Sequence analysis of the α-galactosidase MEL gene governing the efficient production of ethanol from raffinose-rich molasses in the yeast Lachancea thermotolerans

Andersen KE, Bjergegaard C, Møller P, Sørensen JC, Sørensen H (2005) Compositional variations for α-galactosides in different species of leguminosae, brassicaceae, and barley: a chemotaxonomic study based on chemometrics and high-performance capillary electrophoresis. J Agri Food Chem 53:5809–5817

Cliften PF, Fulton RS, Wilson RK, Johnston M (2006) After the duplication: gene loss and adaptation in Saccharomyces genomes. Genetics 172:863–872

Kilian S, Kritzinger S, Rycroft C, Gibson G, du Preez J (2002) The effects of the novel bifidogenic trisaccharide, neokestose, on the human colonic microbiota. World J Microbiol Biotechnol 18:637–644

Kurtzman CP (2003) Phylogenetic circumscription of Saccharomyces, Kluyveromyces and other members of the Saccharomycetaceae, and the proposal of the new genera Lachancea, Nakaseomyces, Naumovia, Vanderwaltozyma and Zygotorulaspora. FEMS Yeast Res 4:233–245

Liljeström PL (1985) The nucleotide sequence of the yeast MEL1 gene. Nucleic Acids Res 13:7257–7268

Liu YG, Whittier RF (1995) Thermal asymmetric interlaced PCR: automatable amplification and sequencing of insert end fragments from P1 and YAC clones for chromosome walking. Genomics 25:674–681

Martínez-Villaluenga C, Frías J, Vidal-Valverde C, Gómez R (2005) Raffinose family of oligosaccharides from lupin seeds as prebiotics: application in dairy products. J Food Prot 68:1246–1252

Matsuura-Endo C, Kobayashi A, Noda T, Takigawa S, Yamauchi H, Mori M (2004) Changes in sugar content and activity of vacuolar acid invertase during low-temperature storage of potato tubers from six Japanese cultivars. J Plant Res 117:131–137

Mikata K (1983) Descriptive catalogue of IFO yeast collection IV. IFO Res Commun 11:77–80

Nagura T, Hachimura S, Hashiguchi M, Ueda Y, Kanno T, Kikuchi H, Sayama K, Kaminogawa S (2002) Suppressive effect of dietary raffinose on T-helper 2 cell-mediated immunity. Br J Nutr 88:421–426

Naumova ES, Korshunova IV, Naumov GI (2003) Molecular analysis of α-galactosidase MEL genes from Saccharomyces sensu stricto. Mol Biol 37:699–706

Naumova ES, Serpova EV, Naumov GI (2005) Speciation in the yeast Lachancea thermotolerans: molecular genetic evidence. Dokl Biol Sci 405:469–471

Naumova ES, Turakainen H, Naumov GI, Korhola M (1996) Superfamily of α-galactosidase MEL genes of the Saccharomyces sensu stricto species complex. Mol Gen Genet 253:111–117

Naumov GI, Naumova ES, Korshunova IV, Jakobsen M (2002) Yeast comparative genetics: a new MEL15 α-galactosidase gene of Saccharomyces cerevisiae. Russ J Genet 38:1127–1132

Oda Y, Fujisawa T (2000) Nucleotide sequence of α-galactosidase MEL gene from Zygosaccharomyces mrakii. Curr Microbiol 41:220–222

Oda Y, Fujisawa T (2001) Intraspecific divergence of Saccharomyces kluyveri as revealed by the nucleotide sequences of 18S-28S rRNA spacer regions and α-galactosidase MEL genes. Biosci Biotechnol Biochem 65:164–166

Oda Y, Fukunaga M (1999) Isolation and characterization of MELt gene from Torulaspora delbrueckii IFO 1255. Yeast 15:1797–1801

Oda Y, Tonomura K (1996) α-Galactosidase from the yeast Torulaspora delbrueckii IFO 1255. J Appl Bacteriol 80:203–208

Oda Y, Yabuki M, Tonomura K, Fukunaga M (1997) A phylogenetic analysis of Saccharomyces species by the sequence of 18S-28S rRNA spacer regions. Yeast 13:1243–1250

Rønnow B, Olsson L, Nielsen J, Mikkelsen JD (1999) Derepression of galactose metabolism in melibiase producing bakers’ and distillers’ yeast. J Biotechnol 72:213–228

Sayama K, Kamada T, Oikawa S, Masuda T (1992) Production of raffinose: a new byproduct of the beet sugar industry. Zuckerindustrie 117:893–898

Tamura M, Kimura K, Yunoki K, Matsumoto O, Takakuwa N, Oda Y, Ohnishi M (2006) Simultaneous production of sphingolipids and ethanol by the yeast Kluyveromyces thermotolerans. Folia Microbiol 51:191–195

Turakainen H, Korhola M, Aho S (1991) Cloning, sequence and chromosomal location of a MEL gene from Saccharomyces carlsbergensis NCYC396. Gene 101:97–104

Turakainen H, Hankaanpää M, Korhola M, Aho S (1994a) Characterization of MEL genes in the genus Zygosaccharomyces. Yeast 10:733–745

Turakainen H, Kristo P, Korhola M (1994b) Consideration of the evolution of the Saccharomyces cerevisiae MEL gene family on the basis of the nucleotide sequences of the genes and their flanking regions. Yeast 10:1559–1568

Watanabe H, Sonoyama K, Watanabe J, Yamaguchi N, Kikuchi H, Nagura T, Aritsuka T, Fukumoto K, Kasai T (2004) Reduction of allergic airway eosinophilia by dietary raffinose in Brown Norway rats. Br J Nutr 92:247–255

Yoon SH, Mukerjea R, Robyt JF (2003) Specificity of yeast (Saccharomyces cerevisiae) in removing carbohydrates by fermentation. Carbohydr Res 338:1127–1132