Sex-dependent metabolism of nevirapine in rats: impact on plasma levels, pharmacokinetics and interaction with nortriptyline

International Journal of Antimicrobial Agents - Tập 51 - Trang 707-713 - 2018
Iris Usach1, Pablo Compañ1, José-Esteban Peris1
1Department of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, Avda. V. Andrés Estellés, s/n, 46100 Burjassot, Valencia, Spain

Tài liệu tham khảo

Panel on Antiretroviral Guidelines for Adults and Adolescents Ades, 2000, Economic issues in the prevention of vertical transmission of HIV, Pharmacoeconomics, 18, 9, 10.2165/00019053-200018010-00002 Natarajan, 2007, Safety of nevirapine in pregnancy, HIV Med, 8, 64, 10.1111/j.1468-1293.2007.00433.x Marinho, 2014, Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions, J Antimicrob Chemother, 69, 476, 10.1093/jac/dkt359 Riska, 1999, Biotransformation of nevirapine, a non-nucleoside HIV-1 reverse transcriptase inhibitor, in mice, rats, rabbits, dogs, monkeys, and chimpanzees, Drug Metab Dispos, 27, 1434 Erickson, 1999, Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450, Drug Metab Dispos, 27, 1488 Sharma, 2013, 12-OH-nevirapine sulfate, formed in the skin, is responsible for nevirapine-induced skin rash, Chem Res Toxicol, 26, 817, 10.1021/tx400098z Martignoni, 2006, Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction, Expert Opin Drug Metab Toxicol, 2, 875, 10.1517/17425255.2.6.875 Xue, 2003, Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase, Arch Biochem Biophys, 409, 113, 10.1016/S0003-9861(02)00582-9 Medrano, 2008, Risk for immune-mediated liver reactions by nevirapine revisited, AIDS Rev, 10, 110 Baylor, 2004, Hepatotoxicity associated with nevirapine use, J Acquir Immune Defic Syndr, 35, 538, 10.1097/00126334-200404150-00014 Bersoff-Matcha, 2001, Sex differences in nevirapine rash, Clin Infect Dis, 32, 124, 10.1086/317536 Fagot, 2001, Nevirapine and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis, AIDS, 15, 1843, 10.1097/00002030-200109280-00014 Zhou, 1999, Population pharmacokinetics of nevirapine, zidovudine, and didanosine in human immunodeficiency virus-infected patients. The National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators, Antimicrob Agents Chemother, 43, 121, 10.1128/AAC.43.1.121 Usach, 2014, Pharmacokinetic interaction between nevirapine and nortriptyline in rats: inhibition of nevirapine metabolism by nortriptyline, Antimicrob Agents Chemother, 58, 7041, 10.1128/AAC.03312-14 Penzak, 2000, Depression in patients with HIV infection, Am J Health Syst Pharm, 57, 376, 10.1093/ajhp/57.4.376 Torres-Molina, 1992, Influence of permanent cannulation of the jugular vein on pharmacokinetics of amoxycillin and antipyrine in the rat, Pharm Res, 9, 1587, 10.1023/A:1015864425069 Usach, 2015, In vitro studies: inhibition of nevirapine metabolism by nortriptyline in hepatic microsomes, Bio-protocol, 5, e1607, 10.21769/BioProtoc.1607 van Heeswijk, 2000, The steady-state pharmacokinetics of nevirapine during once daily and twice daily dosing in HIV-1-infected individuals, AIDS, 14, F77, 10.1097/00002030-200005260-00001 Miller, 2001, Gender-based differences in the toxicity of pharmaceuticals—the Food and Drug Administration's perspective, Int J Toxicol, 20, 149, 10.1080/109158101317097728 Gillman, 2007, Tricyclic antidepressant pharmacology and therapeutic drug interactions updated, Br J Pharmacol, 151, 737, 10.1038/sj.bjp.0707253 Murray, 1992, Metabolite intermediate complexation of microsomal cytochrome P450 2C11 in male rat liver by nortriptyline, Mol Pharmacol, 42, 931 Polasek, 2008, Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants, Br J Clin Pharmacol, 65, 87, 10.1111/j.1365-2125.2007.02964.x