Serotonergic dysfunction: Brain imaging and behavioral correlates

Springer Science and Business Media LLC - Tập 6 - Trang 53-61 - 2006
Jana Wrase1, Matthias Reimold2, Imke Puls1, Thorsten Kienast1, Andreas Heinz1
1Klinik für Psychiatrie und Psychotherapie, Charité Universitätsmedizin Berlin, CCM, Berlin, Germany
2University of Tübingen, Tübingen, Germany

Tóm tắt

Identification of gene-environment and gene-gene interactions has become increasingly important in understanding psychiatric disorders. Dysfunction of central serotonergic neurotransmission has been implicated in alcoholism, depression, and anxiety. We review the literature on nonhuman primates that assesses the interaction between the genetic constitution of the regulatory region of the serotonin transporter (5-HTT) and environmental factors. Prospective studies in nonhuman primates that underwent social stress found a reduction of the serotonin turnover rate among carriers of one or two short alleles in a functional polymorphism of the 5-HTT promoter. In these primates, brain imaging studies showed a relative increase in the availability of raphe serotonin transporters. A low serotonin turnover rate and a high availability of serotonin transporters were associated with reduced response to excessive alcohol intake, anxiety, and impulsive aggression. Animal experiments point to a relationship between serotonergic dysfunction, negative mood states, and excessive alcohol intake, which may in part be mediated by reduced alcohol-induced sedation.

Tài liệu tham khảo

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