Serum Tryptophan Metabolite Levels During Sleep in Patients With and Without Irritable Bowel Syndrome (IBS)

Biological Research for Nursing - Tập 18 Số 2 - Trang 193-198 - 2016
Margaret Heitkemper1, Claire J. Han1, Monica Jarrett1, Haiwei Gu2, Danijel Djukovic2, Robert J. Shulman3, Daniel Raftery2,4, Wendy A. Henderson5, Kevin C. Cain6
1Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, USA
2Department of Anesthesiology and Pain Medicine, Northwest Metabolomics Research Center, University of Washington, Seattle, WA, USA
3Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA
4Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
5Digestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, NINR, NIH, DHHS, Bethesda, MD, USA
6Department of Biostatistics and Office of Nursing Research, University of Washington, Seattle, WA, USA

Tóm tắt

Poor sleep and stress are more frequently reported by women with irritable bowel syndrome (IBS) than by healthy control (HC) women. The pathophysiology linking poor sleep and stress to gastrointestinal symptoms remains poorly understood. We used a metabolomic approach to determine whether tryptophan (TRP) metabolites differ between women with and without IBS and whether the levels are associated with sleep indices and serum cortisol levels. This study sample included 38 women with IBS and 21 HCs. The women were studied in a sleep laboratory for three consecutive nights. On the third night of the study, a social stressor was introduced, then blood samples were drawn every 20 min and sleep indices were measured. Metabolites were determined by targeted liquid chromatography tandem mass spectrometry in a sample collected 1 hr after the onset of sleep. The ratios of each metabolite to TRP were used for analyses. Correlations were controlled for age and oral contraceptive use. Melatonin/TRP levels were lower ( p = .005) in the IBS-diarrhea group versus the IBS-constipation and HC groups, and kynurenine/TRP ratios tended to be lower ( p = .067) in the total IBS and IBS-diarrhea groups compared to HCs. Associations within the HC group included melatonin/TRP with polysomnography-sleep efficiency ( r = .61, p = .006) and weaker positive correlations with the other ratios for either sleep efficiency or percentage time in rapid eye movement sleep ( r > .40, p = .025–.091). This study suggests that reductions in early nighttime melatonin/TRP levels may be related to altered sleep quality in IBS, particularly those with diarrhea.

Từ khóa


Tài liệu tham khảo

10.1017/S1461145709990253

10.1177/0269881113499209

10.1186/1471-230X-9-6

10.1155/2014/271802

Drossman D., 2006, Rome III: The functional gastrointestinal disorders, 3

10.1111/j.1365-2982.2008.01195.x

10.1186/s12888-014-0372-y

10.1111/j.1365-2982.2012.01915.x

10.1111/nmo.12489

10.1023/A:1005581226265

10.1007/s00213-014-3767-z

10.1016/j.jval.2012.08.2207

10.1016/j.bbr.2014.07.027

10.1038/npp.2014.194

10.3748/wjg.v20.i10.2492

10.5056/jnm14119

10.1021/pr500494u

Thông tin
Thông tin xuất bản

Biological Research for Nursing

Tập 18 Số 2

193-198

Thông tin tác giả