Serum Paraoxonase 1 Activity and Lipid Peroxidation Levels in Patients with Age-Related Macular Degeneration

Ophthalmologica - Tập 220 Số 1 - Trang 12-16 - 2006
Gülden Başkol1, Sarper Karaküçük2, Ayşe Öner2, Mevlüt Başkol3, Derya Koçer1, Ertuğrul Mirza2, Recep Saraymen1, Muzaffer Üstdal1
1Biochemistry and Clinical Biochemistry,
2Ophthalmology, and
3Internal Medicine, Medical Faculty, Erciyes University, Kayseri, Turkey

Tóm tắt

Our objective was to investigate antioxidant paraoxonase 1 (PON1) activity together with malondialdehyde (MDA) levels to evaluate oxidative stress in patients with age-related macular degeneration (AMD), an important cause of blindness in the elderly population. Serum PON1 activity and MDA levels were analyzed in 37 patients with AMD and compared with 29 healthy controls using a spectrophotometric method. Serum MDA levels were significantly higher in the patient group (2.76 ± 1.28 nmol/ml) than controls (1.00 ± 0.36 nmol/ml; p < 0.001), whereas PON1 activity was lower in the patient group (132.27 ± 63.39 U/l) than controls (312.13 ± 136.23 U/l; p < 0.001). There was a negative correlation between MDA and PON1 levels (r = –0.470, p < 0.001). We conclude that the observed increase in MDA levels may be related to decreased PON1 activity; the present data also demonstrated that an obvious negative correlation between PON1 activity and MDA levels exists in patients with AMD. PON1 is also an antioxidant agent, therefore effective antioxidant therapy to inhibit lipid peroxidation is necessary and agents to increase PON1 activity may be a therapeutic option in AMD.

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Tài liệu tham khảo

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Ophthalmologica

Tập 220 Số 1

12-16

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