Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Journal of Analytical Methods in Chemistry - Tập 2015 - Trang 1-21 - 2015
Bianca Ivãnescu1, Anca Miron2, Andreia Corciovă3
1Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700150 Iasi, Romania
2Department of Pharmacognosy, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700150 Iasi, Romania
3Department of Drug Analysis, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700150 Iasi, Romania

Tóm tắt

Sesquiterpene lactones are a large group of natural compounds, found primarily in plants ofAsteraceaefamily, with over 5000 structures reported to date. Within this family, genusArtemisiais very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides. Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent. Many of the biological activities are attributed to theα-methylene-γ-lactone group in their molecule which reacts through a Michael-addition with free sulfhydryl or amino groups in proteins and alkylates them. Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst. Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis. Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found inArtemisiagenus, as well as the optimal conditions for their extraction and separation.

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Journal of Analytical Methods in Chemistry

Tập 2015

1-21

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