Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes

Journal of Dermatological Science - Tập 101 - Trang 22-29 - 2021
M’Hammed Aguennouz1,2, Fabrizio Guarneri1, Rosaria Oteri1, Francesca Polito3, Roberta Giuffrida1, Serafinella P. Cannavò1
1Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
2Department of Medicine, Mohammed VI University of Health Sciences, Casablanca, Morocco
3Department of Human Pathology of Adulthood and Childhood “G. Barresi”, University of Messina, Messina, Italy

Tài liệu tham khảo

Rodrigues, 2017, Vitiligo Working Group, New discoveries in the pathogenesis and classification of vitiligo, J. Am. Acad. Dermatol., 77, 1, 10.1016/j.jaad.2016.10.048 Teovska Mitrevska, 2012, Quality of life in vitiligo patients, Dermatol Ther., 1, S28, 10.1111/dth.12007 Speeckaert, 2018, Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis, J. Eur. Acad. Dermatol. Venereol., 32, 1089, 10.1111/jdv.14792 Guarneri, 2011, Glutathione S-transferase M1/T1 gene polymorphisms and vitiligo in a Mediterranean population, Pigment Cell Melanoma Res., 24, 731, 10.1111/j.1755-148X.2011.00872.x Glassman, 2011, Vitiligo, reactive oxygen species and T-cells, Clin. Sci. (Lond.), 120, 99, 10.1042/CS20090603 Vita, 2020, Circulating microRNAs profile in patients with transthyretin variant amyloidosis, Front. Mol. Neurosci., 13, 102, 10.3389/fnmol.2020.00102 Su, 2019, miR-9 regulates melanocytes adhesion and migration during vitiligo repigmentation induced by UVB treatment, Exp. Cell Res., 10.1016/j.yexcr.2019.111615 Parihar, 2020, Effect of narrowband ultraviolet B treatment on microRNA expression in active nonsegmental generalized vitiligo, Br. J. Dermatol., 183, 167, 10.1111/bjd.18890 Su, 2020, Role of the p53-TRPM1/miR-211-MMP9 axis in UVB-induced human melanocyte migration and its potential in repigmentation, Int. J. Mol. Med., 45, 1017 Lv, 2019, MicroRNA-155 inhibits the proliferation of CD8+ T cells via upregulating regulatory T cells in vitiligo, Mol. Med. Rep., 20, 3617 Vaish, 2019, Micro RNAs upregulated in vitiligo skin play an important role in its aetiopathogenesis by altering TRP1 expression and keratinocyte-melanocytes cross-talk, Sci. Rep., 9, 10079, 10.1038/s41598-019-46529-6 Sahoo, 2017, MicroRNA-211 regulates oxidative phosphorylation and energy metabolism in human vitiligo, J. Invest. Dermatol., 137, 1965, 10.1016/j.jid.2017.04.025 Shang, 2017, Altered expression of four miRNA (miR-1238-3p, miR-202-3p, miR-630 and miR-766-3p) and their potential targets in peripheral blood from vitiligo patients, J. Dermatol., 44, 1138, 10.1111/1346-8138.13886 Mansuri, 2016, miRNA signatures and transcriptional regulation of their target genes in vitiligo, J. Dermatol. Sci., 84, 50, 10.1016/j.jdermsci.2016.07.003 Šahmatova, 2016, MicroRNA-155 is dysregulated in the skin of patients with vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes, Acta Derm. Venereol., 96, 742 Wang, 2016, Downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines, Immunobiology, 221, 1378, 10.1016/j.imbio.2016.07.008 Shi, 2016, Oxidative stress-induced overexpression of miR-25: the mechanism underlying the degeneration of melanocytes in vitiligo, Cell Death Differ., 23, 496, 10.1038/cdd.2015.117 Cui, 2015, miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1, Arch. Dermatol. Res., 307, 683, 10.1007/s00403-015-1563-1 Wang, 2015, Differential expression analysis of miRNA in peripheral blood mononuclear cells of patients with non-segmental vitiligo, J. Dermatol., 42, 193, 10.1111/1346-8138.12725 Mansuri, 2014, MicroRNA profiling reveals differentially expressed microRNA signatures from the skin of patients with nonsegmental vitiligo, Br. J. Dermatol., 171, 1263, 10.1111/bjd.13109 Shi, 2013, MicroRNA expression profiling identifies potential serum biomarkers for non-segmental vitiligo, Pigment Cell Melanoma Res., 26, 418, 10.1111/pcmr.12086 Huang, 2013, A single-nucleotide polymorphism of miR-196a-2 and vitiligo: an association study and functional analysis in a Han Chinese population, Pigment Cell Melanoma Res., 26, 338, 10.1111/pcmr.12081 Fine, 1999, A proportional hazards model for the subdistribution of a competing risk, J. Am. Stat. Assoc., 94, 496, 10.1080/01621459.1999.10474144 Liang, 2019, Transcriptional response of subcutaneous white adipose tissue to acute cold exposure in mice, Int. J. Mol. Sci., 20, 3968, 10.3390/ijms20163968 Conti, 2016, MiRNA expression profiling in human gliomas: upregulated miR-363 increases cell survival and proliferation, Tumour Biol., 37, 14035, 10.1007/s13277-016-5273-x Dy, 2008, Generation of mice harboring a Sox5 conditional null allele, Genesis, 46, 294, 10.1002/dvg.20392 Stolt, 2008, The transcription factor Sox5 modulates Sox10 function during melanocyte development, Nucleic Acids Res., 36, 5427, 10.1093/nar/gkn527 Yang, 2014, BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells, Exp. Cell Res., 320, 54, 10.1016/j.yexcr.2013.09.017 Rzepka, 2016, From tyrosine to melanin: signaling pathways and factors regulating melanogenesis, Postepy. Hig. Med. Dosw. (Online), 70, 695, 10.5604/17322693.1208033 Wang, 2016, MicroRNA-21a-5p functions on the regulation of melanogenesis by targeting Sox5 in mouse skin melanocytes, Int. J. Mol. Sci., 17 Kordaß, 2016, SOX5 is involved in balanced MITF regulation in human melanoma cells, BMC Med. Genomics, 9, 10, 10.1186/s12920-016-0170-0 Wu, 2015, Mechanism of miR-21 via Wnt/β-catenin signaling pathway in human A549 lung cancer cells and Lewis lung carcinoma in mice, Asian Pac. J. Trop. Med., 8, 479, 10.1016/j.apjtm.2015.05.003 D’Mello, 2016, Signaling pathways in melanogenesis, Int. J. Mol. Sci., 17, 10.3390/ijms17071144 Kuźbicki, 2006, Cyclin-dependent kinase 2 expression in human melanomas and benign melanocytic skin lesions, Melanoma Res., 16, 435, 10.1097/01.cmr.0000232290.61042.ee Liu, 2020, Induction of G0/G1 phase arrest and apoptosis by CRISPR/Cas9-mediated knockout of CDK2 in A375 melanocytes, Mol. Clin. Oncol., 12, 9 Dellago, 2013, High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan, Aging Cell, 12, 446, 10.1111/acel.12069 Serre, 2018, Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation, Int. J. Cosmet. Sci., 40, 328, 10.1111/ics.12466 Yan, 2020, Current insight into the roles of microRNA in vitiligo, Mol. Biol. Rep., 47, 3211, 10.1007/s11033-020-05336-3 Yang, 2011, miR-21 promotes keratinocyte migration and re-epithelialization during wound healing, Int. J. Biol. Sci., 7, 685, 10.7150/ijbs.7.685 Wäster, 2020, Extracellular vesicles released by melanocytes after UVA irradiation promote intercellular signaling via miR21, Pigment Cell Melanoma Res., 33, 542, 10.1111/pcmr.12860 Satzger, 2012, microRNA-21 is upregulated in malignant melanoma and influences apoptosis of melanocytic cells, Exp. Dermatol., 21, 509, 10.1111/j.1600-0625.2012.01510.x Liang, 2016, Integrative analysis of miRNA and mRNA paired expression profiling of primary fibroblast derived from diabetic foot ulcers reveals multiple impaired cellular functions, Wound Repair Regen., 24, 943, 10.1111/wrr.12470 Melnik, 2015, MiR-21: an environmental driver of malignant melanoma?, J. Transl. Med., 13, 202, 10.1186/s12967-015-0570-5 Syed, 2013, MicroRNAs in skin response to UV radiation, Curr. Drug Targets, 14, 1128, 10.2174/13894501113149990184 Vrijens, 2015, MicroRNAs as potential signatures of environmental exposure or effect: a systematic review, Environ. Health Perspect., 123, 399, 10.1289/ehp.1408459