Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12‐q13.1: Part 1

Wiley - Tập 54 Số 1 - Trang 36-43 - 1994
Ann E. Pulver1, Maria Karayiorgou2, Paula Wolyniec1, Virginia K. Lasseter1, Laura Kasch1, Gerald Nestadt1, Stylianos E. Antonarakis1, David Housman2, Haig H. Kazazian1, Deborah A. Meyers1, Jurg Ott3, Malgorzata Lamacz1, Kung‐Yee Liang1, John Hanfelt1, Gail Ullrich1, Nicola DeMarchi1, Ramu Elango2, Paul R. McHugh1, Lawrence Adler1, Marion Thomas1, William T. Carpenter4, Theo C. Manschreck5, Christopher T. Gordon6, Michelle L. Kimberland1, Robert Babb1, Jennifer M. Puck7, Barton Childs1
1Departments of Psychiatry, Pediatrics, and Biostatistics, The Johns Hopkins University School of Medicine, Baltimore
2Center for Cancer Research, The Massachusetts Institute of Technology, Cambridge, Massachusetts
3Department of Genetics and Development and Department of Psychiatry, Columbia University, New York, New York
4Department of Psychiatry, The University of Maryland
5Department of Psychiatry, Dartmouth College, Hanover, New Hampshire
6National Institute of Mental Health, Bethesda, Maryland
7Children's Hospital, Philadelphia, Pennsylvania

Tóm tắt

AbstractTo identify genes responsible for the susceptibility for schizophrenia, and to test the hypothesis that schizophrenia is etiologically heterogeneous, we have studied 39 multiplex families from a systematic sample of schizophrenic patients. Using a complex autosomal dominant model, which considers only those with a diagnosis of schizophrenia or schizoaffective disorder as affected, a random search of the genome for detection of linkage was undertaken. Pairwise linkage analyses suggest a potential linkage (LRH = 34.7 or maximum lod score = 1.54) for one region (22q12‐q13.1). Reanalyses, varying parameters in the dominant model, maximized the LRH at 660.7 (maximum lod score 2.82). This finding is of sufficient interest to warrant further investigation through collaborative studies. © 1994 Wiley‐Liss, Inc.

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Wiley

Tập 54 Số 1

36-43

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