Serious bacterial infections in young children with fever without source after discharge from emergency department: A National Health Insurance database cohort study

Simon, 2013, National trends in emergency department use of urinalysis, complete blood count, and blood culture for fever without a source among children aged 2 to 24 months in the pneumococcal conjugate vaccine 7 era, Pediatr Emerg Care, 29, 560, 10.1097/PEC.0b013e31828e56e1 Baraff, 2000, Management of fever without source in infants and children, Ann Emerg Med, 36, 602, 10.1067/mem.2000.110820 Shapiro, 1986, Risk factors for development of bacterial meningitis among children with occult bacteremia, J Pediatr, 109, 15, 10.1016/S0022-3476(86)80564-9 Baraff, 1993, Effect of antibiotic therapy and etiologic microorganism on the risk of bacterial meningitis in children with occult bacteremia, Pediatrics, 92, 140, 10.1542/peds.92.1.140 Van den Bruel, 2005, Signs and symptoms in children with a serious infection: a qualitative study, BMC Fam Pract, 6, 36, 10.1186/1471-2296-6-36 Bleeker, 2001, Predicting serious bacterial infection in young children with fever without apparent source, Acta Paediatr, 90, 1226, 10.1111/j.1651-2227.2001.tb01566.x Baraff, 2008, Management of infants and young children with fever without source, Pediatr Ann, 37, 673 Lu, 2019, Successful control of streptococcus pneumoniae 19A replacement with a catch-up primary vaccination program in Taiwan, Clin Infect Dis, 69, 1581, 10.1093/cid/ciy1127 Bachur, 2001, Predictive model for serious bacterial infections among infants younger than 3 months of age, Pediatrics, 108, 311, 10.1542/peds.108.2.311 Harper, 2004, Update on the management of the febrile infant, Clin Pediatr Emerg Med, 5, 5, 10.1016/j.cpem.2003.11.008 Craig, 2010, The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses, BMJ, 340, c1594, 10.1136/bmj.c1594 Arora, 2013, Evaluation of child with fever without source: review of literature and update, Pediatr Clin North Am, 60, 1049, 10.1016/j.pcl.2013.06.009 Kadish, 2000, Applying outpatient protocols in febrile infants 1-28 days of age: can the threshold be lowered?, Clin Pediatr (Phila), 39, 81, 10.1177/000992280003900202 Sur, 2007, Evaluating fever of unidentifiable source in young children, Am Fam Physician, 75, 1805 Bandyopadhyay, 2002, Risk of serious bacterial infection in children with fever without a source in the post-haemophilus influenzae era when antibiotics are reserved for culture-proven bacteremia, Arch Pediatr Adolesc Med, 156, 512, 10.1001/archpedi.156.5.512 Watt, 2010, Changing epidemiology of serious bacterial infections in febrile infants without localizing signs, PLoS One, 5, 10.1371/journal.pone.0012448 Su, 2016, Effectiveness of pneumococcal conjugate vaccines of different valences against invasive pneumococcal disease among children in Taiwan: a nationwide study, Pediatr Infect Dis J, 35, e124, 10.1097/INF.0000000000001054 Wei, 2015, Pneumococcal disease and use of pneumococcal vaccines in Taiwan, Clin Exp Vaccine Res, 4, 121, 10.7774/cevr.2015.4.2.121 Gangoiti, 2018, Prevalence of occult bacteremia in infants with very high fever without a source, Pediatr Infect Dis J, 37, e271, 10.1097/INF.0000000000001955 Chen, 2021, Severe bacterial infection in young infants with pyrexia admitted to the emergency department, Medicine (Baltimore), 100 Michelson, 2021, Height of fever and invasive bacterial infection, Arch Dis Child, 106, 594, 10.1136/archdischild-2019-318548 Berger, 1996, A predictive model to estimate the risk of serious bacterial infections in febrile infants, Eur J Pediatr, 155, 468, 10.1007/BF01955183 Bleeker, 2007, Validating and updating a prediction rule for serious bacterial infection in patients with fever without source, Acta Paediatr, 96, 100, 10.1111/j.1651-2227.2006.00033.x Goh, 2006, Predictors of serious bacterial infection in children aged 3 to 36 months with fever without source, Singapore Med J, 47, 276 Pantell, 2021, Evaluation and management of well-appearing febrile infants 8 to 60 days old, Pediatrics, 148, 10.1542/peds.2021-052228 Mintegi, 2009, Predictors of occult bacteremia in young febrile children in the era of heptavalent pneumococcal conjugated vaccine, Eur J Emerg Med, 16, 199, 10.1097/MEJ.0b013e32831cefc9 Waddle, 2009, Outcomes of febrile children without localising signs after pneumococcal conjugate vaccine, Arch Dis Child, 94, 144, 10.1136/adc.2007.130583 Wilkinson, 2009, Prevalence of occult bacteremia in children aged 3 to 36 months presenting to the emergency department with fever in the postpneumococcal conjugate vaccine era, Acad Emerg Med, 16, 220, 10.1111/j.1553-2712.2008.00328.x Herz, 2006, Changing epidemiology of outpatient bacteremia in 3- to 36-month-old children after the introduction of the heptavalent-conjugated pneumococcal vaccine, Pediatr Infect Dis J, 25, 293, 10.1097/01.inf.0000207485.39112.bf Hernandez-Bou, 2015, Occult bacteraemia is uncommon in febrile infants who appear well, and close clinical follow-up is more appropriate than blood tests, Acta Paediatr, 104, e76, 10.1111/apa.12852 Lee, 2001, Management of febrile children in the age of the conjugate pneumococcal vaccine: a cost-effectiveness analysis, Pediatrics, 108, 835, 10.1542/peds.108.4.835