Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura

Springer Science and Business Media LLC - Tập 22 Số 12 - Trang 2067-2072 - 2007
Keith K. Lau1, Robert Wyatt2, Zina Moldoveanu3, Milan Tomana4, Bruce A. Julian4, Ronald J. Hogg5, Jeannette Lee4, Wen-Qiang Huang3, Jiří Městecký4, Jan Novák3
1Department of Pediatrics, University of California at Davis, Davis, USA
2Department of Pediatrics, University of Tennessee Health Sciences Center and Children’s Foundation Research Center, Memphis, USA
3Department of Microbiology, University of Alabama at Birmingham, Birmingham, USA
4Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
5St. Joseph’s Hospital and Medical Center, Phoenix, USA

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D’Amico G (1987) The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med 64:709–727

Delos Santos NM, Wyatt RJ (2004) Pediatric IgA nephropathies: Clinical aspects and therapeutic approaches. Semin Nephrol 24:269–286

Saulsbury FT (2001) Henoch-Schönlein purpura. Curr Opin Rheumatol 13:35–40

Levy M, Broyer M, Arsan A, Levy-Bentolila D, Habib R (1976) Anaphylactoid purpura nephritis in childhood: Natural history and immunopathology. Adv Nephrol 6:183–228

Evans DJ, Gwynn-Williams D, Peters DK, Sissons JG, Boulton-Jones JM, Ogg CS, Cameron JS, Hoffbrand BI (1973) Glomerular deposition of properdin in Henoch-Schönlein purpura syndrome and idiopathic focal glomerulonephritis. Br Med J 11:326–328

Meadow SR, Scott DG (1985) Berger disease: Henoch-Schönlein syndrome without the rash. J Pediatr 106:27–32

Levy M (1989) Familial cases of Berger’s disease and anaphylactoid purpura: more frequent than previously thought. Am J Med 87:246–248

Nakamoto Y, Asano Y, Dohi K, Fujioka M, Iida H, Kida H, Kibe Y, Hattori N, Takeuchi J (1978) Primary IgA glomerulonephritis and Schonlein-Henoch purpura nephritis: clinicopathological and immunohistological characteristics. Q J Med 47:495–516

Waldo FB (1988) Is Henoch-Schönlein purpura the systemic form of IgA nephropathy? Am J Kidney Dis 12:373–377

Andre PM, Le Pogamp P, Chevet D (1990) Impairment of jacalin binding to serum IgA in IgA nephropathy. J Clin Lab Anal 4:115–119

Mestecky J, Tomana M, Crowley-Nowick PA, Moldoveanu Z, Julian BA, Jackson S (1993) Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. Contrib Nephrol 104:172–182

Allen AC, Harper SJ, Feehally J (1995) Galactosylation of N- and O-linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy. Clin Exp Immunol 100:470–474

Tomana M, Matousovic K, Julian BA, Radl J, Konecny K, Mestecky J (1997) Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. Kidney Int 52:509–516

Allen AC, Willis FR, Beattie TJ, Feehally J (1998) Abnormal IgA glycosylation in Henoch-Schönlein purpura restricted to patients with clinical nephritis. Nephrol Dial Transplant 13:930–934

Coppo R, Basolo B, Martina G, Rollino C, De Marchi M, Giacchino F, Mazzucco G, Messina M, Piccoli G (1982) Circulating immune complexes containing IgA, IgG and IgM in patients with primary IgA nephropathy and with Henoch-Schönlein nephritis. Correlation with clinical and histologic signs of activity. Clin Nephrol 18:230–239

Amore A, Cirina P, Conti G, Brusa P, Peruzzi L, Coppo R (2001) Glycosylation of circulating IgA in patients with IgA nephropathy modulates proliferation and apoptosis of mesangial cells. J Am Soc Nephrol 12:1862–1871

Coppo R, Amore A (2004) Aberrant glycosylation in IgA nephropathy (IgAN). Kidney Int 65:1544–1547

Novak J, Tomana M, Matousovic K, Brown R, Hall S, Novak L, Julian BA, Wyatt RJ, Mestecky J (2005) IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells. Kidney Int 67:504–513

Hogg R, Tomana M, Gray J, Mestecky J (1997) Deficient IgA1 galactosylation in children with idiopatic IgA nephropathy (IgAN) and Henoch-Schönlein nephritis (HSPN). J Am Soc Nephrol 8:88A

Moore JS, Kulhavy R, Tomana M, Moldoveanu Z, Suzuki H, Brown R, Hall S, Kilian M, Poulsen K, Mestecky J, Julian BA, Novak J (2007) Reactivities of N-acetylgalactosamine-specific lectins with human IgA1 proteins. Mol Immunol 44:2598–2604

Moldoveanu Z, Wyatt RJ, Lee J, Tomana M, Julian BA, Mestecky J, Huang W-Q, Anreddy SR, Hastings MC, Lau KK, Cook WJ, Novak J (2007) Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Kidney Int 71:134–138

Schwartz GJ, Haycock GB, Edelman CM Jr, Spitzer A (1976) A simple estimate of glomerular filtration rate in children derived from body length and serum creatinine. Pediatrics 58:522–526

Tomana M, Novak J, Julian BA, Matousovic K, Konecny K, Mestecky J (1999) Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J Clin Invest 104:73–81

Yoshikawa N, Ito H, Nakamura H (1992) Prognostic indicators in childhood IgA nephropathy. Nephron 60:60–67

Ariceta G, Gallego N, Lopez-Fernandez Y, Vallo A, Quintella MJ, Rodriquez Soriano J (2001) Long-term prognosis of childhood IgA nephropathy in adult life. Med Clin 116:361–364

Delos Santos NM, Ault BH, Gharavi AG, Kritchevsky SB, Quasney MW, Jackson EC, Fisher KA, Woodford SY, Mitchell BL, Gaber LW, Arheart KL, Wyatt RJ (2002) Angiotensin-converting enzyme genotype and outcome in pediatric IgA nephropathy. Pediatr Nephrol 17:496–502

Yoshikawa N, Iijima K, Matsuyama S, Suzuki J, Kameda A, Okada S, Nakamura H (1990) Repeat renal biopsy in children with IgA nephropathy. Clin Nephrol 33:160–167

Xu LX, Zhao MH (2005) Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy. Kidney Int 68:167–172

Lau KK, Wyatt RJ, Gaber LW (2005) Purpura followed by proteinuria in a 7-year-old girl. Am J Kidney Dis 46:1140–1144