Serum Transaminase Elevations as Indicators of Hepatic Injury Following the Administration of Drugs

Regulatory Toxicology and Pharmacology - Tập 27 Số 2 - Trang 119-130 - 1998
David E. Amacher1
1Drug Safety Evaluation, Pfizer Central Research, Groton, Connecticut, 06340

Tóm tắt

Từ khóa


Tài liệu tham khảo

Adams, 1991, Drug-related lupus. Incidence, mechanisms and clinical implications, Drug Saf., 6, 431, 10.2165/00002018-199106060-00004

Aiges, 1980, The effects of phenobarbital and diphenylhydantoin on liver function and morphology, J. Pediatr., 97, 22, 10.1016/S0022-3476(80)80123-5

Albers, 1997, The use of reporter antigens in the popliteal lymph node assay to assess immunomodulation by chemicals, Toxicol. Appl. Pharmacol., 143, 102, 10.1006/taap.1996.8078

Anderson, 1996, Simultaneous measurement of hundreds of liver proteins: Application in assessment of liver function, Toxicol. Pathol., 24, 72, 10.1177/019262339602400110

Batt, 1995, Manifestations of chemically induced liver damage, Clin. Chem., 41, 1882, 10.1093/clinchem/41.12.1882

Benichou, 1990, Criteria of drug-induced liver disorders. Report of an international consensus meeting, J. Hepatol., 11, 272, 10.1016/0168-8278(90)90124-A

Bigazzi, 1988, Autoimmunity induced by chemicals, Clin. Toxicol., 26, 125, 10.3109/15563658809000343

Billon, 1980, In vivo, Mol. Cell. Endocrinol., 18, 99, 10.1016/0303-7207(80)90085-4

Black, 1987, Hepatotoxic and hepatoprotective potential of histamine (H2, Am. J. Med., 83, 68, 10.1016/0002-9343(87)90814-X

Boelsterli, 1995, Idiosyncratic liver toxicity of nonsteroidal anti-inflammatory drugs: Molecular mechanisms and pathology, Crit. Rev. Toxicol., 25, 207, 10.3109/10408449509089888

Breckenridge, 1996, A clinical pharmacologist's view of drug toxicity, Br. J. Clin. Pharmacol., 42, 53, 10.1046/j.1365-2125.1996.03762.x

Brockmoller, 1994, Assessment of liver metabolic function. Clinical implications, Clin. Pharmacokinet., 27, 216, 10.2165/00003088-199427030-00005

Bryson, 1996, Riluzole. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis, Drugs, 52, 549, 10.2165/00003495-199652040-00010

Burns, 1996, Toxic responses of the immune system

Campbell, 1993, MHC genes in autoimmunity, Curr. Opin. Immunol., 5, 887, 10.1016/0952-7915(93)90101-W

Clampitt, 1978, The tissue activities of some diagnostic enzymes in ten mammalian species, J. Comp. Pathol., 88, 607, 10.1016/0021-9975(78)90014-2

Clermont, 1967, The transaminase tests in liver disease, Medicine, 46, 197, 10.1097/00005792-196703000-00012

Coombs, 1975, Classification of allergic reactions responsible for clinical hypersensitivity and disease, 761

Craxi, 1996, Diagnostic approach to liver enzyme elevation, J. Hepatol., 25, 47

Dansette, 1991, Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes, Biochem. Pharmacol., 41, 553, 10.1016/0006-2952(91)90627-H

Davis, 1989, Drugs and abnormal ‘liver function tests.’, Adverse Drug React. Bull., 139, 520, 10.1097/00012995-198912000-00001

De Mol, 1984, Irreversible binding of the chlorpromazine radical cation and of photoactivated chlorpromazine to biological macromolecules, Chem.–Biol. Interact., 52, 79, 10.1016/0009-2797(84)90084-X

Dhami, 1979, Decreased aminotransferase activity of serum and various tissues in the rat after cefazolin treatment, Clin. Chem., 25, 1263, 10.1093/clinchem/25.7.1263

Dybing, 1976, Oxidation of α-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: Possible mechanism of methyldopa hepatitis, Mol. Pharmacol., 12, 911

Ereshefsky, 1996, Drug–drug interactions involving antidepressants: Focus on venlafaxine, J. Clin. Psychopharmacol., 16, 37S, 10.1097/00004714-199606002-00009

Finlayson, 1973, The adverse effects of drugs on the liver, Br. J. Clin. Pract., 27, 286, 10.1111/j.1742-1241.1973.tb09047.x

Foster, 1989, Serum F protein: A new sensitive and specific test of hepatocellular damage, Clin. Chim. Acta, 184, 85, 10.1016/0009-8981(89)90259-3

Fregia, 1994, Evaluation of abnormal liver tests, Comp. Ther., 20, 50

Fry, 1995, Hepatotoxicity of analgesics and anti-inflammatory agents, Gastroenterol. Clin. N. Am., 24, 875, 10.1016/S0889-8553(21)00232-6

Fronek, 1991, A rare HLA DQB allele sequenced from patients with systemic lupus erythematosus, Hum. Immunol., 30, 77, 10.1016/0198-8859(91)90074-J

Garcia Rodriguez, 1994, Acute liver injury associated with nonsteroidal anti-inflammatory drugs and the role of risk factors, Arch. Intern. Med., 154, 311, 10.1001/archinte.154.3.311

George, 1996, Antibacterial-induced hepatotoxicity. Incidence, prevention, and management, Drug Saf., 15, 79, 10.2165/00002018-199615010-00007

Goldstein, 1994, Biochemistry and molecular biology of the human CYP2C subfamily, Pharmacogenetics, 4, 285, 10.1097/00008571-199412000-00001

Grippon, 1984, Drug induced liver disease in a liver unit. A retrospective study of 46 patients in 3 years, Therapie, 39, 503

Grohmann, 1984, Assessment of adverse drug reactions in psychiatric hospitals, Eur. J. Clin. Pharmacol., 26, 727, 10.1007/BF00541933

Haidukewych, 1986, Chronic valproic acid and coantiepileptic drug therapy and incidence of increases in serum liver enzymes, Ther. Drug Monit., 8, 407, 10.1097/00007691-198612000-00004

Helliwell, 1985, Hepatic necrosis and glutathione depletion in captopril-treated mice, Br. J. Exp. Pathol., 66, 67

Herlong, 1994, Approach to the patient with abnormal liver enzymes, Hosp. Pract., 29, 32, 10.1080/21548331.1994.11443103

Herzfeld, 1979, Effects of cortisol or starvation on the activities of four enzymes in small intestine and liver of the rat during development, J. Dev. Physiol., 1, 315

Hirayanagi, 1991, The significance of serum γ-glutamyl transpeptidase (γ-GTP) elevation caused by antiepileptic drug(s). Using the antipyrine metabolic capacity as a parameter of microsomal enzyme activity, Nippon Ika Daigaku Zasshi, 58, 547, 10.1272/jnms1923.58.547

Hodgson, 1989, Liver injury tests in hazardous waste workers: The role of obesity, J. Occup. Med., 31, 238, 10.1097/00043764-198903000-00009

Hoffmann, 1989, Clinical enzymology, 237

Hultcrantz, 1986, Liver investigation in 149 asymptomatic patients with moderately elevated activities of serum aminotransferases, Scand. J. Gastroenterol., 21, 109, 10.3109/00365528609034632

Iwatsubo, 1997, Prediction ofin vivoin vitro, Pharmacol. Ther., 73, 147, 10.1016/S0163-7258(96)00184-2

Jacobsen, 1976, Liver biopsies in epileptics during anticonvulsant therapy, Acta Med. Scand., 199, 345, 10.1111/j.0954-6820.1976.tb06746.x

Jean-Pastor, 1984, Bilan des accidents hepatiques medicamenteux recueillis par la pharmacovigilance francaise, Therapie, 39, 493

Jick, 1995, Drug-associated asymptomatic elevations of transaminase in drug safety assessments, Pharmacotherapy, 15, 23, 10.1002/j.1875-9114.1995.tb04326.x

Jurima-Romet, 1992, Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione, Biochem. Pharmacol., 44, 1803, 10.1016/0006-2952(92)90075-T

King, 1995, Hepatotoxicity of chemotherapeutic and oncologic agents, Gastroenterol. Clin. N. Am., 24, 969, 10.1016/S0889-8553(21)00236-3

Koch-Weser, 1980, Drug therapy: Valproic acid, New Engl. J. Med., 302, 661, 10.1056/NEJM198003203021204

Lam, 1997, Application of combinatorial library methods in cancer research and drug discovery, Anticancer Drug Des., 12, 145

Larrey, 1997, Genetic predisposition to drug-induced hepatotoxicity, J. Hepatol., 26, 12, 10.1016/S0168-8278(97)80492-8

LeCluyse, 1994, Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration, Am. J. Physiol., 266, C1764, 10.1152/ajpcell.1994.266.6.C1764

Lewis, 1984, Hepatic toxicity of nonsteroidal anti-inflammatory drugs, Clin. Pharm., 3, 128

Lewis, 1989, Amiodarone hepatotoxicity: Prevalence and clinicopathologic correlations among 104 patients, Hepatology, 9, 679, 10.1002/hep.1840090504

McDonald, 1984, Intestinal and liver toxicity of antineoplastic drugs, West. J. Med., 140, 250

Meyer, 1996, Overview of enzymes of drug metabolism, J. Pharmacokinet. Biopharm., 24, 449, 10.1007/BF02353473

Meyer, 1997, Molecular mechanisms of genetic polymorphisms of drug metabolism, Annu. Rev. Pharmacol. Toxicol., 37, 269, 10.1146/annurev.pharmtox.37.1.269

Mijovic, 1987, Serum alanine aminotransferase (ALT) and γ-glutamyltransferase (γ-GT) activities in north London blood donors, J. Clin. Pathol., 40, 1340, 10.1136/jcp.40.11.1340

Miyamoto, 1997, Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid, Chem. Res. Toxicol., 10, 414, 10.1021/tx960190k

Morgan, 1984, Impaired oxidation of debrisoquine in patients with perhexiline liver injury, Gut, 25, 1057, 10.1136/gut.25.10.1057

Mosca, 1985, In vivoin vitro, Br. J. Exp. Pathol., 66, 737

Moslen, 1996, Toxic responses of the liver, 403

Nishimura, 1981, Gamma-glutamyltransferase activity in the liver plasma membrane: Induction following chronic alcohol consumption, Biochem. Biophys. Res. Commun., 99, 141, 10.1016/0006-291X(81)91724-1

Pappas, 1986, Source of increased serum aspartate and alanine aminotransferase: Cycloheximide effect on carbon tetrachloride hepatotoxicity, Clin. Chim. Acta, 154, 181, 10.1016/0009-8981(86)90029-X

Park, 1992, Idiosyncratic drug reactions: A mechanistic evaluation of risk factors, Br. J. Clin. Pharmacol., 34, 377, 10.1111/j.1365-2125.1992.tb05647.x

Pessayre, 1992, III. Mechanisms of drug-induced hepatic injury, 23

Pirmohamed, 1992, Idiosyncratric reactions to antidepressants: A review of possible mechanisms and predisposing factors, Pharmacol. Ther., 53, 105, 10.1016/0163-7258(92)90046-3

Pirmohamed, 1996, Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism, Clin. Pharmacokinet., 31, 215, 10.2165/00003088-199631030-00005

Porubek, 1989, The covalent binding to protein of valproic acid and its hepatotoxic metabolite, 2-n, Drug Metab. Dispos., 17, 123

Pumford, 1997, Protein targets of xenobiotic reactive intermediates, Annu. Rev. Pharmacol. Toxicol., 37, 91, 10.1146/annurev.pharmtox.37.1.91

Pumford, 1997, Covalent binding of xenobiotics to specific proteins in the liver, Drug Metab. Rev., 29, 39, 10.3109/03602539709037572

Rahmat, 1985, Captopril-associated cholestatic jaundice, Ann. Intern. Med., 102, 56, 10.7326/0003-4819-102-1-56

Rej, 1989, Aminotransferases in disease, Diagn. Enzymol., 9, 667

Renner, 1992, Erhohte leberenzyme: Was nun?, Ther. Umsch., 49, 281

Richardson, 1994, Dose-responses in rat hepatic protein modification and expression following exposure to the rat hepatocarcinogen methapyrilene, Carcinogenesis, 15, 325, 10.1093/carcin/15.2.325

Runge-Morris, 1997, Regulation of expression of the rodent cytosolic sulfotransferases, FASEB J., 11, 109, 10.1096/fasebj.11.2.9039952

Sakagishi, 1995, Alanine aminotransferase (ALT), Nippon Rinsho, 53, 1146

Sameshima, 1984, Drug-induced hepatic injury, Jpn. J. Gastroenterol., 81, 37

Scheig, 1996, Evaluation of test used to screen patients with liver disorders. Primary care, Clin. Office Prac., 23, 551, 10.1016/S0095-4543(05)70347-X

Schiaffonati, 1997, Gene expression in liver after toxic injury: Analysis of heat shock response and oxidative stress-inducible genes, Liver, 17, 183, 10.1111/j.1600-0676.1997.tb00804.x

Schmidt, 1990, Progress in the enzyme diagnosis of liver disease: Reality or illusion?, Clin. Biochem., 23, 375, 10.1016/0009-9120(90)90085-9

Sherman, 1991, Alanine aminotransferase in clinical practice. A review, Arch. Intern. Med., 151, 260, 10.1001/archinte.1991.00400020036008

Spina, 1994, CYP2D6-related oxidation polymorphism in Italy, Pharmacol. Res., 29, 281, 10.1016/1043-6618(94)80051-0

Stricker, 1986, Hepatic injury by drugs and environmental agents, 419

Stricker, 1992, IV. Pathology of drug-induced hepatic injury, 51

Stricker, 1992, V. Individual agents: Drugs, 71

Tabibian, 1987, Captopril-induced liver dysfunction, South. Med. J., 80, 1173, 10.1097/00007611-198708090-00023

Teschke, 1983, Hepatic gamma-glutamyltransferase activity in alcoholic fatty liver: Comparison with other liver enzymes in man and rats, Gut, 24, 625, 10.1136/gut.24.7.625

Timbrell, 1980, Isoniazid hepatotoxicity: The relationship between covalent binding and metabolismin vivo, J. Pharmacol. Exp. Ther., 213, 364

Uetrecht, 1988, Mechanism of drug-induced lupus, Chem. Res. Toxicol., 1, 133, 10.1021/tx00003a001

Ulrich, 1995, Cultured hepatocytes as investigational models for hepatic toxicity: Practical applications in drug discovery and development, Toxicol. Lett., 82/83, 107, 10.1016/0378-4274(95)03547-8

Van Dijke, 1986, Bijwerkingen van geneesmiddelen op een afdeling inwendige geneeskunde, Ned. Tijdschr. Geneeskd., 130, 1889

Wall, 1992, Liver function tests in persons receiving anticonvulsant medications, Seizure, 1, 187, 10.1016/1059-1311(92)90024-U

Waner, 1991, The toxicological significance of decreased activities of blood alanine and aspartate aminotransferase, Vet. Res. Commun., 15, 73, 10.1007/BF00497793

Watkins, 1990, Role of cytochromes P450 in drug metabolism and hepatotoxicity, Semin. Liver Dis., 10, 235, 10.1055/s-2008-1040480

Watkins, 1994, Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease, JAMA, 271, 992, 10.1001/jama.1994.03510370044030

Westphal, 1994, Hepatic side effects of antibiotics, J. Antimicrob. Chemother., 33, 387, 10.1093/jac/33.3.387

Wilkinson, 1996, Cytochrome P4503A (CYP3A) metabolism: Prediction ofin vivo, J. Pharmacokinet. Biopharm., 24, 475, 10.1007/BF02353475

Wright, 1988, Liver function testing in a working population: Three strategies to reduce false-positive results, J. Occup. Med., 30, 693

Yamada, 1984, Inhibition of serum aspartate aminotransferase induced by isoniazid administration in mice, Acta Vitaminol. Enzymol., 6, 289

Yamada, 1984, “In vivo, Acta Vitaminol. Enzymol., 6, 29

Zeisel, 1991, Choline, an essential nutrient for humans, FASEB J., 5, 2093, 10.1096/fasebj.5.7.2010061

Zimmerman, 1984, Function and integrity of the liver, 217

Zimmerman, 1974, Editorial: Aspirin-induced hepatic injury, Ann. Intern. Med., 80, 103, 10.7326/0003-4819-80-1-103

Zimmerman, 1978