Sex Affects the Steady-State Pharmacokinetics of Primaquine but Not Doxycycline in Healthy Subjects

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE - Tập 81 Số 5 - Trang 747-753 - 2009
Vu Q. Binh1, Nguyen Ngoc Quang, Nguyen Trong Chinh, Bui Tri Cuong, Thomas Travers, Bui Dai, Michelle L. Gatton2, Nguyễn Xuân Thành
1Department of Infectious Disease, Central Military Hospital, Hanoi, Vietnam.
2Australian Defence Force

Tóm tắt

We evaluated whether sex affects the steady-state pharmacokinetics of the antimalarial drugs, primaquine and doxycycline, in healthy subjects. Seventeen male and 17 female healthy Vietnamese subjects were administered 30 mg (base) of primaquine daily for 14 days. After a 2-week washout period, 14 male and 14 female subjects were administered 100 mg (base) of doxycycline daily for 14 days. Women had significantly higher median values of Cmax (212 versus 122 ng/mL, P< 0.001) and AUC0–24 (1,909 versus 917 ng · h/mL, P < 0.001) of primaquine compared with men. Other than a longer tmax in women, no sex-related differences were seen in the pharmacokinetics of doxycycline. The primaquine pharmacokinetic data suggest that women have increased exposure to primaquine, which may put them at increased risk for toxicity when administered the same maintenance dose as men. The similar pharmacokinetics of doxycycline between the two sexes justifies the same maintenance dose.

Từ khóa


Tài liệu tham khảo

2009

2006, 75, 402

1984

2009

1952, 149, 1563

1997, 126, 963

1987, 1, 1161

1971, 20, 811

1994, 120, 294

1994, 50, 784

1993, 329, 31

2006, 74, 951

2006, 61, 682

1985, 19, 745

1984, 17, 441

1985, 19, 751

2004, 27, 576

1991, 22, 527

2000

2006, 58, 256

1988, 15, 355

2002

1986, 30, 105

1997

2001, 33, 1990

1995, 50, 222

2002, 41, 329

2004, 44, 499

1990, 116, 871

1981, 11, 245

2003, 59, 429

1992, 44, 587

1992, 52, 643

1999, 60, 36

2004, 76, 178

2001, 2, 349

2003, 19, 115

2003, 37, 1659

2004, 39, 1336

2002, 96, 683

Thông tin
Thông tin xuất bản

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Tập 81 Số 5

747-753

Thông tin tác giả