebral cortex in middle-aged and older adults: a multi-occasion longitudinal study, Neuroimage, 172, 21, 10.1016/j.neuroimage.2018.01.032