Severe Asthma in Children: Lessons Learned and Future Directions
Tóm tắt
Từ khóa
Tài liệu tham khảo
Ward, 2015
National Asthma Education and Prevention Panel, 2007, Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007, J Allergy Clin Immunol, 120, S94, 10.1016/j.jaci.2007.09.029
Guilbert, 2014, Severe asthma in children, J Allergy Clin Immunol Pract, 2, 489, 10.1016/j.jaip.2014.06.022
Nordlund, 2014, Prevalence of severe childhood asthma according to the WHO, Respir Med, 108, 1234, 10.1016/j.rmed.2014.05.015
Coverstone, 2015, Severe asthma in school-age children: evaluation and phenotypic advances, Curr Allergy Asthma Rep, 15, 521, 10.1007/s11882-015-0521-5
Jang, 2013, Trends in cost and outcomes among adult and pediatric patients with asthma: 2000-2009, Ann Allergy Asthma Immunol, 111, 516, 10.1016/j.anai.2013.09.007
Ivanova, 2012, Effect of asthma exacerbations on health care costs among asthmatic patients with moderate and severe persistent asthma, J Allergy Clin Immunol, 129, 1229, 10.1016/j.jaci.2012.01.039
Szefler, 2011, Economic burden of impairment in children with severe or difficult-to-treat asthma, Ann Allergy Asthma Immunol, 107, 110, 10.1016/j.anai.2011.04.008
Barnett, 2011, Costs of asthma in the United States: 2002-2007, J Allergy Clin Immunol, 127, 145, 10.1016/j.jaci.2010.10.020
Moorman, 2012, National surveillance of asthma: United States, 2001-2010, Vital Health Stat 3, 1
Fitzpatrick, 2006, Features of severe asthma in school-age children: atopy and increased exhaled nitric oxide, J Allergy Clin Immunol, 118, 1218, 10.1016/j.jaci.2006.08.019
Moore, 2007, Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program, J Allergy Clin Immunol, 119, 405, 10.1016/j.jaci.2006.11.639
Lotvall, 2011, Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome, J Allergy Clin Immunol, 127, 355, 10.1016/j.jaci.2010.11.037
2000, Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society, Am J Respir Crit Care Med, 162, 2341, 10.1164/ajrccm.162.6.ats9-00
Bousquet, 2010, Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma, J Allergy Clin Immunol, 126, 926, 10.1016/j.jaci.2010.07.019
Chung, 2014, International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma, Eur Respir J, 43, 343, 10.1183/09031936.00202013
Moore, 2013, Clinical heterogeneity in the severe asthma research program, Ann Am Thorac Soc, 10, S118, 10.1513/AnnalsATS.201309-307AW
Modena, 2014, Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways, Am J Respir Crit Care Med, 190, 1363, 10.1164/rccm.201406-1099OC
Dweik, 2010, Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma, Am J Respir Crit Care Med, 181, 1033, 10.1164/rccm.200905-0695OC
Sorkness, 1985, Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation, J Appl Physiol, 2008, 394
Aysola, 2008, Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology, Chest, 134, 1183, 10.1378/chest.07-2779
Witt, 2014, Longitudinal changes in airway remodeling and air trapping in severe asthma, Acad Radiol, 21, 986, 10.1016/j.acra.2014.05.001
Fitzpatrick, 2011, Progressive airflow limitation is a feature of children with severe asthma, J Allergy Clin Immunol, 127, 282, 10.1016/j.jaci.2010.10.036
Fitzpatrick, 2010, Severe asthma in children: insights from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program, Pediatr Allergy Immunol Pulmonol, 23, 131, 10.1089/ped.2010.0021
Sorkness, 2011, Sex dependence of airflow limitation and air trapping in children with severe asthma, J Allergy Clin Immunol, 127, 1073, 10.1016/j.jaci.2010.12.1079
Farha, 2009, Effects of the menstrual cycle on lung function variables in women with asthma, Am J Respir Crit Care Med, 180, 304, 10.1164/rccm.200904-0497OC
Rao, 2013, Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the Severe Asthma Research Program, Chest, 143, 984, 10.1378/chest.12-0973
Gamble, 2010, Racial differences in biologic predictors of severe asthma: data from the Severe Asthma Research Program, J Allergy Clin Immunol, 126, 1149, 10.1016/j.jaci.2010.08.049
Levin, 2013, A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations, J Allergy Clin Immunol, 131, 1176, 10.1016/j.jaci.2012.10.002
Torgerson, 2012, Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects, J Allergy Clin Immunol, 130, 622, 10.1016/j.jaci.2012.03.045
Torgerson, 2011, Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations, Nat Genet, 43, 887, 10.1038/ng.888
Moore, 2010, Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program, Am J Respir Crit Care Med, 181, 315, 10.1164/rccm.200906-0896OC
Luyster, 2012, Sleep quality and asthma control and quality of life in non-severe and severe asthma, Sleep Breath, 16, 1129, 10.1007/s11325-011-0616-8
Teodorescu, 2015, Obstructive sleep apnea risk, asthma burden and lower airway inflammation in adults in the Severe Asthma Research Program (SARP) II, J Allergy Clin Immunol Pract, 3, 566, 10.1016/j.jaip.2015.04.002
Holguin, 2011, Obesity and asthma: an association modified by age of asthma onset, J Allergy Clin Immunol, 127, 1486, 10.1016/j.jaci.2011.03.036
Wysocki, 2014, Characterization of factors associated with systemic corticosteroid use in severe asthma: data from the Severe Asthma Research Program, J Allergy Clin Immunol, 133, 915, 10.1016/j.jaci.2013.10.031
Chen, 2014, Pathway from central obesity to childhood asthma. Physical fitness and sedentary time are leading factors, Am J Respir Crit Care Med, 189, 1194, 10.1164/rccm.201401-0097OC
Holguin, 2013, An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype, Am J Respir Crit Care Med, 187, 153, 10.1164/rccm.201207-1270OC
Holguin, 2010, Obesity, asthma, and oxidative stress, J Appl Physiol (1985), 108, 754, 10.1152/japplphysiol.00702.2009
Holguin, 2010, A deep breath bronchoconstricts obese asthmatics, J Asthma, 47, 55, 10.3109/02770900903318330
Sah, 2013, Poor asthma control in obese children may be overestimated because of enhanced perception of dyspnea, J Allergy Clin Immunol Pract, 1, 39, 10.1016/j.jaip.2012.10.006
Kit, 2013, US prevalence and trends in tobacco smoke exposure among children and adolescents with asthma, Pediatrics, 131, 407, 10.1542/peds.2012-2328
Akinbami, 2013, Impact of environmental tobacco smoke on children with asthma, United States, 2003-2010, Acad Pediatr, 13, 508, 10.1016/j.acap.2013.07.003
Howrylak, 2014, Cotinine in children admitted for asthma and readmission, Pediatrics, 133, e355, 10.1542/peds.2013-2422
Comhair, 2011, Detrimental effects of environmental tobacco smoke in relation to asthma severity, PLoS One, 6, e18574, 10.1371/journal.pone.0018574
Comhair, 2005, Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma, Am J Respir Crit Care Med, 172, 306, 10.1164/rccm.200502-180OC
Cohen, 2007, Epithelial cell proliferation contributes to airway remodeling in severe asthma, Am J Respir Crit Care Med, 176, 138, 10.1164/rccm.200607-1062OC
Moore, 2014, Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis, J Allergy Clin Immunol, 133, 1557, 10.1016/j.jaci.2013.10.011
Hastie, 2010, Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes, J Allergy Clin Immunol, 125, 1028, 10.1016/j.jaci.2010.02.008
Wu, 2014, Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data, J Allergy Clin Immunol, 133, 1280, 10.1016/j.jaci.2013.11.042
Haldar, 2008, Cluster analysis and clinical asthma phenotypes, Am J Respir Crit Care Med, 178, 218, 10.1164/rccm.200711-1754OC
Weatherall, 2009, Distinct clinical phenotypes of airways disease defined by cluster analysis, Eur Respir J, 34, 812, 10.1183/09031936.00174408
Siroux, 2011, Identifying adult asthma phenotypes using a clustering approach, Eur Respir J, 38, 310, 10.1183/09031936.00120810
Sutherland, 2012, Cluster analysis of obesity and asthma phenotypes, PLoS One, 7, e36631, 10.1371/journal.pone.0036631
Fitzpatrick, 2010, The molecular phenotype of severe asthma in children, J Allergy Clin Immunol, 125, 851, 10.1016/j.jaci.2010.01.048
Bossley, 2012, Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines, J Allergy Clin Immunol, 129, 974, 10.1016/j.jaci.2012.01.059
Fitzpatrick, 2011, Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program, J Allergy Clin Immunol, 127, 382, 10.1016/j.jaci.2010.11.015
Howrylak, 2014, Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications, J Allergy Clin Immunol, 133, 1289, 10.1016/j.jaci.2014.02.006
Schatz, 2014, Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma, J Allergy Clin Immunol, 133, 1549, 10.1016/j.jaci.2013.10.006
Just, 2012, Two novel, severe asthma phenotypes identified during childhood using a clustering approach, Eur Respir J, 40, 55, 10.1183/09031936.00123411
Just, 2014, Childhood allergic asthma is not a single phenotype, J Pediatr, 164, 815, 10.1016/j.jpeds.2013.11.037
Kuhlen, 2014, Identification of asthma phenotypes in a tertiary care medical center, Am J Med Sci, 348, 480, 10.1097/MAJ.0000000000000346
Patrawalla, 2012, Application of the asthma phenotype algorithm from the Severe Asthma Research Program to an urban population, PLoS One, 7, e44540, 10.1371/journal.pone.0044540
Bourdin, 2014, Prognostic value of cluster analysis of severe asthma phenotypes, J Allergy Clin Immunol, 134, 1043, 10.1016/j.jaci.2014.04.038
Chang, 2014, Childhood asthma clusters and response to therapy in clinical trials, J Allergy Clin Immunol, 133, 363, 10.1016/j.jaci.2013.09.002
Moore, 2011, Safety of investigative bronchoscopy in the Severe Asthma Research Program, J Allergy Clin Immunol, 128, 328, 10.1016/j.jaci.2011.02.042
Jarjour, 2012, Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program, Am J Respir Crit Care Med, 185, 356, 10.1164/rccm.201107-1317PP
Balzar, 2011, Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program, Am J Respir Crit Care Med, 183, 299, 10.1164/rccm.201002-0295OC
Coleman, 2012, Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset, Thorax, 67, 1061, 10.1136/thoraxjnl-2012-201634
Johansson, 2013, Markers of vascular perturbation correlate with airway structural change in asthma, Am J Respir Crit Care Med, 188, 167, 10.1164/rccm.201301-0185OC
Gomez, 2015, Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40, J Allergy Clin Immunol, 136, 51, 10.1016/j.jaci.2014.11.027
Hawkins, 2012, The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma, J Allergy Clin Immunol, 130, 510, 10.1016/j.jaci.2012.03.018
Li, 2012, The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients, J Allergy Clin Immunol, 129, 575, 10.1016/j.jaci.2011.09.040
Li, 2013, Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients, J Allergy Clin Immunol, 132, 313, 10.1016/j.jaci.2013.01.051
Li, 2011, Importance of hedgehog interacting protein and other lung function genes in asthma, J Allergy Clin Immunol, 127, 1457, 10.1016/j.jaci.2011.01.056
Li, 2012, Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases, J Allergy Clin Immunol, 130, 861, 10.1016/j.jaci.2012.04.041
Brasier, 2010, Predicting intermediate phenotypes in asthma using bronchoalveolar lavage-derived cytokines, Clin Transl Sci, 3, 147, 10.1111/j.1752-8062.2010.00204.x
Brown, 2015, Characterization of a high TNF-alpha phenotype in children with moderate-to-severe asthma, J Allergy Clin Immunol, 135, 1651, 10.1016/j.jaci.2014.08.054
Brown, 2012, Airway TGF-beta1 and oxidant stress in children with severe asthma: association with airflow limitation, J Allergy Clin Immunol, 129, 388, 10.1016/j.jaci.2011.11.037
Wedes, 2009, Noninvasive markers of airway inflammation in asthma, Clin Transl Sci, 2, 112, 10.1111/j.1752-8062.2009.00095.x
Cowan, 2015, Biomarker-based asthma phenotypes of corticosteroid response, J Allergy Clin Immunol, 135, 877, 10.1016/j.jaci.2014.10.026
Lara, 2008, Alterations of the arginine metabolome in asthma, Am J Respir Crit Care Med, 178, 673, 10.1164/rccm.200710-1542OC
Levy, 2005, Diminished lipoxin biosynthesis in severe asthma, Am J Respir Crit Care Med, 172, 824, 10.1164/rccm.200410-1413OC
Gaston, 2006, Buffering airway acid decreases exhaled nitric oxide in asthma, J Allergy Clin Immunol, 118, 817, 10.1016/j.jaci.2006.06.040
Liu, 2011, Determinants of exhaled breath condensate pH in a large population with asthma, Chest, 139, 328, 10.1378/chest.10-0163
Ghosh, 2006, Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation, J Immunol, 176, 5587, 10.4049/jimmunol.176.9.5587
Fitzpatrick, 2009, Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma, J Allergy Clin Immunol, 124, 990, 10.1016/j.jaci.2009.08.039
Fitzpatrick, 2009, Severe Asthma Research P. Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress, J Allergy Clin Immunol, 123, 146, 10.1016/j.jaci.2008.10.047
Fitzpatrick, 2008, Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma, J Allergy Clin Immunol, 121, 1372, 10.1016/j.jaci.2008.03.008
Fitzpatrick, 2011, Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma, Pediatr Res, 69, 154, 10.1203/PDR.0b013e3182026370
Fitzpatrick, 2014, Children with severe asthma have unique oxidative stress-associated metabolomic profiles, J Allergy Clin Immunol, 133, 258, 10.1016/j.jaci.2013.10.012
Fitzpatrick, 2011, Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2, J Allergy Clin Immunol, 127, 1604, 10.1016/j.jaci.2011.03.031
Stephenson, 2015, Cysteine oxidation impairs systemic glucocorticoid responsiveness in children with difficult-to-treat asthma, J Allergy Clin Immunol, 136, 454, 10.1016/j.jaci.2015.01.023
Greenwald, 2010, Breath formate is a marker of airway S-nitrosothiol depletion in severe asthma, PLoS One, 5, e11919, 10.1371/journal.pone.0011919
Marozkina, 2015, Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity, Eur Respir J, 45, 87, 10.1183/09031936.00042414