Serotonergic fibres degenerating in the aging rat brain or sprouting from grafted fetal neurons are not affected by the neurotrophic ACTH analogue Org 2766

Appel, 1981, A unifying hypothesis for the cause of amyotrophic lateral sclerosis, Parkinsonism and Alzheimer disease, Ann. Neurol., 10, 499, 10.1002/ana.410100602 Azmitia, 1987, A serotonin-hippocampal model indicates adult neurons survive transplantation and aged target tissue may be deficient in a soluble serotonergic growth factor, Ann. N.Y. Acad. Sci., 495, 362, 10.1111/j.1749-6632.1987.tb23687.x Azmitia, 1987, ACTH neuropeptide stimulation of serotonergic neuronal maturation in tissue culture: modulation by hippocampal cells, Prog. Brain Res., 72, 311, 10.1016/S0079-6123(08)60217-4 Azmitia, 1981, Fetal raphe and hippocampal transplants into adult and aged C57 BL/6N mice: a preliminary immunocytochemical study, Brain Res. Bull., 7, 703, 10.1016/0361-9230(81)90122-2 Azmitia, 1987, Target cell stimulation of dissociated serotonergic neurons in culture, Neuroscience, 20, 47, 10.1016/0306-4522(87)90005-4 Barde, 1989, Trophic factors and neuronal survival, Neuron, 2, 1525, 10.1016/0896-6273(89)90040-8 Bignami, 1980, Glial fibrillary acidic protein (GFA) in normal neural cells and in pathological conditions, Adv. Cell Neurobiol., 1, 285, 10.1016/B978-0-12-008301-5.50012-1 Bijlsma, 1983, Stimulation by ACTH-(4–10) of nerve fiber regeneration following sciatic nerve crush, Muscle and Nerve, 6, 104, 10.1002/mus.880060205 Björklund, 1985, Image analysis of GFA-positive astrocytes from adolescence to senescence, Exp. Brain Res., 58, 163, 10.1007/BF00238964 Butcher, 1989, Neurotrophic agents may exacerbate the pathologic cascade of Alzheimer's disease, Neurobiol. Aging, 10, 557, 10.1016/0197-4580(89)90130-9 Conover, 1976, On some alternative procedures using ranks for the analysis of experimental designs, Commun. Statist. Theor. Meth., A15, 1349, 10.1080/03610927608827447 Crutcher, 1990, Age-related decrease in sympathetic sprouting is primarily due to decreased target receptivity: implications for understanding brain aging, Neurobiol. Aging, 11, 175, 10.1016/0197-4580(90)90543-9 Daval, 1990, Influence of adrenocorticotropic hormone on the growth of isolated neurons in culture, Neurosci. Lett., 36, 299, 10.1016/0304-3940(83)90016-2 De Wied, 1982, Neuropeptides derived from pro-opiocortin: behavioral, psychological and neurochemical effects, Physiol. Rev., 62, 976, 10.1152/physrev.1982.62.3.976 Dekker, 1987, Acceleration of recovery from sciatic nerve damage by the ACTH(4–9) analog Org 2766: different routes of administration, Peptides, 8, 1057, 10.1016/0196-9781(87)90136-7 Edwards, 1984, Evidence that the neurotrophic actions of αMSH may derive its ability to mimic actions of a peptide formed in degenerating nerve stumps, J. Neurol. Sci., 64, 333, 10.1016/0022-510X(84)90181-3 Fekete, 1982, Potency and duration of action of the ACTH 4–9 analog (ORG 2766) as compared to ACTH 4–10 and [D-Phe7]ACTH 4–10 on active and passive avoidance behavior of rats, Pharmacol. Biochem. Behav., 16, 387, 10.1016/0091-3057(82)90439-7 Fischer, 1987, Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor, Nature, 329, 65, 10.1038/329065a0 Gage, 1984, Denervation releases a neuronal survival factor in adult rat hippocampus, Nature, 308, 637, 10.1038/308637a0 Hagg, 1990, Nerve growth factor infusion into the denervated adult rat hippocampal formation promotes its cholinergic reinnervation, J. Neurosci., 10, 3087, 10.1523/JNEUROSCI.10-09-03087.1990 Hajós, 1989, Distribution of glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in the rat brain. II. Mesencephalon, rhombencepalon and spinal cord, Exp. Brain Res., 78, 164, 10.1007/BF00230695 Hannigan, 1985, The effect of Org 2766 on the performance of sham, neocortical, and hippocampal-lesioned rats in a food search task, Pharmacol. Biochem. Behav., 23, 1019, 10.1016/0091-3057(85)90109-1 Hefti, 1986, Cellular and molecular aspects of neural development and regeneration, Neurobiol. Aging, 8, 377, 10.1016/0197-4580(87)90086-8 Hefti, 1986, Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections, J. Neurosci., 6, 2155, 10.1523/JNEUROSCI.06-08-02155.1986 Hefti, 1989, Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases, Neurobiol. Aging, 10, 515, 10.1016/0197-4580(89)90118-8 Isaacson, 1983, An ACHT4–9 analog (ORG 2766) speeds recovery from septal hyperemotionality in the rat, Behav. Neural. Biol., 39, 52, 10.1016/S0163-1047(83)90620-9 Lander, 1987, Molecules that make axons grow, Molec. Neurobiol., 1, 213, 10.1007/BF02936609 Landfield, 1987, Modulation of brain aging correlates by long-term alterations of adrenal steroids and neurally-active peptides, Vol. 72, 279 Landfield, 1981, Brain aging correlates: retardation by hormonalpharmacological treatment, Science, 214, 581, 10.1126/science.6270791 Landfield, 1981, Hippocampal aging in rats: a morphometric study of multiple variables in semithin sections, Neurobiol. Aging, 2, 265, 10.1016/0197-4580(81)90034-8 Lärkfors, 1987, Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain, Molec. Brain Res., 3, 55, 10.1016/0169-328X(87)90044-1 Montero, 1988, Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment, J. Neurosci., 8, 2986, 10.1523/JNEUROSCI.08-08-02986.1988 Needels, 1985, Neuronotrophic activity for cilliary ganglion neurons, Dev. Brain Res., 18, 275, 10.1016/0165-3806(85)90271-8 Nieto-Sampedro, 1982, Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site, Science, 217, 860, 10.1126/science.7100931 Nyakas, 1985, Beneficial effects of chronic treatment with ORG 2766 and α-MSH on impaired reversal learning with rats with bilateral lesions of the parafascicular area, Brain Res. Bull., 15, 257, 10.1016/0361-9230(85)90148-0 Ojika, 1984, Neurotrophic effects of hippocampal extracts on medial septal neurons in vitro, 81, 2567 Otto, 1989, Basic fibroblast growth factor and nerve growth factor administered in gel foam rescue medial septal neurons after fimbria fornix transsection, J. Neurosci. Res., 22, 83, 10.1002/jnr.490220111 Reul, 1988, Neurotrophic ACTH analogue promotes plasticity of corticosteroid receptor subtype in brain of senescent male rats, Neurobiol. Aging, 9, 1, 10.1016/S0197-4580(88)80062-9 Rigter, 1984, Spatial learning and the hippocampal corticosterone receptor system of old rats: effect of the ACTH4–9 analogue ORG 2766, Brain Res., 309, 393, 10.1016/0006-8993(84)90612-7 Scheff, 1980, Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal, Brain Res., 199, 21, 10.1016/0006-8993(80)90227-9 Scheff, 1978, Decrease in adrenergic axon sprouting in the senescent rat, Science, 202, 775, 10.1126/science.715443 Seiger, 1985, Preparation of immature central nervous system regions for transplantations, 71 Shehab, 1990, Preferential histochemical staining of protoplasmic and fibrous astrocytes in rat CNS with GFAP antibodies using different fixatives, Brain Res., 518, 347, 10.1016/0006-8993(90)90996-O Shimura, 1991, Brain transfer of a new neuromodulating ACTH analog, Ebiratide, in rats, Peptides, 12, 509, 10.1016/0196-9781(91)90093-5 Snider, 1989, Neurotrophic molecules, Ann. Neurol., 26, 489, 10.1002/ana.410260402 Spruijt, 1990, ORG2766 improves performance of rats with unilateral lesions in the fimbria fornix in a spatial learning task, Brain Res., 527, 192, 10.1016/0006-8993(90)91137-6 Spruijt, 1986, Behavioural plasticity in aging rats: role of melanocortins, Mod. Trends Aging Res., 147, 495 Spruijt, 1990, Neuropeptides and brain aging, 353 Steinbusch, 1988, The serotonergic and dopaminergic system in the aged rat brain as studied by immunocytochemistry with antibodies to serotonin and dopamine. Preliminary observations, 193 Steinbusch, 1990, Aging and regenerative capacity of the rat serotonergic system. A morphological, neurochemical and behavioural analysis after transplantation of fetal raphe cells, 600, 384 Stephens, 1988, Age-related variations in plasticity of rat basal forebrain cholinergic neurons after cortical lesions, Brain Res., 448, 320, 10.1016/0006-8993(88)91270-X Strand, 1989, ACTH modulation of nerve development and regeneration, Progr. Neurobiol., 33, 45, 10.1016/0301-0082(89)90035-X Van der Neut, 1988, Trophic influences of alpha-MSH and ACTH4–10 on neuronal outgrowth in vitro, Peptides, 9, 1015, 10.1016/0196-9781(88)90082-4 Van Luijtelaar, 1988, Aberrant morphology of serotonergic fibers in the forebrain of the aged rat, Neurosci. Lett., 95, 93, 10.1016/0304-3940(88)90638-6 Van Luijtelaar, 1989, Similarities between aberrant serotonergic fibers in the aged and 5,7-DHT denervated young adult rat brain, Exp. Brain Res., 78, 81, 10.1007/BF00230689 Van Luijtelaar, 1991, Morphological, neurochemical and behavioral studies following grafting of fetal serotonergic raphe cells into the denervated rat hippocampus, Neuroscience, 42, 365, 10.1016/0306-4522(91)90381-W Van Luijtelaar, 1992, Aging of the serotonergic system in the rat forebrain: an immunocytochemical and neurochemical study, Neurobiol. Aging, 13, 201, 10.1016/0197-4580(92)90032-S Whittemore, 1985, Neuronotrophic factors for mammalian brain neurons: injury induction in neonatal, adult and aged rat brain, Dev. Brain Res., 20, 169, 10.1016/0165-3806(85)90102-6 Will, 1985, Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions, Behav. Brain Res., 17, 17, 10.1016/0166-4328(85)90004-X Wolterink, 1990, Functional recovery after destruction of dopamine systems in the nucleus accumbens of the rat. III. Further analysis of the facilitating effect of the ACTH(4–9) analog ORG 2766, Brain Res., 507, 109, 10.1016/0006-8993(90)90528-J Wolterink, 1990, Functional recovery after destruction of dopamine systems in the nucleus accumbens of the rat. II. Facilitation by the ACTH(4–9) analog ORG 2766, Brain Res., 507, 101, 10.1016/0006-8993(90)90527-I Zhou, 1987, Denervation of serotonergic fibers in the hippocampus induced a trophic factor which enhances maturation of transplanted serotonergic but not noradrenergic neurons, J. Neurosci. Res., 17, 235, 10.1002/jnr.490170306